Doxorubicin covalently conjugated heparin displays anti-cancer activity as a self-assembled nanoparticle with a low-anticoagulant effect

Article Polymer Science

Recent Progress on Heparin-Protamine Particles for Biomedical Application

Yuuki Hata et al.

Summary: Heparin-protamine particles possess self-assembly and adhesive properties, making them functional materials for various biomedical applications.

POLYMERS (2022)

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Review Chemistry, Applied

Heparin: An old drug for new clinical applications

Peipei Wang et al.

Summary: Heparin, an old but first-line anticoagulant, has various pharmacological functions such as anticoagulant, anti-viral, anti-tumor, and anti-inflammatory activities. Recent studies have also shown that heparin can decrease mortality in COVID-19 patients through its non-anticoagulant properties.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Bifunctional Dalteparin/Enoxaparin coated nanosilver formulation to prevent bloodstream infections during hemodialysis

Mukesh Kumar Meher et al.

Summary: Catheter-related bloodstream infections are a major concern for hemodialysis patients. A study has developed a low molecular weight heparin coated nanosilver with dual functions as an anticoagulant and antimicrobial/anti-biofilm agent. The heparinized nanosilver showed good blood compatibility and strong inhibitory/eradicating effects on microbial biofilms.

CARBOHYDRATE POLYMERS (2022)

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Review Chemistry, Applied

Strategies for sustained release of heparin: A review

Xuewen Yang et al.

Summary: Heparin, a sulfate-containing linear polysaccharide, has shown clinical efficacy in various disorders, but its short half-life requires frequent administration. Additionally, the use of heparin to coat blood-contacting medical devices is limited by its short-term durability on the device surface, and various sustained-release strategies have been developed to extend its in vivo half-life.

CARBOHYDRATE POLYMERS (2022)

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Article Biochemistry & Molecular Biology

Heparin-Superparamagnetic Iron Oxide Nanoparticles for Theranostic Applications

Nicolo Massironi et al.

Summary: In this study, a heparin-based nanoparticle system was successfully developed by engineering superparamagnetic iron oxide nanoparticles (SPIONs) with an organic coating composed of low molecular weight heparin (LMWH) and bovine serum albumin (BSA). The system showed promising potential for targeted theranostic applications and demonstrated enhanced antitumor effects when loaded with the chemotherapeutic agent paclitaxel (PTX). Furthermore, the nanoparticles exhibited effective inhibition on the heparanase enzyme and showed comparable relaxivity values to commercial contrast agents, indicating their potential in magnetic resonance imaging (MRI).

MOLECULES (2022)

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Article Pharmacology & Pharmacy

Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model

Sumanta Samanta et al.

Summary: The poor permeability of theranostic agents across the blood-brain barrier significantly hampers the development of new treatment modalities for neurological diseases. A new biomimetic nanocarrier coated with heparin has been discovered, which effectively passes the blood-brain barrier and targets glioblastoma. The nanocarrier is labeled with three different imaging modalities, allowing for excellent penetration and distribution in the brain tissues.

ADVANCED THERAPEUTICS (2022)

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Review Chemistry, Multidisciplinary

Carrier-free nanodrugs for safe and effective cancer treatment

Sena Karaosmanoglu et al.

Summary: The clinical applications of many anti-cancer drugs are limited by their hydrophobic nature, leading to the development of carrier-based nanoparticles. However, these strategies often fail to efficiently encapsulate drugs and may cause toxicity problems in the long term. Therefore, elegantly designed strategies for carrier-free nanodrugs, including simple self-assembly and chemical modifications, are desired for high quality, stability, and performance.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biochemistry & Molecular Biology

Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules

Nipa Banik et al.

Summary: Heparin and its derivatives play an important role in clinical applications and therapeutic research, with their high safety and biocompatibility making them excellent bioactive molecules. In recent years, new heparin-based biomolecules and conjugates have been widely studied and are currently being evaluated for their clinical applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Applied

Tumor microenvironment-responsive PEGylated heparin-pyropheophorbide-a nanoconjugates for photodynamic therapy`

Yahui Wu et al.

Summary: PEGylated heparin-based nanomedicines prepared in this study showed significant anticancer efficacy in vivo for photodynamic therapy. By modulating the conjugation of PEG moieties, the penetration and anticancer effects of the nanoparticles on tumor tissues were successfully enhanced.

CARBOHYDRATE POLYMERS (2021)

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Review Biochemistry & Molecular Biology

Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

Aikaterini Berdiaki et al.

Summary: The tumor microenvironment (TME) is composed of various cells and extracellular matrix components. Changes in the structure and sulfation pattern of GAGs are associated with cancer progression. GAGs and GAG-based molecules show promise as potential effectors for anticancer therapy due to their unique properties.

BIOMOLECULES (2021)

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Review Chemistry, Multidisciplinary

Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications

Alexandra Brito et al.

