☆ 4.7 Review

A review of chitosan in gene therapy: Developments and challenges

CARBOHYDRATE POLYMERS (2024)

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Article Chemistry, Multidisciplinary

Engineering the Intestinal Lymphatic Transport of Oral Nanoparticles to Educate Macrophages for Cancer Combined Immunotherapy

Lu Xu et al.

Summary: The commonly used therapy for treating TNBC has low effectiveness. In this study, MTG nanoparticles were engineered to encapsulate siSIRP alpha and pMUC1, which can educate macrophages via oral route and exert cooperative antitumor effects. The MTG-based NPs accumulated in macrophages in lymph nodes and tumor tissues, leading to strong cellular immunity responses, inhibiting the growth and metastasis of TNBC.

ACS NANO (2023)

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Review Biotechnology & Applied Microbiology

Chitosan and chito-oligosaccharide: a versatile biopolymer with endless grafting possibilities for multifarious applications

Popat Mohite et al.

Summary: This review provides an in-depth study on the recent advances in the grafting of chitosan-derived chito-oligosaccharides (COS) for drug delivery applications. The review elaborates on the various strategies and techniques used for grafting, as well as the properties and applications of grafted COS in drug delivery. It also discusses the effectiveness of grafted COS in improving the pharmacokinetics and pharmacodynamics of drugs, and presents challenges and future research directions. The insights provided in this review are valuable for researchers and drug development professionals interested in using grafted COS for multifarious applications.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Article Biotechnology & Applied Microbiology

Liposome-trimethyl chitosan nanoparticles codeliver insulin and siVEGF to treat corneal alkali burns by inhibiting ferroptosis

Xiaojing Xiong et al.

Summary: In this study, a new combination therapy using liposomes and trimethyl chitosan (TMC) for the codelivery of insulin (INS) and vascular endothelial growth factor small interfering RNA (siVEGF) to treat alkali-burned corneas was designed. The therapy effectively inhibited oxidative stress, inflammation, and VEGF expression in vitro and maintained corneal transparency, accelerated epithelialization, and inhibited corneal neovascularization (CNV) in vivo. Metabolomic analysis suggested that the therapeutic mechanism of siVEGF-TIL might be associated with the inhibition of the ferroptosis signaling pathway. Overall, siVEGF-TIL NPs could be a safe and effective therapy for corneal alkali burn.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

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Article Biochemistry & Molecular Biology

Chitosan targets PI3K/Akt/FoxO3a axis to up-regulate FAM172A and suppress MAPK/ERK pathway to exert anti-tumor effect in osteosarcoma

Zhaozhou Ren et al.

Summary: This study reveals that chitosan binds with the PI3K p85 subunit to suppress the activity of the PI3K/Akt pathway, upregulating the expression of FAM172A, and exerting its inhibitory effect on osteosarcoma growth by suppressing the phosphorylation of MEK1/2 and blocking the activity of the MAPK/ERK signaling pathway.

CHEMICO-BIOLOGICAL INTERACTIONS (2023)

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Article Biochemistry & Molecular Biology

Chitosan polyplexes: Energetics of formation and conformational changes in DNA upon binding and release

Valerij Y. Grinberg et al.

Summary: The energetics of chitosan (CS) polyplexes and the conformational stability of bound DNA were analyzed at pH 5.0 using ITC and HS-DSC, respectively. The CS-DNA binding mechanism was found to involve cooperative attachment of interacting CS ligands to the DNA matrix, as shown by the well-fitted McGhee-von Hippel model. The melting thermograms of polyplexes revealed the transformation of different conformational forms of bound DNA depending on the CS/DNA weight ratio.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Chemistry, Applied

GE11-modified carboxymethyl chitosan micelles to deliver DOX•PD-L1 siRNA complex for combination of ICD and immune escape inhibition against tumor

Panpan Song et al.

Summary: A dual-responsive carboxymethyl chitosan (CMCS) micelle functionalized with a targeting peptide GE11 (G-CMssOA) was developed for simultaneous delivery of PD-L1 siRNA and doxorubicin (DOX) in a complex form (D&P). The complex-loaded micelles (G-CMssOA/D&P) exhibited good physiologic stability and pH/reduction responsiveness, and enhanced intratumoral infiltration of CD4(+) and CD8(+) T cells, reduced Tregs (TGF-beta) and increased immune-stimulatory cytokine secretion (TNF-alpha). The combination of DOX-induced immunogenic cell death (ICD) and PD-L1 siRNA-mediated immune escape inhibition significantly improved antitumor immune response and suppressed tumor growth. This complex delivery strategy provides a novel approach for effective siRNA delivery and enhanced anti-tumor immunotherapy.

CARBOHYDRATE POLYMERS (2023)

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Review Biochemistry & Molecular Biology

Where should siRNAs go: applicable organs for siRNA drugs

Insook Ahn et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2023)

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Article Oncology

Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis

Hossein Sendi et al.

Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.

CANCER RESEARCH (2022)

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Article Chemistry, Applied

Polyethylenimine grafted-chitosan based Gambogic acid copolymers for targeting cancer cells overexpressing transferrin receptors

Seong-Cheol Park et al.

Summary: The study introduces a copolymer, GPgWSC, capable of targeting transferrin receptors in HCT116 cancer cell lines, showing superior antitumor activity. In vitro experiments and a mouse model demonstrate the potential efficacy of GPgWSC in inhibiting tumor growth.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Applied

Carboxylated chitosan-mediated improved efficacy of mesoporous silica nanoparticle-based targeted drug delivery system for breast cancer therapy

Garima Lohiya et al.

Summary: In this study, a chitosan-coated nanoparticle was developed for targeting breast cancer cells, showing higher cellular uptake and cytotoxicity compared to non-targeted nanoparticles. The chitosan coating provided pH-responsiveness and endo/lysosomal escape ability to the nanoparticles, enhancing the efficacy of anticancer drug delivery.

CARBOHYDRATE POLYMERS (2022)

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Review Chemistry, Applied

Analysis of clinical trials on biomaterial and therapeutic applications of chitosan: A review

Maithili N. Kantak et al.

Summary: Chitosan, a modified natural carbohydrate polymer, has a wide range of medical and pharmaceutical applications. It can be used as a biomaterial in medical devices and as an excipient, drug carrier, or therapeutic agent in pharmaceuticals. Numerous clinical studies are being conducted to investigate the safety and efficacy of chitosan and its biomaterials/nanoparticles.

CARBOHYDRATE POLYMERS (2022)

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Article Biophysics

New insights on the mechanism of polyethylenimine transfection and their implications on gene therapy and DNA vaccines

Juan Sabin et al.

Summary: Polyethylenimine (PEI) has a strong affinity with cell membranes, which sheds light on its mechanism of DNA release. PEI alone cannot enter the cell nucleus but forms a peripheral aureole. The hydrophobic and electrostatic interactions between PEI and lipidic layers allow it to intercalate through the model membranes. This understanding can contribute to the development of better gene therapy and DNA vaccines.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Chemistry, Multidisciplinary

Non-viral vectors for RNA delivery

Yi Yan et al.

