4.7 Article

Molybdenum and/or cadmium induce NLRP3 inflammasome production by causing mitochondria-associated endoplasmic reticulum membrane dysfunction in sheep hepatocytes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Environmental Sciences

The key role of proteostasis at mitochondria-associated endoplasmic reticulum membrane in vanadium-induced nephrotoxicity using a proteomic strategy

Xiaoyu Wang et al.

Summary: Excessive vanadium contamination is a growing concern due to its negative effects on human health and ecosystems, particularly nephrotoxicity. The role of mitochondria-associated endoplasmic reticulum membrane (MAM) in vanadium-induced nephrotoxicity has been investigated. Proteomics analysis revealed that vanadium primarily affects MAM-mediated metabolic pathways, particularly the endoplasmic reticulum (ER) proteostasis pathway. These findings provide promising insights into the toxicological mechanisms of vanadium and the critical role of MAM.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

Article Environmental Sciences

Selenium alleviates cadmium-induced mitophagy through FUNDC1-mediated mitochondrial quality control pathway in the lungs of sheep

Shixuan Lin et al.

Summary: Cadmium is a toxic metal element that causes mitochondrial dysfunction. Selenium can reduce the damage of Cd to various organs of animals, but the protective mechanism of Se in Cd-induced lung injury has not been fully elucidated.

ENVIRONMENTAL POLLUTION (2023)

Article Environmental Sciences

Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health

Jing-Bo Liu et al.

Summary: Long-term exposure to GLY adversely affects BTB integrity and disrupts spermatogenesis.

ENVIRONMENT INTERNATIONAL (2022)

Article Biochemistry & Molecular Biology

Cadmium induced Fak-mediated anoikis activation in kidney via nuclear receptors (AHR/CAR/PXR)-mediated xenobiotic detoxification pathway

Jing Ge et al.

Summary: Cadmium is a toxic heavy metal that poses a threat to food safety and human health. This study investigated the mechanisms of cadmium-induced kidney damage and the detoxification response. The results showed that cadmium exposure caused renal injuries and affected detoxification enzyme activities. These findings contribute to our understanding of the toxicity and detoxification mechanisms of cadmium.

JOURNAL OF INORGANIC BIOCHEMISTRY (2022)

Article Cell Biology

Ca2+ transfer via the ER-mitochondria tethering complex in neuronal cells contribute to cadmium-induced autophagy

Tao Wang et al.

Summary: This study reveals that cadmium-induced neurotoxicity alters MAMs and mitochondrial Ca2+ levels, with Mfn2 playing a crucial role. Defects in Mfn2 affect mitochondrial Ca2+ uptake efficiency and autophagy. The mechanism involving IP3R-Grp75-VDAC1 tethers in MAMs is associated with the regulation of autophagy by Mfn2 and their role in mediating mitochondrial Ca2+ uptake from ER stores.

CELL BIOLOGY AND TOXICOLOGY (2022)

Article Environmental Sciences

Mitochondrial redox-driven mitofusin 2 S-glutathionylation promotes neuronal necroptosis via disrupting ER-mitochondria crosstalk in cadmium-induced neurotoxicity

Lin Che et al.

Summary: Cadmium exposure disrupts mitochondrial redox balance, leading to increased mitoROS levels and enhanced S-glutathionylation of Mfn2, ultimately inducing neuronal necroptosis. Antioxidant intervention can reduce S-glutathionylation of Mfn2 and antagonize Cd-induced necroptosis and neurotoxicity.

CHEMOSPHERE (2021)

Article Agriculture, Multidisciplinary

Lycopene Ameliorates Di(2-ethylhexyl) Phthalate-Induced Pyroptosis in Spleen via Suppression of Classic Caspase-1/NLRP3 Pathway

Xue-Yan Dai et al.

Summary: The study demonstrated that lycopene could alleviate spleen injury induced by DEHP by inhibiting pyroptosis and the inflammatory response. This suggests that lycopene may be a new strategy to mitigate DEHP-induced spleen injury.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Environmental Sciences

Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1/M2 imbalance

Shi Xu et al.

Summary: The study found that subacute CdCl2 exposure leads to lung tissue fibrosis in pigs, resulting in symptoms such as increased Cd content, down-regulation of miR-20a-3p, imbalance of M1/M2, and decreased LXA4/FPR2 content, activating multiple pathways leading to an increase in fibrosis-related factor expression.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Food Science & Technology

Chronic oral exposure to cadmium causes liver inflammation by NLRP3 inflammasome activation in pubertal mice

Xusheng Li et al.

Summary: Pubertal mice exposed to low-dose cadmium exhibit liver inflammation and severe injury, including inflammatory hepatocyte infiltration, increased apoptotic cells, and upregulation of cytokine expression.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Environmental Sciences

Activation of the ROS/HO-1/NQO1 signaling pathway contributes to the copper-induced oxidative stress and autophagy in duck renal tubular epithelial cells

Yukun Fang et al.

