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Targeting microRNAs as a promising anti-cancer therapeutic strategy against traffic-related air pollution-mediated lung cancer

CANCER AND METASTASIS REVIEWS (2023)

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Review Public, Environmental & Occupational Health

Ambient air pollution exposure and telomere length: a systematic review and meta-analysis

Z. -q. Zong et al.

Summary: This study aimed to investigate the associations between air pollution exposure during pre-and post-birth and adulthood with telomere length. A systematic review and meta-analysis was conducted using data from 18 studies. The results showed moderate evidence that prenatal PM2.5 and NO2 exposures were related to shortened telomere length. However, other exposures such as prenatal SO2 and CO, childhood PM2.5, PM10, and NO2, as well as short-term adulthood PM2.5 and PM10 exposures were not associated with telomere length. High-quality studies are needed for further investigation.

PUBLIC HEALTH (2023)

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Article Chemistry, Medicinal

MicroRNA-32 Suppression: its Effects on Prostate Cancer Cells' Capability to Proliferate and Migrate

Farah A. Al-Marzook et al.

Summary: This study aimed to investigate the role of microRNA-32 (miR-32) in the growth, migration, and expression of metastatic genes in PC3 cells of prostate cancer in vitro. Transfection of PC3 cells with miR-32 mimics and inhibitor was performed, and cell proliferation, apoptosis, and the expression of metastatic and angiogenesis genes were measured. The results showed that miR-32 was overexpressed in PC3 cells and its down-regulation inhibited cell proliferation and migration while enhancing apoptosis. In addition, miR-32 negatively regulated the expression of VEGF and MMP2 in PC3 cells.

DRUG RESEARCH (2023)

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Review Biochemistry & Molecular Biology

MiRNAs in Hematopoiesis and Acute Lymphoblastic Leukemia

Diana Karen Mendiola-Soto et al.

Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, and although cure rates have increased, a significant number of patients still relapse. The role of microRNAs (miRNAs) as non-coding RNA genes in ALL has gained interest in terms of understanding the disease's molecular mechanisms and identifying clinical biomarkers. Consistent findings suggest that miRNAs can be useful in distinguishing between different types of leukemia and predicting chemotherapy response. However, there is limited research on the molecular interplay between miRNAs and their targeted genes. This review aims to discuss the various ways miRNAs could be involved in ALL and their clinical implications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Environmental Sciences

Histological types of lung cancer attributable to fine particulate, smoking, and genetic susceptibility

Xiaojie Wang et al.

Summary: The relationship between PM2.5, smoking, and lung cancer subtypes is unclear. This study found that PM2.5, smoking, and genetic risk were significantly associated with incident lung cancer. Smoking and PM2.5 were more closely associated with squamous cell lung cancer.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Environmental Sciences

The PM2.5 concentration reduction improves survival rate of lung cancer in Beijing

Lei Yang et al.

Summary: Long-term exposure to ambient PM2.5 is associated with an increased incidence of lung cancer, and this study found that it also decreases the survival rate for lung cancer patients. However, the implementation of clean air actions in Beijing has been shown to prolong the survival time of these patients by reducing PM2.5 levels.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Environmental Sciences

Source-oriented risk and lung-deposited surface area (LDSA) of ultrafine particles in a Southeast Asia urban area

Tse-Lun Chen et al.

Summary: This study investigates the sources of submicron and ultrafine particles (UFP) using a positive matrix factorization model. It found that UFP exposure is epidemiologically and toxicologically linked to pulmonary, neurodegenerative, and cardiovascular diseases. The study identified the contributions of particle chemical composition and size distribution to lung deposition and excess cancer risks.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Environmental Sciences

PM2.5 air pollution components and mortality in Denmark

Ole Raaschou-Nielsen et al.

Summary: This study found significant associations between natural cause mortality and sulfate particles (SO4--) and secondary organic aerosol (SOA) in PM2.5. Additionally, elemental carbon and mineral dust were found to be strongly associated with higher respiratory and lung cancer mortality.