Summary: RNA-based therapy is a promising strategy for disease treatment, and recent advances in non-viral delivery systems have shown potential in protecting RNA, facilitating cell internalization, and controlled release of therapeutics.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Pharmacology & Pharmacy

Increased Targeting Area in Tumors by Dual-Ligand Modification of Liposomes with RGD and TAT Peptides

Mohamadreza Amin et al.

Summary: Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids improve the pharmacokinetics of chemotherapeutics and reduce side-effects. However, cellular delivery and tumor heterogeneity are the main obstacles against tumor targeting. This study designed liposomes decorated with two ligands for enhanced cellular delivery and targeting of tumor vasculature and tumor cells.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury

Weimin Tang et al.

Summary: This study demonstrates the synthesis of a novel siRNA carrier, C-CS, which shows potential for targeted delivery to injured kidneys. The C-CS/siRNA nanoparticles effectively accumulate and deliver therapeutic siRNAs to injured kidneys through CXCR4 binding, providing a new approach for AKI therapy.

BIOMATERIALS (2022)

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Article Chemistry, Applied

Co-delivery of doxorubicin and siRNA by all-trans retinoic acid conjugated chitosan-based nanocarriers for multiple synergistic antitumor efficacy

Chang Liu et al.

Summary: In this study, double grafted TMC nanoparticles were developed for the co-delivery of DOX and siRNA, selectively inhibiting the proliferation of tumor cells and exhibiting superior in vivo and in vitro anti-tumor efficiency.

CARBOHYDRATE POLYMERS (2022)

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Article Nanoscience & Nanotechnology

Dual pH-Responsive and Tumor-Targeted Nanoparticle-Mediated Anti-Angiogenesis siRNA Delivery for Tumor Treatment

Xiangyang Zhang et al.

Summary: The researchers prepared a multifunctional siRNA delivery system (CHCE/siRNA nanoparticles) by self-assembling carboxymethyl chitosan modified with histidine, cholesterol, and anti-EGFR antibody. The nanoparticles showed tumor-targeting and pH response capabilities, allowing for efficient gene silencing and tumor inhibition both in vitro and in vivo.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Polymer Science

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Meng Zhang et al.

Summary: Chitosan is a biodegradable natural polymer with wide applications in the fields of medicine and agriculture. Through modification and other configurations, the range of chitosan applications can be significantly expanded. It can be used for nerve repair, wound auxiliaries, tissue engineering repair materials, drug slow-release and volume expansion, and even shows potential in fighting against COVID-19. Additionally, chitosan can enhance crop growth and be used as an antioxidant coating in agriculture.

POLYMERS (2022)

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Article Biotechnology & Applied Microbiology

Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

Xiangyang Zhang et al.

Summary: The development of multidrug resistance (MDR) in cancer chemotherapy is a major challenge. This study identified MVP and BCL2 as potential factors driving MDR in ESCC. A self-assembling nanoparticle platform was designed to deliver Adriamycin and siRNAs targeting MVP and BCL2, reducing drug efflux and promoting apoptosis. The nanoparticles effectively inhibited cancer cell growth and tumor development.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

The Potential of Chitosan in Nanomedicine: An Overview of the Cytotoxicity of Chitosan Based Nanoparticles

Julie Frigaard et al.

Summary: Nanotechnology has found unique applications in drug delivery, cosmetics, fabrics, water treatment, and food packaging. Chitosan, a nanoparticle derived from natural polysaccharide chitin, has gained attention in modern medicine for its unique properties. This review examines the cytotoxicity of chitosan nanoparticles in biomedical research, revealing low cytotoxicity regardless of particle composition or assay method. However, thorough characterization and cytotoxicity assessment are recommended for new chitosan derivatives and compositions before market implementation.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Multidisciplinary Sciences

Blood-brain barrier-penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy

Yan Zou et al.

Summary: We designed a unique nanocapsule for efficient and safe gene therapy of glioblastoma. Our nanocapsules can penetrate the blood-brain barrier, target tumor cells, and selectively release the Cas9/sgRNA complex. Experiments demonstrated accurate and efficient gene editing in glioblastoma tissue with minimal off-target effects in high-risk tissues. Treatment with nanocapsules significantly extended survival time.

SCIENCE ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Amphiphilic Chitosan Bearing Double Palmitoyl Chains and Quaternary Ammonium Moieties as a Nanocarrier for Plasmid DNA

Thev Pol et al.

Summary: Amphiphilic chitosan derivative bPalm-CS-HTAP was synthesized and found to self-assemble into nanosized particles. It effectively condensed plasmid DNA and enabled gene expression in cells without causing cytotoxicity, making it a promising nonviral gene carrier.

ACS OMEGA (2022)

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Article Chemistry, Multidisciplinary

Folic Acid Enables Targeting Delivery of Lipodiscs by Circumventing IgM-Mediated Opsonization

Huan Wang et al.

Summary: In this study, folic acid-functionalized lipodiscs (FA-Disc) were successfully constructed to avoid opsonization by IgM and achieve folate targeting. FA-Disc retained folate binding activity and could effectively target folate receptor positive tumors in vivo. This study provides a solution to avoid negative regulation by IgM and achieve folate-enabled targeting by exploring disc-shaped nanocarriers.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

G-Quadruplex-Proximized Aptamers (G4PA) Efficiently Targeting Cell-Surface Transferrin Receptors for Targeted Cargo Delivery

Yi Du et al.

Summary: DNA-assembled multiaptamer systems offer a promising approach for targeted delivery of nucleic acid cargoes. In this study, a G-quadruplex-proximized aptamer system was engineered for efficient transmembrane delivery of siRNA, showing great potential for precise anticancer therapy.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer

Mi Zhou et al.

Summary: Chemoresistance is a major challenge in gastric cancer treatment. This study identifies a novel lncRNA TMEM44-AS1 related to 5-FU resistance and develops a new nanocarrier CGE for efficient delivery of si-TMEM44-AS1, leading to the reversal of 5-FU resistance and enhanced therapeutic effect in a mouse model.

ADVANCED SCIENCE (2022)

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Article Chemistry, Applied

Stepwise responsive carboxymethyl chitosan-based nanoplatform for effective drug-resistant breast cancer suppression

Hui Peng et al.

Summary: In this study, a multi-functional carboxymethyl chitosan (CMC) based core-shell nanoplatform was developed for co-delivery of MDR1 gene-silenced siRNA and doxorubicin (DOX). The nanoplatform could release payloads in an acid/redox triggered fashion and possessed tumor-targeting and endo/lysosomal escape functions. The experimental results showed that the nanoplatform efficiently silenced genes, inhibited P-gp expression, and exhibited synergistic therapeutic effects.

CARBOHYDRATE POLYMERS (2022)

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Article Materials Science, Biomaterials

Optimization of chitosan-based polyelectrolyte nanoparticles for gene delivery, using design of experiment: in vitro and in vivo study

Masoumeh Baghaei et al.

Summary: Gene therapy is a novel approach for cancer treatment, and the study of suitable gene delivery systems is crucial. The preparation of a polyelectrolyte complex containing polysaccharides was optimized and resulted in nanoparticles with high gene loading capacity. Both in vitro and in vivo studies confirmed the efficiency and safety of the prepared nanoparticles, suggesting their potential as a promising cancer gene delivery system.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Clinical Neurology

Targeting CD146 using folic acid-conjugated nanoparticles and suppression of tumor growth in a mouse glioma model

Naoki Fukui et al.

