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Sensory gamma entrainment: Impact on amyloid protein and therapeutic mechanism

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BRAIN RESEARCH BULLETIN
卷 202, 期 -, 页码 -

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2023.110750

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Alzheimer's disease; Sensory gamma entrainment; Amyloid beta peptide; Amyloid precursor protein

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This article reviews the generation and clearance pathways of A8, aberrant gamma oscillation in AD, and the therapeutic effect of sensory gamma entrainment on AD, and discusses these results based on stimulus parameters and possible potential mechanisms. This provides support for sensory gamma entrainment targeting A8 to improve AD.
The deposition of amyloid 8 peptide (A8) is one of the main pathological features of AD. The much-talked sensory gamma entrainment may be a new treatment for A8 load. Here we reviewed the generation and clearance pathways of A8, aberrant gamma oscillation in AD, and the therapeutic effect of sensory gamma entrainment on AD. In addition, we discuss these results based on stimulus parameters and possible potential mechanisms. This provides the support for sensory gamma entrainment targeting A8 to improve AD.

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