ENVIRONMENT INTERNATIONAL (2023)

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Article Environmental Sciences

Association of outdoor air pollution, lifestyle, genetic factors with the risk of lung cancer: A prospective cohort study

Huaying Liang et al.

Summary: In this study involving 367,623 participants, it was found that long-term exposure to air pollution is associated with an increased risk of lung cancer. The modifying role of lifestyle and genetic susceptibility in the association between air pollution and lung cancer was also observed. Integrated interventions for environmental pollution and adherence to a healthy lifestyle are advocated for lung cancer prevention.

ENVIRONMENTAL RESEARCH (2023)

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Article Green & Sustainable Science & Technology

Applications of nanotechnology in biodiesel combustion and post-combustion stages

Homa Hosseinzadeh-Bandbafha et al.

Summary: Diesel fuel is efficient, durable, and profitable, but it is a major source of airborne pollutants. Biodiesel has been developed as a potential replacement, but its combustion has drawbacks, especially in nitrogen oxide emissions. Nanotechnology has shown promise in improving biodiesel combustion and reducing emissions, but there are challenges to overcome.

RENEWABLE & SUSTAINABLE ENERGY REVIEWS (2023)

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Review Biotechnology & Applied Microbiology

Current and emerging applications of saccharide-modified chitosan: a critical review

Hamed Kazemi Shariat Panahi et al.

Summary: The article introduces the importance of chitosan and its derivative chitin in biomaterials, particularly in terms of their antimicrobial, antioxidant, and anticancer activities. The article also points out some drawbacks in the structure of chitosan and discusses a modification method using lactose and galactose as main raw materials to prepare soluble branched chitosan.

BIOTECHNOLOGY ADVANCES (2023)

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Review Pharmacology & Pharmacy

Unraveling Therapeutic Opportunities and the Diagnostic Potential of microRNAs for Human Lung Cancer

Osama Sweef et al.

Summary: Lung cancer is a significant public health issue and a leading cause of cancer-related deaths worldwide. MicroRNAs have emerged as potential biomarkers and therapeutic targets for lung cancer due to their crucial roles in regulating cell proliferation, differentiation, and apoptosis. This review summarizes the roles of microRNAs in lung carcinogenesis, especially those induced by exposure to environmental pollutants, and discusses the recent advances in miRNA-based cancer therapeutics and diagnostics.

PHARMACEUTICS (2023)

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Article Oncology

miR-452-5p suppressed the metastasis of Non-small cell lung cancer through regulating Moesin

Jing Zhuang et al.

Summary: This study found that miR-452-5p can regulate the cell proliferation, migration, and invasion ability of NSCLC through targeting MSN, and it also affects the EMT process. These findings might provide a novel prevention and treatment target for NSCLC.

JOURNAL OF CANCER (2023)

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Article Microbiology

Down-regulation of microRNA-155 suppressed Candida albicans induced acute lung injury by activating SOCS1 and inhibiting inflammation response

Xiaohua Li et al.

Summary: This study suggests that improving acute lung injury caused by C. albicans, suppressing inflammatory response and fungal infection, and inhibiting cell apoptosis can be achieved by inhibiting miR-155 through the SOCS1 pathway.

JOURNAL OF MICROBIOLOGY (2022)

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Review Pathology

microRNAs as novel diagnostic biomarkers in endometriosis patients: a systematic review and meta-analysis

Narges Zafari et al.

Summary: The research investigated the effectiveness of using miRNAs as noninvasive biomarkers to differentiate endometriosis patients from non-endometriosis women. Results showed high sensitivity and specificity of miRNAs in distinguishing between the two groups, indicating their potential as noninvasive biomarkers.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2022)

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Review Environmental Sciences

Long-term exposure to traffic-related air pollution and selected health outcomes: A systematic review and meta-analysis

H. Boogaard et al.

Summary: Traffic-related air pollution (TRAP) has significant health effects, particularly on children and pregnant women. Long-term exposure to TRAP is associated with respiratory diseases, cardiovascular diseases, lung cancer, asthma, and acute lower respiratory infections in children. It is important to prioritize the reduction of TRAP to improve public health.

