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Clinical significance of antinuclear antibodies in primary immune thrombocytopenia

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Article Hematology

Impact of age at diagnosis, sex, and immunopathological manifestations in 886 patients with pediatric chronic immune thrombocytopenia

Thomas Pincez et al.

Summary: This study investigated the long-term outcomes of pediatric chronic immune thrombocytopenia (cITP) and found that age at diagnosis, sex, and immunopathological manifestations (IMs) impacted the results. Adolescents with cITP had a higher risk of severe bleeding, second-line treatment use, clinical and biological IMs, and diagnosis of systemic lupus erythematosus (SLE). Female sex and biological IMs were independently associated with higher risks of biological IMs and SLE diagnosis, second-line treatment use, and SLE diagnosis.

AMERICAN JOURNAL OF HEMATOLOGY (2023)

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The effect of antinuclear antibody titre and its variation on outcomes in children with primary immune thrombocytopenia

Jing Liu et al.

Summary: A single-center retrospective cohort study conducted in China found that antinuclear antibody (ANA) is positive in children with primary immune thrombocytopenia (ITP). However, the effect of ANA titre on the outcomes of children with primary ITP remains unclear.

BRITISH JOURNAL OF HAEMATOLOGY (2023)

Article Rheumatology

Increasing Prevalence of Antinuclear Antibodies in the United States

Gregg E. Dinse et al.

Summary: This study found a significant increase in the prevalence of antinuclear antibodies (ANA) in the US in recent years. The increase was more pronounced in adolescents, men, older adults, and non-Hispanic white individuals. These increases could not be explained by changes in weight, smoking, or alcohol consumption.

ARTHRITIS & RHEUMATOLOGY (2022)

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Prognostic factors for the development of systemic lupus erythematosus in patients with immune thrombocytopenia

Soo Min Ahn et al.

Summary: This study aimed to investigate the clinical characteristics and risk factors for the development of systemic lupus erythematosus (SLE) in patients with primary immune thrombocytopenia (ITP). The results showed that young age, organ bleeding, and positive antinuclear antibody (ANA) were significantly associated with the development of SLE. Close follow-up is recommended for patients with primary ITP, especially those with the mentioned risk factors.

ARTHRITIS RESEARCH & THERAPY (2022)

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European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance

Martin Aringer et al.

Summary: The study analyzed the performance of individual criteria items in the classification criteria for systemic lupus erythematosus, finding varying sensitivity among the specific items. By introducing a new entry criterion and attribution rule, the overall specificity of the criteria set was significantly improved.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Rheumatology

ANA-positive primary immune thrombocytopaenia: a different clinical entity with increased risk of connective tissue diseases

Yuan Liu et al.

Summary: The study clarified the higher risk of developing CTDs, especially SLE, among ANA-positive primary ITP patients, supporting the idea that ANA-positive primary ITP is a distinct clinical entity.

LUPUS SCIENCE & MEDICINE (2021)

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American Society of Hematology 2019 guidelines for immune thrombocytopenia

Cindy Neunert et al.

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Prevalence and clinical significance of elevated antinuclear antibody test in children and adult patients with idiopathic thrombocytopenic purpura

Abdullah Altintas et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2007)

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Development of autoantibodies before the clinical onset of systemic lupus erythematosus

MR Arbuckle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)