Summary: This study aimed to develop gene therapy targeting GSCs using chitosan oligosaccharide lactate (COL) nanoparticles (NPs) conjugated with folic acid-polyethylene glycol (FA-PEG-COL NPs) for delivery of CD146 small-interfering RNA (siCD146) and evaluate the therapeutic effects of CD146 knockdown on tumor growth. The results showed that delivery of siCD146 significantly reduced tumor growth in mouse glioma models, indicating the potential of folic acid-conjugated NPs delivering siRNA for gene therapy in malignant gliomas.

JOURNAL OF NEUROSURGERY (2021)

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Review Ophthalmology

Immune responses to retinal gene therapy using adeno-associated viral vectors-Implications for treatment success and safety

Kirsten Bucher et al.

Summary: Recombinant adeno-associated virus (AAV) is a leading vector for gene therapy in the retina, efficiently transducing retinal cells but also causing intraocular inflammation and immune responses. The eye, being an immune-privileged site, may mitigate these responses, but further research is needed to understand influencing factors.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel

Yun-qiu Miao et al.

Summary: Introduction of chitosan oligosaccharide (CSO) modification on liposomes enhances the delivery of chemotherapeutics to lung tumors, leading to improved therapeutic outcomes for lung cancer treatment.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Biochemistry & Molecular Biology

Human-derived NLS enhance the gene transfer efficiency of chitosan

Diogo B. Bitoque et al.

Summary: This study found that co-complexation or covalent ligation of IGFBP-3 derived NLS peptide with chitosan polyplexes can enhance the efficiency of non-viral vectors, showing a 2-fold increase in transfection efficiency.

BIOSCIENCE REPORTS (2021)

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Article Chemistry, Applied

Enhanced antitumor efficacy of glutathione-responsive chitosan based nanoparticles through co-delivery of chemotherapeutics, genes, and immune agents

Linlin Zhang et al.

Summary: The co-delivery of chemotherapeutic drugs, genes, and immune agents by redox-sensitive chitosan-based nanoparticles showed promising results in enhancing antitumor efficacy and improving tumor-induced immunosuppression at a low dose.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Layer by Layer Assembled Chitosan-Coated Gold Nanoparticles for Enhanced siRNA Delivery and Silencing

Elnaz Shaabani et al.

Summary: Chitosan-coated gold nanoparticles fabricated through a layer by layer self-assembly method show excellent protection of siRNA, good cellular uptake, and improved RNA silencing effect. This work highlights the potential of LBL assembled CS-AuNPs as promising nanocarriers for enhanced intracellular siRNA delivery and silencing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Echogenic, Ultrasound-Sensitive Chitosan Nanodroplets for Spatiotemporally Controlled DKK-2 Gene Delivery to Prostate Cancer Cells

Xinxin Liu et al.

Summary: The study synthesized echogenic chitosan/perfluorohexane nanodroplets (CNDs) and demonstrated their potential for gene delivery, showing promising applications in ultrasound-mediated gene delivery and cell therapy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Instruments & Instrumentation

An overview of chitosan and its application in infectious diseases

Qingye Meng et al.

Summary: Infectious diseases like COVID-19, SARS, Ebola, and AIDS pose a global health threat, leading researchers to develop new antiviral and antibacterial drugs. Natural material chitosan, when used in collaboration with traditional medicine, has shown to enhance anti-infection capabilities.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Oncology

Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors

Lili Ye et al.

Summary: The study synthesized a novel nanomaterial combining gene therapy and photothermal therapy for the treatment of colon cancer. The nanomaterial showed effective delivery of genes to cancer cells and achieved combined photothermal therapy and gene therapy, with significantly better treatment outcomes for colon cancer cells compared to single-mode treatments. Animal experiments confirmed the nanomaterial's ability to achieve tumor thermal imaging, targeted CT imaging, photothermal therapy, and gene therapy in vivo.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Medicine, Research & Experimental

Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice

Shima Bastaki et al.

Summary: The immunotherapy method using potential tumor microenvironment modulators showed promising therapeutic responses in cancer treatment. The delivery system designed to deliver small interfering RNAs to silence the targeted genes resulted in significant downregulation of PD-L1 and STAT3 genes, as well as notable effects on tumor cell proliferation, migration, and angiogenesis, and tumor growth in vivo.

LIFE SCIENCES (2021)

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Review Biochemistry & Molecular Biology

mRNA vaccine for cancer immunotherapy

Lei Miao et al.

Summary: mRNA vaccines have emerged as a promising platform for cancer immunotherapy, showcasing high potency, safe administration, rapid development potentials, and cost-effective manufacturing. However, challenges such as stability, innate immunogenicity, and inefficient in vivo delivery restrict their applications. In addressing these challenges, structural modifications and formulation methods are being researched to enhance the anti-tumor immune response.

MOLECULAR CANCER (2021)

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Article Chemistry, Multidisciplinary

Controlled Synthesis and Surface Engineering of Janus Chitosan-Gold Nanoparticles for Photoacoustic Imaging-Guided Synergistic Gene/Photothermal Therapy

Xiaoguang Dai et al.

Summary: The study developed a series of symmetrical and unsymmetrical chitosan/gold nanoparticles, utilizing the active motion derived from Janus structure, selective surface functionalization of polysaccharide domain, and photothermal effect of gold nanorods to construct Janus-structured chitosan/gold nanohybrids for breast cancer treatment. Investigating the morphology effect of chitosan/gold nanostructures on enhanced PTT, cellular uptake, and gene transfection, as well as exploring the feasibility of PA imaging to track the accumulation of J-ACP and guide PTT.

SMALL (2021)

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Article Multidisciplinary Sciences

siRNA delivery using intelligent chitosan-capped mesoporous silica nanoparticles for overcoming multidrug resistance in malignant carcinoma cells

Razieh Heidari et al.

Summary: This study introduced a potent siRNA transfer system for cancer gene therapy, which targeted cancer cells and had a high loading capacity to inhibit drug resistance. The amino-modified mesoporous silica nanoparticles showed promising potential for targeted gene delivery, with functionalized chitosan coating providing protection for siRNA and the targeting moieties enhancing the delivery efficiency. The results indicated that the functionalized chitosan-coated siRNA-MSNs could be a promising carrier for targeted cancer therapy, showing improved cytotoxicity and targeting efficiency.

SCIENTIFIC REPORTS (2021)

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Article Engineering, Biomedical

Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

Ye Liang et al.

Summary: This study developed a CD44 targeted gene delivery system based on natural macromolecules for effective bladder cancer treatment, which could be more conducive to clinical application due to its simple preparation and high biological safety.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Temperature-Sensitive Lipid-Coated Carbon Nanotubes for Synergistic Photothermal Therapy and Gene Therapy

Yinan Zhao et al.

Summary: The combination of peptide lipid (PL) and sucrose laurate (SL) coated carbon nanotubes has shown great potential for achieving controlled release of genes for anti-tumor activity through photothermal effects. The resulting SCNT-PS/siRNA delivery system exhibited high anti-tumor activity and efficient systemic delivery to tumor sites.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Caveolae-Mediated Endocytosis Drives Robust siRNA Delivery of Polymeric Nanoparticles to Macrophages

Yudong Song et al.

