Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline

Editorial Material Immunology

T cells drive aging of the brain

Adrian Liston et al.

Summary: Aging is often associated with cognitive decline caused by brain degeneration. Recent research provides further evidence of the connection between CD8(+) T cells, interferon-gamma production in the brain, and neurodegeneration.

NATURE IMMUNOLOGY (2023)

添加到收藏夹

Article Neurosciences

Young adult and aged female rats are vulnerable to amygdala-dependent, but not hippocampus-dependent, memory impairment following short-term high-fat diet

Stephanie M. Muscat et al.

Summary: Global populations are consuming diets high in saturated fats and refined carbohydrates, which are associated with inflammation and neurological dysfunction. Older individuals, especially females, are vulnerable to the impact of unhealthy diet on cognition. The present study found that short-term consumption of high-fat diet (HFD) impaired auditory-cued memory in both young and aged female rats, while contextual memory remained unaffected. Dysregulation of IL-1 beta and PACAP signaling may contribute to these differential effects.

BRAIN RESEARCH BULLETIN (2023)

添加到收藏夹

Article Clinical Neurology

Association of Age at Menopause and Hormone Therapy Use With Tau and b-Amyloid Positron Emission Tomography

Gillian T. Coughlan et al.

Summary: Postmenopausal females have a higher risk of developing Alzheimer's disease, with elevated levels of tau compared to males. The factors associated with higher tau deposition in females, such as age at menopause and hormone therapy use, are still unknown.

JAMA NEUROLOGY (2023)

添加到收藏夹

Article Immunology

Ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses

Kevin Sanchez et al.

Summary: Estrogens promote the development and maintenance of the female reproductive system and secondary sex characteristics, and also modulate immune responses. Loss of estrogens can lead to behavioral changes associated with menopause. This study examined how the loss of estrogens affects microglia and leads to changes in affective behaviors. Results showed that ovariectomy modulated baseline and inflammatory-induced affective behaviors, and this was associated with downregulation of a microglial receptor. Hormone replacement with estradiol ameliorated these behavioral changes and reduced inflammatory responses in the brain. Overall, these findings suggest that the lack of estrogens may increase vulnerability to adverse behavioral changes by sensitizing microglia to immune stimuli.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2023)

添加到收藏夹

Article Clinical Neurology

Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography

Gillian T. Coughlan et al.

Summary: This study found that postmenopausal females have higher levels of tau protein compared to age-matched males, particularly in the presence of elevated Aβ. Earlier age at menopause and late initiation of hormone therapy are associated with increased tau vulnerability.

JAMA NEUROLOGY (2023)

添加到收藏夹

Review Immunology

Brain-resident regulatory T cells and their role in health and disease

Adrian Liston et al.

Summary: Regulatory T cells (Tregs) control inflammation and maintain immune homeostasis through direct and indirect suppression of conventional T cell activation. Recent research has identified brain-resident Tregs as important players in neuroinflammatory conditions, regulating astrogliosis, microglia polarization, and inflammatory responses.

IMMUNOLOGY LETTERS (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches

Xiaotao Zhang et al.

Summary: This study found that in the normal aging process, aged microglia transition to a pro-inflammatory and chemotactic state, and promote the infiltration of peripheral T cells by releasing chemokines and upregulating adhesion molecules on brain venous endothelial cells.

IMMUNITY & AGEING (2022)

添加到收藏夹

Article Neurosciences

The role of antiviral CD8+ T cells in cognitive impairment

Katie L. Reagin et al.

Summary: The impact of the immune system, specifically CD8(+) T cells, on neurodegenerative diseases is significant. These cells can both improve survival and contribute to the pathology of these diseases.

CURRENT OPINION IN NEUROBIOLOGY (2022)

添加到收藏夹

Article Neurosciences

CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

Tugberk Kaya et al.

Summary: This study identified age-related alterations of oligodendrocyte cell state in aging murine white matter and found interferon (IFN)-responsive oligodendrocytes in proximity to CD8(+) T cells. Functional lymphocytes were shown to influence the number of IFN-responsive oligodendrocytes, with T-cell checkpoint inhibition exacerbating the aging response.

NATURE NEUROSCIENCE (2022)

添加到收藏夹

Article Clinical Neurology

2022 Alzheimer's disease facts and figures

Joseph Gaugler et al.

