Phytochemical Profiling and Pharmacological Evaluation of Leaf Extracts of Ruellia tuberosa L.: An In Vitro and In Silico Approach

Article Pharmacology & Pharmacy

Ruellia tuberosa Ethyl Acetate Leaf Extract Induces Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7

Fui Fui Lem et al.

Summary: The ethyl acetate extract of Ruellia tuberosa L. (RTEAL) selectively inhibits the proliferation of MCF-7 cells by inducing apoptosis and cell cycle arrest, suggesting its potential therapeutic effect against breast cancer.

SCIENTIA PHARMACEUTICA (2022)

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Review Infectious Diseases

Medicinal plants consumption against urinary tract infections: a narrative review of the current evidence

Efthymios Poulios et al.

Summary: Urinary tract infections (UTIs) are common diseases caused by different strains of microorganisms. Many antibiotics have been used to treat these infections, but the development of multidrug-resistant strains poses a major challenge. Medicinal plants are being explored as alternative complementary agents to prevent and treat UTIs, with current evidence showing potential benefits against UTIs through various mechanisms such as preventing bacterial adherence and inhibiting inflammation cascades. However, more well-designed clinical trials focusing on individual medicinal plants are needed to fully understand their effectiveness in preventing and co-treating UTIs.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2021)

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Article Biochemistry & Molecular Biology

Corn starch and methylcellulose edible films incorporated with fireweed (Chamaenerion angustifolium L.) extract: Comparison of physicochemical and antioxidant properties

Dariusz Kowalczyk et al.

Summary: The addition of fireweed extract had positive effects on the edible films, improving their color and UV-absorbing effect, delaying starch retrogradation, and enhancing radical scavenging activity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Chemical Composition and Pharmacological Evaluation and of Toddalia asiatica (Rutaceae) Extracts and Essential Oil by in Vitro and in Silico Approaches.

Devina Lobine et al.

Summary: The study evaluated the pharmacological and chemical composition of T. asiatica in Mauritius, finding that the methanol extract is a superior source of antioxidant compounds with notable effects on AChE and BChE. Additionally, the essential oil showed antioxidant properties and potential inhibition of enzymes related to diabetes.

CHEMISTRY & BIODIVERSITY (2021)

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Article Plant Sciences

Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway

Sariya Mapoung et al.

Summary: The study found that the hyperoside-enriched fraction from Houttuynia cordata has significant photoprotective effects against UVB-induced skin aging by inhibiting intracellular ROS production, inflammatory cytokine secretions, and promoting collagen synthesis. The active compounds identified in the H. cordata extract play a key role in regulating the MAPK signaling pathway to prevent UVB-induced skin aging. These findings suggest that H. cordata extract could be a potential ingredient in pharmaceutical or cosmetic formulations to combat skin aging.

PLANTS-BASEL (2021)

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Review Chemistry, Medicinal

Potential therapeutic applications of phytoconstituents as immunomodulators: Pre-clinical and clinical evidences

Syed Afroz Ali et al.

Summary: Natural products have been studied for their multi-targeted activities and immunomodulatory properties, showing anti-inflammatory, phagocytosis induction, and immune cell stimulation activities to reduce inflammation, prevent disease progression, and enhance treatment efficacy. However, the exact mechanisms of immunomodulation require further investigation.

PHYTOTHERAPY RESEARCH (2021)

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Article Plant Sciences

A Comparative Study on Photo-Protective and Anti-Melanogenic Properties of Different Kadsura coccinea Extracts

Joong Suk Jeon et al.

Summary: The extracts from KC showed significant photoprotective effects by improving keratinocyte viability, reducing apoptosis, and melanin production, offering potential for developing skin-whitening and photoprotective agents.

PLANTS-BASEL (2021)

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Review Pharmacology & Pharmacy

Antimicrobial Potential of Naturally Occurring Bioactive Secondary Metabolites

Khaled S. Allemailem

Summary: The global use of traditional medicines of natural origin has been prevalent since ancient times due to the great diversity of secondary metabolites produced by plants. The naturally occurring bioactive constituents in food and other plant materials have shown widespread attention for their use as alternative medicine to prevent and cure microbial growth, with the least toxic manifestations. These contents play a crucial role in improving the therapeutic efficacy of classical drugs against various pathogenic microorganisms.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2021)

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Article Engineering, Environmental

Cytotoxic effects of silver nanoparticles on Ruellia tuberosa: Photocatalytic degradation properties against crystal violet and coomassie brilliant blue

Vasantharaj Seerangaraj et al.

Summary: Nanotechnology has shown promising applications in biomedicine and environmental fields, with green synthesis of silver nanoparticles demonstrating effective antimicrobial and anticancer properties, as well as potential for photocatalytic degradation.

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Topical collection on Chromatin Biology and Epigenetics

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Review on natural products databases: where to find data in 2020

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Comparative antioxidant and antimicrobial potentials of leaf successive extract fractions of poison bulb, Crinum asiaticum L.

Souren Goswami et al.

INDUSTRIAL CROPS AND PRODUCTS (2020)

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Article Chemistry, Medicinal

Photoprotective activity and increase of SPF in sunscreen formulation using lyophilized red propolis extracts from Alagoas

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REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2019)

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Investigation of the Biological Activities and Characterization of Bioactive Constituents of Ophiorrhiza rugosa var. prostrata (D.Don) & Mondal Leaves through In Vivo, In Vitro, and In Silico Approaches

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Total Phenolic Content, Flavonoid Content and Antioxidant Potential of Wild Vegetables from Western Nepal

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Article Biochemistry & Molecular Biology

Biosynthesis of iron oxide nanoparticles using leaf extract of Ruellia tuberosa: Antimicrobial properties and their applications in photocatalytic degradation

Seerangaraj Vasantharaj et al.

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Isolation and identification of compounds from the resinous exudate of Escallonia illinita Presl. and their anti-oomycete activity

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BMC CHEMISTRY (2019)

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Synthesis, anti-microbial activity, cytotoxicity of some novel substituted (5-(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxybenzyl) benzofuran-2-yl)(phenyl)methanone analogs

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CHEMISTRY CENTRAL JOURNAL (2018)

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Article Chemistry, Physical

Antioxidant and antibacterial activity of different extracts from herbs obtained by maceration or supercritical technology

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JOURNAL OF SUPERCRITICAL FLUIDS (2018)

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Article Mathematical & Computational Biology

Molecular docking analysis of phyto-constituents from Cannabis sativa with pfDHFR

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The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release

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INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (2017)

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In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts

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REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2016)

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Comparative study of the anti-oxidant activity of the total polyphenols extracted from Hibiscus Sabdariffa L., Glycine max L. Merr., yellow tea and red wine through reaction with DPPH free radicals

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In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts

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Modified DPPH and ABTS Assays to Assess the Antioxidant Profile of Untreated Oils

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Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica

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Evaluation of antibacterial activity of crude protein extracts from seeds of six different medical plants against standard bacterial strains

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Chemical constituents from the leaves of Ruellia tuberosa

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Theoretical Investigation on Antioxidant Activity of Bromophenols from the Marine Red Alga Rhodomela confervoides: H-Atom vs Electron Transfer Mechanism

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Total phenolic contents and antioxidant activity of corn tassel extracts

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Phytochemical Profiling and Pharmacological Evaluation of Leaf Extracts of Ruellia tuberosa L.: An In Vitro and In Silico Approach

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