☆ 4.7 Article

DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells

De-Chen Yu et al.

Summary: This study used bioinformatics strategies to identify key genes associated with osteosarcoma (OS) and validated the role of TRIP13. Knockdown of TRIP13 can inhibit the proliferation, migration, and invasion of U2OS cells by downregulating the PI3K/AKT signaling pathway, providing new insights for the early diagnosis and treatment of osteosarcoma.

MOLECULAR BIOLOGY REPORTS (2022)

添加到收藏夹

Article Oncology

Gallbladder Cancer Cell-Derived Exosome-Mediated Transfer of Leptin Promotes Cell Invasion and Migration by Modulating STAT3-Mediated M2 Macrophage Polarization

Songling Zhao et al.

Summary: Exosomal leptin derived from gallbladder cancer cells promotes invasion and migration of cells by polarizing macrophages.

ANALYTICAL CELLULAR PATHOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization

Lifang Zhao et al.

Summary: This study reveals the protumor function of TGR5 in non-small cell lung cancer (NSCLC) by regulating tumor-associated macrophage (TAM) polarization and suppressing anti-tumor immunity. Mechanistically, TGR5 promotes the transformation of TAMs into protumorigenic M2-like phenotypes through the activation of the cAMP-STAT3/STAT6 signaling pathway. The study also shows that the expression of TGR5 is associated with TAM infiltration in NSCLC tissues, and the co-expression of TGR5 and high TAM infiltration correlates with the prognosis and overall survival of NSCLC patients.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Article Allergy

MiR-224 ameliorates inflammation and symptoms in mouse model of allergic rhinitis by targeting CDK9

Sang Wang et al.

Summary: The study revealed that miR-224 affects the pathogenesis of allergic rhinitis by targeting CDK9, suggesting that miR-224 could be a novel potential therapeutic target for AR.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2021)

添加到收藏夹

Article Environmental Sciences

Cadmium induces epithelial-mesenchymal transition and migration of renal cancer cells by increasing PGE2 through a cAMP/PKA-COX2 dependent mechanism

Haifeng Shi et al.

Summary: This study found that low-dose Cd exposure promoted migration of renal cancer Caki-1 cells, which was not dependent on Cd-induced ROS and intracellular Ca2+ levels. Cd exposure induced cAMP/PKA-COX2 signaling pathway, mediating cell migration and invasion, and decreasing expression of EMT marker E-cadherin while increasing expressions of N-cadherin and Vimentin. Moreover, Cd-induced secretion of PGE2 feedback on activation of cAMP/PKA-COX2 signaling, also promoting EMT, migration, and invasion of renal cancer Caki-1 cells.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

cAMP levels regulate macrophage alternative activation marker expression

Swamy Polumuri et al.

Summary: The capacity for macrophages to polarize into distinct functional activation states is critical for tuning inflammatory responses. In addition to IL-4/IL-13, signals from the inflammatory milieu can further modulate M2 marker expression, with cAMP playing a role in increasing M2 markers through a PKA/C/EBP beta/CREB dependent pathway.

INNATE IMMUNITY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Pan-cancer analysis and experiments with cell lines reveal that the slightly elevated expression of DLGAP5 is involved in clear cell renal cell carcinoma progression

Yun Feng et al.

Summary: DLGAP5 is upregulated in various cancers, including ccRCC, and its expression is positively correlated with immune infiltration levels in ccRCC. Elevated DLGAP5 expression is associated with ccRCC progression and may serve as a prognostic risk factor, but not an independent one.

LIFE SCIENCES (2021)

添加到收藏夹

Article Allergy

Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents: a performance

Ana Carolina Rozalem Reali et al.

Summary: Phadiatop Infant (R) is a useful tool to assess allergic sensitization in children under 5 years old. A study in Brazilian children showed high positivity of the test, especially in cases of food allergy and atopic dermatitis. The test had high sensitivity and specificity compared to specific serum IgE dosage, making it a valuable screening method for allergic diseases in non-European countries.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2021)

添加到收藏夹

Article Allergy

Epalrestat suppresses inflammatory response in lipopolysaccharide-stimulated RAW264.7 cells

Keisuke Sato et al.

Summary: This study demonstrated that EPS suppresses inflammatory response in LPS-stimulated RAW264.7 cells by regulating the levels of pro-inflammatory cytokines and inflammatory mediators. This suggests that targeting the regulation of these molecules by EPS could be a promising therapeutic approach for treating inflammatory injury. EPS, with confirmed safety and pharmacokinetics clinically, is expected to be useful for the treatment of inflammatory diseases.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis

Hui Wang et al.

Summary: Colorectal cancer (CRC) is a highly prevalent and lethal malignant tumor in the digestive system. Tumor-associated macrophages (TAMs) play a crucial role in various mechanisms of CRC progression, such as promoting tumor proliferation, invasion, angiogenesis, and immunosuppression, although their exact role is still debated in clinical evidence.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis

Tianli Chen et al.

