4.7 Article

In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates

期刊

CHEMICO-BIOLOGICAL INTERACTIONS
卷 383, 期 -, 页码 -

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2023.110678

关键词

Acetylcholinesterase; Organophosphorus surrogates; Inhibitors; Reactivation

向作者/读者索取更多资源

This study compared the toxicity of representatives from the V and A series nerve agents through in vitro experiments, and found similar inhibition potency between both agents.
Nerve agents (NA) pose as a great risk in the modern world. NA from the V-series, such as VX, are currently recognized as the most toxic among those compounds. However, the emergence of new classes of toxicants recently included in the Chemical Weapons Convention (CWC), such as the A-series NA, a class of organo-phosphorus compounds related to phosphoramidates, pose a new source of concern due to the lack of information. In order advance in the investigation on the toxicity of such toxic chemicals, we performed in vitro studies to compare representatives of the V-and A-series using affordable surrogates. Results suggest a similar inhibition potency between both agents.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据