期刊
CELLULOSE
卷 30, 期 16, 页码 10313-10339出版社
SPRINGER
DOI: 10.1007/s10570-023-05491-3
关键词
Microporous cellulosic sponge; Antioxidant activity; Antimicrobial activity; Biocompatibility; Hemocompatibility
This study aimed to develop a multifunctional bioactive wound dressing using two invasive plant species. The researchers successfully functionalized a microporous cellulosic sponge from Gleditsia triacanthos pods and added Phytolacca americana fruit extract for its bioactive properties. The sponge demonstrated controlled release of bioactive compounds, promoted wound healing, inhibited microbial growth, and had anti-inflammatory effects.
This study aimed to exploit two invasive plant species to develop a novel, multifunctional, bioactive wound dressing based on a microporous cellulosic sponge (CS) from Gleditsia triacanthos pods and functionalizing them with Phytolacca americana fruit extract. The CS was functionalized, lyophilized, and characterized by Attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, contact angle, water absorption, and retention capacity. In addition, two parameters were evaluated in temporal dynamics: controlled release of phenolic compounds and antioxidant activities. The hemolytic index, blood clotting kinetics, lactate dehydrogenase release, and wound scratch assays proved their hemo- and bio-compatibility, as well as their ability to promote cell proliferation and migration promoting-activity and to inhibit microbial growth. Furthermore, the obtained spongious material exhibited an anti-inflammatory effect by modulating the macrophages' secretion profile of IL-6 and IL-10. In conclusion, the microporous cellulosic sponge obtained from G. triacanthos could be used as a vehicle to ensure the controlled release of bioactive principles with pro-wound healing activities extracted from invasive plants. [GRAPHICS] .
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