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Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives

CARBOHYDRATE POLYMERS (2024)

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Natural biopolymers derived hydrogels with injectable, self-healing and tissue adhesive abilities for wound healing

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An injectable and self-healing hydrogel with antibacterial and angiogenic properties for diabetic wound healing

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Abdalla H. Karoyo et al.

Summary: Hydrogels are hydrophilic 3D networks made of natural polymers with excellent properties for biomedical applications. They have high water absorption capacity and biocompatibility, and require variable time to reach equilibrium swelling at different diffusion rates.

MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

Zifeng Yang et al.

Summary: By grafting cationic polyelectrolyte brushes onto polydopamine/polyacrylamide hydrogels, the mechanical and antibacterial properties of the hydrogels were enhanced, leading to stable coverage, long-lasting antibacterial effects, and fast wound healing.

ADVANCED SCIENCE (2021)

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Article Multidisciplinary Sciences

Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages

Yuanman Yu et al.

Summary: A study found that semisynthetic sulfated chitosan (SCS) can induce angiogenesis by increasing the secretion of VEGF by macrophages, aiding in the treatment of ischemic diseases. SCS works through the VEGF-VEGFR2 signaling pathway, and inhibiting VEGF or VEGFR2 signals can affect the role of macrophages in angiogenesis.

SCIENCE ADVANCES (2021)

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Review Pharmacology & Pharmacy

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Shery Jacob et al.

Summary: Hydrogels are popular biomaterials known for their tunable physical properties, encapsulation capabilities, water holding capacity, and degradability. This review extensively discusses functionalization strategies and applications, covering different cross-linking techniques, materials, advantages, and disadvantages of hydrogels in drug delivery systems and wound dressing materials. Their unique features make hydrogels promising in the fields of drug delivery systems and applied biomedicine.

PHARMACEUTICS (2021)

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Review Biotechnology & Applied Microbiology

Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

Peipei Feng et al.

Summary: Hydrogels are effective wound dressings with unique properties, while chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. Hydrogel-like functional wound dressings made from chitosan and its derivatives have received extensive attention for their effectiveness in promoting skin wound repair.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Engineering, Environmental

Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release

Cheng Hu et al.

Summary: The study successfully overcame the challenges in healing chronic diabetic wounds, such as bacterial infections and difficulty in angiogenesis, by using a pH-responsive double-crosslinking hydrogel.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Materials Science, Multidisciplinary

pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing

Zuhao Li et al.

Summary: A self-healing, injectable, and pH responsive hydrogel was successfully synthesized and incorporated with insulin glargine, showing promising potential in accelerating the healing of diabetic foot ulcers by shortening the inflammatory phase, promoting tissue formation, and improving treatment outcomes.

MATERIALS & DESIGN (2021)

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Article Biochemistry & Molecular Biology

Enzymatic and Chemical Cross-Linking of Bacterial Cellulose/Fish Collagen Composites-A Comparative Study

Agata Sommer et al.

Summary: This study compares the properties of bacterial cellulose/fish collagen composites (BC/Col) after enzymatic and chemical cross-linking, revealing that enzymatic cross-linking can enhance thermal stability and crystallinity of the material, while oxBC/Col resulting from chemical cross-linking shows lower thermal stability and crystallinity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Medicinal

An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management

Elena-Emilia Tudoroiu et al.

Summary: Cellulose derivatives, with excellent properties such as biocompatibility, biodegradability, and antibacterial effect, have shown great potential in wound-healing applications. They can efficiently absorb and retain wound exudates, as well as incorporate various bioactive agents to promote skin tissue restoration.

PHARMACEUTICALS (2021)

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Review Biology

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Jingjing Su et al.

Summary: Wounds are a leading cause of death worldwide, and the development of multifunctional hydrogel wound dressings is crucial for effective treatment of chronic wounds. The unique properties of hydrogels make them an ideal candidate for wound care, overcoming the limitations of traditional dressings. However, there are still challenges in the development and widespread use of hydrogel dressings.

