Applications of engineered exosomes in drugging noncoding RNAs for cancer therapy

Noncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly. A huge number of studies have mentioned the significant role of ncRNAs in cancer prevention and therapy that make them an interesting subject for cancer therapy. However, there are several limitations, including delivery, uptake, and short half-life, in the application of ncRNAs in cancer treatment. Exosomes are introduced as promising options for the delivery of ncRNAs to the target cells. In this review, we will briefly discuss the application and barriers of ncRNAs. After that we will focus on exosome-based ncRNAs delivery and their advantages as well as the latest achievements in drugging ncRNAs with exosomes.

Automated summary

Noncoding RNAs play important roles in key cell biological and pathological events, and their altered expression is directly and indirectly linked to cancer progression. Numerous studies have highlighted the significant role of ncRNAs in cancer prevention and therapy, making them an interesting subject for cancer treatment. However, there are limitations in the application of ncRNAs in cancer treatment, such as delivery, uptake, and short half-life. Exosomes are introduced as promising options for delivering ncRNAs to target cells. This review briefly discusses the application and barriers of ncRNAs, with a focus on exosome-based ncRNA delivery, advantages, and the latest achievements in drugging ncRNAs with exosomes.