ENVIRONMENT INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

Synthetic Circular miR-21 Sponge as Tool for Lung Cancer Treatment

Ana R. Rama et al.

Summary: This study presents a circular RNA-based miRNA capture system for studying the role of miR-21 in lung cancer. The miR-21 circular sponge was found to inhibit the growth, colony formation, and migration of lung cancer cells, indicating the potential of this method as a tool for capturing other miRNAs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

Delivery of miRNA-126 through folic acid-targeted biocompatible polymeric nanoparticles for effective lung cancer therapy

Forough N. Golafzani et al.

Summary: In this study, a folate-decorated chitosan nanocarrier was designed and synthesized for targeted delivery of miR-126 to lung cancer cells. The experimental results demonstrate that FA-CS-miR-126 shows high biocompatibility and effective therapeutic performance as a drug delivery system.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2022)

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Article Biology

Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets

Zhuang Liu et al.

Summary: This study identified 17 pathologically relevant miRNAs that are involved in chronic wound pathology and showed their high cooperativity. By targeting these miRNAs, innovative wound treatments with higher efficacy and specificity could be developed.

ELIFE (2022)

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Review Health Care Sciences & Services

The Role of the Selected miRNAs as Diagnostic, Predictive and Prognostic Markers in Non-Small-Cell Lung Cancer

Michal Szczyrek et al.

Summary: Lung cancer, a leading cause of global cancer-related deaths, is often diagnosed at advanced stages due to limited diagnostic possibilities. However, the use of miRNAs as diagnostic, predictive, and prognostic markers in non-small-cell lung cancer (NSCLC) has gained attention in recent years. Abnormal expression levels of miRNAs can detect NSCLC in its early asymptomatic stages, potentially improving clinical outcomes and serving as predictive factors for NSCLC treatment.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Review Pharmacology & Pharmacy

Engineering nanosystems to overcome barriers to cancer diagnosis and treatment

Suhaila O. Alhaj-Suliman et al.

Summary: In the past two decades, there has been increasing interdisciplinary research on the development of nanoparticles for medical applications. However, nanoparticles still face biological barriers and biodistribution challenges, limiting their overall clinical potential. To overcome these limitations, innovative modifications have been made to nanoparticle formulations designed for cancer imaging and treatment, aiming to enhance specificity and target diseased tissues. Recent advancements in technology and chemistry have been employed to modify the surface and characteristics of nanoparticles, in combination with identifying critical biomarkers, providing new strategies for improving nanoparticle specificity in cancer diagnosis and therapy. This review discusses the latest advances in nanoparticle design and engineering, and outlines future directions for the development of next-generation nanomedicines.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Polymer Science

Dendrimers as prospective nanocarrier for targeted delivery against lung cancer

Virali Arora et al.

Summary: Dendrimers are synthetic nano-molecules with a spherical structure and a stardust topology. They are effective in solving the solubility problem in drug delivery and have been successfully used in chemotherapeutic drug delivery. Research has shown that dendrimers have potential in treating lung cancer and outperform other nanoparticles in terms of bioavailability and stability.

EUROPEAN POLYMER JOURNAL (2022)

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Review Oncology

Emerging Role of Noncoding RNAs in EGFR TKI-Resistant Lung Cancer

Jingwei Li et al.

Summary: This review summarizes the potential mechanisms of noncoding RNAs in EGFR TKI-resistant lung cancer and their clinical applications, and highlights the barriers that need to be addressed.

CANCERS (2022)

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Article Energy & Fuels

Wood combustion nanoparticles emitted by conventional and advanced technology cordwood boilers, and their interactions in vitro with human lung epithelial monolayers

Barbara Panessa-Warren et al.

Summary: Biomass-burning boilers and stoves, widely used globally, produce combustion emissions that pose health risks. A study found that combustion emission nanoparticles (NPs) from wood burning boilers caused cytotoxicity in human lung tissue. The research highlights the importance of controlling the burn cycle and using advanced technology to minimize the health and environmental impacts of wood biofuel combustion.