LIFE-BASEL (2021)

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Article Biotechnology & Applied Microbiology

Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing

Biyun Lan et al.

Summary: The hybrid hydrogel dressing developed for localized delivery of MMP-9 siRNA showed significant reduction in MMP-9 expression and improved diabetic wound closure in diabetic rats. The dressing exhibited negligible cytotoxicity in vitro and sustained release of siMMP-9 for up to 7 days. This delivery system offers a platform for in vivo delivery of siRNA for the treatment of various diseases.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing

Manhui Zheng et al.

Summary: The study introduces a mechanically-flexible, electroactive, and self-healable hydrogel (MESGel) with outstanding biocompatibility and multifunctional therapeutic properties. Experimental results demonstrate that MESGel can effectively promote cell proliferation, accelerate skin wound healing, and has the potential to be a novel flexible electronic skin sensor.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing

Pan Liu et al.

Summary: A multifunctional and conductive hydrogel dressing developed in this study based on polymerized ionic liquid and konjac glucomannan showed excellent mechanical properties, biocompatibility, and an efficient sterilization effect. When combined with electrical stimulation, it significantly improved fibroblast cell migration and proliferation, as well as the treatment effect on diabetic skin wounds, providing a novel strategy for efficiently treating chronic wounds.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Materials Science, Biomaterials

Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels

Syed Ahmed Shah et al.

Summary: This study presents an injectable hydrogel based on chondroitin sulphate and sodium alginate loaded with curcumin for diabetic wound repair. The hydrogel demonstrated good biocompatibility and tissue regeneration ability, with controlled release of curcumin showing promising results in promoting wound healing.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Surgery

Updates in Diabetic Wound Healing, Inflammation, and Scarring

Nina Dasari et al.

Summary: Diabetic patients are prone to wound complications, with changes such as excessive inflammation and reduced angiogenesis affecting the healing process. Factors like nutritional status and glycemic control play a significant role in diabetic wound outcomes. Various treatments are available to address diabetic wounds.

SEMINARS IN PLASTIC SURGERY (2021)

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Review Genetics & Heredity

Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components

Susana G. Martins et al.

Summary: Oxidative stress and DNA damage can disrupt the normal physiological equilibrium of cells and tissues, particularly in the process of ECM remodeling. Mutations in ECM genes have a significant impact on tissue homeostasis, leading to increased oxidative stress and potential accumulation of DNA damage, ultimately resulting in negative impacts on tissue and organ function.

FRONTIERS IN GENETICS (2021)

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Review Biochemistry & Molecular Biology

Modern Wound Dressings: Hydrogel Dressings

Valentin Brumberg et al.

Summary: This article discusses the treatment of chronic wounds and the application of related dressings, focusing on the advantages of hydrogels and comparing them with other technologies.

BIOMEDICINES (2021)

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Review Health Care Sciences & Services

Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds

Andreea Barbu et al.

Summary: Chronic wounds pose a major public health issue with high costs globally. An ideal wound dressing should possess various characteristics such as adhesion, non-antigenicity, biocompatibility, semi-permeability, and biodegradability. This paper explores the use of biopolymer materials, specifically alginate forms, in advanced wound healing applications, focusing on hydrogels, nanofibers networks, and 3D-scaffolds.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Review Chemistry, Applied

Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

Ankur Sood et al.

Summary: This paper highlights the versatile use of polysaccharides based biomaterials in various biomedical applications such as drug delivery and tissue regeneration. It covers the structure, unique properties, functionalization strategies, as well as physical and chemical crosslinking approaches of different polysaccharides. The studies reviewed here motivate the fabrication of novel polysaccharides based biomaterials with outstanding properties and functionality, and discuss various future possibilities for their widespread commercial use.

CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS (2021)

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Review Engineering, Biomedical

Development of Hydrogel-Based Sprayable Wound Dressings for Second- and Third-Degree Burns

Jacqueline Jialu He et al.

Summary: Sprayable wound dressings are essential for managing high-degree burns, providing convenient and quick dressing changes, along with infection prevention and secondary trauma avoidance.

ADVANCED NANOBIOMED RESEARCH (2021)

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Review Chemistry, Multidisciplinary

Recent advances in polysaccharide-based hydrogels for synthesis and applications

Zili Li et al.

Summary: Polysaccharide-based hydrogels are formed by utilizing polysaccharides as building blocks through physical or chemical crosslinking, showcasing good biocompatibility and biodegradability, as well as unique physicochemical properties and excellent mechanical performance.

AGGREGATE (2021)

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Article Polymer Science

Gelation Based on Host-Guest Interactions Induced by Multi-Functionalized Nanosheets

Hao Ding et al.

Summary: This study presents a novel gelation system based on host-guest interactions, with adamantyl groups acting as reversible crosslinkers within the beta-cyclodextrin polymer. The gelation process occurs quickly at room temperature, without the formation of covalent bonds, showing potential for further research in this area.

GELS (2021)

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Article Materials Science, Multidisciplinary

An injectable serotonin-chondroitin sulfate hydrogel for bio-inspired hemostatic adhesives with high wound healing capability

Xingxia Zhang et al.

Summary: A new hydrogel inspired by platelet coagulation mediator has been developed with improved hemostatic performance and wound healing capability. The hydrogel is prepared using highly biocompatible serotonin and chondroitin sulfate, exhibiting rapid hemostasis and wound healing.

MATERIALS ADVANCES (2021)

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Article Nanoscience & Nanotechnology

Pristine Gellan Gum Collagen Interpenetrating Network Hydrogels as Mechanically Enhanced Anti-inflammatory Biologic Wound Dressings for Burn Wound Therapy

Jian Yao Ng et al.

Summary: The combination of gellan gum and collagen to create a full interpenetrating network hydrogel has shown to enhance wound healing properties and promote regeneration by utilizing adipose-derived mesenchymal stem cells. The introduced hydrogel fabrication process demonstrated temperature-dependent simultaneous interpenetrating network, leading to improved mechanical properties and the ability to retain sufficient mass for cell-based therapy. Additionally, the incorporation of stem cells within the hydrogel structure showed increased stiffness and enhanced cell adhesion, ultimately resulting in successful application for burn wound therapy.

ACS APPLIED BIO MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A Multifunctional Pro-Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment

Yingnan Zhu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Novel Double-Crosslinking-Double-Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

Lei Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation

Chunyi Tong et al.

BIOMATERIALS (2020)

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Article Dermatology

A Device to Predict Short-Term Healing Outcome of Chronic Wounds

Hong Vu et al.

ADVANCES IN WOUND CARE (2020)

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Review Chemistry, Applied

Hyaluronic acid-Based wound dressings: A review

Mariana F. P. Graca et al.

CARBOHYDRATE POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Photo -responsive supramolecular hyaluronic acid hydrogels for accelerated wound healing

Weiyi Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Biochemistry & Molecular Biology

Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications

Carmen P. Jimenez-Gomez et al.

MOLECULES (2020)

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Review Cell Biology

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Marija Petkovic et al.

CELLS (2020)

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Article Biotechnology & Applied Microbiology

Chemical Modification of Bacterial Cellulose for the Development of an Antibacterial Wound Dressing

Isabel Orlando et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Microbiology

Biofilms in Diabetic Foot Ulcers: Significance and Clinical Relevance

Cassandra Pouget et al.

MICROORGANISMS (2020)

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Article Biochemistry & Molecular Biology

A composite hydrogel loading natural polysaccharides derived from Periplaneta americana herbal residue for diabetic wound healing

Ting Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases

Griselda A. Cabral-Pacheco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Polymer Science

Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications

Shahid Bashir et al.

