☆ 4.7 Review

How should we be using biomarkers in trials of disease modification in Parkinson's disease?

BRAIN (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Neurosciences

Age-Related Association Between APOE ε4 and Cognitive Progression in de novo Parkinson's Disease

Jia-Yao Liu et al.

Summary: The APOE epsilon 4 genotype in PD is associated with worsened pathology and increased risk of dementia. The effect of APOE epsilon 4 on cognitive progression in de novo PD depends on age. In elderly PD patients, APOE epsilon 4 carriers show faster decline in cognition and higher risk of cognitive progression compared with non-carriers, while no significant relationship is found in middle-aged PD patients.

JOURNAL OF ALZHEIMERS DISEASE (2023)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid Biomarkers of Synaptic Dysfunction Are Altered in Parkinson's Disease and Related Disorders

Johanna Nilsson et al.

Summary: The study aims to identify and validate biomarkers of synaptic dysfunction in Parkinson's disease and related disorders. The findings show alterations in synaptic proteins in parkinsonian disorders compared with Alzheimer's disease and healthy controls.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Neuromelanin-Sensitive Magnetic Resonance Imaging Changes in the Locus Coeruleus/Subcoeruleus Complex in Patients with Typical and Atypical Parkinsonism

Alexis Nobileau et al.

Summary: The LC/LsC damage is common in patients with Parkinson's disease and atypical parkinsonism, and it is associated with age. The damage is more severe in patients with multiple system atrophy.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Cutaneous a-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease

Christopher Gibbons et al.

Summary: This study demonstrates that the expression of phosphorylated α-synuclein in skin biopsies is significantly higher in patients with multiple system atrophy (MSA) compared to patients with Parkinson disease (PD), providing a highly accurate means of differentiation. The study aims to identify a reliable diagnostic and prognostic biomarker for MSA, with a critical need to distinguish it from other synucleinopathies, particularly PD.

NEUROLOGY (2023)

添加到收藏夹

Article Clinical Neurology

Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease

Joseph Blommer et al.

Summary: The protein cargo of neuronal extracellular vesicles may serve as a biomarker for cognitive impairment in Parkinson's disease, with differences in alpha-synuclein, phosphorylated tau, and proteins associated with insulin signaling observed between patients with and without cognitive impairment. These findings could provide insights into the underlying pathogenic processes and improve diagnosis and prognosis of Parkinson's disease. Plasma samples from 273 participants were used in the study, and immunoassays were utilized to quantify biomarkers in plasma extracellular vesicles enriched for neuronal origin. Alpha-synuclein, phosphorylated tau, and insulin receptor substrate-1 phosphorylated tyrosine showed diagnostic classification contributions between groups, indicating that both alpha-synuclein and tau pathologies, along with impaired insulin signaling, may underlie Parkinson's disease with cognitive impairment. Plasma neuronal extracellular vesicles biomarkers may inform cognitive prognosis in Parkinson's disease.

BRAIN (2023)

添加到收藏夹

Letter Clinical Neurology

Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson's Disease

Giorgio Vivacqua et al.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Association of CSF Glucocerebrosidase Activity With the Risk of Incident Dementia in Patients With Parkinson Disease

Linn Oftedal et al.

Summary: This study found that reduced activity of the enzyme in cerebrospinal fluid is associated with an increased risk of developing dementia in newly diagnosed Parkinson's disease patients. The findings have important implications for the design of clinical trials and patient management.

NEUROLOGY (2023)

添加到收藏夹

Article Clinical Neurology

Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study

Andrew Siderowf et al.

LANCET NEUROLOGY (2023)

添加到收藏夹

Article Clinical Neurology

A Double-Blind, Randomized, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease

Thomas Payne et al.

Summary: The study demonstrated that high-dose UDCA is safe and well tolerated in early PD patients. P-31-MRS results showed improved ATP hydrolysis in the midbrain of the UDCA treatment group, and sensor-based gait analysis indicated possible improvement in gait parameters. Larger trials are necessary to further evaluate the disease-modifying effect of UDCA in PD.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease

Danna Jennings et al.

Summary: This study evaluates the safety, tolerability, pharmacokinetics, and pharmacodynamics of the LRRK2 inhibitor BIIB122 in healthy participants and patients with Parkinson's disease. The results show that BIIB122 can significantly inhibit peripheral LRRK2 kinase and regulate the lysosomal pathway downstream of LRRK2.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls

Jonas M. den Heijer et al.

Summary: This study assessed the variability of various glycosphingolipids (GSLs) in plasma, peripheral blood mononuclear cells (PBMCs), and cerebrospinal fluid (CSF) across GBA-PD, iPD, and HVs. The results showed that plasma levels of glucosylceramide were slightly higher in GBA-PD compared with iPD and HVs, while intracellular levels were comparable. There was no correlation between GSLs in different matrices.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease

Laura Munoz-Delgado et al.

