4.7 Article

Characterization of mismatch-repair (MMR)/microsatellite instability (MSI)-discordant endometrial cancers

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Obstetrics & Gynecology

Pembrolizumab Plus Chemotherapy in Advanced Endometrial Cancer

Ramez N. Eskander et al.

Summary: Endometrial cancer is a type of cancer with increasing incidence and mortality rates, but with no improvement in survival over the past 40 years. Standard first-line treatment involves paclitaxel plus carboplatin. Immune checkpoint inhibitors like pembrolizumab have shown promise in combination with chemotherapy for various solid tumors, and as a second-line monotherapy for dMMR endometrial cancer. This phase 3 trial aimed to evaluate the efficacy of paclitaxel plus carboplatin with pembrolizumab or placebo in patients with advanced or recurrent endometrial cancer.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2023)

Article Oncology

Endometrial Cancer: Who Lives, Who Dies, Can We Improve Their Story?

Casey M. Cosgrove et al.

Summary: This cohort study investigated the clinical and pathologic features associated with endometrial cancer-specific death for 771 patients cared for at a comprehensive cancer center. Findings showed that nonendometrioid histology and advanced stage were predictors of recurrence and EC death, with mismatch repair status significantly associated with EC-specific survival in endometrioid EC patients. The study also highlighted the urgent need for improved therapy and early detection of endometrial cancer diagnosis and recurrence.

ONCOLOGIST (2021)

Article Oncology

Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Molecularly Classified Endometrial Carcinoma

Mikko Loukovaara et al.

Summary: In this retrospective study, the aggressiveness of MMR deficient endometrial carcinomas was examined. MMR deficiency was associated with poor disease-specific survival and increased risk of cancer-related death. The findings highlight the need for improved triage to adjuvant therapy and new therapeutic approaches in MMR deficient endometrial carcinomas.

CANCERS (2021)

Article Oncology

Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer

A. Guyot D'Asnieres De Salins et al.

Summary: The study confirmed a high degree of concordance between MSI and MMR IHC tests, emphasizing the importance of reviewing discordant cases and analysis by expert teams.

ESMO OPEN (2021)

Article Oncology

Interpretation of somatic POLE mutations in endometrial carcinoma

Alicia Leon-Castillo et al.

JOURNAL OF PATHOLOGY (2020)

Article Oncology

Size matters: Dissecting key parameters for panel-based tumor mutational burden analysis

Ivo Buchhalter et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Oncology

Endometrial cancer risk and survival by tumor MMR status

Christina M. Nagle et al.

JOURNAL OF GYNECOLOGIC ONCOLOGY (2018)

Review Oncology

Evolving Roles of Histologic Evaluation and Molecular/Genomic Profiling in the Management of Endometrial Cancer

Rajmohan Murali et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2018)

Article Obstetrics & Gynecology

Practice Bulletin No. 147

OBSTETRICS AND GYNECOLOGY (2014)

Article Multidisciplinary Sciences

Integrated genomic characterization of endometrial carcinoma

Gad Getz et al.

NATURE (2013)

Article Multidisciplinary Sciences

Prevalence of Lynch Syndrome among Patients with Newly Diagnosed Endometrial Cancers

Cecilia Egoavil et al.

PLOS ONE (2013)

Article Genetics & Heredity

Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history

BM Buttin et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2004)

Article Multidisciplinary Sciences

Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers

PJ Goodfellow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)