期刊
MEDICINAL CHEMISTRY RESEARCH
卷 25, 期 5, 页码 941-950出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-016-1522-1
关键词
Antiproliferative activity; Indole hydrazide-hydrazones; MTT assay
资金
- CSIR
- UGC, New Delhi
A series of N'-((1-(substituted)-1H-indol-3-yl)methylene)hydrazides were synthesized and evaluated for their in vitro antiproliferative activities against various cancer cell lines. Formation of indole hydrazide-hydrazones was accomplished by the reaction of indole 3-carboxaldehyde with aryl/alkyl hydrazides in the presence of acetic acid. Out of synthesized twenty-two compounds, some of the analogs exhibited specificity toward breast (18b, 18d, 18f and 18j) and prostate (18t and 18v) cancer cells. Among the prepared derivatives, compounds 18b, 18d and 18j were most cytotoxic (IC50 = 0.9, 0.4 and 0.8 A mu M, respectively) against the screened cancer cell lines. Exposure of PC3 cells to either 18d or 18j resulted in increased levels of cleaved PARP1, indicating that indolyl hydrazide-hydrazones induce apoptosis in PC3 cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据