BIOFUEL RESEARCH JOURNAL-BRJ (2022)

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Review Cell Biology

Role of miRNAs interference on ovarian functions and premature ovarian failure

Narjes Nouri et al.

Summary: Premature ovarian failure is a complex problem with diverse causes and clinical manifestations. Lack of ovarian sex hormones is believed to be a major factor in its occurrence. Despite limited scientific research progress, clinical medicine has made significant strides in optimizing the quality of life and long-term health of women with premature ovarian insufficiency through timely intervention. Recent investigations have focused on the regulating effects of small RNA molecules on various ovarian processes. This literature review discusses the mechanisms of miRNAs in regulating gene expression in the ovary after transcription.

CELL COMMUNICATION AND SIGNALING (2022)

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Review Gastroenterology & Hepatology

Long Noncoding RNAs in Gastrointestinal Cancer: Tumor Suppression Versus Tumor Promotion

Mina Khajehdehi et al.

Summary: LncRNAs, a heterogeneous group of RNA transcripts, play critical roles in the development and progression of GI cancers by serving as both tumor suppressor genes and tumor promoter genes. The expression patterns and roles of lncRNAs may exhibit context dependency across different types of GI cancers.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Article Environmental Sciences

Long-term low-level ambient air pollution exposure and risk of lung cancer - A pooled analysis of 7 European cohorts

Ulla Arthur Hvidtfeldt et al.

Summary: This study, pooling data from seven cohorts across Europe, found that long-term low-level PM2.5 exposure was associated with lung cancer incidence, even below current EU limit values. There was no observed association between NO2, BC, or O-3 and lung cancer incidence. The results suggest a linear or supra-linear association between PM2.5 exposure and lung cancer risk, with no evidence of a threshold.

ENVIRONMENT INTERNATIONAL (2021)

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Article Environmental Sciences

Commute patterns, residential traffic-related air pollution, and lung cancer risk in the prospective UK Biobank cohort study

Jason Y. Y. Wong et al.

Summary: Commuters living in high-NO2 areas who frequently use public transportation may have an increased risk of lung cancer compared to regular automobile users. Further investigation is needed to determine the specific component(s) of public transportation that contribute to this elevated risk.

ENVIRONMENT INTERNATIONAL (2021)

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Review Integrative & Complementary Medicine

Mechanisms of Kidney Cell Pyroptosis in Chronic Kidney Disease and the Effects of Traditional Chinese Medicine

Baozhu Ding et al.

Summary: Chronic kidney disease is a major global public health issue, with pyroptosis being an important mechanism underlying kidney cell damage. Traditional Chinese medicine and extracts can intervene in kidney cell pyroptosis through various pathways, offering new perspectives for CKD treatment.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Article Multidisciplinary Sciences

Integrated mRNA and miRNA expression profile analysis of female and male gonads in Hyriopsis cumingii

Ya-Yu Wang et al.

Summary: This study on Hyriopsis cumingii identified differentially expressed genes and miRNAs related to sex determination and differentiation, as well as candidate genes and pathways associated with sex differentiation. The findings provide significant insights into understanding the mechanisms of sex differentiation and determination in H. cumingii.

SCIENTIFIC REPORTS (2021)

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Article Medicine, Research & Experimental

Long non-coding RNA linc00665 inhibits CDKN1C expression by binding to EZH2 and affects cisplatin sensitivity of NSCLC cells

Daolu Yang et al.

Summary: lncRNA linc00665 is significantly upregulated in NSCLC tissues, affecting drug sensitivity and tumor progression. The study demonstrates that linc00665 inhibits CDKN1C transcription by recruiting EZH2, thus influencing NSCLC cell proliferation and migration.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Biochemistry & Molecular Biology

Association between microRNA-146a, -499a and -196a-2 SNPs and non-small cell lung cancer: a case-control study involving 2249 subjects

Hao Qiu et al.

Summary: The study suggests that miR-196a-2 rs11614913 may be a protective factor for the development of NSCLC among female patients. However, there were no differences in the genotypic distributions of other miR-SNPs between NSCLC cases and controls in overall comparisons.