Summary: Carbohydrate-containing biopolymers are crucial building blocks used by biological systems, and their simplified synthetic analogs are increasingly utilized for developing supramolecular biomaterials. These amphiphilic molecules can mimic structural features and interact with biological systems, showing promising therapeutic potential.

CHEM (2021)

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Article Chemistry, Applied

Anticoagulation and antibacterial properties of heparinized nanosilver with different morphologies

Mukesh Kumar Meher et al.

Summary: This study synthesized heparinized silver nanoparticles using a chemical reduction method and found that the concentration of heparin plays a crucial role in determining the size and shape of the nanosilver. Different morphologies of heparin-coated nanosilver exhibited varying anticoagulation and antimicrobial activities, highlighting the potential for sustainable applications in nanotechnology.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

The preparation of pH and GSH dual responsive thiolated heparin/DOX complex and its application as drug carrier

Juan Wen et al.

CARBOHYDRATE POLYMERS (2020)

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Article Pharmacology & Pharmacy

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

Huan He et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Chemistry, Medicinal

Emerging carrier-free nanosystems based on molecular self-assembly of pure drugs for cancer therapy

Xuanbo Zhang et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Review Cell Biology

The anti-cancer properties of heparin and its derivatives: a review and prospect

Sai-Nan Ma et al.

CELL ADHESION & MIGRATION (2020)

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Article Biochemistry & Molecular Biology

Control of doxorubicin-induced, reactive oxygen-related apoptosis by glutathione peroxidase 1 in cardiac fibroblasts

James H. Doroshow et al.

BIOCHEMISTRY AND BIOPHYSICS REPORTS (2020)

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Article Chemistry, Applied

The preparation and morphology control of heparin-based pH sensitive polyion complexes and their application as drug carriers

Qingxuan Li et al.

CARBOHYDRATE POLYMERS (2019)

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Article Pharmacology & Pharmacy

The non-anticoagulant promise of heparin and its mimetics

Barbara Mulloy

CURRENT OPINION IN PHARMACOLOGY (2019)

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Article Chemistry, Multidisciplinary

Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy

Man Kyu Shim et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Cell Biology

Mechanisms of Anthracycline-Enhanced Reactive Oxygen Metabolism in Tumor Cells

James H. Doroshow

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Chemistry, Physical

Molecular mechanism and binding free energy of doxorubicin intercalation in DNA

Bahaa Jawad et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2019)

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Review Medicine, Research & Experimental

Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment

Jooho Park et al.

THERANOSTICS (2019)

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Article Pharmacology & Pharmacy

Self-assembled nanocomplex of PEGylated protamine and heparin-suramin conjugate for accumulation at the tumor site

Jooho Park et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Engineering, Biomedical

Doxorubicin/heparin composite nanoparticles for caspase-activated prodrug chemotherapy

Nisar Ul Khaliq et al.

BIOMATERIALS (2016)

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Article Hematology

An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL

Yun Mai et al.

BLOOD (2016)

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Article Chemistry, Multidisciplinary

An unusual role of folate in the self-assembly of heparin-folate conjugates into nanoparticles

Jianquan Wang et al.

NANOSCALE (2015)

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Review Biochemistry & Molecular Biology

Determinants of Glycosaminoglycan (GAG) Structure

Kristian Prydz

BIOMOLECULES (2015)

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Review Engineering, Biomedical

Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

Yingkai Liang et al.

ACTA BIOMATERIALIA (2014)

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Review Oncology

Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (Review)

Yan-Jun Zhong et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

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Editorial Material Biology

CANCER How does doxorubicin work?

Anand G. Patel et al.

ELIFE (2012)

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Article Biochemistry & Molecular Biology

Semi-Rigid Solution Structures of Heparin by Constrained X-ray Scattering Modelling: New Insight into Heparin-Protein Complexes

Sanaullah Khan et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

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Article Biochemical Research Methods

Heparin-Paclitaxel Conjugates as Drug Delivery System: Synthesis, Self-Assembly Property, Drug Release, and Antitumor Activity

Ying Wang et al.

BIOCONJUGATE CHEMISTRY (2009)

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Review Biochemistry & Molecular Biology

Doxorubicin: The Good, the Bad and the Ugly Effect

Cristina Carvalho et al.

CURRENT MEDICINAL CHEMISTRY (2009)

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Article Chemistry, Applied

Synthesis and characterization of N-succinyl-chitosan and its self-assembly of nanospheres

Zhu Aiping et al.

CARBOHYDRATE POLYMERS (2006)

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Review Biochemistry & Molecular Biology

Heparin and heparan sulfate: structure and function

DL Rabenstein

NATURAL PRODUCT REPORTS (2002)

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Article Pharmacology & Pharmacy

Drug targeting

VP Torchilin

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2000)

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Doxorubicin covalently conjugated heparin displays anti-cancer activity as a self-assembled nanoparticle with a low-anticoagulant effect

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