POLYMERS (2020)

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Review Chemistry, Medicinal

The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs

Simona Federica Spampinato et al.

PHARMACEUTICALS (2020)

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Article Biophysics

Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing

Syed Muntazir Andrabi et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Review Materials Science, Biomaterials

Rational design and latest advances of polysaccharide-based hydrogels for wound healing

Hao Hu et al.

BIOMATERIALS SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Electroconductive Hydrogels for Tissue Engineering: Current Status and Future Perspectives

Zachary J. Rogers et al.

BIOELECTRICITY (2020)

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Article Pharmacology & Pharmacy

Sustained release of recombinant thrombomodulin from cross-linked gelatin/hyaluronic acid hydrogels potentiate wound healing in diabetic mice

Yun-Yan Hsu et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Review Polymer Science

The production and application of hydrogels for wound management: A review

Abhishek Gupta et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Injectable and self-healing polysaccharide-based hydrogel for pH-responsive drug release

Chao Qian et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Polymer Science

Synthesis and characterization of polysaccharide hydrogel based on hydrophobic interactions

Rahul Fredrick et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2019)

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Review Medicine, Research & Experimental

Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

Satish Patel et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Biochemistry & Molecular Biology

Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation

Changye Sun et al.

FEBS OPEN BIO (2019)

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Article Endocrinology & Metabolism

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Pouya Saeedi et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2019)

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Article Biochemistry & Molecular Biology

Novel biodegradable pH-sensitive hydrogels: An efficient controlled release system to manage ulcerative colitis

Mudassir Abbasi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Review Biochemistry & Molecular Biology

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

Junpeng Xu et al.

MOLECULES (2019)

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Article Engineering, Biomedical

Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages

Jiang Wu et al.

BIOMATERIALS (2019)

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Article Polymer Science

In situ cross-linked chitosan hydrogels via Michael addition reaction based on water-soluble thiol-maleimide precursors

Olatz Guaresti et al.

EUROPEAN POLYMER JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Mariana Adina Matica et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Dynamic Hydrogels from Host-Guest Supramolecular Interactions

Siena M. Mantooth et al.

MACROMOLECULAR BIOSCIENCE (2019)

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Review Materials Science, Biomaterials

Advances in crosslinking strategies of biomedical hydrogels

Weikang Hu et al.

BIOMATERIALS SCIENCE (2019)

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Article Pharmacology & Pharmacy

Hydrogels as Emerging Materials for Translational Biomedicine

Kun Xue et al.

ADVANCED THERAPEUTICS (2019)

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Review Engineering, Multidisciplinary

Healing through Histidine: Bioinspired Pathways to Self-Healing Polymers via Imidazole-Metal Coordination

Stefan Zechel et al.

BIOMIMETICS (2019)

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Review Medicine, Research & Experimental

Targeting RAGE Signaling in Inflammatory Disease

Barry I. Hudson et al.

ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

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Article Engineering, Biomedical

A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing

Qian Xu et al.

ACTA BIOMATERIALIA (2018)

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Review Multidisciplinary Sciences

Update on management of diabetic foot ulcers

Estelle Everett et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2018)

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Article Biochemistry & Molecular Biology

Diels Alder Click-Cross-Linked Hydrogels with Increased Reactivity Enable 3D Cell Encapsulation

Laura J. Smith et al.

BIOMACROMOLECULES (2018)

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Review Chemistry, Applied

Carrageenan based hydrogels for drug delivery, tissue engineering and wound healing

Ramanathan Yegappan et al.

CARBOHYDRATE POLYMERS (2018)

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Review Cardiac & Cardiovascular Systems

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Steven J. Forrester et al.