BIOSCIENCE REPORTS (2021)

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Article Environmental Sciences

Contribution of Long-Term Exposure to Outdoor Black Carbon to the Carcinogenicity of Air Pollution: Evidence regarding Risk of Cancer in the Gazel Cohort

Emeline Lequy et al.

Summary: This study aimed to estimate the associations between long-term exposure to BC and risk of cancer among French adults. The results suggest that BC may partly explain the association between PM2.5 and lung cancer. Further studies are needed to confirm and disentangle the effects of BC, total PM2.5, and other constituents.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

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Review Oncology

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Jieyu He et al.

Summary: Osteosarcoma is a common and highly malignant bone tumor, with dysregulated lncRNA expression potentially playing a crucial role in its progression. Particularly, LncRNAs associated with the Wnt signaling pathway may have significant implications for osteosarcoma development and treatment.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

MiR-155 targeting FoxO3a regulates oral cancer cell proliferation, apoptosis, and DDP resistance through targeting FoxO3a

Xiaoting Li et al.

CANCER BIOMARKERS (2020)

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Article Medicine, Research & Experimental

MiR-155-5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2

Meng Wu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Oncology

Epidemiology of lung cancer and lung cancer screening programs in China and the United States

Dawei Yang et al.

CANCER LETTERS (2020)

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Article Pathology

Clinical impact of TROP2 in non-small lung cancers and its correlation with abnormal p53 nuclear accumulation

Remi Mito et al.

PATHOLOGY INTERNATIONAL (2020)

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Article Oncology

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

David S. Hong et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Respiratory System

Identification key genes, key miRNAs and key transcription factors of lung adenocarcinoma

Jinghang Li et al.

JOURNAL OF THORACIC DISEASE (2020)

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Review Medicine, General & Internal

Integrated miRNA-mRNA network revealing the key molecular characteristics of ossification of the posterior longitudinal ligament

Guoyong Xu et al.

MEDICINE (2020)

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Article Cell Biology

MiR-17-5p promotes the endothelialization of endothelial progenitor cells to facilitate the vascular repair of aneurysm by regulating PTEN-mediated PI3K/AKT/VEGFA pathway

Ye Tian et al.

CELL CYCLE (2020)

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Article Environmental Sciences

Incidence and mortality for respiratory cancer and traffic-related air pollution in Sao Paulo, Brazil

Adeylson Guimaraes Ribeiro et al.

ENVIRONMENTAL RESEARCH (2019)

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Review Genetics & Heredity

Association of mir-196a-2 rs11614913 and mir-149 rs2292832 Polymorphisms With Risk of Cancer: An Updated Meta-Analysis

Jalal Choupani et al.

FRONTIERS IN GENETICS (2019)

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Review Cell Biology

Revisiting Telomere Shortening in Cancer

Keiji Okamoto et al.

CELLS (2019)

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Review Genetics & Heredity

The Potential for microRNA Therapeutics and Clinical Research

Johora Hanna et al.

FRONTIERS IN GENETICS (2019)

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Article Oncology

Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation

Xi Tang et al.

CANCER LETTERS (2019)

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Article Biochemistry & Molecular Biology

miR-182 contributes to cell proliferation, invasion and tumor growth in colorectal cancer by targeting DAB2IP

Xiaoli Li et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Genetics & Heredity

MiR-486-5p Serves as a Good Biomarker in Nonsmall Cell Lung Cancer and Suppresses Cell Growth With the Involvement of a Target PIK3R1

Fei Tian et al.

FRONTIERS IN GENETICS (2019)

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Article Oncology

Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: a single-institution experience

Kamal Chamoun et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Oncology

The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway

Zhangao Li et al.

JOURNAL OF CANCER (2019)

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Article Oncology

Telomere Length and Lung Cancer Mortality among Heavy Smokers

Jennifer A. Doherty et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2018)

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Article Biochemistry & Molecular Biology

miR-196a Is Able to Restore the Aggressive Phenotype of Annexin A1 Knock-Out in Pancreatic Cancer Cells by CRISPR/Cas9 Genome Editing

Raffaella Belvedere et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, Research & Experimental

Evaluation of MUC1-Aptamer Functionalized Hybrid Nanoparticles for Targeted Delivery of miRNA-29b to Nonsmall Cell Lung Cancer

Maryna Perepelyuk et al.

