4.5 Review

Finding an Optimal Level of GDNF Overexpression: Insights from Dopamine Cycling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease

V. Mesa-Infante et al.

Summary: Research suggests that short-term GDNF treatment enhances rat midbrain neuronal activity, whereas long-term or high-dose continuous treatment can lead to degeneration. The need for more effective long-acting therapeutic approaches to manage the beneficial effects of GDNF in relevant diseases is highlighted.

MOLECULAR AND CELLULAR NEUROSCIENCE (2022)

Review Cell Biology

Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic

James A. Conway et al.

Summary: The GDNF/RET signaling system plays an important role in the survival and physiology of dopaminergic neurons, but its clinical efficacy in treating Parkinson's disease is limited. Further research on the basic biology of this signaling system is needed to facilitate its use in the clinic.

NEURAL REGENERATION RESEARCH (2022)

Article Biochemistry & Molecular Biology

Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells

Hong Li et al.

Summary: This study is significant as it uses small-molecule compounds to generate Parkinson's disease-related neurons from human induced pluripotent stem cells, providing valuable insights for PD research and treatment development.

MOLECULAR PSYCHIATRY (2022)

Article Biochemistry & Molecular Biology

Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia

Kart Matlik et al.

Summary: This study found that increased striatal dopamine signaling in a subgroup of schizophrenia patients may be related to the increase of GDNF. A possible mediator of GDNF-driven dopaminergic abnormalities is A(2A)R. By inhibiting A(2A)R with a drug, striatal and cortical dopamine levels can be partially normalized. These results provide potential therapeutic targets for the treatment of schizophrenia.

MOLECULAR PSYCHIATRY (2022)

Article Neurosciences

Elevated expression of endogenous glial cell line-derived neurotrophic factor impairs spatial memory performance and raises inhibitory tone in the hippocampus

Pepin Marshall et al.

Summary: This study revealed the important role of GDNF in regulating PV+ neurons in the brain, impacting memory and learning, and potentially having similar effects in the hippocampus. Gdnf(wt/hyper) mice showed impaired long-term memory performance and increased inhibitory tone in the hippocampus, as well as changes in PV+ cell numbers and seizure threshold.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Retrorubral field is a hub for diverse threat and aversive outcome signals

Mahsa Moaddab et al.

Summary: Adaptive fear scales according to threat levels and requires diverse neural signals, with the retrorubral field (RRF) containing A8 dopamine proposed as the neural origin. RRF neurons exhibit extreme firing patterns in response to danger and safety, with intermediate firing in uncertainty, as well as unique threat-selective cues. The diversity in firing patterns following threat and aversive outcomes suggest a crucial role for RRF in adaptive fear.

CURRENT BIOLOGY (2021)

Article Biotechnology & Applied Microbiology

SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson's Disease

Stefano Espinoza et al.

MOLECULAR THERAPY (2020)

Review Cell Biology

RET-independent signaling by GDNF ligands and GFRα receptors

Carlos F. Ibanez et al.

CELL AND TISSUE RESEARCH (2020)

Article Medicine, Research & Experimental

Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice

Giorgio Turconi et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Review Cell Biology

GDNF/RET signaling in dopamine neurons in vivo

James A. Conway et al.

CELL AND TISSUE RESEARCH (2020)

Review Neurosciences

GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop

Roger A. Barker et al.

JOURNAL OF PARKINSONS DISEASE (2020)

Editorial Material Geriatrics & Gerontology

The Future of GDNF in Parkinson's Disease

Fredric P. Manfredsson et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Article Clinical Neurology

Hyperdopaminergic behavioral spectrum in Parkinson's disease: A review

Matthieu Bereau et al.

REVUE NEUROLOGIQUE (2018)

Article Biochemistry & Molecular Biology

The substantia nigra and ventral tegmental dopaminergic neurons from development to degeneration

YuHong Fu et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2016)

Review Neurosciences

GDNF-induced cerebellar toxicity: A brief review

Matthias Luz et al.

NEUROTOXICOLOGY (2016)

Review Biochemistry & Molecular Biology

GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

Edgar R. Kramer et al.

FEBS LETTERS (2015)

Letter Neurosciences

GDNF is not required for catecholaminergic neuron survival in vivo

Jaakko Kopra et al.

NATURE NEUROSCIENCE (2015)

Article Neurosciences

Firing Modes of Dopamine Neurons Drive Bidirectional GIRK Channel Plasticity

Arnaud L. Lalive et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Medicine, Research & Experimental

Involvement of N-cadherin in the protective effect of glial cell line-derived neurotrophic factor on dopaminergic neuron damage

Tao Zuo et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Article Cell Biology

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin

Maxim M. Bespalov et al.

JOURNAL OF CELL BIOLOGY (2011)

Article Clinical Neurology

Clinical Progression in Parkinson Disease and the Neurobiology of Axons

Hsiao-Chun Cheng et al.

ANNALS OF NEUROLOGY (2010)

Article Anatomy & Morphology

Heterogeneity and diversity of striatal GABAergic interneurons

James M. Tepper et al.

FRONTIERS IN NEUROANATOMY (2010)

Article Neurosciences

Integrin β1 is involved in the signaling of glial cell line-derived neurotrophic factor

Jun-Ping Cao et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2008)

Article Biochemistry & Molecular Biology

Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine

Jelena Mijatovic et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Neurosciences

RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice

Sanjay Jain et al.

JOURNAL OF NEUROSCIENCE (2006)

Article Neurosciences

Striatal expression of GDNF and differential vulnerability of midbrain dopaminergic cells

P Barroso-Chinea et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2005)

Article Biochemistry & Molecular Biology

Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor

N Kobori et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra

MF Salvatore et al.

JOURNAL OF NEUROCHEMISTRY (2004)

Article Neurosciences

GDNF enhances the synaptic efficacy of dopaminergic neurons in culture

MJ Bourque et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2000)