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Editorial Material
Polymer Science
Robert T. Woodward et al.
EXPRESS POLYMER LETTERS
(2023)
Review
Medicine, Research & Experimental
Jie Yang et al.
Summary: Cancer remains a severe threat to human health. The marriage of nanomaterials and therapeutic methods, especially metal-organic frameworks (MOFs), provides a practical possibility to improve the deficiencies in cancer therapy. MOFs have been widely applied in cancer therapy to overcome the drawbacks of other therapeutic methods through their controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, and good biocompatibility.
Article
Chemistry, Multidisciplinary
Shanshan Zhang et al.
Summary: In this study, COF nanobowls were synthesized and utilized as activatable nanosensitizers with tumor-specific sonodynamic activity. The high crystallinity of the COF nanobowls enables efficient loading of the sonosensitizer and the in situ growth of manganese oxide inhibits non-specific damage to normal tissues. When reacting with tumor-overexpressed glutathione, the gatekeeper manganese oxide is decomposed to restore the ROS generation capability, leading to increased intracellular ROS stress and enhanced sonodynamic efficacy.
Article
Chemistry, Multidisciplinary
Yuze Wang et al.
Summary: A new cationic conjugated microporous polymers (CCMPs)-based coating with dual-modal antimicrobial inactivation is developed, showing efficient eradication of model microbes under solar illumination and in the absence of light. The CCMPs coatings demonstrate excellent durability, reusability, and antimicrobial stability in humid environment, making them promising for developing reusable and self-sterilizing antimicrobial fabrics.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Varun Sridhar et al.
Summary: Tailored micromachines enable therapeutic applications in biological environments, but require sophisticated designs for controlled motion and targeted drug delivery. Covalent organic frameworks (COFs) offer new perspectives for light-driven microswimmers in biological media, such as intraocular fluids, for applications like retinal drug delivery. Two types of COFs, spherical TABP-PDA-COF sub-micrometer particles and nanoporous TpAzo-COF micrometer particles, are described as efficient visible-light-driven drug carriers in aqueous ionic and cellular media, with biocompatibility and the ability to load insoluble drugs for on-demand release. ICG dye loading in the COF pores enables real-time imaging and heat therapy for therapeutic applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yege Jing et al.
Summary: Fully conjugated porous aromatic frameworks (PAFs) were synthesized through Gilch reaction. The obtained PAFs exhibited rigid conjugated backbones, high specific surface area, and excellent stability. They were successfully applied in perovskite solar cells (PSCs) as efficient nucleation templates, regulating perovskite crystallinity, passivating defects, and promoting carrier transport in the perovskite film. The PAF-doped unencapsulated devices showed outstanding long-term stability, retaining 80% of their initial efficiencies after six months of storage in ambient conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sainan Liu et al.
Summary: The special structural morphology of hollow covalent organic frameworks (HCOFs) has a significant impact on their applications. However, the precise control of morphology for HCOFs remains challenging. In this study, a two-step strategy based on solvent evaporation and oxidation of imine bond is presented, enabling the controllable synthesis of HCOFs. The oxidation of imine bond via hydroxyl radicals (.OH) generated from Fenton reaction results in the construction of seven kinds of HCOFs with diverse nanostructures, including bowl-like, yolk-shell, capsule-like, and flower-like morphologies. The obtained HCOFs, with their large cavities, are ideal candidates for drug delivery and have been successfully used for enhanced sonodynamic cancer therapy in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Yue-Dang Xia et al.
Summary: Highly conjugated 2D-COFs show aggregation-caused quenching but conducive to aggregation-induced emission luminogens (AIEgens) due to their viscous microenvironment. In this study, salicylaldehyde azine (SA) was formed for the first time through condensation between non-AIE monomers in a 2D azine COF (ACOF). A hollow ACOF (HACOF) with improved dispersibility and accessibility was achieved by growing the ACOF on a sacrificial template and digesting it under mild acidic conditions. The HACOF exhibited strong red emission, high quantum yield, and broad response range for sensing ammonia (NH3). The emission mechanism of HACOF was attributed to intramolecular hydrogen bonding, which could be quenched by NH3. This novel HACOF provides insights into structure-dependent emission and quenching mechanisms for functionalized AIE COFs.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yufeng Zhang et al.
Summary: We report a preprotection strategy using dynamic covalent chemistry of covalent organic frameworks (COFs) to encapsulate enzymes. This strategy allows for effective protection of enzymes during the synthesis process and results in high-performance immobilized biocatalysts with maintained biological activity and superior stability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Polymer Science
Weijie Zhang et al.
Summary: Heterogeneous photocatalysis is a versatile platform for efficient transformation systems. Conjugated microporous polymers (CMPs) have emerged as attractive semiconductor materials due to their synthetic versatility, stability, non-toxicity, organic properties, tunable structures, and visible-light absorbance. This review summarizes the latest advances in carbazolic CMPs, focusing on design strategies for tailor-made skeletons that directly impact their charge dynamics and photocatalytic performances, particularly for organic transformations. The review also identifies bottlenecks and future research directions in CMPs for photocatalysis.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Seokmin Kang et al.
Summary: Organic nanomaterials as nanocarrier platforms were successfully prepared in the form of two-dimensional covalent organic nanosheets (CONs), which can serve as efficient in vivo bioimaging probes. The CONs were obtained by condensing 1,3,5-triformylglucinol (Tp) and 2,7-diaminopyrene (Py) to produce covalent organic frameworks (COFs), followed by a liquid exfoliation process. The CONs dispersed well in water, exhibited favorable photoluminescence properties, and showed low cytotoxicity. In vivo fluorescence imaging studies using tumor-bearing mice confirmed the persistent and strong fluorescence signals in the tumor region after intravenous injection of the CONs dispersed in phosphate-buffered saline (PBS), with low background signals from normal tissues.