MOLECULAR PHARMACEUTICS (2018)

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Review Engineering, Environmental

Trends in onroad transportation energy and emissions

H. Christopher Frey

JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION (2018)

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Article Biotechnology & Applied Microbiology

B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma

Ting-Ting Yul et al.

ONCOTARGETS AND THERAPY (2018)

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Article Medicine, General & Internal

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Spencer L. G. James et al.

LANCET (2018)

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Article Oncology

miR-182 and miR-183 Promote Cell Proliferation and Invasion by Targeting FOXO1 in Mesothelioma

Rui Suzuki et al.

FRONTIERS IN ONCOLOGY (2018)

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Review Respiratory System

Particulate matter-induced epigenetic changes and lung cancer

Jinghong Li et al.

CLINICAL RESPIRATORY JOURNAL (2017)

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Article Pathology

Effects of microRNA-183 on epithelial-mesenchymal transition, proliferation, migration, invasion and apoptosis in human pancreatic cancer SW1900 cells by targeting MTA1

Xizhou Lin et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2017)

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Article Oncology

Case-control study of cumulative cigarette tar exposure and lung and upper aerodigestive tract cancers

Travis J. Meyers et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Oncology

miR-181b-5p mediates TGF-β1-induced epithelial-to-mesenchymal transition in non-small cell lung cancer stem-like cells derived from lung adenocarcinoma A549 cells

Xuetao Li et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

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Article Oncology

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

Nico van Zandwijk et al.

LANCET ONCOLOGY (2017)

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Article Oncology

Long Noncoding RNA GAS5 Inhibits Tumorigenesis and Enhances Radiosensitivity by Suppressing miR-135b Expression in Non-Small Cell Lung Cancer

Yingbo Xue et al.

ONCOLOGY RESEARCH (2017)

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Article Medicine, General & Internal

Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study

Dirga Kumar Lamichhane et al.

YONSEI MEDICAL JOURNAL (2017)

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Article Endocrinology & Metabolism

MiR-195 Inhibits Tumor Growth and Metastasis in Papillary Thyroid Carcinoma Cell Lines by Targeting CCND1 and FGF2

Yali Yin et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2017)

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Article Oncology

MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA

Amr A. Al-Haidari et al.

ONCOTARGET (2017)

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Article Oncology

Association of tumor TROP2 expression with prognosis varies among lung cancer subtypes

Kentaro Inamura et al.

ONCOTARGET (2017)

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Review Genetics & Heredity

Advances in the delivery of RNA therapeutics: from concept to clinical reality

James C. Kaczmarek et al.

GENOME MEDICINE (2017)

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Article Genetics & Heredity

Differential Expression of Serum MicroRNAs Supports CD4+ T Cell Differentiation into Th2/Th17 Cells in Severe Equine Asthma

Alicja Pacholewska et al.

GENES (2017)

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Review Oncology

microRNA inhibitors: Natural and artificial sequestration of microRNA

Li Tang et al.

CANCER LETTERS (2017)

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Article Oncology

Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection

Ana B. Pavel et al.

CANCER PREVENTION RESEARCH (2017)

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Article Oncology

PDL1 Regulation by p53 via miR-34

Maria Angelica Cortez et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

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Article Oncology

PDL1 Regulation by p53 via miR-34

Maria Angelica Cortez et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2016)

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Article Engineering, Biomedical

Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for effective miR-200c in vivo delivery to inhibit drug resistant lung cancer

Yan Peng et al.

BIOMATERIALS (2016)

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Article Environmental Sciences

The association between lung cancer incidence and ambient air pollution in China: A spatiotemporal analysis

Yuming Guo et al.

ENVIRONMENTAL RESEARCH (2016)

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Article Immunology

MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages

Cheng Huang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Review Genetics & Heredity

A network-biology perspective of microRNA function and dysfunction in cancer

Cameron P. Bracken et al.