Summary: Delivery of siRNA into cells remains a challenge, but understanding the cellular uptake and processing of siRNA systems can enhance the development of siRNA-based therapies. Research indicates that caveolae-mediated endocytosis plays a crucial role in efficient siRNA delivery, along with the Golgi complex and endoplasmic reticulum. Additionally, syntaxin6 and Niemann-Pick C1 protein are essential regulators in the delivery of siRNA to macrophages.

ACS NANO (2021)

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Review Biotechnology & Applied Microbiology

Recent advances in selective photothermal therapy of tumor

Liping Zhao et al.

Summary: Photothermal therapy (PTT) is a promising approach in cancer treatment, but challenges such as accurate laser exposure and potential side effects need to be addressed. Enhancing the selectivity of PTT involves increasing the accumulation of photothermal agents at tumor sites and giving them self-regulating photothermal conversion functions.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Applied

Cationic nanoparticles self-assembled from amphiphilic chitosan derivatives containing poly(amidoamine) dendrons and deoxycholic acid as a vector for co-delivery of doxorubicin and gene

Shanshan Chen et al.

Summary: PAMAM-Cs-DCA nanoparticles exhibit good gene transfection efficiency and low cytotoxicity, successfully encapsulating the anticancer drug DOX and forming complexes with pDNA, while the co-delivery of DOX enhances transgene expression synergistically.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation

Laura Nicolle et al.

Summary: The study developed a novel chitosan-derivative, dCS-Suc-LPEI-14, showing promising biocompatibility, cytotoxicity, and transfection efficiency. Through in vitro and in vivo experiments, its potential for non-viral gene therapy was confirmed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

The effect of RGD-targeted and non-targeted liposomal Galbanic acid on the therapeutic efficacy of pegylated liposomal doxorubicin: From liposomal preparation to in-vivo studies

Maryam Ebrahimi Nik et al.

Summary: The study developed new liposomal formulations to enhance the anti-cancer therapeutic application of Galbanic acid, and demonstrated that RGD peptide decoration could improve targeted delivery to tumor vasculature. The results showed that the targeted liposomes could enhance receptor-mediated endocytosis both in vitro and in vivo, leading to increased accumulation in colon tumors.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Chitosan Oleate Coated PLGA Nanoparticles as siRNA Drug Delivery System

Dalila Miele et al.

Summary: Oligonucleotide therapeutics such as miRNAs and siRNAs are developed to modulate gene expression, but face issues of instability and easy degradation. Viral and non-viral vectors are used for efficient delivery, with non-viral vectors like polymeric nanocarriers providing safer and more effective means of delivery.

PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Quantitative Description of Surface Complementarity of Antibody-Antigen Interfaces

Lorenzo Di Rienzo et al.

Summary: This study applied the 3D Zernike formalism to analyze the surface properties of antibody complementary determining regions (CDRs), and found that shape and electrostatic 3DZD descriptors of the CDRs can predict antigen specificity and the correct paratope-epitope interaction with high accuracy. Additionally, the 3DZD descriptors detected significantly higher surface complementarity to the paratope compared to other surface descriptors.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Stimulus-Responsive Nanocarriers for Gene Therapy

Cheng Yu et al.

Summary: Gene therapy presents a promising approach for treating genetic disorders, but challenges remain with viral vectors. The emergence of nanomedicine has revolutionized the field of gene therapy, with recent advancements in stimulus-responsive nonviral nanocarriers showing high efficiency in delivering therapeutic nucleic acids.

ADVANCED SCIENCE (2021)

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Article Engineering, Biomedical

Multifunctional antibody-conjugated coiled-coil protein nanoparticles for selective cell targeting

Marcos Gil-Garcia et al.

Summary: The study presents a novel approach to create highly functional, non-amyloid, and fluorescent inclusion bodies (IBs) using natural coiled-coil self-assembly properties. These protein-based nanoparticles effectively capture antibodies and are utilized for specific and simultaneous targeting of two unrelated cell types, potentially valuable in bioimaging and immunotherapy applications.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large et al.

Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Applied

Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer

Xiongjie Zhu et al.

Summary: The novel T7 peptide-modified nanoparticles based on carboxymethyl chitosan can target lung cancer cells, precisely regulate drug release, and improve treatment effects.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21

Fatemeh Khatami et al.

Summary: The novel AACS nanocomplex was developed for targeted co-delivery of DOX and antimiR-21, showing promising results in inhibiting cancer cell growth through cellular uptake and cytotoxicity assessments.

CARBOHYDRATE POLYMERS (2021)

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Review Pharmacology & Pharmacy

Novel nanomedicines to overcome cancer multidrug resistance

Zhenwei Su et al.

Summary: Chemotherapy is powerful in eliminating malignant cells, but its efficacy is often hindered by drug resistance. Nanomedicine, focusing on targeted drug delivery to tumor tissues using nano-sized formulations, shows promise in improving treatment outcomes, minimizing adverse effects, and overcoming cancer drug resistance. This approach involves strategies such as passive and active targeted delivery, delivering multidrug combinations, and multimodal combination therapy to pave the way for effective cancer treatment and holds great potential in overcoming drug resistance.

DRUG RESISTANCE UPDATES (2021)

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Review Nanoscience & Nanotechnology

Functionalized Graphene Platforms for Anticancer Drug Delivery

Shabnam Sattari et al.

Summary: Two-dimensional nanomaterials, such as graphene, are promising candidates for various biomedical applications due to their high surface area and efficient cellular uptake. Functionalization of graphene is essential to improve its dispersion in water and functionality for future nanomedicine applications. Techniques involving covalent or non-covalent methods have been explored to enhance the physicochemical properties of graphene and graphene oxide.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Medicine, Research & Experimental

Fe3O4 magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN

Shuzhen Chen et al.

Summary: The study demonstrated that Fe3O4 MNPs can enhance radiosensitivity of lung adenocarcinoma cells by targeting delivery of siBIRC5 and AS-ODN, reducing resistance and offering a potential innovative solution for overcoming radiotherapy resistance in lung adenocarcinoma patients.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Chemistry, Medicinal

Gut Organoid as a New Platform to Study Alginate and Chitosan Mediated PLGA Nanoparticles for Drug Delivery

Zahra Davoudi et al.

Summary: This study investigated the effects of different surface charges on the delivery of nanoparticles into intestinal organoids, showing that positively charged nanoparticles were more readily transported across the epithelium into the lumen.

MARINE DRUGS (2021)

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Article Materials Science, Biomaterials

Smart co-delivery of miR-34a and cytotoxic peptides (LTX-315 and melittin) by chitosan based polyelectrolyte nanocarriers for specific cancer cell death induction

Marjan Motiei et al.

Summary: Novel polyelectrolyte nanocarriers synthesized through layer-by-layer self-assembly show controlled-release of gene and peptides, with a synergistic effect on chemoresistance human breast adenocarcinoma cells.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Potential of chitosan/alginate nanoparticles as a non-viral vector for gene delivery: Formulation and optimization using D-optimal design

Maryam Zohri et al.