CIRCULATION RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Chemical crosslinking of biopolymeric scaffolds: Current knowledge and future directions of crosslinked engineered bone scaffolds

Ahmad Oryan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Chemistry, Multidisciplinary

Click chemistry in polymeric scaffolds: Bioactive materials for tissue engineering

Yuan Zou et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Polymer Science

Dual-Crosslinked Amorphous Polysaccharide Hydrogels Based on Chitosan/Alginate for Wound Healing Applications

Yang Hu et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2018)

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Review Materials Science, Biomaterials

Click Chemistry and Material Selection for in Situ Fabrication of Hydrogels in Tissue Engineering Applications

Zihao Xu et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Review Materials Science, Biomaterials

Click Chemistry and Material Selection for in Situ Fabrication of Hydrogels in Tissue Engineering Applications

Zihao Xu et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Review Medicine, Research & Experimental

Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity

Biplab Giri et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Biochemistry & Molecular Biology

Treatment Strategies for Infected Wounds

Irina Negut et al.

MOLECULES (2018)

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Review Biochemistry & Molecular Biology

Hypoxic Microenvironment and Metastatic Bone Disease

Toru Hiraga

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Immunology

Recent novel approaches to limit oxidative stress and inflammation in diabetic complications

Raelene J. Pickering et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2018)

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Review Chemistry, Multidisciplinary

Hydrogels based on pH-responsive reversible carbon-nitrogen double-bond linkages for biomedical applications

Zhen Zhang et al.

MATERIALS CHEMISTRY FRONTIERS (2018)

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Article Dermatology

Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process

Christopher Dunnill et al.

INTERNATIONAL WOUND JOURNAL (2017)

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Article Biochemistry & Molecular Biology

Effect of crosslinking functionality on microstructure, mechanical properties, and in vitro cytocompatibility of cellulose nanocrystals reinforced poly (vinyl alcohol)/sodium alginate hybrid scaffolds

Anuj Kumar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Article Chemistry, Medicinal

Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective

Salvatore Bongarzone et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Review Polymer Science

Recent Advances in Metal-Containing Polymer Hydrogels

Hui Li et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2017)

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Article Polymer Science

Tough Supramolecular Hydrogel Based on Strong Hydrophobic Interactions in a Multiblock Segmented Copolymer

Marko Mihajlovic et al.

MACROMOLECULES (2017)

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Review Materials Science, Biomaterials

A mini review on hydrogels classification and recent developments in miscellaneous applications

Kokkarachedu Varaprasad et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Review Cell Biology

Oxidative Stress: Harms and Benefits for Human Health

Gabriele Pizzino et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Article Chemistry, Multidisciplinary

pH- and ligand-induced release of loads from DNA-acrylamide hydrogel microcapsules

Wei-Ching Liao et al.

CHEMICAL SCIENCE (2017)

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Article Engineering, Biomedical

An Advanced Multifunctional Hydrogel-Based Dressing for Wound Monitoring and Drug Delivery

Bahram Mirani et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Review Pharmacology & Pharmacy

Cross-Linked Hydrogel for Pharmaceutical Applications: A Review

Rabinarayan Parhi

ADVANCED PHARMACEUTICAL BULLETIN (2017)

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Review Materials Science, Paper & Wood

Glucose, not cellobiose, is the repeating unit of cellulose and why that is important

Alfred D. French

CELLULOSE (2017)

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Review Biotechnology & Applied Microbiology

Biocompatibility of hydrogel-based scaffolds for tissue engineering applications

Sheva Naahidi et al.

BIOTECHNOLOGY ADVANCES (2017)

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Article Engineering, Biomedical

pH-responsive self-healing injectable hydrogel based on N-carboxyethyl chitosan for hepatocellular carcinoma therapy

Jin Qu et al.

ACTA BIOMATERIALIA (2017)

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Review Pharmacology & Pharmacy

Polysaccharide-based nanoparticles for theranostic nanomedicine

M. Swierczewska et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Chemistry, Applied

Epidermal growth factor loaded heparin-based hydrogel sheet for skin wound healing

MeeiChyn Goh et al.

