4.7 Article

Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2 & alpha;/ATF4/CHOP and secretory autophagy pathways

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biology

Targeting Ca2+ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells

Vivian W. R. Moraes et al.

Summary: Mitochondria play crucial roles in cellular physiology, and their dysregulation has been linked to cancer cells. Thioridazine (TR) induces cytotoxicity in human leukemia cells through a mechanism involving calcium imbalance, mitochondrial permeabilization, endoplasmic reticulum stress, and apoptosis. Additionally, TR shows potential as an adjuvant in antitumor chemotherapy.

LIFE-BASEL (2022)

Review Oncology

Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy

Vikram Shaw et al.

Summary: The recent development of high throughput compound screening has allowed for drug repurposing, leading to the discovery of FDA-approved antipsychotic drugs like fluspirilene, penfluridol, and pimozide, which have shown promising anti-cancer effects in various cancer types by inhibiting proliferation and inducing apoptosis and suppressing metastasis.

SEMINARS IN CANCER BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Immunogenic cell death in colon cancer prevention and therapy

Hang Ruan et al.

MOLECULAR CARCINOGENESIS (2020)

Article Oncology

Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy

Yan Wang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Oncology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Biochemistry & Molecular Biology

The Resistance Mechanisms of Checkpoint Inhibitors in Solid Tumors

Evangelos Koustas et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/-Catenin Signaling Pathway in Glioma Cells

Cheng-Wei Chu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

Immunogenic cell death in cancer therapy: Present and emerging inducers

Jingyi Zhou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Medicine, Research & Experimental

ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine

Mahendra Seervi et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Cell Biology

The autophagic network and cancer

Marissa D. Rybstein et al.

NATURE CELL BIOLOGY (2018)

Article Oncology

Genetic Mechanisms of Immune Evasion in Colorectal Cancer

Catherine S. Grasso et al.

CANCER DISCOVERY (2018)

Article Oncology

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

Lorenzo Galluzzi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Oncology

Cancer Statistics, 2016

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

Article Biotechnology & Applied Microbiology

Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine

Haiying Yue et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Review Cell Biology

ER stress: Autophagy induction, inhibition and selection

Harun-Or Rashid et al.

AUTOPHAGY (2015)

Review Oncology

eIF2α phosphorylation as a biomarker of immunogenic cell death

Oliver Kepp et al.

SEMINARS IN CANCER BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Molecular mechanisms of ATP secretion during immunogenic cell death

I. Martins et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Oncology

Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation

Caitlin A. Schonewolf et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2014)

Article Biochemistry & Molecular Biology

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Katy J. Petherick et al.

EMBO JOURNAL (2013)

Review Cell Biology

Strange attractors: DAMPs and autophagy link tumor cell death and immunity

W. Hou et al.

CELL DEATH & DISEASE (2013)

Review Pharmacology & Pharmacy

Applications of Connectivity Map in drug discovery and development

Xiaoyan A. Qu et al.

DRUG DISCOVERY TODAY (2012)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Immunogenic death of colon cancer cells treated with oxaliplatin

A. Tesniere et al.

ONCOGENE (2010)

Review Immunology

The three Es of cancer immunoediting

GP Dunn et al.

ANNUAL REVIEW OF IMMUNOLOGY (2004)