Article
Chemistry, Multidisciplinary
Yongqiang Shi et al.
Summary: Covalent organic frameworks (COFs) are crystalline organic porous materials with porosity, large surface area, and biocompatibility, making them excellent candidates for various applications. Recent research has shown that COFs have great potential for biomedical applications such as photodynamic therapy, gene delivery, photothermal therapy, drug delivery, bioimaging, biosensing, and combined therapies. This review covers the recent progress of COF materials in these applications and discusses the challenges and future perspectives for using COFs in biology-facing applications.
Review
Chemistry, Multidisciplinary
Yaping He et al.
Summary: Gene therapy shows promise in treating cancer, viral infection, and gene disorders, while genetic detection is crucial for disease diagnosis and prevention. However, the existing delivery vectors have limitations. Metal-organic frameworks (MOFs) have gained attention for their high surface areas and tunable structures. This review highlights the potential of MOFs as nonviral vectors in gene delivery and detection.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanhui Qin et al.
Summary: A multifunctional core-shell nanoparticle, OPCPT, was constructed by coating PEGylated COF on photothermal carbon nanospheres. The COF shell dissociates in the acidic tumor microenvironment, leading to tumor-specific photothermal therapy and enhanced apoptosis of cancer cells. This study reveals the potential of COF-based nanomaterials for extended biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Ying Zhang et al.
Summary: In this study, a ratiometric fluorescence covalent organic framework (TD-COF) was constructed for tracking-by-detection of Fe3+. The TD-COF exhibited dual emission, with a color change from yellow to red to black in the presence of Fe3+. The TD-COF showed a wide linear range and low detection limit for Fe3+ detection. A smartphone visual sensing platform integrated with TD-COF was developed and successfully applied to real-time monitoring of Fe3+ in tap water.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Yu Zhao et al.
Summary: The unique structural characteristics of three-dimensional (3D) covalent organic frameworks (COFs) make them promising platforms for various functional applications. In this study, we successfully designed and synthesized a 3D non-interpenetrated stp net COF named TUS-64 with the largest pore size and record-low density. TUS-64 exhibits high stability and a highly interconnected mesoporous structure, enabling efficient drug loading and controlled release in a simulated body fluid environment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Engineering, Biomedical
Nem Singh et al.
Summary: Nanomedicines based on nanoscale covalent organic frameworks (nCOFs) have potential in cancer therapy due to their unique properties and enhanced biocompatibility. This review summarizes the recent applications of nCOFs in various cancer treatments and highlights the modifications of nCOFs to improve their efficacy and clinical translation.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Environmental
Ziqi Zhao et al.
Summary: In this study, beta-ketoenamine-linked covalent organic frameworks (COFs) were successfully synthesized and showed unprecedented selectivity reversal towards 1-PE in the organic medium. TpBZ-COF with moderate pore size outperformed other analogues, and demonstrated strong adsorption affinity towards 1-PE as well as excellent stability in recycling experiments. The practical application potential and remarkable recyclability of TpBZ-COF were confirmed through dynamic breakthrough experiments.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Environmental
Qingsong Cheng et al.
Summary: This paper reviews the progress of chiral graphene materials for enantiomer separation, discussing their synthesis strategies, separation mechanism, and applications, as well as exploring related issues and future prospects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Shuangling Wang et al.
Summary: This study developed a multifunctional nanoplatform based on copper sulfide nanoparticles for synergistic photothermal therapy, chemotherapy, and chemodynamic therapy. The nanoplatform exhibited pH-dependent fluorescence behavior, mesoporous structure, and cancer-targeting efficiency, making it suitable for cancer cell imaging and drug delivery. The nanoplatform achieved a synergistic effect in PTT/chemotherapy/CDT and showed excellent therapeutic efficacy with negligible systemic toxicity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Biomaterials
Tong Li et al.
Summary: The emergence of nanocarriers has greatly improved the therapeutic efficacy of chemotherapeutic drugs. Covalent organic frameworks (COFs) have been increasingly used in biomedicine. However, existing COF nanocarriers hardly undergo in vivo degradation, which may pose potential safety hazards.
BIOMATERIALS SCIENCE
(2023)
Article
Medicine, Research & Experimental
Sam Benson et al.
Summary: Bacterial infections pose significant challenges to human health, leading to high antibiotic usage, morbidity, hospitalizations, and approximately 8 million deaths worldwide annually. The overuse of antibiotics and lack of antimicrobial innovations have resulted in antimicrobial resistant pathogens that may reverse the progress of modern medicine. Photodynamic therapeutics have the potential to kill bacteria, but there are limited agents that can target pathogens effectively with minimal off-target effects.
Review
Medicine, Research & Experimental
Deyana Nasri et al.
Summary: Hypoxia leads to the expression of signaling molecules that regulate cell division, promote angiogenesis, increase resistance to chemotherapy and radiotherapy, and induce metastasis in the tumor microenvironment. Photoacoustic imaging (PAI) utilizes the unique absorption characteristics of chromophores in tissues to construct high-resolution images. This review discusses the physiological characteristics of tumor hypoxia and the current applications of PAI using both label-free and exogenous contrast agents. It analyzes the efficacy of various methods in determining physiological and proteomic phenomena. The review demonstrates that PAI has the potential to understand tumor growth and metastasis development by measuring regulatory molecule concentrations, oxygen gradients, and vascular distribution.
Article
Electrochemistry
Xueli Li et al.
Summary: Covalent organic polymers (COPs) are a unique class of luminescent polymers with pre-designed quasi-ordered architectures. However, their layered stacks and limited solubility have hindered their large-scale application in devices. This study proposes a universal strategy to adjust the electron donor-acceptor (D-A) moieties of the building blocks in COPs, achieved by in situ charge exfoliation of COP blocks into few-layer true solutions. The resulting soluble COPs can be easily processed into uniform films and show potential for efficient and stable perovskite electroluminescence on indium tin oxide.