CARBOHYDRATE POLYMERS (2016)

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Article Polymer Science

Metal-Coordination Complexes Mediated Physical Hydrogels with High Toughness, Stick-Slip Tearing Behavior, and Good Processability

Si Yu Zheng et al.

MACROMOLECULES (2016)

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Review Endocrinology & Metabolism

The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation

Sandra Matabi Ayuk et al.

JOURNAL OF DIABETES RESEARCH (2016)

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Article Nanoscience & Nanotechnology

Multifunctional Hydrogel with Good Structure Integrity, Self-Healing, and Tissue-Adhesive Property Formed by Combining Die Is Alder Click Reaction and Acylhydrazone Bond

Feng Yu et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Biochemistry & Molecular Biology

Thermal-Responsive Behavior of a Cell Compatible Chitosan/Pectin Hydrogel

Nathan P. Birch et al.

BIOMACROMOLECULES (2015)

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Review Dermatology

The Effect of pH on the Extracellular Matrix and Biofilms

Eleri M. Jones et al.

ADVANCES IN WOUND CARE (2015)

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Review Endocrinology & Metabolism

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

Surapon Tangvarasittichai

WORLD JOURNAL OF DIABETES (2015)

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Review Biochemistry & Molecular Biology

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

Craig S. McKay et al.

CHEMISTRY & BIOLOGY (2014)

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Review Pharmacology & Pharmacy

Advanced Glycation End Products and Diabetic Complications

Varun Parkash Singh et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2014)

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Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

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Review Multidisciplinary Sciences

Advances in skin grafting and treatment of cutaneous wounds

Bryan K. Sun et al.

SCIENCE (2014)

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Review Cell Biology

Wound repair and regeneration: Mechanisms, signaling, and translation

Sabine A. Eming et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Review Cell Biology

The effects of pH on wound healing, biofilms, and antimicrobial efficacy

Steven L. Percival et al.

WOUND REPAIR AND REGENERATION (2014)

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Review Dermatology

Skin pH: From Basic Science to Basic Skin Care

Saba M. Ali et al.

ACTA DERMATO-VENEREOLOGICA (2013)

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Review Engineering, Biomedical

Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering

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Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis

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Review Chemistry, Multidisciplinary

Fabrication and Functionalization of Hydrogels through Click Chemistry

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Dextran based photodegradable hydrogels formed via a Michael addition

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Review Pharmacology & Pharmacy

Chitosan-based hydrogels for controlled, localized drug delivery

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In Situ Simultaneous Protein-Polysaccharide Bioconjugation and Hydrogelation Using Horseradish Peroxidase

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Modular enzymatically crosslinked protein polymer hydrogels for in situ gelation

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A Clinical Investigation into the Relationship between Increased Periwound Skin Temperature and Local Wound Infection in Patients with Chronic Leg Ulcers

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Influence of molecular weight of chemically sulfated citrus pectin fractions on their antithrombotic and bleeding effects

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Review Chemistry, Physical

Biodegradable Cellulose-based Hydrogels: Design and Applications

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MATERIALS (2009)

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Polysaccharides-based nanoparticles as drug delivery systems

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ADVANCED DRUG DELIVERY REVIEWS (2008)

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Review Chemistry, Multidisciplinary

In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery

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Hydrogels in drug delivery: Progress and challenges

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Mechanisms of controlled drug release from drug-eluting stents

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Michael addition reactions in macromolecular design for emerging technologies

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Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair

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Degradable thiol-acrylate photopolymers: polymerization and degradation behavior of an in situ forming biomaterial

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Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes.: Part 1:: Development and physicochernical characteristics

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Chondroitin sulfate in palatal wound healing

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Photopolymerizable hydrogels for tissue engineering applications

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BIOMATERIALS (2002)

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Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes

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Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients

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Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro

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