Summary: By optimizing the Chi/Alg nanoparticles as a non-viral vector using a D-optimal design, the researchers successfully prepared well-shaped nanoparticles for gene delivery. Through toxicity and transfection studies, it was found that the optimized Chi/Alg/S nanoparticles exhibited no toxicity and slightly lower transfection efficiency compared to commercial reagents Lipofectamine and PEI.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Engineering, Multidisciplinary

Preparation and anti-tumor application of hyaluronic acid-based material for disulfide and copper ions co-delivery

Pang Long et al.

Summary: In this study, a hyaluronic acid (HA) based carrier system was developed for the co-delivery of disulfide (DSF) and Cu2+. By improving the distribution of drugs in tumor cells and releasing the drugs in an acidic micro-environment, the carrier system demonstrated enhanced anti-tumor effects and low biological toxicity both in vitro and in vivo.

SCIENCE CHINA-TECHNOLOGICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Yue Su et al.

Summary: Biodegradable microspheres are widely used in medicine for drug delivery with advantages of low dose and low side effects. PLGA is one of the most widely used biodegradable materials with good biocompatibility. PLGA microspheres have been extensively studied and applied in drug delivery.

DRUG DELIVERY (2021)

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Review Chemistry, Multidisciplinary

Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery

Liwang Shi et al.

Summary: This review discusses the impact of PEG coverage density and thickness on the biophysical and chemical properties of nanoparticles, as well as the related techniques used to detect these coverages.

NANOSCALE (2021)

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Article Pharmacology & Pharmacy

Experimental study on preparation and anti-tumor efficiency of nanoparticles targeting M2 macrophages

Zheng Zeng et al.

Summary: The study aimed to develop a novel therapy targeting M2 macrophages, using MIC-NPs to inhibit M2 cell growth effectively and have a positive impact on anti-tumor immune responses.

DRUG DELIVERY (2021)

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Article Engineering, Biomedical

Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles

Mei-Hwa Lee et al.

Summary: This study utilized the CRISPR/Cas9 system to activate OSKM genes in HEK293T cells, achieved by the combination of gRNA and dCas9-VPR. The findings demonstrated precise control over cell differentiation by activating one OSKM gene up to three-fold higher than the others.

MATERIALS TODAY BIO (2021)

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Review Biochemistry & Molecular Biology

Viral vector platforms within the gene therapy landscape

Jote T. Bulcha et al.

Summary: The field of gene therapy has made significant progress in combating human diseases and providing hope to patients and families with limited treatment options, but it has also faced setbacks. Viral-based vectors have played a crucial role in developing powerful drug platforms, but challenges still limit their full potential.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Cardiac & Cardiovascular Systems

CRISPR/Cas9 gene-editing strategies in cardiovascular cells

Eva Vermersch et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Development of chitosan-coated liposome for pulmonary delivery o N-acetylcysteine

Hamed Hamedinasab et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Tailor-made ternary nanopolyplexes of thiolated trimethylated chitosan with pDNA and folate conjugated cis-aconitic amide-polyethylenimine for efficient gene delivery

Qing Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Stimuli-Responsive Polysaccharide Enveloped Liposome for Targeting and Penetrating Delivery of survivin-shRNA into Breast Tumor

Huiying Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

siRNA release kinetics from polymeric nanoparticles correlate with RNAi efficiency and inflammation therapy via oral delivery

Chunbai He et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Physical

Understanding loading, diffusion and releasing of Doxorubicin and Paclitaxel dual delivery in graphene and graphene oxide carriers as highly efficient drug delivery systems

Hassan Hashemzadeh et al.

APPLIED SURFACE SCIENCE (2020)

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Article Chemistry, Applied

Reconstructed chitosan with alkylamine for enhanced gene delivery by promoting endosomal escape

Guojun Huang et al.

CARBOHYDRATE POLYMERS (2020)

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Article Engineering, Environmental

Efficient CRISPR/Cas9 gene-chemo synergistic cancer therapy via a stimuli-responsive chitosan-based nanocomplex elicits anti-tumorigenic pathway effect

Bing-Chen Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Biochemistry & Molecular Biology

pH-dependent RNA isolation from cells encapsulated in chitosan-based biomaterials

Mahmoud Farrag et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Pharmacology & Pharmacy

Apoptosis of A549 cells by small interfering RNA targeting survivin delivery using poly-beta-amino ester/guanidinylated O-carboxymethyl chitosan nanoparticles

Yue Tang et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Engineering, Biomedical

Near-infrared/pH dual-responsive nanocomplexes for targeted imaging and chemo/gene/photothermal tri-therapies of non-small cell lung cancer

Ziying Li et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Analytical

Multi-Dimensionally Extended Functionalization Innovates to an Entropy-Driven Detection of Multi-miRNAs for One-Step Cancer Screening and Diagnosis in Living Cells

Ying Zhang et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biophysics

Arginine-modified chitosan complexed with liposome systems for plasmid DNA delivery

Bianca B. M. Garcia et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Cell Biology

Coinhibition of S1PR1 and GP130 by siRNA-loaded alginate-conjugated trimethyl chitosan nanoparticles robustly blocks development of cancer cells

Narges Rostami et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

New insights into the synthesis, toxicity and applications of gold nanoparticles in CT imaging and treatment of cancer

Yao Yu et al.

NANOMEDICINE (2020)

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Article Nanoscience & Nanotechnology

Tumor microenvironment-responsive polymer with chlorin e6 to interface hollow mesoporous silica nanoparticles-loaded oxygen supply factor for boosted photodynamic therapy

Xuemei Wang et al.

NANOTECHNOLOGY (2020)

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Review Oncology

Exploiting the folate receptor α in oncology

Mariana Scaranti et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Chemistry, Applied

Chitosan based pH-responsive polymeric prodrug vector for enhanced tumor targeted co-delivery of doxorubicin and siRNA

Tingsheng Yan et al.

CARBOHYDRATE POLYMERS (2020)

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Article Biochemistry & Molecular Biology

Preparation and evaluation of alginate nanoparticles prepared by green method for drug delivery applications

Deepa Thomas et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biotechnology & Applied Microbiology

Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA

Qi Chang Zheng et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Silencing of HIF-1α/CD73 axis by siRNA-loaded TAT-chitosan-spion nanoparticles robustly blocks cancer cell progression

Farnaz Hajizadeh et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Chemistry, Multidisciplinary

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Reza Mohammadinejad et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Medicine, Research & Experimental

Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds

Marjan Omer et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Nanoscience & Nanotechnology

Virus Mimetic Shell-Sheddable Chitosan Micelles for siVEGF Delivery and FRET-Traceable Acid-Triggered Release

Shengyu Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Materials Science, Biomaterials

Liposomes modified with bio-substances for cancer treatment

Yanan Li et al.

BIOMATERIALS SCIENCE (2020)

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Review Medicine, Research & Experimental

Ultrasmall gold nanoparticles in cancer diagnosis and therapy

Miao Fan et al.

THERANOSTICS (2020)

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Review Oncology

CRISPR/Cas9 for cancer research and therapy

Tianzuo Zhan et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Review Medicine, Research & Experimental

Entering the Modern Era of Gene Therapy

Xavier M. Anguela et al.

ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)

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Review Polymer Science

pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2019)

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Review Biotechnology & Applied Microbiology

The current state and future directions of RNAi-based therapeutics

Ryan L. Setten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Oncology

CRISPR-Cas9 for cancer therapy: Opportunities and challenges

Minjiang Chen et al.

