Cis-regulatory arbitrators of regeneration

Mammals favor healing with scaring over functional tissue regeneration.(1) In this issue of Cell Stem Cell, Mack et al. use super-healermice to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regeneration.(2)

Automated summary

The preference of mammals to heal with scaring rather than functional tissue regeneration has been discovered. In this research, super-healermice were used to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts, and complement factor H was found to be a molecular driver of skin regeneration.