4.7 Article

RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Association of Concurrent Metabolic Syndrome with Long-term Oncological Prognosis Following Liver Resection for Hepatocellular Carcinoma Among Patients with Chronic Hepatitis B Virus Infection: A Multicenter Study of 1753 Patients

Ming-Da Wang et al.

Summary: Concurrent metabolic syndrome is associated with poorer long-term prognosis in patients with HBV-related HCC after liver resection. These patients should undergo enhanced surveillance for tumor recurrence even after 2 years of surgery to detect late HCC recurrence early.

ANNALS OF SURGICAL ONCOLOGY (2023)

Article Surgery

Risk factors and long-term prognosis of beyond-Milan recurrence after hepatectomy for BCLC stage 0/A hepatocellular carcinoma: A large-scale multicenter study

Zi-Han Feng et al.

Summary: This study aimed to identify risk factors and assess the prognosis of patients who experienced beyond-Milan recurrence after hepatectomy for early-stage hepatocellular carcinoma. Out of 753 patients, 18.3% developed beyond-Milan recurrence. Factors such as high preoperative alpha-fetoprotein level, large tumor size, multifocal disease, microvascular invasion, and no/irregular recurrence surveillance were independently associated with increased risk of beyond-Milan recurrence. The median post-recurrence survival among patients with beyond-Milan recurrence was 8.4 months. Child-Pugh grade B/C, early recurrence, macrovascular invasion/distant metastasis, and noncurative treatment of recurrence were independent risk factors associated with worse post-recurrence survival.

SURGERY (2022)

Review Medicine, General & Internal

Hepatocellular carcinoma

Arndt Vogel et al.

Summary: Hepatocellular carcinoma is a common cancer worldwide, with non-alcoholic fatty liver disease becoming a dominant cause. Treatment options are varied, including surgery, radiation, and medication. With the approval of new drugs and the development of immunotherapy, the outlook for hepatocellular carcinoma patients has improved, but the optimal sequencing of drugs and predictive biomarkers still need further research.

LANCET (2022)

Article Immunology

Comprehensive analysis of the clinical significance, immune infiltration, and biological role of MARCH ligases in HCC

Jun Cao et al.

Summary: The MARCH ligase has been found to be associated with immune function and has potential as an immunotherapy target. This study reveals its correlation with prognosis, clinicopathological characteristics, and the tumor immune microenvironment in hepatocellular carcinoma patients. Construction of a risk score based on MARCH ligase-related genes provides important guidance for prognosis and treatment selection.

FRONTIERS IN IMMUNOLOGY (2022)

Article Immunology

The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation

Lin-Wen Zeng et al.

Summary: In this study, MARCH2 and MARCH3 were identified as negative regulators of IL-5-triggered signaling. They regulate allergic airway inflammation by degrading IL-5 receptor α chain. Double knockout of MARCH2 and MARCH3 exacerbates eosinophilia and inflammatory cell infiltration.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα

Lu Feng et al.

Summary: This study reveals that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling. MARCH3 is associated with IL-3R alpha, promoting its degradation and inhibiting IL-3-induced physiological functions and inflammatory diseases. MARCH3 deficiency aggravates IL-3-amplified expression of inflammatory cytokines, organ damage, and inflammatory death in sepsis.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Review Biochemistry & Molecular Biology

Roles of cell fusion between mesenchymal stromal/stem cells and malignant cells in tumor growth and metastasis

Li-Na Zhang et al.

Summary: Invasion and metastasis are key characteristics of malignant tumors, with epithelial-mesenchymal transition (EMT) recognized as the initial step. Cell fusion, particularly involving mesenchymal stromal/stem cells (MSCs), plays a critical role in cancer development and progression, potentially influencing tumor growth and metastasis.

FEBS JOURNAL (2021)

Review Oncology

The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review

Matthias Pinter et al.