CANCER LETTERS (2019)

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Article Chemistry, Applied

Methyl methacrylate modified chitosan: Synthesis, characterization and application in drug and gene delivery

Shefali Jaiswal et al.

CARBOHYDRATE POLYMERS (2019)

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Article Chemistry, Applied

Redox-responsive chitosan oligosaccharide-SS-Octadecylamine polymeric carrier for efficient anti-Hepatitis B Virus gene therapy

Jing Miao et al.

CARBOHYDRATE POLYMERS (2019)

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Review Biochemistry & Molecular Biology

Chitosan oligosaccharide (COS): An overview

Muhammad Naveed et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Nanoscience & Nanotechnology

Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer

Wenhua Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Nanoscience & Nanotechnology

In vitro cytotoxicity and transfection efficiency of pDNA encoded p53 gene-loaded chitosan-sodium deoxycholate nanoparticles

Fahima M. Hashem et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Chemistry, Medicinal

Recent Advances in Chitosan-Based Carriers for Gene Delivery

Ye Cao et al.

MARINE DRUGS (2019)

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Article Pharmacology & Pharmacy

pH-Sensitive Chitosan-Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells

Iuliia Pilipenko et al.

PHARMACEUTICS (2019)

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Article Chemistry, Multidisciplinary

Kinetic Control in Assembly of Plasmid DNA/Polycation Complex Nanoparticles

Yizong Hu et al.

ACS NANO (2019)

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Review Biochemistry & Molecular Biology

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Bolat Sultankulov et al.

BIOMOLECULES (2019)

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Article Nanoscience & Nanotechnology

New Water-Soluble Oxyamino Chitosans as Biocampatible Vectors for Efficacious Anticancer Therapy via Co-Delivery of Gene and Drug

Mohini Kamra et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Applied

Taguchi method optimization for synthesis of Fe3O4 @chitosan/Tragacanth Gum nanocomposite as a drug delivery system

Shahin Shafiee et al.

CARBOHYDRATE POLYMERS (2019)

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Article Biophysics

Performance of TMC-g-PEG-VAPG/miRNA-145 complexes in electrospun membranes for target-regulating vascular SMCs

Meiling Wen et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Polymer Science

PLGA cationic nanoparticles, obtained from nano-emulsion templating, as potential DNA vaccines

Eduard Soler Besumbes et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Rapid and efficient extraction of chitin and chitosan for scale-up production: Effect of process parameters on deacetylation degree and molecular weight

H. El Knidri et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Nanoscience & Nanotechnology

ROS-Sensitive Cross-Linked Polyethylenimine for Red-Light-Activated siRNA Therapy

Junxia Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

Marcin Wojnilowicz et al.

ACS NANO (2019)

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Article Gastroenterology & Hepatology

A Molecular Targeted Immunotherapeutic Strategy for Ulcerative Colitis via Dual-targeting Nanoparticles Delivering miR-146b to Intestinal Macrophages

Feihong Deng et al.

JOURNAL OF CROHNS & COLITIS (2019)

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Review Oncology

Nanotechnology in cancer diagnosis: progress, challenges and opportunities

Ye Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Nanoscience & Nanotechnology

Delivery of Liver-Specific miRNA-122 Using a Targeted Macromolecular Prodrug toward Synergistic Therapy for Hepatocellular Carcinoma

Qjan Ning et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Pharmacology & Pharmacy

Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles

Hai-Zhen Zhu et al.

DRUG DELIVERY (2019)

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Article Chemistry, Multidisciplinary

Cytosolic delivery of CRISPR/Cas9 ribonucleoproteins for genome editing using chitosan-coated red fluorescent protein

Jie Qiao et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Medicine, Research & Experimental

Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment

Fang Li et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles

Lotte M. P. Vermeulen et al.

ACS NANO (2018)

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Article Biochemistry & Molecular Biology

Aqueous-Soluble, Acid-Transforming Chitosan for Efficient and Stimuli-Responsive Gene Silencing

Julius A. Edson et al.

BIOMACROMOLECULES (2018)

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Article Engineering, Biomedical

Enhanced antitumor efficacy of arginine modified amphiphilic nanoparticles co-delivering doxorubicin and iSur-pDNA via the multiple synergistic effect

Yudong Song et al.

BIOMATERIALS (2018)

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Review Engineering, Biomedical

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

Ling Li et al.

BIOMATERIALS (2018)

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Article Chemistry, Applied

GABAB receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery

Suhui Ni et al.

CARBOHYDRATE POLYMERS (2018)

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Article Chemistry, Applied

Efficient gene delivery by oligochitosan conjugated serum albumin: Facile synthesis, polyplex stability, and transfection

Monika Kumari et al.

CARBOHYDRATE POLYMERS (2018)

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Article Biophysics

TAT-conjugated chitosan cationic micelle for nuclear-targeted drug and gene co-delivery

Guan-Hai Wang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Biophysics

pH sensitive surfactant-stabilized Fe3O4 magnetic nanocarriers for dual drug delivery

Bijaideep Dutta et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Pharmacology & Pharmacy

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA

Victoria Capel et al.

DRUG DELIVERY (2018)

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Article Pharmacology & Pharmacy

Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer

Ga Hee Kim et al.

DRUG DELIVERY (2018)

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Article Biochemistry & Molecular Biology

Evaluation of hyaluronic acid-combined ternary complexes for serum-resistant and targeted gene delivery system

Woong-Gil Hong et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Nanoscience & Nanotechnology

In vivo therapeutic efficacy of TNFα silencing by folate-PEG-chitosan-DEAE/siRNA nanoparticles in arthritic mice

Qin Shi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Pharmacology & Pharmacy

Lipid coated chitosan-DNA nanoparticles for enhanced gene delivery

Elias Baghdan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Chemistry, Physical

Lyophilisation and concentration of chitosan/siRNA polyplexes: Influence of buffer composition, oligonucleotide sequence, and hyaluronic acid coating

Daniel Veilleux et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2018)

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Article Chemistry, Physical

Self-controlled release of Oxaliplatin prodrug from d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) functionalized mesoporous silica nanoparticles for cancer therapy

Chaoyu Liang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2018)

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Article Chemistry, Physical

Design and evaluation of galactosylated chitosan/graphene oxide nanoparticles as a drug delivery system

Chen Wang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2018)

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Review Materials Science, Biomaterials

Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics

Dawei Ding et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Review Biotechnology & Applied Microbiology

Design of Polymeric Gene Carriers for Effective Intracellular Delivery

Wing-Fu Lai et al.

TRENDS IN BIOTECHNOLOGY (2018)

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Article Materials Science, Biomaterials

Transferrin-functionalized chitosan-graft-poly(L-lysine) dendrons as a high-efficiency gene delivery carrier for nasopharyngeal carcinoma therapy

Tao Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Pharmacology & Pharmacy

Mesoporous silica nanoparticles for drug and gene delivery

Yixian Zhou et al.

ACTA PHARMACEUTICA SINICA B (2018)

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Article Engineering, Biomedical

Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells

Yudong Song et al.

