4.7 Review

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C

Pegah Golabi et al.

Summary: The study assessed the causes of death in patients with different types of chronic liver diseases in the United States. The results showed that liver-related mortality was the leading cause of death for all types of CLD, followed by cardiac causes and extrahepatic cancer as common causes of death. Liver cancer was found to be the leading cause of cancer-related mortality among deceased patients with CLD.

ANNALS OF HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and risk of incident chronic kidney disease: an updated meta-analysis

Alessandro Mantovani et al.

Summary: This meta-analysis confirms a significant association between non-alcoholic fatty liver disease (NAFLD) and increased risk of chronic kidney disease (CKD). It also suggests that the severity of NAFLD may influence the risk of CKD.
Review Gastroenterology & Hepatology

Bariatric Surgery in NAFLD

Mahak Chauhan et al.

Summary: Currently, there are no approved medications for patients with NASH-related liver disease. Lifestyle modifications are often ineffective in achieving weight reduction in these patients. Bariatric surgery may be considered as an option for those who fail to lose weight through lifestyle changes. It has shown to improve liver histology and other comorbidities, as well as reduce cardiovascular morbidity and mortality.

DIGESTIVE DISEASES AND SCIENCES (2022)

Review Gastroenterology & Hepatology

The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases

Lingxuan An et al.

Summary: Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty liver disease and alcoholic liver disease, strongly linked with obesity. Gut dysbiosis and gut barrier dysfunction crucially contribute to the development of chronic liver disease. Treatments targeting the gut microbiome and gut barrier have shown potential benefits in attenuating liver inflammation.

JOURNAL OF GASTROINTESTINAL SURGERY (2022)

Article Gastroenterology & Hepatology

Baveno VII - Renewing consensus in portal hypertension

Roberto de Franchis et al.

Summary: The Baveno VII workshop focused on personalized care for portal hypertension in patients with compensated cirrhosis or cACLD, discussing various aspects including diagnosis, treatment, and prevention measures in 9 main topics, resulting in a series of consensus recommendations.

JOURNAL OF HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men

Jun Li et al.

Summary: This study found that high intake of red meat and choline was significantly associated with TMAO concentrations, especially among participants identified as microbial TMAO-producers. Alistipes shahii strengthened the positive association between red meat intake and HbA1c levels. The results underscore the interaction between diet and gut microbiome in producing potentially bioactive metabolites that may modulate cardiometabolic health.
Article Gastroenterology & Hepatology

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Ferenc Emil Mozes et al.

Summary: Liver biopsy is still necessary for fibrosis staging in patients with non-alcoholic fatty liver disease. This study evaluated the diagnostic performance of liver stiffness measurement, FIB-4 Index, and NAFLD Fibrosis Score, and showed that sequential combinations of markers can reduce the need for liver biopsies.
Review Gastroenterology & Hepatology

Population screening for liver fibrosis: Toward early diagnosis and intervention for chronic liver diseases

Pere Gines et al.

Summary: Cirrhosis is a highly prevalent global disease caused mainly by non-alcoholic fatty liver disease and alcohol-related liver diseases. Noninvasive methods can accurately assess liver fibrosis, and screening high-risk populations for liver fibrosis may have the potential to prevent disease progression.

HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study

Mary E. Rinella et al.

Summary: Non-invasive tests (NITs) have potential applications in evaluating fibrosis and treatment response in patients with non-alcoholic steatohepatitis (NASH). Treatment with obeticholic acid (OCA) can lead to reduced levels of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyltransferase, as well as improvements in Fibrosis-4, FibroTest, FibroMeter, and FibroScan-AST scores.

JOURNAL OF HEPATOLOGY (2022)

Article Immunology

Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease

Yamei Duan et al.

Summary: This study found a significant association between inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD). Increased concentrations of C-reactive protein (CRP), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 (ICAM-1) were significantly associated with increased risks of NAFLD.

FRONTIERS IN IMMUNOLOGY (2022)

Letter Gastroenterology & Hepatology

Global multi-stakeholder endorsement of the MAFLD definition

Nahum Mendez-Sanchez et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

Review Gastroenterology & Hepatology

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review

Michelle T. Long et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to serious complications and death. This article summarizes the epidemiological characteristics, prognosis, and mortality of lean individuals with NAFLD, and provides clinical practice recommendations.

