期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202302227
关键词
allylsilanes; allylic substitution; enantioselectivity; Grignard reagents; N-heterocyclic carbenes
Access to enantioenriched tertiary and quaternary α-chiral allysilanes without any transition-metal catalyst is achieved by enantioselective allylic displacement. This process involves Lewis base activation of Grignard reagents using a bidentate chiral NHC ligand and shows high β-regio- and enantioselectivity, while being compatible with various silyl groups on the substrates.
Access to enantioenriched tertiary and quaternary a-chiral allysilanes without any transition-metal catalyst is reported. This was achieved by enantioselective allylic displacement of ?-silylated allylic bromides through Lewis base activation of Grignard reagents by a bidentate chiral NHC ligand. The process afforded both high ?-regio- and enantioselectivity and is compatible with a wide range of silyl groups on the substrates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据