BIOMATERIALS (2018)

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Article Chemistry, Applied

Glutathione responsive chitosan-thiolated dextran conjugated miR-145 nanoparticles targeted with AS1411 aptamer for cancer treatment

Farnaz Sadat Mirzazadeh Tekie et al.

CARBOHYDRATE POLYMERS (2018)

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Review Biochemistry & Molecular Biology

Carboxymethyl chitosan: Properties and biomedical applications

Zahra Shariatinia

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Engineering, Biomedical

Small-Sized Cationic miRi-PCNPs Selectively Target the Kidneys for High-Efficiency Antifibrosis Treatment

Xinran Geng et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Biochemistry & Molecular Biology

Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro

Shanshan Cui et al.

REDOX BIOLOGY (2018)

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Article Nanoscience & Nanotechnology

EMERGING ADVANCED NANOMATERIALS FOR CANCER PHOTOTHERMAL THERAPY

Haohao Zhang et al.

REVIEWS ON ADVANCED MATERIALS SCIENCE (2018)

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Article Biochemistry & Molecular Biology

siRNA Delivery with Chitosan: Influence of Chitosan Molecular Weight, Degree of Deacetylation, and Amine to Phosphate Ratio on in Vitro Silencing Efficiency, Hemocompatibility, Biodistribution, and in Vivo Efficacy

Mohamad Alameh et al.

BIOMACROMOLECULES (2018)

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Article Nanoscience & Nanotechnology

siRNA-loaded poly(histidine-arginine)(6)-modified chitosan nanoparticle with enhanced cellpenetrating and endosomal escape capacities for suppressing breast tumor metastasis

Ping Sun et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Chemistry, Physical

Automated in-line mixing system for large scale production of chitosan-based polyplexes

Ashkan Tavakoli Naeini et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2017)

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Article Chemistry, Multidisciplinary

Synergistic antitumor effects of combination treatment with metronomic doxorubicin and VEGF-targeting RNAi nanoparticles

Gijung Kwak et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Review Chemistry, Multidisciplinary

Reinforcing nanomedicine using graphene family nanomaterials

Jumana Abdul Jaleel et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Review Chemistry, Multidisciplinary

Revisiting structure-property relationship of pH-responsive polymers for drug delivery applications

Salime Bazban-Shotorbani et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Pharmacology & Pharmacy

Nebulized anionic guanidinylated O-carboxymethyl chitosan/N-2-hydroxypropyltimehyl ammonium chloride chitosan nanoparticles for siRNA pulmonary delivery: preparation, characterization and in vitro evaluation

Suhui Ni et al.

JOURNAL OF DRUG TARGETING (2017)

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Article Biotechnology & Applied Microbiology

In vitro and in vivo gene delivery using chitosan/hyaluronic acid nanoparticles: Influences of molecular mass of hyaluronic acid and lyophilization on transfection efficiency

Toshinori Sato et al.

JOURNAL OF GENE MEDICINE (2017)

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Review Chemistry, Medicinal

Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy

Anish Babu et al.

MARINE DRUGS (2017)

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Review Materials Science, Biomaterials

TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy

Poomima Agrawal et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Materials Science, Biomaterials

Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides

Huijie Zhang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Review Pharmacology & Pharmacy

MicroRNAs as biomarkers for early breast cancer diagnosis, prognosis and therapy prediction

Farah J. Nassar et al.

PHARMACOLOGY & THERAPEUTICS (2017)

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Article Materials Science, Biomaterials

Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy

Yue Cao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Article Nanoscience & Nanotechnology

Synthesis and Characterization of an Injectable and Hydrophilous Expandable Bone Cement Based on Poly(methyl methacrylate)

Zhao Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Applied

Stability and binding affinity of DNA/chitosan complexes by polyanion competition

Pei Lian Ma et al.

CARBOHYDRATE POLYMERS (2017)

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Article Nanoscience & Nanotechnology

Intraorgan Targeting of Gold Conjugates for Precise Liver Cancer Treatment

Yuan-Yue Gao et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Applied

Targeted gene delivery of polyethyleneimine-grafted chitosan with RGD dendrimer peptide in αvβ3 integrin-overexpressing tumor cells

Young-Min Kim et al.

CARBOHYDRATE POLYMERS (2017)

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Article Biophysics

Preparation of chitosan/tripolyphosphate nanoparticles with highly tunable size and low polydispersity

Nader Sawtarie et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Chemistry, Multidisciplinary

MUC1 Aptamer Targeted SERS Nanoprobes

Suchetan Pal et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Article Chemistry, Applied

Binding efficacy and kinetics of chitosan with DNA duplex: The effects of deacetylation degree and nucleotide sequences

Yanmei Yang et al.

CARBOHYDRATE POLYMERS (2017)

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Article Oncology

Chitosan-modified PLGA nanoparticles tagged with 5TR1 aptamer for in vivo tumor-targeted drug delivery

Sahar Taghavi et al.

CANCER LETTERS (2017)

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Article Biophysics

Redox-responsive nanocarriers for drug and gene co-delivery based on chitosan derivatives modified mesoporous silica nanoparticles

Jian-Tao Lin et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Review Biochemistry & Molecular Biology

G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms

Paula J. Bates et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

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Article Chemistry, Physical

Impact of physicochemical properties of porous silica materials conjugated with dexamethasone via pH-responsive hydrazone bond on drug loading and release behavior

Thanapha Numpilai et al.

APPLIED SURFACE SCIENCE (2017)

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Article Chemistry, Applied

Nano polyelectrolyte complexes of carboxymethyl dextran and chitosan to improve chitosan-mediated delivery of miR-145

Farnaz Sadat Mirzazadeh Tekie et al.

CARBOHYDRATE POLYMERS (2017)

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Article Nanoscience & Nanotechnology

Multifunctional Peptide-Amphiphile End-Capped Mesoporous Silica Nanoparticles for Tumor Targeting Drug Delivery

Yin-Jia Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Chemistry, Applied

N,N,N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicine

Abhijeet D. Kulkarni et al.

CARBOHYDRATE POLYMERS (2017)

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Review Chemistry, Applied

Utilization of chitosan-caged liposomes to push the boundaries of therapeutic delivery

Sonia Alavi et al.

CARBOHYDRATE POLYMERS (2017)

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Article Pharmacology & Pharmacy

PK11195-chitosan-graft-polyethylenimine-modified SPION as a mitochondria-targeting gene carrier

You-Kyoung Kim et al.

JOURNAL OF DRUG TARGETING (2016)

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Article Engineering, Biomedical

A high-throughput bioimaging study to assess the impact of chitosan-based nanoparticle degradation on DNA delivery performance

Carla P. Gomes et al.

ACTA BIOMATERIALIA (2016)

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Review Pharmacology & Pharmacy

Co-delivery of drugs and plasmid DNA for cancer therapy

Pei Yun Teo et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Engineering, Biomedical

Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing

Bei-Ke Wang et al.

BIOMATERIALS (2016)

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Article Chemistry, Applied

Fine-tuned PEGylation of chitosan to maintain optimal siRNA-nanoplex bioactivity

Andra Gutoaia et al.

CARBOHYDRATE POLYMERS (2016)

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Article Chemistry, Applied

Thermal and magnetic properties of chitosan-iron oxide nanoparticles

Paula I. P. Soares et al.