Article
Nanoscience & Nanotechnology
Yucheng Zou et al.
Summary: Covalent organic frameworks (COFs) have emerged as promising drug carriers in biomedical applications, but their potential in wound healing has not been extensively studied. In this study, a curcumin-loaded COF was prepared and incorporated into polycaprolactone nanofibrous membranes to develop a pH-triggered drug release platform for wound dressing. The CUR@COF-based membranes exhibited excellent properties and promoted wound healing and skin regeneration by reducing inflammation and enhancing angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Hao Zhao et al.
Summary: A discretely integrated nanofabrication (DIN) platform has been developed to optimize phototherapy efficacy and enhance antitumor immunity.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of multienzyme-mimicking covalent organic frameworks (COFs) have been engineered to induce pyroptosis and remodel the tumor microenvironment, boosting cancer immunotherapy.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Congyong Wang et al.
Summary: This review summarizes recent research advances in 2D COFs, focusing on the preparation of 2D COF powders, single crystals, and thin films, as well as their advanced optical, electrical, and magnetic functionalities. Challenging issues and potential research outlook for 2D COFs in terms of structure, synthesis, and functionalities are also discussed.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Changxia Li et al.
Summary: In this work, a set of covalent organic framework (COF)-derived Ni-N-C catalysts were prepared and the Ni-N-x content was adjusted. The existence of single-site Ni-N motifs was confirmed by microscopy and X-ray techniques, and the relationship between active site density and turnover frequency was discussed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Tian Sun et al.
Summary: This study successfully demonstrated a rapid synthetic method for crystalline CTFs and revealed their polymerization mechanism. Photocatalytic studies with CTFs of different crystallinity showed that large crystalline domains can significantly enhance catalytic performance. Moreover, single-layer and few-layer crystalline 2D triazine polymer nanosheets can be obtained through simple ball-milling exfoliation, leading to nearly fivefold improvement in photocatalytic hydrogen evolution rate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ya-Qian Lan et al.
Summary: Researchers have successfully prepared a series of highly sensitive and specific COF 2D nanomaterials for room-temperature NO2 sensing. By designing H-2-TPCOF with modifiable sites on its surfaces and post-metallization, remarkable improvements in sensing performance were achieved. Among them, Co-TPCOF exhibited the highest sensitivity and ultra-low limit-of-detection, with fast response and recovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Johannes Karges
Summary: Research has shown that photodynamic therapy is gaining increasing attention in the treatment of cancer. However, currently available photosensitizers have numerous limitations such as poor solubility and stability. Therefore, researchers have started focusing on incorporating metal ions to overcome these issues.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Engineering, Environmental
Xin Wang et al.
Summary: Synthesizing N-doped carbon via high-temperature treatment often leads to random distribution of nitrogen atoms, hindering mechanism study and controllable synthesis of high-performance electrode materials. HAT-based polymers (HATPs) are gaining attention for energy-related applications due to their defined structure and controllable components. Progress has been made in developing cost-efficient HATPs catalysts/electrodes for renewable energy technologies, with emphasis on in-situ characterizations for revealing interactions between intermediates and active sites.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Minghui Wang et al.
Summary: The outbreak of COVID-19 has emphasized the importance of new diagnostic technologies. This research introduces a novel COF capsule design for naked-eye detection of SARS-CoV-2 RNA, demonstrating exceptional analytical performance and promising applications.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Nana Sun et al.
Summary: The incorporation of molecular switches with light, heat, and electricity responsibility into artificial solids has proven to be a successful strategy in constructing stimuli-responsive functional materials. However, the precise manipulation of molecular geometries and electronic structures to control the properties of macroscopic materials remains a fundamental challenge. In this study, a photoresponsive covalent organic framework (o-COF) with a square lattice was fabricated, showing reversible photoisomerization upon UV irradiation. Spectroscopic investigations and theoretical simulations revealed different photocatalytic activities in two COFs due to distinct energy transfer pathways, which could be easily tuned in a reversible manner by adjusting the ring-closed/open form of dithienylethene units using UV and visible light.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Lei Xing et al.
Summary: This study explores the application of two-dimensional covalent organic frameworks (2D COFs) in single molecule DNA analysis. The results show that COF nanopores exhibit high selectivity for fluorescent dyes and DNA molecules, suggesting potential applications.
Review
Chemistry, Multidisciplinary
Jianxin Ma et al.
Summary: Luminescent covalent organic frameworks (LCOFs) have garnered significant attention for their tunable structures and photophysical properties at the molecular level. They offer advantages such as predesigned structure properties, unique photoluminescence, low toxicity, good biocompatibility, and tumor penetration, expanding their applications in biosensing and bioimaging. The key role of chemical linkages in the synthetic chemistry of LCOFs affects their optical properties and potential sensing applications, while structure management determines their brightness and potential applications in biosensing and bioimaging. Challenges and opportunities in LCOFs development are discussed in terms of their current progress in chemistry, physics, and applications.
Article
Engineering, Biomedical
Dong Liang et al.
Summary: In this study, a fluorescent signal amplified miRNA biosensor was constructed using dispersed magnetic covalent organic framework nanospheres (MCOF) as cores and high-crystalline COF as shells. The biosensor showed sensitive detection of miRNA-182 in different matrixes and could quantify miRNA-182 in serum of glioma patients, suggesting its potential application in sensitive detection and accurate diagnosis/prognosis of glioma.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A novel porphyrin-based staggered stacking covalent organic framework, COF-618-Cu, is designed to overcome the photobleaching and aggregation-caused quench defects of photosensitizers and the intrinsic antioxidant tumor microenvironment. COF-618-Cu exhibits excellent catalase-like activity and glutathione peroxidase mimic activity, which can alleviate tumor hypoxia by consuming hydrogen peroxide and decrease ROS scavenging by depleting intracellular glutathione. The unique staggered stacking mode of COF-618-Cu effectively relieves both photobleaching and aggregation-caused quench effects. Additionally, COF-618-Cu shows great potential for inducing immunogenic cell death and remodeling the tumor microenvironment to boost antitumor immunity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hao Zhang et al.
