4.7 Review

A comprehensive insight into the correlation between ncRNAs and the Wnt/beta-catenin signalling pathway in gastric cancer pathogenesis

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Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, and chemotherapy is an important treatment method. However, most patients develop resistance to chemotherapy drugs. Recent studies have found that lncRNAs are involved in gastric cancer drug resistance and they regulate drug resistance through various mechanisms. Some lncRNAs have potential clinical applications.

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Hypoxia associated lncRNA HYPAL promotes proliferation of gastric cancer as ceRNA by sponging miR-431-5p to upregulate CDK14

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Summary: HYPAL is significantly upregulated in gastric cancer cells and tissues, correlating with poor prognosis, and activates the Wnt/β-catenin signaling pathway to promote gastric cancer cell proliferation. It may serve as a potential molecular target for gastric cancer therapy.

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Male-specific long non-coding RNA testis-specific transcript, Y-linked 15 promotes gastric cancer cell growth by regulating Wnt family member 1/β-catenin signaling by sponging microRNA let-7a-5p

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Summary: The present study aims to investigate the regulatory effects and related mechanism of long noncoding RNA testis-specific transcript, Y-linked 15 (TTTY15) in gastric carcinoma (GC) cell proliferation, migration, invasion, apoptosis, and epithelial-mesenchymal transition (EMT). TTTY15 promotes GC progression by regulating the let-7a-5p/Wnt1 axis to activate the Wnt/β-catenin pathway.

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The current and future incidence and mortality of gastric cancer in 185 countries, 2020-40: A population-based modelling study

Eileen Morgan et al.

Summary: This study analyzed the global patterns of gastric cancer in 2020 and predicted the burden for 2040. The incidence and mortality rates of gastric cancer varied by sex, country, and level of human development. Eastern Asia had the highest rates, while Africa had the lowest. The predicted burden of gastric cancer is expected to increase by 2040.

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MiR-507 inhibits the progression of gastric carcinoma via targeting CBX4-mediated activation of Wnt/β-catenin and HIF-1α pathways

Xin Fang et al.

Summary: The study found that miR-507 is significantly downregulated in gastric carcinoma (GC) tissues and cell lines. Upregulation of miR-507 can inhibit the proliferation and invasion of GC cells and induce apoptosis. CBX4 is identified as a downstream target of miR-507 and its expression can reverse the effects of miR-507 on GC cells. Additionally, miR-507 can suppress the activation of Wnt/beta-catenin and HIF-1 alpha pathways by inhibiting CBX4 expression. This suggests that miR-507 plays a role in inhibiting the progression of GC through regulating CBX4-mediated activation of Wnt/beta-catenin and HIF-1 alpha pathways.

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lncRNAs UC.145 and PRKG1-AS1 Determine the Functional Output of DKK1 in Regulating the Wnt Signaling Pathway in Gastric Cancer

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Summary: This study suggests that the long non-coding RNA UC.145 may serve as a potential novel biomarker for the diagnosis, prognosis, and prediction of gastric cancer. UC.145 regulates the expression of DKK1 through the interaction with PRKG1-AS1 and EZH2, and is involved in the canonical Wnt signaling pathway. Inactivation of UC.145 induces apoptosis and inhibits the growth and migratory, invasive, and colony-forming abilities of gastric cancer cells.

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Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling

Jian Ding et al.

Summary: Previous studies have shown that dysregulation of long non-coding RNAs plays an important role in tumors. LINC01503 is a newly discovered lncRNA that promotes development of various tumor types. This research revealed that elevated expression of LINC01503 can promote proliferation and metastasis of gastric cancer through positively regulating the Wnt/beta-catenin pathway.

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SNHG10 Promotes Cell Proliferation and Migration in Gastric Cancer by Targeting miR-495-3p/CTNNB1 Axis

Xiu Yuan et al.

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Long noncoding RNA DLGAP1-AS2 facilitates Wnt1 transcription through physically interacting with Six3 and drives the malignancy of gastric cancer

Jiawei Lu et al.

Summary: DLGAP1-AS2 functions as an oncogenic factor by directly interacting with Six3 to relieve its suppression on Wnt1 expression, driving the malignancy of gastric cancer. This signaling axis could potentially serve as a diagnostic and therapeutic target for gastric cancer.

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lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway and Oncogenic Autophagy

Qiong Wu et al.

Summary: SNHG11 serves as an oncoIncRNA in gastric cancer by promoting oncogenic autophagy and malignant behaviors through both the miR-483-3p/miR-1276 pathway and the Wnt/β-catenin pathway. Its upregulation is transcriptionally induced by TCF7L2 and may be a potential prognostic and therapeutic target for gastric cancer.

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Gene regulation by long non-coding RNAs and its biological functions

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Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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LncRNA NCK1-AS1 exerts oncogenic property in gastric cancer by targeting the miR-22-3p/BCL9 axis to activate the Wnt/β-catenin signaling

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Summary: The lncRNA NCK1-AS1 is highly expressed in gastric cancer and acts as an oncogene by competitively binding to miR-22-3p to upregulate BCL9 expression, leading to the activation of the Wnt/β-catenin signaling pathway and promoting gastric cancer progression.

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MiRNA-20b/SUFU/Wnt axis accelerates gastric cancer cell proliferation, migration and EMT

Yin Peng et al.

Summary: miRNA-20b is highly expressed in gastric cancer and promotes cell proliferation, migration, and EMT by activating the Wnt signaling pathway through targeting SUFU.

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Downregulating circRNA_0044516 Inhibits Cell Proliferation in Gastric Cancer Through miR-149/Wnt1/β-catenin Pathway

Jun Fang et al.

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Long non -coding RNA OIP5-AS1 promotes the growth of gastric cancer through the miR-367-3p/HMGA2 axis

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