GASTROENTEROLOGY (2022)

Article Gastroenterology & Hepatology

Macronutrient and Micronutrient Intake in Adolescents With Non-alcoholic Fatty Liver Disease: The Association With Disease Severity

Ariel Porto et al.

Summary: This study aimed to evaluate the macronutrient and micronutrient intake in adolescents with NAFLD and determine nutritional predictors of disease severity. The results showed that NAFLD patients had similar intake of total calories, protein, fat, and carbohydrates as those without NASH, but NASH patients had higher sugar intake. The severity of the liver disease was correlated with total carbohydrate and added sugar intake.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2022)

Review Nutrition & Dietetics

Important Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials

Danielle Lee et al.

Summary: This systematic review and meta-analysis investigated the effects of fructose-containing sugars from different food sources and different levels of energy control on non-alcoholic fatty liver disease (NAFLD) markers. The results showed that fructose-containing sugars increased intrahepatocellular lipid (IHCL), especially from sugar-sweetened beverages (SSBs), while the removal of energy from mixed sources (with SSBs) decreased aspartate aminotransferase (AST). However, there is still uncertainty about the effects of other important food sources of fructose-containing sugars.

NUTRIENTS (2022)

Review Gastroenterology & Hepatology

GCKIII kinases in lipotoxicity: Roles in NAFLD and beyond

Margit Mahlapuu et al.

Summary: This review provides an overview of recent studies on the role of GCKIII kinases in NAFLD/NASH. Significant progress has been made in understanding the involvement of GCKIII kinases in hepatic fat accumulation and the progression of NAFLD, but there are still unresolved questions. More research is needed to fully understand the potential of GCKIII kinases as therapeutic targets for NAFLD and its comorbidities.

HEPATOLOGY COMMUNICATIONS (2022)

Article Gastroenterology & Hepatology

Prevalence and Risk Factors of Advanced Liver Fibrosis in a Population-Based Study in Germany

Yvonne Huber et al.

Summary: This study explores liver enzymes and surrogate scores of hepatic steatosis and advanced hepatic fibrosis in the German population. The findings show that elevated liver enzymes were seen in almost a fifth of the German population, and the prevalence of advanced fibrosis was estimated at 1%.

HEPATOLOGY COMMUNICATIONS (2022)

Review Gastroenterology & Hepatology

Role of Cholesterol-Associated Steatohepatitis in the Development of NASH

Christian L. Horn et al.

Summary: The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related cirrhosis in the United States and globally emphasizes the importance of understanding the mechanisms causing progression of hepatic steatosis to fibrosing steatohepatitis and cirrhosis. Accumulating evidence suggests that hepatic free cholesterol (FC) overload plays a key role in necroinflammation and fibrosis, contributing to the development and progression of nonalcoholic steatohepatitis (NASH).

HEPATOLOGY COMMUNICATIONS (2022)

Article Cardiac & Cardiovascular Systems

Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability

Yen Chin Koay et al.

Summary: The study found that changes in the microbiome induced by both 'healthy' and 'unhealthy' diets can increase plasma TMAO levels in mice. Interestingly, TMAO can be directly oxidized in the gut. However, there was no direct association of plasma TMAO with the extent of atherosclerosis in two well-accepted mouse models of the disease.

CARDIOVASCULAR RESEARCH (2021)

Article Gastroenterology & Hepatology

From NAFLD to MAFLD: Implications of a Premature Change in Terminology

Zobair M. Younossi et al.

Summary: The article discusses the proposal to rename NAFLD to MAFLD, highlighting the shortcomings of the new term and warning that changing the name without a comprehensive understanding may have negative implications for the field. The recommendation is to establish a true international consensus group to assess the impact and consequences of the terminology change and make recommendations based on available evidence to move the field forward.

HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

Microbiomics, Metabolomics, Predicted Metagenomics, and Hepatic Steatosis in a Population-Based Study of 1,355 Adults

Louise J. M. Alferink et al.

Summary: This study found a decrease in gut microbial diversity in patients with steatosis, and identified associations of Coprococcus and Ruminococcus Gnavus with steatosis. The metabolic profile in patients with steatosis showed opposite correlations with alpha diversity, indicating a complex relationship between gut microbiome, metabolism, and liver health.

HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort

Tracey G. Simon et al.

Summary: Population-based data in Sweden showed that all histological stages of NAFLD were linked with significantly increased overall mortality, and the risk escalated progressively with worsening histology. Excess mortality was mainly attributed to extrahepatic cancer and cirrhosis, while cardiovascular disease and HCC made modest contributions.
Article Medicine, General & Internal

A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

Sven M. Francque et al.

Summary: In a randomized trial, the pan-PPAR agonist Lanifibranor showed significant improvement in histologic features of NASH at a dose of 1200 mg. However, adverse events such as weight gain, anemia, peripheral edema, diarrhea, and nausea were more common with Lanifibranor compared to placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

News Item Gastroenterology & Hepatology

Research in brief

Holly Baker

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Multidisciplinary Sciences

Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality

Xing Liu et al.

Summary: Higher intake of dietary fiber and whole grains is associated with lower risk of liver cancer and chronic liver disease mortality, with fiber from vegetables, beans, and grains showing potential protective effects.

NATURE COMMUNICATIONS (2021)

Review Medicine, General & Internal

Non-alcoholic fatty liver disease

Elizabeth E. Powell et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.

LANCET (2021)

Article Gastroenterology & Hepatology

A nonbile acid farnesoid X receptor agonist tropifexor potently inhibits cholestatic liver injury and fibrosis by modulating the gut-liver axis

Yongtao Xiao et al.

Summary: TXR potently ameliorated cholestatic liver injury and fibrosis by modulating the gut-liver axis in piglets, supporting its potential as a therapeutic strategy for cholestatic liver diseases.

LIVER INTERNATIONAL (2021)

Article Medicine, General & Internal

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

Philip N. Newsome et al.

Summary: This phase 2 trial demonstrated that treatment with semaglutide resulted in a significantly higher percentage of patients with NASH resolution compared to placebo in patients with NASH, but did not show a significant between-group difference in the percentage of patients with an improvement in fibrosis stage.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Gastroenterology & Hepatology

Therapeutic aspects of bile acid signalling in the gut-liver axis

Benedikt Simbrunner et al.

Summary: Bile acids play a crucial role in maintaining bile acid homeostasis and regulating the development of liver diseases through the gut-liver axis. The nuclear bile acid farnesoid X receptor (FXR) has emerged as a key therapeutic target in bile acid signalling pathways. Experimental evidence suggests that bile acid signalling can improve the intestinal barrier and protect against bacterial translocation in cirrhosis, showing efficacy in cholestatic and metabolic liver diseases. However, further research is needed to demonstrate similar effects in advanced liver disease, particularly in patients with decompensated cirrhosis.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

Article Gastroenterology & Hepatology

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease

Fasiha Kanwal et al.

Summary: NAFLD is a common disease that affects a significant proportion of US adults. Management typically occurs in primary care or endocrine clinics, where accurate staging for fibrosis risk through screening is crucial, requiring consistent, timely, evidence-based, and easily testable management processes.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update

Annalisa Berzigotti et al.

Summary: The article provides the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for assessing liver disease severity and prognosis, with a focus on topics with relevant evidence published in the last 5 years.

JOURNAL OF HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

24-Norursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

Ci Zhu et al.

Summary: NorUDCA has immunomodulatory effects by reducing hepatic innate and adaptive immune cells, including CD8+ T cells, and targeting mTORC1 signaling in CD8+ T cells, which contributes to its therapeutic efficacy in immune-mediated liver diseases such as primary sclerosing cholangitis.

JOURNAL OF HEPATOLOGY (2021)

Review Endocrinology & Metabolism

Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

Herbert Tilg et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a global pandemic that particularly affects patients with obesity and type 2 diabetes. The complex interplay between metabolic dysregulation, altered gut microbiome and dysregulated innate and adaptive immunity contributes to the pathology and progression of NAFLD.

NATURE METABOLISM (2021)

Article Gastroenterology & Hepatology

STE20-Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in Hepatocytes

Mara Caputo et al.

Summary: In the pathogenesis of NAFLD, MST4 is identified as a critical regulator that affects lipid accumulation by regulating beta-oxidation and triacylglycerol secretion. In addition, MST4 has been found to influence oxidative stress and endoplasmic reticulum stress in hepatocytes, indicating its potential as a therapeutic target for preventing or treating NAFLD.