Summary: An electrochemical sensor based on carboxylatopillar[5]arene-coated nitrogen-doped carbon dots has been developed for sensitive detection of the pesticide paraquat. The sensor exhibits excellent anti-interference capability, selectivity, stability, and reproducibility, and has a lower cost and simpler preparation processes compared to other electrochemical sensors.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Jianyang Lu et al.
Summary: In this study, we proposed a functionalization strategy for covalent organic frameworks (COFs) using DNA. The DNA-functionalized COFs exhibited good hybridization ability and cargo loading ability. Based on this, an electrochemical biosensor for the detection of exosomes was developed. The functionalized COFs enabled the recognition and capture of exosomes, while the encapsulation of methylene blue in the COFs enhanced the sensitivity of the biosensor.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Siyun Zhang et al.
Summary: By in situ synthesizing a L-tyrosine functionalized covalent organic framework (L-Tyr-COF), the pore size of nanochannels can be reduced to match with naproxen enantiomers (S/R-NPX) and improve enantioselective gating. The L-Tyr-COF packed nanochannels exhibited high enantioselectivity for S-NPX and achieved enantioseparation with high selectivity and flux.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Chunyan Xing et al.
Summary: In this study, covalent organic frameworks (COFs) were used as a platform for enzyme encapsulation. By optimizing the covalent interactions, the stability and activity of immobilized cytochrome c (Cyt c) were significantly enhanced. Covalent bonding induced conformational perturbation, making the active sites more accessible.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Shimei Li et al.
Summary: This study proposes an integrated strategy derived from MOF@COF for remarkably augmenting single MWTT to reduce tumor recurrence.
Article
Chemistry, Multidisciplinary
Zhenjie Mu et al.
Summary: In this study, a series of COFs with different pore apertures were successfully constructed using designed building blocks, demonstrating their potential applications in enzyme separation and protection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Zhenyan Zhang et al.
Summary: The study analyzes 4572 metagenomic samples to illustrate the global patterns of antibiotic resistance gene (ARG) distribution in diverse habitats. They quantitatively evaluate the health risk to humans of 2561 ARGs by integrating human accessibility, mobility, pathogenicity, and clinical availability. With machine learning, they map the antibiotic resistance threats in global marine habitats with over 75% accuracy.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zhuojun Yan et al.
Summary: A carbazole-based porous aromatic framework (PAF) has been successfully synthesized and deposited on fabric surface, demonstrating high superhydrophobicity and separation efficiency even under extreme conditions. This research represents an important advancement in the field of superhydrophobic applications.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xuxiao Liu et al.
Summary: Covalent organic frameworks (COFs) with porphyrins as structural units are a new type of porous organic polymers that exhibit regular structure, abundant porosity, and good stability. A new COF structure, TA-Por-sp(2)-COF, was constructed by linking porphyrin with the triazine ring through the self-polymerization of a cyano group-terminated porphyrin. The resulting highly ordered two-dimensional topological structure exhibited high photocatalytic performance in organic reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Gui-Ping Yang et al.
Summary: A covalent organic framework called TAPP-BDP with a conjugated donor-acceptor structure has been developed for efficient photoinduced bacteriostasis. It demonstrates triple and synergistic bacterial inhibition through integration of photodynamic, photothermal, and peroxidase-like enzymatic activities under irradiation with near-infrared light. TAPP-BDP exhibits excellent antibacterial efficiency against both Gram-negative and Gram-positive bacteria.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Hong-Kai Li et al.
Summary: The development of covalent organic framework nanosheet (COF NS) is an important research field due to its high permeability, ordered structure, high utilization of functional site, favourable dispersability, and large aspect ratio. In this study, Tp-Bpy COF NS was fabricated and used as a functional material for constructing an electrochemical aptasensor, showing enhanced biosensing performance for tobramycin detection.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Yana Chen et al.
Summary: In this study, a signal on-off ratiometric electrochemical immunosensor was developed for ultrasensitive detection of A beta oligomer, which serves as a reliable biomarker for early diagnosis of Alzheimer's disease. The sandwich-like electrochemical immunosensor exhibited high sensitivity and low detection limit, and was able to determine the content of A beta oligomer in real cerebrospinal fluid samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yunlong Zheng et al.
Summary: Enzyme immobilization is crucial for large-scale biocatalytic processes. This study presents a green and scalable approach to prepare high-performance biocatalysts through the assembly of enzymes with covalent organic frameworks. These biocatalysts have exceptional reusability and stability, making them efficient catalysts for important industrial reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biophysics
Yongchun Pan et al.
Summary: This study develops a CRISPR/aptamer-based sensor, sheltered by a hollow COF, for ATP imaging in living animals. This strategy not only expands the applications of the CRISPR-Cas system, but also provides potential for the use of other proteins in clinical diagnostics, medical research, and biomimetic nanodevices.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Hao Chen et al.
Summary: Traditional photothermal therapy is limited by high-temperature tolerance and weak immune responses. This study successfully synthesized PdHs nanoparticles with dendritic urchin structures and demonstrated their potential for photothermal immunotherapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Shuo Wang et al.
Summary: This study presents a carrier-free nanoplatform that can be used for deep tumor-penetrating photo-immunotherapy. The nanoparticles demonstrate prolonged blood circulation and can penetrate into the core sites of tumors. The research provides a prospective intelligent nanodelivery system that holds promise for efficient and low side-effect immunotherapy against primary and distal tumors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Meng-Hao Li et al.
