4.8 Article

Structural basis for membrane-proximal proteolysis of substrates by ADAM10

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors

Chek Ziu Koo et al.

Summary: The interaction between Tspan15 and GPVI is crucial for the cleavage of GPVI and Tspan15 plays a more important role in this process. The extracellular region of Tspan15 is critical in promoting the cleavage of GPVI.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

Colin H. Lipper et al.

Summary: Tspan15, a member of the TspanC8 subfamily, forms a complex that regulates protein cleavage by binding to ADAM10. The structure of Tspan15's large extracellular loop shows a unique core helical framework supporting a variable region that differs from other tetraspanin LEL structures.

STRUCTURE (2022)

Article Biology

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

Ruben Sanchez-Garcia et al.

Summary: Sanchez-Garcia et al. introduce DeepEMhancer, a deep learning-based method for automatic post-processing of raw cryo-electron microscopy density maps. It globally improves local quality of density maps and shows potential as a useful tool for structures without readily available PDB models.

COMMUNICATIONS BIOLOGY (2021)

Article Multidisciplinary Sciences

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81

Katherine J. Susa et al.

Summary: The structure of the CD19-CD81 complex bound to a therapeutic antigen-binding fragment was determined by cryo-electron microscopy, revealing the contact interface between the ectodomains and the conformational changes of CD81 upon binding to CD19. This provides insights into the assembly of the CD19-CD81 complex and offers a basis for designing therapies for B cell dysfunction.

SCIENCE (2021)

Review Biophysics

Biophysics of Notch Signaling

David Sprinzak et al.

Summary: Notch signaling is a conserved system that influences cell fate decisions in the development of multicellular organisms. NICD plays a key role in this pathway by regulating gene expression. The article reviews the molecular basis of Notch signal transduction and its implications in different cellular contexts.

ANNUAL REVIEW OF BIOPHYSICS, VOL 50, 2021 (2021)

Review Biochemistry & Molecular Biology

Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential

Neale Harrison et al.

Summary: ADAM10 acts as a molecular scissor by cleaving membrane protein substrates through ectodomain shedding, interacting with various substrates and particularly with the TspanC8 subgroup of tetraspanins. Recent studies suggest that different TspanC8/ADAM10 complexes have distinct substrates, offering therapeutic potential for diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Article Biochemistry & Molecular Biology

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

Chek Ziu Koo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

Sampath K. Loganathan et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Structural insights into tetraspanin CD9 function

Rie Umeda et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Open conformation of tetraspanins shapes interaction partner networks on cell membranes

Yihu Yang et al.

EMBO JOURNAL (2020)

Article Biology

TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life

Etienne Eschenbrenner et al.

LIFE SCIENCE ALLIANCE (2020)

Article Oncology

Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma

Kazuya Hiroshima et al.

EXPERIMENTAL CELL RESEARCH (2019)

Article Biochemistry & Molecular Biology

In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15

Lisa Seipold et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Review Biochemistry & Molecular Biology

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments

Stefan F. Lichtenthaler et al.

EMBO JOURNAL (2018)

Review Immunology

The emerging role of ADAM metalloproteinases in immunity

Bart N. Lambrecht et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

Humsa S. . Venkatesh et al.

NATURE (2017)

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

Article Biochemistry & Molecular Biology

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

Tom C. M. Seegar et al.

Article Biochemistry & Molecular Biology

The metalloproteinase ADAM10: A useful therapeutic target?

Sebastian Wetzel et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Review Biochemistry & Molecular Biology

Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins

Alexandra L. Matthews et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2017)

Article Biochemistry & Molecular Biology

TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

Stephanie Jouannet et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Biochemistry & Molecular Biology

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

Brandon Zimmerman et al.

Editorial Material Biology

Collaboration gets the most out of software

Andrew Morin et al.

Article Biochemical Research Methods

Towards automated crystallographic structure refinement with phenix.refine

Pavel V. Afonine et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10

Johannes Prox et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Biochemistry & Molecular Biology

TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling

Cheng Liu et al.

MOLECULAR CELL (2009)

Review Cell Biology

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer

Jessica Pruessmeyer et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2009)

Article Neurosciences

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1

Kengo Uemura et al.

NEUROSCIENCE LETTERS (2006)

Article Biochemistry & Molecular Biology

Automated electron microscope tomography using robust prediction of specimen movements

DN Mastronarde

JOURNAL OF STRUCTURAL BIOLOGY (2005)

Review Cell Biology

Tetraspanin functions and associated microdomains

ME Hemler

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Multidisciplinary Sciences

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and, β-catenin translocation

T Maretzky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemical Research Methods

Coot:: model-building tools for molecular graphics

P Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)

Article Multidisciplinary Sciences

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

AP Weng et al.

SCIENCE (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Regulation of the α-secretase ADAM10 by its prodomain and proprotein convertases

A Anders et al.

FASEB JOURNAL (2001)