HEPATOLOGY COMMUNICATIONS (2021)

Article Gastroenterology & Hepatology

Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH

Stephen A. Harrison et al.

Summary: The study demonstrated significant improvements in liver fat reduction, lipid metabolism, and fibrosis markers reduction in NASH patients treated with resmetirom for 36 weeks. Resmetirom showed good tolerability and safety in patients with NASH.

HEPATOLOGY COMMUNICATIONS (2021)

Article Biotechnology & Applied Microbiology

Akkermansia muciniphila Prevents Fatty Liver Disease, Decreases Serum Triglycerides, and Maintains Gut Homeostasis

Sejeong Kim et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2020)

Article Gastroenterology & Hepatology

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

Silvia Sookoian et al.

Article Gastroenterology & Hepatology

Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD

Guido Carpino et al.

HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis

Mohammad Shadab Siddiqui et al.

JOURNAL OF HEPATOLOGY (2020)

Article Chemistry, Medicinal

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis

Donatella Chianelli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Gastroenterology & Hepatology

The microbiome modulating activity of bile acids

Yuan Tian et al.

GUT MICROBES (2020)

Article Endocrinology & Metabolism

Association of glucose-lowering medications with cardiovascular outcomes: an umbrella review and evidence map

Jianhong Zhu et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

Review Gastroenterology & Hepatology

Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Michitaka Matsuda et al.

SEMINARS IN LIVER DISEASE (2020)

Review Gastroenterology & Hepatology

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease

Tiangang Li et al.

HEPATOBILIARY SURGERY AND NUTRITION (2020)

Review Gastroenterology & Hepatology

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

Judith Aron-Wisnewsky et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Editorial Material Gastroenterology & Hepatology

From NAFLD to MAFLD: when pathophysiology succeeds

Herbert Tilg et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Pharmacology & Pharmacy

Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH)

Stefano Fiorucci et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)

Article Gastroenterology & Hepatology

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis

Guillaume Lassailly et al.

GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

MAFLD identifies patients with significant hepatic fibrosis better than NAFLD

Sakura Yamamura et al.

LIVER INTERNATIONAL (2020)

Review Gastroenterology & Hepatology

Intestinal permeability in human nonalcoholic fatty liver disease: A systematic review and meta-analysis

Toon J. I. De Munck et al.

LIVER INTERNATIONAL (2020)

Article Cell Biology

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Sarah Alsamman et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Letter Gastroenterology & Hepatology

Circulating microbiome in blood of different circulatory compartments

Robert Schierwagen et al.

Article Endocrinology & Metabolism

Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes

Ralph A. DeFronzo et al.

DIABETES & VASCULAR DISEASE RESEARCH (2019)

Article Multidisciplinary Sciences

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

Soumik BasuRay et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Environmental Sciences

Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications

Claudio Tana et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

Article Gastroenterology & Hepatology

Cholesterol Crystals in Hepatocyte Lipid Droplets Are Strongly Associated With Human Nonalcoholic Steatohepatitis

George N. Ioannou et al.

HEPATOLOGY COMMUNICATIONS (2019)

Review Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Zobair Younossi et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

Cynthia Lebeaupin et al.

JOURNAL OF HEPATOLOGY (2018)

Article Biochemistry & Molecular Biology

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Lesley Hoyles et al.

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

Taylor K. Soderborg et al.

NATURE COMMUNICATIONS (2018)

Review Gastroenterology & Hepatology

NAFLD and diabetes mellitus

Herbert Tilg et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Editorial Material Gastroenterology & Hepatology

How to Approach a Patient With Nonalcoholic Fatty Liver Disease

Herbert Tilg

GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

Bi-directional analysis between fatty liver and cardiovascular disease risk factors

Jiantao Ma et al.

JOURNAL OF HEPATOLOGY (2017)

Article Medicine, General & Internal

Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis A Meta-analysis

Giovanni Musso et al.

JAMA INTERNAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Weifei Zhu et al.

Article Biochemistry & Molecular Biology

STK25 is a critical determinant in nonalcoholic steatohepatitis

Manoj Amrutkar et al.

FASEB JOURNAL (2016)

Article Gastroenterology & Hepatology

Changes in Blood Microbiota Profiles Associated With Liver Fibrosis in Obese Patients: A Pilot Analysis

Benjamin Lelouvier et al.

HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

Giulio Marchesini et al.

JOURNAL OF HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

Giovanni Targher et al.

JOURNAL OF HEPATOLOGY (2016)

Review Endocrinology & Metabolism

The Role of Cholesterol in the Pathogenesis of NASH

George N. Ioannou

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)

Review Endocrinology & Metabolism

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis

Mark A. Herman et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)

Article Cardiac & Cardiovascular Systems

Quantifying the Association Between Physical Activity and Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis

Ahad Wahid et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Biochemistry & Molecular Biology

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH

Manoj Amrutkar et al.

FASEB JOURNAL (2015)

Article Gastroenterology & Hepatology

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

Eduardo Vilar-Gomez et al.

GASTROENTEROLOGY (2015)

Article Endocrinology & Metabolism

High Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels

Paola Portillo-Sanchez et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Review Endocrinology & Metabolism

Short-chain fatty acids in control of body weight and insulin sensitivity

Emanuel E. Canfora et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Article Pharmacology & Pharmacy

Toll-like receptor-4 signalling in the progression of non-alcoholic fatty liver disease induced by high-fat and high-fructose diet in mice

Jing Liu et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Hanna Ruhanen et al.

JOURNAL OF LIPID RESEARCH (2014)

Article Multidisciplinary Sciences

Alterations of the human gut microbiome in liver cirrhosis

Nan Qin et al.

NATURE (2014)

Article Gastroenterology & Hepatology

Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease

Maitreyi Raman et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2013)

Article Medicine, General & Internal

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

W. H. Wilson Tang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease (NAFLD) is associated with low level of physical activity: a population-based study

L. Gerber et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2012)

Review Neurosciences

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

Ekihiro Seki et al.

JOURNAL OF PHYSIOLOGY-LONDON (2012)

Article Gastroenterology & Hepatology

Physical Activity Recommendations, Exercise Intensity, and Histological Severity of Nonalcoholic Fatty Liver Disease

Kristin D. Kistler et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2011)

Review Cell Biology

Crosstalk of reactive oxygen species and NF-kappa B signaling

Michael J. Morgan et al.

CELL RESEARCH (2011)

Article Gastroenterology & Hepatology

Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States

Michael R. Charlton et al.

GASTROENTEROLOGY (2011)

Article Gastroenterology & Hepatology

Characterization of Fecal Microbial Communities in Patients with Liver Cirrhosis

Yanfei Chen et al.

HEPATOLOGY (2011)

Article Multidisciplinary Sciences

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Naoki Kumashiro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase

Yin Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Gastroenterology & Hepatology

Reduced Mortality Rates Following Elective Percutaneous Liver Biopsies

Joe West et al.

GASTROENTEROLOGY (2010)

Article Medicine, General & Internal

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis.

Arun J. Sanyal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Gastroenterology & Hepatology

Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance

Giovanni Tarantino et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

Article Gastroenterology & Hepatology

Histopathology of nonalcoholic fatty liver disease

Elizabeth M. Brunt et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

Article Gastroenterology & Hepatology

Effects of weight loss induced by bariatric surgery on hepatic adipocytokine expression

Alexander R. Moschen et al.

JOURNAL OF HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis

Guruprasad P. Aithal et al.

GASTROENTEROLOGY (2008)

Article Genetics & Heredity

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Stefano Romeo et al.

NATURE GENETICS (2008)

Article Endocrinology & Metabolism

Habitual physical activity is associated with intrahepatic fat content in humans

Gianluca Perseghin et al.

DIABETES CARE (2007)

Article Gastroenterology & Hepatology

Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases

C Loguercio et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2005)

Article Biochemistry & Molecular Biology

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

DS Cai et al.

NATURE MEDICINE (2005)

Article Biochemistry & Molecular Biology

IKK-β links inflammation to obesity-induced insulin resistance

MC Arkan et al.

NATURE MEDICINE (2005)

Article Biochemistry & Molecular Biology

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

VT Samuel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

The gut microbiota as an environmental factor that regulates fat storage

F Bäckhed et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

AJ Brown et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Medicine, General & Internal

Mechanisms of disease: Cytokines in alcoholic and nonalcoholic steatohepatitis.

H Tilg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)