Summary: Covalent organic frameworks (COFs) are emerging porous materials with tailor-made functionalities for improved photocatalytic activity. This study reports a covalent hybridization approach of integrating rigid macrocyclic struts (pillararenes) into the extended network of COFs, leading to enhanced photochemical performance. It provides a new strategy for constructing macrocycle-derived COFs and demonstrates their potential in efficient catalytic reactions.
CHEMISTRY OF MATERIALS
(2022)
Article
Engineering, Environmental
Hongxu Zhang et al.
Summary: In this study, an antibacterial 2D covalent organic framework was synthesized and used as a carrier for uniform dispersion of silver nanoparticles (AgNPs), forming nanocomposites with excellent antibacterial properties. The nanocomposites showed stability and low cytotoxicity to erythrocytes when dispersed in water. The minimum inhibitory concentrations of the nanocomposites for E. coli and S. aureus were determined, and it was confirmed that the main mechanism of sterilization was the destruction of bacterial cell walls.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Minghui Wang et al.
Summary: This study presents an electrochemical biosensor based on 2D COF NSs and CRISPR Cas 12a for the detection of PD-L1(+) exosomes. The sensor shows high sensitivity and a wide linear range, and can be used for clinical diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Debabrata Dutta et al.
Summary: This study presents the use of covalent organic framework (COF) nanoparticles loaded with the near-infrared (NIR) dye cypate for oxygen-independent generation of singlet oxygen (O-1(2)), allowing for concurrent photothermal therapy (PTT) and photodynamic therapy (PDT) under NIR irradiation. The COF nanoparticles protect cypate from photodegradation and improve its photostability and photothermal conversion efficiency. Upon NIR irradiation, the COF nanoparticles release the stored O-1(2) and induce ablation of tumors through oxygen-independent concurrent PTT/PDT.
Article
Chemistry, Multidisciplinary
Baohong Sun et al.
Summary: This study reports a versatile integrated nanoagent for comprehensive treatment of diabetic wounds. The nanoagent effectively scavenges reactive oxygen species, induces anti-inflammatory response, and exhibits bactericidal capabilities. In vivo experiments demonstrate that the nanoagent can accelerate the healing of infected diabetic wounds with better therapeutic benefits than monotherapy or individual antibiotics.
Review
Nanoscience & Nanotechnology
Arindam Mal et al.
Summary: Covalent organic frameworks (COFs) are functional nanoporous materials with potential applications in biomedical research, such as drug delivery, bioimaging, phototherapy, and antibacterial properties, due to their robust covalent connectivity and chromophoric networks.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xinye Wang et al.
Summary: In this study, we developed a thiol-targeting nanoinhibitor based on an enzyme-responsive covalent organic framework, which was co-loaded with silver nanoparticles and ebselen, to achieve synergistic antibacterial effects. The nanoinhibitor showed excellent bactericidal performance for both Gram-positive and Gram-negative bacteria in vitro, and exhibited low toxicity to normal cells. Additionally, it demonstrated favorable biocompatibility, anti-inflammatory properties, and effective wound healing abilities in mice.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Saikat Das et al.
Summary: Three-dimensional covalent organic frameworks (COFs) are a new type of crystalline solids with intriguing structures and porosity. Synthesizing 3D COFs from pre-designed building units remains challenging due to the lack of suitable units and reversible linkages. In this study, a new 3D COF, TUS-84, was reported by linking a tetragonal prism node with a square planar node, exhibiting a two-fold interpenetrated structure, well-defined porosity, and high surface area. TUS-84 also demonstrated efficient drug loading and sustained release profile in drug delivery applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zhixiang Lu et al.
Summary: This study presents the synthesis of a covalent organic framework with sonosensitive properties for the efficient loading of MnO2 and Poly(I:C). The developed nanomaterial is capable of reversing the reductive tumor microenvironment, generating magnetic resonance imaging signals, promoting reactive oxygen species production, inducing immunogenic cell death, and boosting the immune response. This multifunctional nanosystem represents a promising strategy for cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Dianwei Wang et al.
Summary: A covalent organic framework (COF) sonosensitizer is developed using a new nanoscale COF preparation strategy, which improves the therapeutic effect of sonodynamic therapy (SDT). The COF structure prevents aggregation of the sonosensitizer molecules and enhances their chemical stability. Additionally, the coordination of Fe3+ to COF enables chemodynamic therapy performance and glutathione consumption ability. The combination of enhanced SDT and alpha-PD-L1 antibody achieves effective antitumor effects.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Peng Gao et al.
Summary: This study developed COF-DNA bicolor probes for simultaneous imaging of tumor-associated mRNAs and found that the nanoprobe prepared by the freezing method exhibited better performance with higher signal-to-noise ratio and signal intensity. It offers a promising tool for improved cancer diagnostic imaging.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zheyuan Guo et al.
Summary: Covalent organic framework (COF) membranes hold great promise for molecular separations due to their tunable ordered channels and free organic groups. This study develops a defect engineering strategy to fabricate efficient COF membranes for CO2 separation. The presence of abundant amino groups and ordered channels in the COF membranes enables high CO2 permeances and excellent separation selectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Environmental
Minghua Wang et al.
Summary: A novel bifunctional sensing strategy based on a porphyrin-based covalent-organic framework (p-COF) was developed for the sensitive and selective determination of nitrogen oxide (NO) released from cancer cells. The sensor exhibited low detection limits, high selectivity, excellent stability, and reproducibility, making it suitable for early diagnosis of cancer.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Haixin Chen et al.
Summary: This study presents a method using high-performance covalent organic frameworks (COFs) as crystalline sponges to directly extract and produce highly pure and active enzymes from complex biological systems. The COFs show high uptake and selectivity attributed to their well-tuned pore microenvironment, and the encapsulated enzymes can be conveniently released through pH adjustment. Compared to conventional separation media, COFs sponges demonstrate superior selectivity, efficiency, and reusability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Engineering, Environmental
Shimei Li et al.
