Decreased FoxO1 expression contributes to facet joint osteoarthritis pathogenesis by impairing chondrocyte migration and extracellular matrix synthesis

Review Rheumatology

Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum

Noah Fine et al.

Summary: This review discusses the similarities and differences between intervertebral disc degeneration and osteoarthritis of the facet joint, arguing that both diseases should be viewed as part of the same molecular disease spectrum.

NATURE REVIEWS RHEUMATOLOGY (2023)

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Review Cell Biology

Chondrocyte death involvement in osteoarthritis

S. Salucci et al.

Summary: This review focuses on the different forms of chondrocyte death, particularly chondroptosis, which is a non-classical form of cell death observed in chondrocytes. The study highlights the morpho-functional alterations of articular cartilage and various types of chondrocyte death involved in degeneration. Understanding these death mechanisms can lead to the identification of potential therapeutic targets in joint diseases.

CELL AND TISSUE RESEARCH (2022)

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Article Orthopedics

Spontaneous Facet Joint Osteoarthritis in NFAT1-Mutant Mice Age-Dependent Histopathologic Characteristics and Molecular Mechanisms

Jinxi Wang et al.

Summary: This study identified a novel animal model of spontaneous FJOA by investigating mice with mutant NFAT1 transcription factor and developed the first FJOA scoring system. The study elucidated the molecular mechanisms of NFAT1 mutation-induced FJOA.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2022)

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Article Pharmacology & Pharmacy

Wharton's jelly mesenchymal stem cell-derived small extracellular vesicles as natural nanoparticles to attenuate cartilage injury via microRNA regulation

Penghong Chen et al.

Summary: The main strategy of tissue repair and regeneration involves the application of mesenchymal stem cells and cell-based nanoparticles, but there are challenges that may impact safety and efficacy. Cell-free nanotechnology can overcome these obstacles. This study focuses on using sEVs derived from Wharton's jelly mesenchymal stem cells for chondrogenesis and modulation of immune reactivity in the treatment of osteoarthritis. The results show promising outcomes and the potential of sEVs as a cell-free nanotherapy for OA treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Biotechnology & Applied Microbiology

Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading

Meagan E. E. Ita et al.

Summary: Chronic joint pain is a significant healthcare challenge with a large socioeconomic burden. This study investigates the role of MMP-1 in mediating pain in synovial joints and its effects on the collagen network, biomechanical response, and neuronal regulation of the capsular ligament. The findings suggest that MMP-1 may play a crucial role in neuronal signaling in joint pain and that MMP-1 presence in the joint space could lead to altered responses to loading. These findings have implications for the development of new treatments for degenerative joint pain.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Orthopedics

Establishment of a bipedal rat model of lumbar facet joint osteoarthritis using intraarticular injection of urinary plasminogen activator

Di Yang et al.

Summary: The results of the experiment show that intraarticular injection of uPA can induce LFJOA in bipedal rats, leading to significant articular cartilage damage, synovitis, and increased expression of inflammatory factors such as iNOS, IL-1 beta, and TNF-a.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Influences of the IL-6 cytokine family on bone structure and function

Natalie A. Sims

Summary: The IL-6 family of cytokines act through the formation of a signaling complex with the gp130 receptor, regulating the activities of various bone cells and playing important roles in skeletal growth and development, as well as being implicated in musculoskeletal pathologies.

CYTOKINE (2021)

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Article Engineering, Biomedical

The tissue origin effect of extracellular vesicles on cartilage and bone regeneration

Qi Li et al.

Summary: Extracelluar vesicles (EVs) of mesenchymal stem cells (MSCs) from different tissue origins have varying effects on chondrogenesis and osteogenesis, with EVs from adipose-derived MSCs showing the highest efficiency. Proteomics analysis revealed potential mechanisms underlying this difference.

ACTA BIOMATERIALIA (2021)

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Article Cell Biology

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling

Jessica Fiebelkow et al.

Summary: The study shows that SHP2 not only increases robustness of basal and cytokine-induced STAT3 activity, but also ensures information transmission. SHP2 increases the dynamic range of pathway activation in JAK/STAT signalling, contributing to communication in multicellular organisms.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Identification of N-glycoproteins of hip cartilage in patients with osteonecrosis of femoral head using quantitative glycoproteomics

Xueliang Lu et al.

Summary: This study identified glycoproteins in ONFH hip cartilage and found differentially expressed glycoproteins related to cartilage degeneration processes. Analysis of KEGG pathways and protein-protein interactions indicated that these significantly differential glycoproteins are associated with multiple signaling pathways and protein biosynthesis processes.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Materials Science, Biomaterials

Evaluation of osteochondral-like tissues using human freeze-dried cancellous bone and chondrocyte sheets to treat osteochondral defects in rabbits

Sopita Wongin et al.

Summary: The study evaluated the potential of human freeze-dried cancellous bones combined with human chondrocyte sheets for treating osteochondral defects in rabbits, and assessed the key roles of extracellular matrix and released cytokines in osteochondral repair.

BIOMATERIALS SCIENCE (2021)

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Article Endocrinology & Metabolism