☆ 4.5 Article

Model-based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug-resistant tuberculosis

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Immunology

Analysis of Dynamic Efficacy Endpoints of the Nix-TB Trial

Belen P. Solans et al.

Summary: This study investigated the pharmacokinetic characteristics, patient characteristics, and efficacy endpoints of MDR-TB and XDR-TB patients. The results showed that patients with higher body mass index had fewer unfavorable treatment outcomes, and patients with lower baseline burden had a shorter time to stable culture conversion. However, patients with higher disease burden and high-risk phenotypes had delayed time to culture conversion and bacterial clearance. There was no significant relationship between drug pharmacokinetics and efficacy outcomes.

CLINICAL INFECTIOUS DISEASES (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Bacterial growth dynamics and pharmacokinetic-pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice

Morris Muliaditan et al.

Summary: The study aims to develop a drug-disease model that distinguishes between drug- and system-specific properties, providing theoretical basis for the clinical application of anti-tubercular drugs.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹

Article Immunology

Proposed Linezolid Dosing Strategies to Minimize Adverse Events for Treatment of Extensively Drug-Resistant Tuberculosis

Marjorie Z. Imperial et al.

Summary: Limited information is available about optimal linezolid dosing strategies in patients with tuberculosis. We provide practical recommendations about linezolid dosing to minimize severe adverse events.

CLINICAL INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Laurynas Mockeliunas et al.

Summary: This study developed a population pharmacokinetic model and a model-informed precision dosing (MIPD) algorithm for linezolid to ensure safe and efficacious dosing in patients with multidrug- and extensively drug-resistant tuberculosis. By using information from two or three pharmacokinetic sampling occasions, the proportion of patients reaching the efficacy and safety targets increased compared to flat dosing.

PHARMACEUTICS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Efficient simulation of clinical target response surfaces

Daniel Lill et al.

Summary: Simulation of combination therapies is challenging due to computational complexity. Existing methods either neglect parameter variability and uncertainty or are limited to a few selected doses. In this study, we propose new algorithms to efficiently search for combination doses that achieve a predefined efficacy target, taking into account parameter uncertainty, resulting in a response surface of confidence levels.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Assessing Prolongation of the Corrected QT Interval with Bedaquiline and Delamanid Coadministration to Predict the Cardiac Safety of Simplified Dosing Regimens

Lenaig Tanneau et al.

Summary: This study investigated the relationship between plasma concentrations of delamanid and bedaquiline and the prolongation of QT interval corrected using Fridericia's formula (QTcF). The study found that the metabolites of each drug were responsible for the drug-related QTcF prolongation. The combination of the two drugs had a close to additive effect. The study also predicted that simplified, once-daily dosing regimens would have a similar QT prolonging potential compared to the approved regimens.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

添加到收藏夹

Review Infectious Diseases

Bedaquiline: Current status and future perspectives

Saeed Khoshnood et al.

Summary: The development of drug-resistant tuberculosis is a major global threat, with over 500,000 new cases annually. Bedaquiline is a novel anti-TB drug with significant inhibitory concentrations against drug-resistant TB, recently approved for the therapy of multidrug-resistant TB.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

添加到收藏夹

Article Infectious Diseases

Pretomanid with bedaquiline and linezolid for drug-resistant TB: a comparison of prospective cohorts

S. Oelofse et al.

Summary: The study showed that the 6-9 month oral three-drug Nix regimen (bedaquiline, pretomanid and linezolid [BPaL]) had significantly better outcomes for drug-resistant TB patients compared to conventional regimens containing bedaquiline and linezolid. Despite higher baseline bacterial load and prior second-line drug exposure, the BPaL regimen showed improved culture conversion time, time to unfavorable outcome, and time to death. Prospective controlled studies are needed for definitive answers to the question.

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2021)

添加到收藏夹

Article Medicine, General & Internal

Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization

Natasha Strydom et al.

PLOS MEDICINE (2019)

添加到收藏夹

Review Immunology

Bedaquiline Resistance: Its Emergence, Mechanism, and Prevention

Thi Van Anh Nguyen et al.

CLINICAL INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Infectious Diseases

Modelling of mycobacterial load reveals bedaquiline's exposure-response relationship in patients with drug-resistant TB

Elin M. Svensson et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis

Murat Cokol et al.

SCIENCE ADVANCES (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Translational Pharmacometric Evaluation of Typical Antibiotic Broad-Spectrum Combination Therapies Against Staphylococcus Aureus Exploiting In Vitro Information

S. G. Wicha et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2017)

添加到收藏夹

Article Infectious Diseases

A multistate tuberculosis pharmacometric model: a framework for studying anti-tubercular drug effects in vitro

Oskar Clewe et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Prediction of Drug Penetration in Tuberculosis Lesions

Jansy P. Sarathy et al.

ACS INFECTIOUS DISEASES (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Application of the Multistate Tuberculosis Pharmacometric Model in Patients With Rifampicin-Treated Pulmonary Tuberculosis

R. J. Svensson et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2016)

添加到收藏夹

Review Infectious Diseases

Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them

Dimitrios Evangelopoulos et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2015)

添加到收藏夹

Letter Medicine, General & Internal

Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis

Guido V. Bloemberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Article Infectious Diseases

The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations

Ruth Bowness et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2015)

添加到收藏夹

Review Infectious Diseases

Bedaquiline: a review of human pharmacokinetics and drug-drug interactions

R. P. G. van Heeswijk et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Anil Koul et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis

Anil Koul et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

K Andries et al.

SCIENCE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.