Summary: This article discusses the impact of Alzheimer's disease on public health, including its incidence, prevalence, mortality and morbidity rates, healthcare costs and caregivers' burden. It also addresses the perspectives of consumers and primary care physicians on mild cognitive impairment (MCI) and the need for improved awareness, diagnosis, and treatment. The article emphasizes the increasing number of individuals living with Alzheimer's and the challenges faced by caregivers and healthcare providers, particularly during the COVID-19 pandemic.

ALZHEIMERS & DEMENTIA (2022)

添加到收藏夹

Article Cell Biology

Sex differences in EAE reveal common and distinct cellular and molecular components

Jack Wiedrick et al.

Summary: The study found stronger pro-inflammatory responses in male compared to female C57BL/6 mice who were immunized to induce EAE, but this was partially offset by increased anti-inflammatory cell subsets in males. These sex differences in immune responses may explain the reduced cellular infiltration in the CNS of male mice and the similar clinical EAE disease severity observed in both male and female groups. Overall, the severity of EAE disease seems to be influenced not only by CNS infiltration and demyelination, but also by the balance of pro-inflammatory and regulatory immune cell types and their secreted molecules.

CELLULAR IMMUNOLOGY (2021)

添加到收藏夹

Article Biology

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease

Marie-Victoire Guillot-Sestier et al.

Summary: The study demonstrated sex-related differences in microglia in postmortem brain tissue from Alzheimer's disease patients and in the APP/PS1 AD mouse model, showing differential gene expression associated with microglial activation and metabolism between male and female animals. These differences were also reflected in morphology and may contribute to the understanding of sexual dimorphism in Alzheimer's disease.

COMMUNICATIONS BIOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Sex Differences in Cognitive Decline Among US Adults

Deborah A. Levine et al.

Summary: This study suggests that women may have better cognitive reserve but faster cognitive decline than men in global cognition, executive function, and memory, which could contribute to sex differences in late-life dementia.

JAMA NETWORK OPEN (2021)

添加到收藏夹

Article Neurosciences

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Julia Marschallinger et al.

NATURE NEUROSCIENCE (2020)

添加到收藏夹

Review Immunology

Neuroimmune Connections in Aging and Neurodegenerative Diseases

Hannah Scheiblich et al.

TRENDS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Critical Care Medicine

Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells

Sarah J. Doran et al.

JOURNAL OF NEUROTRAUMA (2019)

添加到收藏夹

Article Immunology

GPR34 in spinal microglia exacerbates neuropathic pain in mice

Akira Sayo et al.

JOURNAL OF NEUROINFLAMMATION (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Single-cell analysis reveals T cell infiltration in old neurogenic niches

Ben W. Dulken et al.

NATURE (2019)

添加到收藏夹

Article Immunology

The Transcriptional Landscape o Microglial Genes in Aging and Neurodegenerative Disease

Luke W. Bonham et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Microglial subtypes: diversity within the microglial community

Vassilis Stratoulias et al.

EMBO JOURNAL (2019)

添加到收藏夹

Review Clinical Neurology

Ageing as a risk factor for neurodegenerative disease

Yujun Hou et al.

NATURE REVIEWS NEUROLOGY (2019)

添加到收藏夹

Article Immunology

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

Timothy R. Hammond et al.

IMMUNITY (2019)

添加到收藏夹

Review Immunology

Sex differences in vaccine-induced humoral immunity

Stephanie Fischinger et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

添加到收藏夹

Article Immunology

Neuroinflammatory priming to stress is differentially regulated in male and female rats

Laura K. Fonken et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

添加到收藏夹

Article Neurosciences

Regional Distribution of CNS Antigens Differentially Determines T-Cell Mediated Neuroinflammation in a CX3CR1-Dependent Manner

Aditya Rayasam et al.

JOURNAL OF NEUROSCIENCE (2018)

添加到收藏夹

Review Immunology

The Confluence of Sex Hormones and Aging on Immunity

Melanie R. Gubbels Bupp et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Geriatrics & Gerontology

Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction

Laura K. Fonken et al.

NEUROBIOLOGY OF AGING (2018)

添加到收藏夹

Article Clinical Neurology

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

Danielle S. Davies et al.

BRAIN PATHOLOGY (2017)

添加到收藏夹

Article Neurosciences

Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats

Joaquin Pardo et al.

HIPPOCAMPUS (2017)

添加到收藏夹

Article Geriatrics & Gerontology

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

Sarah J. Spencer et al.

