Comparison of the blink reflex in classical and idiopathic trigeminal neuralgia

BackgroundPrevious findings indicate that the blink reflex is useful to distinguish between primary (classical/idiopathic) and secondary trigeminal neuralgia. No prior studies have investigated whether the blink reflex could identify differences in electrophysiological responses between classical and idiopathic trigeminal neuralgia. With this in mind, we investigated the blink reflex in a cohort of classical and idiopathic trigeminal neuralgia patients. MethodsParticipants were consecutively enrolled in the study. According to magnetic resonance imaging findings, the patients were subgrouped into either classical or idiopathic trigeminal neuralgia. Assessors were blinded to the subgroup and pain side, and the blink reflex was examined to assess R1 and R2 latencies, as well as the area under the curve. ResultsThe study group constituted of 55 patients with primary trigeminal neuralgia: 25 patients with classical trigeminal neuralgia and 30 patients with idiopathic trigeminal neuralgia. None of the blink reflex latencies (R1 and R2) or the area under the curve significantly differed between the two subgroups when adjusted for age and sex (p > 0.05). ConclusionsOur findings suggest that the blink reflex cannot be used to differentiate classical and idiopathic trigeminal neuralgia patients, and that both subgroups may share common pathophysiological mechanisms.

Automated summary

In this study, the blink reflex in classical and idiopathic trigeminal neuralgia patients was investigated. The results showed that there were no significant differences in blink reflex latencies and area under the curve between the two subgroups after adjusting for age and sex. Therefore, the blink reflex cannot be used to differentiate classical and idiopathic trigeminal neuralgia patients, indicating the presence of common pathophysiological mechanisms in both subgroups.