Summary: Recent advancements in the treatment of advanced hepatocellular carcinoma (HCC) have led to the approval of new systemic therapies such as angiogenesis inhibitors and immune checkpoint blockers, indicating important progress in the field. Strategies to target immunosuppression in tumors, such as vascular endothelial growth factor pathway inhibition and transforming growth factor-beta pathway inhibition, show promise in enhancing the efficacy of immunotherapy in HCC. Successes and failures of these treatments have provided insights into implementing novel systemic therapy in HCC and improving immunotherapy efficacy for this disease.

JAMA ONCOLOGY (2021)

Article Immunology

The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis

Heng Lin et al.

Summary: The E3 ubiquitin ligase MARCH3 negatively regulates the activation of STAT3 triggered by IL-6 and OSM. MARCH3 deficiency increases inflammation and cancer development in mice, and is downregulated in human colorectal cancer tissues, suggesting it plays a pivotal role in inflammation-associated carcinogenesis.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Biochemistry & Molecular Biology

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Asmin Tulpule et al.

Summary: A membraneless, protein granule-based subcellular structure has been identified to organize RTK/RAS/MAPK signaling in cancer cells, actively signaling within the cytoplasm and activating RAS independently of lipid membranes. The formation of RTK protein granules is critical for oncogenic RAS/MAPK signaling output in these cells. This study reveals a distinct subcellular platform for organizing oncogenic RTK and RAS signaling through higher-order cytoplasmic protein assembly.
Review Oncology

Improving Outcomes of Tyrosine Kinase Inhibitors in Hepatocellular Carcinoma: New Data and Ongoing Trials

Lisha Mou et al.

Summary: Targeted therapies like TKIs are crucial for advanced HCC treatment, with combination therapies involving immune checkpoint inhibitors showing promise. Nanoparticle-based TKI delivery techniques are also expected to enhance treatment efficacy, making it more efficient.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

The Ubiquitin Proteasome System in Genome Stability and Cancer

Jonathan J. Morgan et al.

Summary: This article examines the importance of genomic stability in tumour development and the role of ubiquitination in maintaining genome integrity. Faithful DNA replication during cell division is crucial for genome stability, and dysregulation of the UPS may contribute to cancer progression.

CANCERS (2021)

Article Cell Biology

EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions

Sachin Surve et al.

Summary: The study demonstrated that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and do not colocalize with endosomal EGFR upon EGF stimulation. It was suggested that a small pool of surface EGFRs sustain signaling within the RAS-ERK1/2 pathway.

JOURNAL OF CELL BIOLOGY (2021)

Article Oncology

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation

Jingyuan Sun et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Biotechnology & Applied Microbiology

RNF128 Promotes Malignant Behaviors via EGFR/MEK/ERK Pathway in Hepatocellular Carcinoma

Xue-Song Bai et al.

ONCOTARGETS AND THERAPY (2020)

Article Oncology

Overexpression of RNF38 facilitates TGF- signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Rui Peng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Gastroenterology & Hepatology

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Gastroenterology & Hepatology

Targeted and Immune-Based Therapies for Hepatocellular Carcinoma

Tim F. Greten et al.

GASTROENTEROLOGY (2019)

Review Cell Biology

New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Cell Biology

EMT Transition States during Tumor Progression and Metastasis

Ievgenia Pastushenko et al.

TRENDS IN CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

MARCH3 attenuates IL-1 beta-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI

Heng Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biotechnology & Applied Microbiology

Overexpression of UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance

Rui Peng et al.

ONCOTARGETS AND THERAPY (2017)

Review Oncology

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

Geoffrey T. Gibney et al.

LANCET ONCOLOGY (2016)

Review Cell Biology

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Lori Buetow et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1

Yingying Qu et al.

MOLECULAR CANCER (2014)

Article Biochemistry & Molecular Biology

Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1

Caleb B. McDonald et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)

Review Oncology

Viral and cellular MARCH ubiquitin ligases and cancer

Xiaoli Wang et al.

SEMINARS IN CANCER BIOLOGY (2008)

Article Biochemistry & Molecular Biology

MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II

H Fukuda et al.

JOURNAL OF BIOCHEMISTRY (2006)