NEUROBIOLOGY OF AGING (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Mauricio D. Dorfman et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

Benjamin M. Davis et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Neurosciences

Dark microglia: A new phenotype predominantly associated with pathological states

Kanchan Bisht et al.

GLIA (2016)

添加到收藏夹

Article Neurosciences

The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming

Laura K. Fonken et al.

JOURNAL OF NEUROSCIENCE (2016)

添加到收藏夹

Review Geriatrics & Gerontology

Modeling menopause: The utility of rodents in translational behavioral endocrinology research

Stephanie V. Koebele et al.

MATURITAS (2016)

添加到收藏夹

Article Geriatrics & Gerontology

Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization

Laura K. Fonken et al.

NEUROBIOLOGY OF AGING (2016)

添加到收藏夹

Review Immunology

Sex differences in immune responses

Sabra L. Klein et al.

NATURE REVIEWS IMMUNOLOGY (2016)

添加到收藏夹

Article Neurosciences

Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

Adam D. Bachstetter et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)

添加到收藏夹

Article Neurosciences

Altered Microglial Phagocytosis in GPR34-Deficient Mice

Julia Preissler et al.

GLIA (2015)

添加到收藏夹

Review Neurosciences

The neuroprotective actions of oestradiol and oestrogen receptors

Maria-Angeles Arevalo et al.

NATURE REVIEWS NEUROSCIENCE (2015)

添加到收藏夹

Article Geriatrics & Gerontology

Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats

Roman A. Kireev et al.

AGE (2014)

添加到收藏夹

Review Neurosciences

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

Cristina Limatola et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

添加到收藏夹

Article Geriatrics & Gerontology

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome

Shona H. Wood et al.

AGE (2013)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The effect of aging of the immune system on vaccination responses

Janet M. Lord

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)

添加到收藏夹

Article Geriatrics & Gerontology

Slower immune system aging in women versus men in the Japanese population

Katsuiku Hirokawa et al.

IMMUNITY & AGEING (2013)

添加到收藏夹

Article Endocrinology & Metabolism

A Lack of Ovarian Function Increases Neuroinflammation in Aged Mice

Valeria Benedusi et al.

ENDOCRINOLOGY (2012)

添加到收藏夹

Article Immunology

CX3CR1 drives cytotoxic CD4+CD28- T cells into the brain of multiple sclerosis patients

Bieke Broux et al.

JOURNAL OF AUTOIMMUNITY (2012)

添加到收藏夹

Article Neurosciences

Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

Ruth M. Barrientos et al.

JOURNAL OF NEUROSCIENCE (2012)

添加到收藏夹

Article Geriatrics & Gerontology

Influence of Variation in the Follicle-Stimulating Hormone Receptor Gene (FSHR) and Age at Menopause on the Development of Alzheimer's Disease in Women

Rosa Maria Corbo et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

Sanae Sasaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Review Immunology

Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge

Yuan-Zhong Xu et al.

BRAIN BEHAVIOR AND IMMUNITY (2010)

添加到收藏夹

Article Immunology

Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo

Matthew G. Frank et al.

JOURNAL OF NEUROIMMUNOLOGY (2010)

添加到收藏夹

Article Immunology

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

Angela W. Corona et al.

JOURNAL OF NEUROINFLAMMATION (2010)

添加到收藏夹

Article Immunology

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

Ruth M. Barrientos et al.

BRAIN BEHAVIOR AND IMMUNITY (2009)

添加到收藏夹

Article Immunology

Gender as risk factor for autoimmune diseases

Norbert Gleicher et al.

JOURNAL OF AUTOIMMUNITY (2007)

添加到收藏夹

Article Geriatrics & Gerontology

Peripheral infection and aging interact to impair hippocampal memory consolidation

RM Barrientos et al.

NEUROBIOLOGY OF AGING (2006)

添加到收藏夹

Article Biochemical Research Methods

Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: Immunophenotypic and functional characteristics

MG Frank et al.

JOURNAL OF NEUROSCIENCE METHODS (2006)

添加到收藏夹

Article Multidisciplinary Sciences

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

J Kipnis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

Article Genetics & Heredity

Age at onset in two common neurodegenerative diseases is genetically controlled

YJ Li et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2002)

添加到收藏夹

Article Biochemical Research Methods

Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method

KJ Livak et al.

METHODS (2001)

添加到收藏夹

Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline

相关参考文献

导出引文

分享论文