Summary: In this article, we provide a detailed review of covalent organic frameworks (COFs) as an emerging class of crystal materials with unique properties. We summarize the different types of chemical linkages used in the formation of COFs and classify them. The biomedical applications of COFs, such as cargo carriers, cancer therapy, biosensing, and biocatalysis, are outlined. The prospects and challenges for further expanding the application value of COFs are also discussed.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Limin Zheng et al.
Summary: Nanozymes, a type of catalytic nanomaterials with enzymatic properties, have gained significant interest in recent years due to their stability and cost-effectiveness. Metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs) as emerging organic framework materials have attracted attention for their high surface area and flexible nano-scale porosity, which can be designed to mimic ideal enzyme activities. This review introduces MOFs-based and COFs-based nanozymes, discusses their construction and composition, summarizes their applications in sensing and therapy, and briefly discusses the current development status, challenges, and future prospects of MOFs and COFs-based nanozymes to promote wider applications.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Mingming Zhang et al.
Summary: Atomically dispersed metal catalysts have become a new research frontier in heterogeneous catalysis. Covalent organic frameworks show great potential for confining these catalysts, offering predictable structure and adjustable pores.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Jiarong Liang et al.
Summary: The covalent organic framework@carbon dot (COF@CD) composite was successfully constructed, exhibiting high-flux charge transfer and efficient photocatalytic activity for antibacterial photocatalytic therapy. By establishing intramolecular charge transfer between donor-acceptor semiconductors and polymers with hydrogen-bonding groups, a charge transfer channel was created using a D-A COF semiconductor and hydrophilic CDs. The introduction of CDs greatly enhanced the charge separation efficiency and resulted in the generation of more reactive oxygen species. COF@CDs showed significant photocatalytic antibacterial activity, with a sterilization efficiency of over 95% in 1 hour under visible light irradiation.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Review
Pharmacology & Pharmacy
Xinyue Wang et al.
Summary: With the development of the biotherapeutic field, biomacromolecules with definite curative effects and small side effects have become a hot topic in the research and development of new drugs. However, there are technical difficulties in using biomacromolecules as drug candidates, mainly related to drug stability and in vivo transport and delivery. To address these challenges, diverse nanodrug delivery systems have been used to deliver biomacromolecules, offering improved stability, bioavailability, and targeted distribution.
ADVANCED THERAPEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Hean Zhang et al.
Summary: In this work, ultrasmall gold nanoclusters (AuNCs) were synthesized in situ in the nanopores of covalent organic framework (COF) nanoparticles, resulting in enhanced fluorescence, improved photosensitizing capabilities, and promising antibacterial performance. The incorporation of AuNCs into COFs led to efficient electron transfer and increased separation of photogenerated electron-hole pairs, significantly enhancing the light-triggered reactive oxygen species (ROS) production of COFs. The resulting nanocomposites exhibited efficient photodynamic killing on Escherichia coli under visible light exposure. This study provides a facile strategy for the preparation of COF/AuNC nanocomposites for ROS-related applications.
ACS APPLIED BIO MATERIALS
(2022)
Article
Medicine, Research & Experimental
Bingshuai Zhou et al.
Summary: This study developed a near-infrared strategy for antibacterial photodynamic therapy using a nanoplatform that can simultaneously generate oxygen and carbon monoxide. The nanoplatform exhibited effective antibacterial and anti-inflammatory effects in vitro and in vivo.
Article
Materials Science, Biomaterials
Yiying Zhang et al.
Summary: The study found that boron-based COFs can produce various reactive oxygen species (ROS) under visible light irradiation, leading to bactericidal effects. This study provides a new idea for the application of boron-based COFs as multifunctional photocatalysts.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Jie Yang et al.
Summary: By utilizing water-soluble macrocyclic hosts like CLT6 and CBpP6, this study successfully loaded the chemotherapy drug oxaliplatin, and achieved drug release through competitive binding, leading to enhanced cytotoxicity in cancer cells while reducing toxicity in normal cells, offering a new approach to reduce side effects of anticancer drugs.
CHINESE CHEMICAL LETTERS
(2021)
Article
Nanoscience & Nanotechnology
Guorong Li et al.
Summary: The use of two-dimensional covalent organic frameworks (COFs) in the development of organic artificial enzymes has shown promising potential due to their superior properties. A donor-acceptor 2D COF exhibited high enzymatic catalytic activity, thus serving as a robust colorimetric probe for cheap, highly sensitive, and rapid detection of glutathione.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Sainan Liu et al.
Summary: In this research, a cubic porphyrin-based COF named CTP with excellent hydrophilicity was prepared for the first time using a simple method. By linking the porphyrin monomer into the COF, solubility and biocompatibility issues were overcome, and the band gap was narrowed. The resulting CTP showed enhanced sonodynamic effect and photothermal conversion under external irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Yilin Wan et al.
Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Lu Zhang et al.
Summary: The study presents a high-efficiency peroxidase mimic MOF@COF nanozyme, utilizing the interaction between MOFs and COFs to achieve enhanced bacterial inhibition.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Thanh Chung Pham et al.
Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.
Review
Biochemistry & Molecular Biology
JianSong Gan et al.
Summary: In recent years, the synthesis and application of green and sustainable products have become global ecological and societal issues. Immobilization of enzymes is a favorable approach to enhance stability and recyclability, and COFs (covalent organic frameworks) may serve as ideal host materials for improving enzyme properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Zhusheng Huang et al.
Summary: The study demonstrates a strategy of using gadolinium-based nanoscale coordination polymers to enhance radiation-induced immunogenic cell death, thereby boosting anti-tumor immune responses.
NATURE COMMUNICATIONS
(2021)
Review
Engineering, Biomedical
Arezoo Esrafili et al.
