期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/bjh.19002
关键词
B-cell monoclonality; HCV; lymphoproliferative disorders; new direct antiviral agents
类别
We examined 23 hepatitis C virus (HCV)-infected patients with lymphoproliferative diseases or monoclonal B lymphocytosis who were treated with direct agent antiviral (DAAs) per clinical practice. DAA therapy resulted in undetectable HCV-RNA and complete remission of cryoglobulinemia vasculitis, but did not effectively eliminate pathological B-cell clones.
We investigated 23 hepatitis C virus (HCV)-infected patients with overt lymphoproliferative diseases (15 cases) or monoclonal B lymphocytosis (8 cases) treated with direct agent antiviral (DAAs) per clinical practice. DAA therapy yielded undetectable HCV-RNA, the complete response of cryoglobulinemia vasculitis and related signs, whilst the presence of B-cell clones (evaluated by flow cytometry, IGHV, and BCL2-IGH rearrangements), detected in 19/23 cases at baseline, was maintained (17/19). Similarly, IGHV intraclonal diversification, supporting an antigen-driven selection mechanism, was identified in B-cell clones at baseline and end of follow-up. DAA therapy alone, despite HCV eradication and good immunological responses, was less effective on the pathological B-cell clones.
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