Summary: This study found that Cu can induce oxidative stress and autophagy through the ROS/HO-1/NQO1 pathway, and inhibition of HO-1 can alleviate Cu-induced oxidative stress and autophagy.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Cell Biology

In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes

Ulises Ahumada-Castro et al.

Summary: Recent studies have shown that cross-organelle communication plays a significant role in metabolism, with calcium ions playing a crucial role in this process, especially in cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury

Guixi Mo et al.

Summary: This study revealed the important role of IP3R1 in myocardial ischemia/reperfusion by regulating Ca2+ levels, inflammation, and pyroptosis to improve injury. The binding of ERP44 to IP3R1 can inhibit Ca2+ overload, alleviating pyroptosis and myocardial ischemia/reperfusion injury.

CELL DEATH DISCOVERY (2021)

Article Immunology

The ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct

Abhinit Nagar et al.

Summary: The NLRP3:ASC speck is not synonymous with the NLRP3 inflammasome, but is a dynamic structure that can amplify the NLRP3 response to weak stimuli.

FRONTIERS IN IMMUNOLOGY (2021)

Article Chemistry, Multidisciplinary

Dissolution of 2D Molybdenum Disulfide Generates Differential Toxicity among Liver Cell Types Compared to Non-Toxic 2D Boron Nitride Effects

Jiulong Li et al.

Summary: 2D boron nitride (BN) and molybdenum disulfide (MoS2) materials have novel chemical, electronic, and optical properties, but recent research has shown potential hazards of MoS2 under certain biological conditions. MoS2 induces dose-dependent cytotoxicity in Kupffer cells (KCs), while the BN derivatives are non-toxic. The toxicity of MoS2 is attributed to nanosheet dissolution and the release of hexavalent Mo, leading to mitochondrial reactive oxygen species generation and apoptosis in KCs. Further, the phagocytosis of MoS2 aggregates triggers a separate response pathway involving lysosomal damage, NLRP3 inflammasome activation, and cytokine production.
Review Biochemistry & Molecular Biology

iNOS as a metabolic enzyme under stress conditions

Sarit Anavi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Pathology

Endothelial Cell Calcium Signaling during Barrier Function and Inflammation

Prarthana J. Dalal et al.

AMERICAN JOURNAL OF PATHOLOGY (2020)

Review Cell Biology

Toward targeting inflammasomes: insights into their regulation and activation

Shelbi Christgen et al.

CELL RESEARCH (2020)

Review Biochemistry & Molecular Biology

Functional mononuclear molybdenum enzymes: challenges and triumphs in molecular cloning, expression, and isolation

Breeanna Mintmier et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2020)

Review Environmental Sciences

The Effects of Cadmium Toxicity

Giuseppe Genchi et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Review Biochemistry & Molecular Biology

Lactate Dehydrogenase Inhibition: Biochemical Relevance and Therapeutical Potential

Giuseppina Lagana et al.

CURRENT MEDICINAL CHEMISTRY (2019)

Article Gastroenterology & Hepatology

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

Alexander Wree et al.

HEPATOLOGY (2018)

Editorial Material Cell Biology

ER-mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release

Janos Steffen et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Pharmacology & Pharmacy

Flavonoids interfere with NLRP3 inflammasome activation

Hyun Lim et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Review Cell Biology

Mitochondria-associated membranes (MAMs) and inflammation

Sonia Missiroli et al.

CELL DEATH & DISEASE (2018)

Article Biochemistry & Molecular Biology

Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production

Zizhen Gong et al.

MOLECULAR IMMUNOLOGY (2018)

Review Neurosciences

Inflammasomes, Hormesis, and Antioxidants in Neuroinflammation: Role of NRLP3 in Alzheimer Disease

Manuela Pennisi et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Review Biochemistry & Molecular Biology

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

Jedrzej Szymanski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Gastroenterology & Hepatology

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Auvro R. Mridha et al.

JOURNAL OF HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

Endoplasmic reticulum-mitochondria calcium signaling in hepatic metabolic diseases

Jennifer Rieusset

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Review Cell Biology

Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

Young-Su Yi et al.

MEDIATORS OF INFLAMMATION (2014)

Article Biochemistry & Molecular Biology

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM)

Tiziana Anelli et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Biochemistry & Molecular Biology

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

T. Verfaillie et al.

CELL DEATH AND DIFFERENTIATION (2012)

Article Nutrition & Dietetics

Molybdenum intake influences molybdenum kinetics in men

Janet A. Novotny et al.

JOURNAL OF NUTRITION (2007)

Article Cell Biology

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

Gyorgy Szabadkai et al.

JOURNAL OF CELL BIOLOGY (2006)