Summary: Covalent organic frameworks (COFs) are porous organic polymeric materials with desirable properties like high stability, low density, and large surface area, making them suitable for applications in the energy sector and drug delivery. This review discusses different types of COFs, synthesis methods, and their potential applications in the biomedical field, highlighting the specific advantages that can be utilized for specialized biomedical applications such as immune engineering.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Luo-Gang Ding et al.
Summary: The study introduced a IBU@DhaTph-membrane with effective antibacterial and anti-inflammatory effects through light-induced singlet oxygen generation and controlled IBU release. Both in vitro and in vivo experiments demonstrated its significant therapeutic effects on chronic wounds.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Ming-Xue Wu et al.
Summary: This review comprehensively introduces the recent development of MOFs-COFs composites, including their syntheses and enhanced applications, highlighting the preparation methods, catalytic performance, and potential applications in adsorption and separation, energy storage, and sensing. The opportunities and challenges faced by MOFs-COFs composites are further discussed, with the aim of inspiring the development of these promising but still emerging materials.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Fan-Lin Meng et al.
Summary: This study demonstrates a conjugation-regulating strategy for designing and synthesizing Por-COFs with high photosensitizing activity for photodynamic inactivation of bacteria. By optimizing conjugation degree, the conjugation of DhaTph and JNU-2 is enhanced, leading to the increase of intersystem crossing process and significant improvement in photosensitizing activity towards bacteria.
Article
Chemistry, Multidisciplinary
Rui Xia et al.
Summary: This study successfully developed a series of COFs based on the electron donor-acceptor strategy with excellent colloidal stability and adjustable sizes, as well as varying absorption spectra. By altering the electron-donating ability of the monomers, these COFs exhibit a wide range of absorption spectra and potent photothermal activity, effectively inhibiting tumor growth.
Article
Chemistry, Multidisciplinary
Weihua Chen et al.
Summary: The study introduces a biocompatible all-in-one organic semiconductor that can efficiently split water to generate oxygen and produce singlet oxygen under laser irradiation. This organic semiconductor shows potential for developing cancer therapeutic agents with nucleus targeting capacity for direct and efficient DNA photocleavage.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Engineering, Environmental
Tianqi Liu et al.
Summary: The separation of chiral compounds, especially enantiomers, is a topic of great interest due to their similar chemical properties and different pharmacological activities. Membrane separation technology, as an emerging method, shows great potential in this field due to its high efficiency, simplicity, low energy consumption, and continuous operation. Various types of chiral solid membranes have been developed from polymer, carbon nanomaterials, metal organic frameworks, and other inorganic materials, but systematic summaries are still lacking.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Lei Ge et al.
Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.
Review
Chemistry, Analytical
Bezhan Chankvetadze
Summary: Separation of enantiomers serves different purposes, with variations in method refinement based on the final application. This overview focuses on the specific requirements of bioanalytical applications, comparing different separation methods and discussing current developments and future trends in the field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Imann Mosleh et al.
Summary: The study explored the use of ionic COF Py-BPy+-COF as an ion exchange material for biomolecule separation, demonstrating high adsorption capacities and selectivity for different amino acids and proteins. Desorption experiments showed successful separation of proteins based on isoelectric point, hydrophobicity, and ability to penetrate the crystalline material, suggesting Py-BPy2+-COF can be a robust anion exchange biomolecule separation material.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Yu-Shi Liu et al.
Summary: The study presents a smart nanoplatform with synergistic chemo-phototherapy function for targeted imaging and efficient sterilization of bacteria, with minimal side effects on normal tissues.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Baohong Sun et al.
Summary: Chronic wound healing is hindered by bacterial infections and drug resistance. Antibacterial phototherapy combined with COFs offers a potential strategy for treating wound infections.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Lei-Lei Yang et al.
Summary: The combination of immune checkpoint blockade therapy and photodynamic therapy shows promising potential in inducing efficient immunogenic cell death and immune response, offering new hope for cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Dong An et al.
Summary: Non-invasive cancer photothermal therapy (PTT) shows potential as a replacement for traditional cancer treatments, with recent developments focusing on NIR-II PTT and the use of inorganic 2D nanomaterials as photothermal agents (PTAs) to enhance efficiency. Strategies integrating NIR-II responsive PTT with other treatment approaches are promising for advancing cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Yao Gao et al.
Summary: This study developed a high-performance photocathode for precise immunosensing of alpha-synuclein by integrating a DNAzyme-induced signal cycle amplification strategy with Ag nanoparticles-mediated liposomal immunoassay. The proposed approach achieved an ultralow detection limit and a wide linear range, showing great promise for biomedical and related applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xueqing Li et al.
Summary: This study develops a hypoxia-responsive nanocomposite for mild-photothermal therapy through gene editing in tumors. The technology has the potential to enhance tumor ablation efficiency and reduce damage to surrounding healthy tissues.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Guorui Cai et al.
Summary: Metal-organic frameworks (MOFs) are fascinating materials with high porosity and tailored structures, but their narrow pores limit applications. The development of hierarchically porous MOFs and derivatives has attracted attention to broaden the scope of traditional MOF-based materials.
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of three-dimensional (3D) covalent organic frameworks (COFs) were designed and synthesized as inducers for immunogenic cell death (ICD) in cancer immunotherapy. These COFs exhibit outstanding ICD-inducing efficiency and one member, COF-609, showed significant therapeutic effects in a mouse model of breast cancer.
Article
Chemistry, Multidisciplinary
Yite Li et al.
Summary: The study developed a cascade catalyst triggered by glucose, which efficiently converts glucose into hydrogen peroxide to improve peroxidase activity and generate more toxic hydroxyl radicals against bacterial wound infections, enhancing the healing effects.
Article
Chemistry, Multidisciplinary
Le-Le Zhou et al.
Summary: A nanodrug, RSL3@COF-Fc (2b), based on covalent organic framework (COF) has been fabricated to enhance cellular damage induced by CDT through promoting Fenton-like reactions and inhibiting GPX4 irreversibly. This approach synergistically results in massive lipid peroxide accumulation, subsequent cell damage, and ultimately ferroptosis, not being limited by intracellular glutathione, providing new insights for developing COF-based nanomedicine.