Summary: The study revealed that FGF19 and FGFR4 are adverse prognostic biomarkers for gallbladder carcinoma, with their co-expression being a more sensitive predictor. FGF19 can promote GBC progression by stimulating FGFR4 activation via an autocrine pathway with bile as a potential carrier.

ONCOGENE (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Knockdown of DLGAP5 suppresses cell proliferation, induces G2/M phase arrest and apoptosis in ovarian cancer

Huijun Zhang et al.

Summary: DLGAP5 is significantly upregulated in ovarian cancer and its higher expression is associated with poor survival prognosis. Knockdown of DLGAP5 can suppress cell proliferation, induce G(2)/M phase cell cycle arrest and apoptosis, suggesting it may be a promising prognostic therapeutic target for OC treatment.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Overexpression of PLXDC2 in Stromal Cell-Associated M2 Macrophages Is Related to EMT and the Progression of Gastric Cancer

Yiming Guan et al.

Summary: PLXDC2 is a gene associated with the tumor microenvironment, linked to poor prognosis and advanced disease in gastric cancer patients, and correlated with the expression of M2 macrophages and inflammatory signaling pathways. Its expression in stromal cells and interaction with tumor-associated macrophages may induce the EMT process, contributing significantly to cancer biology.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Andrology

Devazepide suppresses cell proliferation and migration, and induces apoptosis in bladder carcinoma

Hengzhe Zhang et al.

Summary: The study demonstrated that devazepide significantly inhibits the proliferation and migration of human bladder cancer 5637 cells, while inducing cell apoptosis by arresting the G1-S cell cycle.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

添加到收藏夹

Article Cell Biology

MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling

Jiang Ke et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Genetics & Heredity

Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner

Wajima Safi et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

添加到收藏夹

Article Oncology

Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer

Senlin Zhao et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Identification and prognostic value of DLGAP5 in endometrial cancer

Ruoyi Zheng et al.

PEERJ (2020)

添加到收藏夹

Review Immunology

Tumor-Associated Macrophages in Tumor Immunity

Yueyun Pan et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer

Yueh-Shan Weng et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

Chen Wei et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Surgery

Gallbladder Cancer Diagnosis, Surgical Management, and Adjuvant Therapies

Laura Hickman et al.

SURGICAL CLINICS OF NORTH AMERICA (2019)

添加到收藏夹

Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

Paulina Pathria et al.

TRENDS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

A review on the role of M2 macrophages in bladder cancer; pathophysiology and targeting

Laleh Sharifi et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

添加到收藏夹

Article Oncology

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

Jingqin Lan et al.

CANCER RESEARCH (2019)

添加到收藏夹

Article Oncology

Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3K gamma to Promote Pancreatic Cancer Metastasis

Xiaofeng Wang et al.

CANCER RESEARCH (2018)

添加到收藏夹

Review Oncology

Updates on Gallbladder Cancer Management

Mohammad Yahya Zaidi et al.

CURRENT ONCOLOGY REPORTS (2018)

添加到收藏夹

Article Oncology

Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling

Fei Xu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Nucleolar and Spindle Associated Protein 1 (NUSAP1) Inhibits Cell Proliferation and Enhances Susceptibility to Epirubicin In Invasive Breast Cancer Cells by Regulating Cyclin D Kinase (CDK1) and DLGAP5 Expression

Xi Zhang et al.

MEDICAL SCIENCE MONITOR (2018)

添加到收藏夹

Article Oncology

Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

Yulei Chen et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dysregulation of POPDC1 promotes breast cancer cell migration and proliferation

Johanna Ndamwena Amunjela et al.

BIOSCIENCE REPORTS (2017)

添加到收藏夹

Article

Quantitative Changes in Tumor-Associated M2 Macrophages Characterize Cholangiocarcinoma and their Association with Metastasis

Malinee Thanee et al.

Asian Pacific Journal of Cancer Prevention (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure of the GH1 domain of guanylate kinase-associated protein from Rattus norvegicus

Junsen Tong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Silencing of DLGAP5 by siRNA Significantly Inhibits the Proliferation and Invasion of Hepatocellular Carcinoma Cells

Weijia Liao et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Prognostic Value of Discs Large Homolog 7 Transcript Levels in Prostate Cancer

Christian R. Gomez et al.

PLOS ONE (2013)

添加到收藏夹

Article Clinical Neurology

Identification of Gene Markers Associated With Aggressive Meningioma by Filtering Across Multiple Sets of Gene Expression Arrays

Jourdan E. Stuart et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

添加到收藏夹

Article Oncology

Gene Expression Profiling Reveals a New Classification of Adrenocortical Tumors and Identifies Molecular Predictors of Malignancy and Survival

Aurelien de Reynies et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

P38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

G Sabio et al.

EMBO JOURNAL (2005)

添加到收藏夹

Review Oncology

A decade's studies on metastasis of hepatocellular carcinoma

ZY Tang et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma

AP Tsou et al.

ONCOGENE (2003)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1

S Bassal et al.

GENOMICS (2001)

添加到收藏夹

Article Neurosciences

Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein

S Naisbitt et al.

JOURNAL OF NEUROSCIENCE (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.