4.7 Letter

Principal component analysis-based latent-space dimensionality under-estimation, with uncorrelated latent variables

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Summary: For years, dissociation studies on neurological single-case patients with brain lesions were used to infer cognitive functions in neuropsychology, but the association between deficits was considered of less value. In contrast, computational methods such as principal component analysis became popular for identifying cognitive functions in stroke patients. However, the anatomy of stroke lesions alone influenced the dimensionality of data and limited the interpretability of cognitive deficits and insights into human cognitive architecture. It is suggested to use qualitative criteria and dissociation patterns to refine estimates and optimize interpretation strategies in cognitive deficit studies.
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Summary: This study compared different types of multi-assessment batteries and tested a new data-driven reduced version. The results showed that the data-driven battery can save time while maintaining sensitivity, ability to grade deficits, and the underlying component structure observed in post-stroke aphasia.

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