4.3 Article

Synthesis, Structural Characterization of a Novel Ferrocene Derivative and Preliminarily Anticancer Activity

期刊

MEDICINAL CHEMISTRY
卷 12, 期 5, 页码 426-431

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573406412666151112125345

关键词

Ferrocene derivative; synthesis; characterization; NMR; XRD; anticancer activity

资金

  1. National Natural Science Foundation of China [21373221]
  2. open program of Mengchao Hepatobiliary Hospital of Fujian Medical University [2014ZDSY2004]

向作者/读者索取更多资源

A novel structure of ferrocene derivative 1 was synthesized with cyanuric chloride and ferrocenemethanol as starting materials. The synthesized compound was fully characterized using H-1 NMR, C-13 NMR, MS and XRD. Subsequently, the in vitro anticancer effect against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated by the MTT method. The result showed that this compound exhibits good cytotoxic effect on A549, HCT116 and MCF-7 cell lines.

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