Article
Chemistry, Multidisciplinary
Kai Sun et al.
Summary: Traditional chemo-immunotherapy can induce T cell immune response through immunogenic cell death (ICD), but the limited ICD hinders lasting antitumor immunotherapeutic efficacy. A novel tadpole-ovoid Au@HMnMSNs nanoreactor is constructed to generate intratumoral hydroxyl radicals for enhanced ICD induction and DC maturation, along with DOX and ASA for recruitment of immune cells and inhibition of immunosuppressive cells.
Article
Engineering, Biomedical
Cuiping Zhang et al.
Summary: TPDA, an acridine-based COF photosensitizer, has been synthesized with multiple active sites and shows high antibacterial activities, wide optical absorption spectrum, and efficient protection against skin infections in fish within a short time.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: This review focuses on the optical properties of covalent organic frameworks (COFs) and how they correlate with the microscopic structure of COFs. It explores the relationship between key structural factors like connection, orientation, and alignment of molecular building blocks, and the optical properties of COFs. Additionally, the properties of COFs are analyzed from both energy and dynamic aspects to provide insights into the possible underlying mechanisms.
Review
Chemistry, Multidisciplinary
Cheng Xu et al.
Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Ruoyang Liu et al.
Summary: Covalent organic frameworks provide a platform for integrating organic units into ordered polymers, allowing for pre-designed structures and enhanced capabilities in designing organic materials. The progress in COF design and exploration has laid a foundation for the field, demonstrating potential in developing unique organic materials. By analyzing historical developments, understanding structural components and functional design strategies, a clearer picture of COFs' materials and applications emerges, revealing principles for designing unique functions inherent to structures.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Niklas Keller et al.
Summary: COFs are crystalline porous materials constructed from molecular building blocks using diverse linkage chemistries, allowing for tailor-made design and a variety of building blocks for different functionalities. They have been integrated with various building blocks for applications in optoelectronics, semiconductors, sensors, photocatalysts, supercapacitors, batteries, and more.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Jin-Yue Zeng et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Didem Sen Karaman et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Review
Chemistry, Multidisciplinary
Yuyang Tian et al.
Article
Polymer Science
Shuai Liu et al.
MACROMOLECULAR RAPID COMMUNICATIONS
(2020)
Review
Chemistry, Multidisciplinary
Jie Yang et al.
Review
Chemistry, Multidisciplinary
Sukanya Bhunia et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Mingmin Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Ting Zhou et al.
Article
Chemistry, Multidisciplinary
Qun Guan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Hui Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Farah Benyettou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Chemistry, Multidisciplinary
Felipe L. Oliveira et al.
Article
Biophysics
Minghui Wang et al.
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Materials Science, Biomaterials
Yutao Jia et al.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Review
Chemistry, Multidisciplinary
Mingwang Yang et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Peng Gao et al.
Review
Nanoscience & Nanotechnology
Marie Christine Scicluna et al.
ACS APPLIED NANO MATERIALS
(2020)
Review
Chemistry, Multidisciplinary
Xinyu Guan et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Review
Chemistry, Multidisciplinary
Jet-Sing M. Lee et al.
Review
Chemistry, Multidisciplinary
Zhifang Wang et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Tingting Sun et al.
MATERIALS CHEMISTRY FRONTIERS
(2020)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Multidisciplinary
Zhen Mi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biophysics
Huan Liang et al.
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Engineering, Biomedical
Dianwei Wang et al.
Review
Chemistry, Multidisciplinary
Sharath Kandambeth et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Chen Yuan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Qi Sun et al.
ADVANCED MATERIALS
(2019)
Article
Multidisciplinary Sciences
Qun Guan et al.
Review
Materials Science, Biomaterials
He Zhang et al.
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Nanoscience & Nanotechnology
Jan Hynek et al.
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Multidisciplinary
Qi Sun et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Multidisciplinary Sciences
Guiyang Zhang et al.
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Xinle Li et al.
NATURE COMMUNICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Sainan Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Review
Chemistry, Multidisciplinary
Shuaihua Zhang et al.
Article
Chemistry, Multidisciplinary
Shreya Goel et al.
ADVANCED MATERIALS
(2018)
Article
Biochemistry & Molecular Biology
Tingting Liu et al.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Yongwu Peng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Multidisciplinary
Shouvik Mitra et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Review
Chemistry, Multidisciplinary
Wanjun Wang et al.
ENVIRONMENTAL SCIENCE-NANO
(2017)
Article
Chemistry, Multidisciplinary
Bobo Gu et al.
ADVANCED MATERIALS
(2017)
Review
Chemistry, Multidisciplinary
Ming-Xue Wu et al.
CHINESE CHEMICAL LETTERS
(2017)
Review
Immunology
Lorenzo Galluzzi et al.
NATURE REVIEWS IMMUNOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Jing Tan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Article
Chemistry, Multidisciplinary
Shouvik Mitra et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Review
Chemistry, Multidisciplinary
Hwan Myung Kim et al.
Article
Chemistry, Multidisciplinary
Qianrong Fang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Multidisciplinary Sciences
Song Lin et al.
Article
Chemistry, Multidisciplinary
Peiyuan Wang et al.
CHINESE JOURNAL OF CHEMISTRY
(2014)
Article
Chemistry, Multidisciplinary
Bishnu P. Biswal et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2013)
Article
Infectious Diseases
Ramanan Laxminarayan et al.
LANCET INFECTIOUS DISEASES
(2013)
Article
Oncology
Patrizia Agostinis et al.
CA-A CANCER JOURNAL FOR CLINICIANS
(2011)
Article
Multidisciplinary Sciences
AP Côté et al.
Review
Chemistry, Multidisciplinary
S Kobayashi et al.
