4.6 Letter

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark

期刊

BRITISH JOURNAL OF DERMATOLOGY
卷 -, 期 -, 页码 -

出版社

OXFORD UNIV PRESS
DOI: 10.1093/bjd/ljad330

关键词

-

向作者/读者索取更多资源

Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Dysregulated pathways, including Hippo and Wnt, NF kappa B, TNF, MAPK, and cholesterol metabolism, were identified in this study. These findings suggest the potential for developing new therapeutics targeting these dysregulated pathways in the treatment of PWB.
Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NF kappa B, TNF, MAPK and cholesterol metabolism, are dysregulated. These data suggest new therapeutics can be developed to target such dysregulated pathways in the treatment of PWB.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据