NATURE REVIEWS GENETICS (2016)

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Article Genetics & Heredity

Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

Glen Reid et al.

EPIGENOMICS (2016)

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Article Oncology

MiR-429 reverses epithelial-mesenchymal transition by restoring E-cadherin expression in bladder cancer

Chia-Lun Wu et al.

ONCOTARGET (2016)

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Article Medicine, General & Internal

Long-term exposure to ambient ozone and mortality: a quantitative systematic review and meta-analysis of evidence from cohort studies

R. W. Atkinson et al.

BMJ OPEN (2016)

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Article Multidisciplinary Sciences

MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease

Gang Wang et al.

SCIENTIFIC REPORTS (2016)

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Review Chemistry, Medicinal

Aptamer-Mediated Targeted Delivery of Therapeutics: An Update

Silvia Catuogno et al.

PHARMACEUTICALS (2016)

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Article Medicine, Research & Experimental

miR-183 induces cell proliferation, migration, and invasion by regulating PDCD4 expression in the SW1990 pancreatic cancer cell line

Ying-Ying Lu et al.

BIOMEDICINE & PHARMACOTHERAPY (2015)

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Article Oncology

MicroRNA library screening identifies growth-suppressive microRNAs that regulate genes involved in cell cycle progression and apoptosis

Young-Chul Choi et al.

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N6-methyladenosine marks primary microRNAs for processing

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MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1

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Aptamer-Dendrimer Bioconjugates for Targeted Delivery of miR-34a Expressing Plasmid and Antitumor Effects in Non-Small Cell Lung Cancer Cells

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miR-4782-3p Inhibited Non-Small Cell Lung Cancer growth via USP14

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Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway

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MicroRNA-21 (miR-21) Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by Targeting PTEN, RECK and Bcl-2 in Lung Squamous Carcinoma, Gejiu City, China

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Small RNA combination therapy for lung cancer

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells

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TUMOR BIOLOGY (2014)

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Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma

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ANNALS OF ONCOLOGY (2013)

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miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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Studies on stabilization mechanism and stealth effect of poloxamer 188 onto PLGA nanoparticles

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Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5′ Untranslated Region

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Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)

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miR-200b targets GATA-4 during cell growth and differentiation

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MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

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NATURE COMMUNICATIONS (2013)

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MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma

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MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma

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MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGF beta R2) in colon cancer cells

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Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer

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Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

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MicroRNA-574-5p Was Pivotal for TLR9 Signaling Enhanced Tumor Progression via Down-Regulating Checkpoint Suppressor 1 in Human Lung Cancer

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Telomeres, lifestyle, cancer, and aging

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CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2011)

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miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes

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The Impact of miRNA Target Sites in Coding Sequences and in 3′UTRs

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MicroRNA miR-183 Functions as an Oncogene by Targeting the Transcription Factor EGR1 and Promoting Tumor Cell Migration

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MicroRNA-Based Therapeutics for Cancer

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MicroRNA miR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors

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CANCER RESEARCH (2009)

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The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

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Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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(micro)genomic medicine microRNAs as therapeutics and biomarkers

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RNA BIOLOGY (2009)

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EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines

G. J. Weiss et al.

ANNALS OF ONCOLOGY (2008)

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MicroRNAs and cancer: past, present, and potential future

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MOLECULAR CANCER THERAPEUTICS (2008)

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SMAD proteins control DROSHA-mediated microRNA maturation

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NATURE (2008)

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Size and composition distributions of particulate matter emissions: Part 1 - Light-duty gasoline vehicles

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JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION (2007)

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Size and composition distributions of particulate matter emissions: Part 2- Heavy-duty diesel vehicles

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JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION (2007)

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Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies

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ENVIRONMENTAL HEALTH PERSPECTIVES (2007)

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被撤回的出版物: DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs (Retracted article. See vol. 16, pg. 1126, 2014)

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Chemical composition and sources of PM10 and PM2.5 aerosols in Guangzhou, China

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