CARBOHYDRATE POLYMERS (2016)

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Article Biophysics

Transcutaneous iontophoretic delivery of STAT3 siRNA using layer-by-layer chitosan coated gold nanoparticles to treat melanoma

Suman Labala et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Review Pharmacology & Pharmacy

Graphene in therapeutics delivery: Problems, solutions and future opportunities

Catriona McCallion et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

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Article Biochemistry & Molecular Biology

Linear and Branched PEIs (Polyethylenimines) and Their Property Space

Claudiu N. Lungu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Pharmacology & Pharmacy

Heparin modification enhances the delivery and tumor targeting of paclitaxel-loaded N-octyl-N-trimethyl chitosan micelles

Feiran Zhang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Article Materials Science, Biomaterials

Synthesis, characterisation and preliminary investigation of the haemocompatibility of polyethyleneimine-grafted carboxymethyl chitosan for gene delivery

Xuan Liu et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Article Medicine, Research & Experimental

Delivery of Splice Switching Oligonucleotides by Amphiphilic Chitosan-Based Nanoparticles

Pedro M. D. Moreno et al.

MOLECULAR PHARMACEUTICS (2016)

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Article Medicine, Research & Experimental

Doxorubicin and siRNA Codelivery via Chitosan-Coated pH-Responsive Mixed Micellar Polyplexes for Enhanced Cancer Therapy in Multidrug-Resistant Tumors

Adeel Masood Butt et al.

MOLECULAR PHARMACEUTICS (2016)

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Meeting Abstract Biotechnology & Applied Microbiology

Optimizing Conditions for Aptamer Folding Using a High-Throughput Aptamer Fluorescence Binding and Internalization (AFBI) Assay

David D. Dickey et al.

MOLECULAR THERAPY (2016)

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Article Materials Science, Biomaterials

Highly efficient Gab2 siRNA delivery to ovarian cancer cells mediated by chitosan-polyethyleneimine nanoparticles

Lei Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Medicine, Research & Experimental

Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites

Abdulaziz M. Aldayel et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2016)

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Article Engineering, Biomedical

Optimization of multifunctional chitosan-siRNA nanoparticles for oral delivery applications, targeting TNF-α silencing in rats

Chunbai He et al.

ACTA BIOMATERIALIA (2015)

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Article Engineering, Biomedical

Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy

Hao Zheng et al.

BIOMATERIALS (2015)

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Article Engineering, Biomedical

Effects of mannose density on in vitro and in vivo cellular uptake and RNAi efficiency of polymeric nanoparticles

Shuang Chu et al.

BIOMATERIALS (2015)

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Article Chemistry, Applied

Aptamer decorated hyaluronan/chitosan nanoparticles for targeted delivery of 5-fluorouracil to MUC1 overexpressing adenocarcinomas

Zahra Ghasemi et al.

CARBOHYDRATE POLYMERS (2015)

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Article Chemistry, Applied

Preparation and anti-tumor metastasis of carboxymethyl chitosan

Zhiwen Jiang et al.

CARBOHYDRATE POLYMERS (2015)

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Article Chemistry, Multidisciplinary

Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan-poly(ethylene imine) hybrid nanoparticles: A mechanistic insight

Heloise Ragelle et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Biochemistry & Molecular Biology

Tuning the Buffering Capacity of Polyethylenimine with Glycerol Molecules for Efficient Gene Delivery: Staying In or Out of the Endosomes

Bijay Singh et al.

MACROMOLECULAR BIOSCIENCE (2015)

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Review Chemistry, Medicinal

Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications

Islem Younes et al.

MARINE DRUGS (2015)

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Review Pharmacology & Pharmacy

Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment

Lin Kang et al.

ACTA PHARMACEUTICA SINICA B (2015)

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Article Chemistry, Multidisciplinary

Nanomagnetic Activation as a Way to Control the Efficacy of Nucleic Acid Delivery

Bartosz F. Grzeskowiak et al.

PHARMACEUTICAL RESEARCH (2015)

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Article Engineering, Biomedical

Oral delivery of shRNA and siRNA via multifunctional polymeric nanoparticles for synergistic cancer therapy

Lu Han et al.

BIOMATERIALS (2014)

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Article Chemistry, Multidisciplinary

Non-Viral Gene Delivery via Membrane-Penetrating, Mannose-Targeting Supramolecular Self-Assembled Nanocomplexes

Lichen Yin et al.

ADVANCED MATERIALS (2013)

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Review Chemistry, Applied

Biomedical applications of carboxymethyl chitosans

Laxmi Upadhyaya et al.

CARBOHYDRATE POLYMERS (2013)

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Article Engineering, Biomedical

Targeted siRNA delivery by anti-HER2 antibody-modified nanoparticles of mPEG-chitosan diblock copolymer

Yiyi Wang et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2013)

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Review Pharmacology & Pharmacy

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications

Emanuel Fleige et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Engineering, Biomedical

The effects of coating pDNA/chitosan complexes with chondroitin sulfate on physicochemical characteristics and cell transfection

Kenji Hagiwara et al.

BIOMATERIALS (2012)

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Article Engineering, Biomedical

Effects of hydrophobic and hydrophilic modifications on gene delivery of amphiphilic chitosan based nanocarriers

Bingqing Wang et al.

BIOMATERIALS (2011)

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Editorial Material Oncology

Early Diagnosis of Hepatocellular Carcinoma by Multiple microRNAs: Validity, Efficacy, and Cost-Effectiveness

Chien-Jen Chen et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

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Meeting Abstract Chemistry, Multidisciplinary

Understanding the role of the C3-hydroxyl group in glycyrrhetinic acid on liver targeting

Qin Tian et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Biotechnology & Applied Microbiology

Imidazole-grafted chitosan-mediated gene delivery: in vitro study on transfection, intracellular trafficking and degradation

Liliana R. Pires et al.

NANOMEDICINE (2011)

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Article Oncology

Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles

Hee Dong Han et al.

CLINICAL CANCER RESEARCH (2010)

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Article Oncology

Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma

Hildegard M. Schuller et al.

CARCINOGENESIS (2008)

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Review Pharmacology & Pharmacy

Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery

Caroline Bouzin et al.

DRUG RESISTANCE UPDATES (2007)

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Article Chemistry, Multidisciplinary

Thiolated chitosan/DNA nanocomplexes exhibit enhanced and sustained gene delivery

Dongwon Lee et al.

PHARMACEUTICAL RESEARCH (2007)

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Article Oncology

Mannosylated chitosan nanoparticle-based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells

Tae Hee Kim et al.

MOLECULAR CANCER THERAPEUTICS (2006)

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Article Chemistry, Multidisciplinary

Transfection efficiency of chitosan vectors: Effect of polymer molecular weight and degree of deacetylation

M Huang et al.

JOURNAL OF CONTROLLED RELEASE (2005)

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Article Engineering, Biomedical

The effect of the degree of chitosan deacetylation on the efficiency of gene transfection

T Kiang et al.

BIOMATERIALS (2004)

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Article Biotechnology & Applied Microbiology

Deoxyribonuclease II is a lysosomal barrier to transfection

DPG Howell et al.

MOLECULAR THERAPY (2003)

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Article Engineering, Biomedical

In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency

T Sato et al.

BIOMATERIALS (2001)

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