Summary: Two independent studies found that peripheral immune responses are associated with dopaminergic degeneration in Parkinson's disease (PD), with a main correlation found with lymphocyte count.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Propagative α-synuclein seeds as serum biomarkers for synucleinopathies

Ayami Okuzumi et al.

Summary: A modified assay system (IP/RT-QuIC) has been developed to detect pathogenic alpha-synuclein seeds in the serum of individuals with synucleinopathies. The system showed high diagnostic performance for differentiating Parkinson's disease and multiple system atrophy from controls.

NATURE MEDICINE (2023)

添加到收藏夹

Review Neurosciences

Proposal for a Biologic Staging System of Parkinson's Disease

Lana M. Chahine et al.

Summary: The Parkinson's disease research field has made progress in understanding the disease's clinical features and identifying potential biomarkers, but a biologically based staging system is still lacking. This system would provide a framework for modeling the disease, developing biomarkers, guiding therapeutic development, and informing clinical trial design. This article proposes a biologically based staging system for Parkinson's disease, highlighting the presence of aggregated neuronal alpha-synuclein, dopaminergic neuron dysfunction/degeneration, and clinical signs and symptoms as key markers for Lewy body pathology and disease progression.

JOURNAL OF PARKINSONS DISEASE (2023)

添加到收藏夹

Review Clinical Neurology

LRRK2 and Parkinson's disease: from genetics to targeted therapy

Yuri L. Sosero et al.

Summary: LRRK2 variants are associated with both familial and sporadic PD. LRRK2-PD presents with benign clinical features and variable pathology, including inconsistent presence of Lewy bodies and significant Alzheimer's disease pathology. The mechanisms of LRRK2-PD are still unclear, but inflammation, vesicle trafficking, lysosomal homeostasis, and ciliogenesis have been suggested. Understanding the role and function of LRRK2 in PD is important as novel therapies targeting LRRK2 are being developed.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2023)

添加到收藏夹

Article Clinical Neurology

Central and peripheral α-synuclein in Parkinson disease detected by seed amplification assay

Lana G. Chahine et al.

Summary: The accuracy of a-synuclein seed amplification assay was tested in cerebrospinal fluid and submandibular gland, and compared to total a-synuclein measures. Within-subject relationships of central and peripheral a-synuclein measures were investigated.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2023)

添加到收藏夹

Article Clinical Neurology

A Combined Panel of Salivary Biomarkers in de novo Parkinson's Disease

Maria Ilenia De Bartolo et al.

Summary: This study aimed to investigate molecular biomarkers of a-synuclein and tau aggregation, autophagy, and inflammation in the saliva of de novo Parkinson's disease (PD) patients and their potential diagnostic power. The results showed that oligomeric a-synuclein, total-tau, MAP-LC3beta, and TNFalpha levels were significantly higher in PD patients compared to healthy subjects. The combination of salivary biomarkers targeting different molecular pathways, including oligomeric a-synuclein and MAP-LC3beta, showed accurate diagnostic performance.

ANNALS OF NEUROLOGY (2023)

添加到收藏夹

Article Neurosciences

Plasma GFAP in Parkinson's disease with cognitive impairment and its potential to predict conversion to dementia

Yilin Tang et al.

Summary: The levels of plasma GFAP were measured in PD patients with normal cognition, mild cognitive impairment (PD-MCI), dementia (PDD), and healthy controls. The results showed that plasma GFAP levels were elevated in PDD and PD-MCI patients compared to healthy controls, and were negatively correlated with MMSE score in PD participants. Plasma GFAP was found to have potential value in distinguishing PDD patients and predicting MCI-to-dementia conversion in PD, with higher accuracy than NfL, Tau, and pTau181.

NPJ PARKINSONS DISEASE (2023)

添加到收藏夹

Review Clinical Neurology

alpha-Synuclein Seed Amplification Assays in the Diagnosis of Synucleinopathies Using Cerebrospinal Fluid-A Systematic Review and Meta-Analysis

Anna Grossauer et al.

Summary: This systematic review and meta-analysis evaluated the diagnostic accuracy of alpha Syn seed amplification assays (alpha Syn-SAAs), including RT-QuIC and PMCA, for differentiating synucleinopathies from controls using cerebrospinal fluid (CSF). Results showed that alpha Syn-SAAs have high sensitivity and specificity in differentiating synucleinopathies with Lewy bodies from controls, but the diagnostic accuracy for multiple system atrophy was lower.

MOVEMENT DISORDERS CLINICAL PRACTICE (2023)

添加到收藏夹

Review Clinical Neurology

Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis

Mary Xylaki et al.

Summary: Parkinson's disease (PD) biomarkers are important for diagnosis, study populations, and therapeutic response monitoring. Extracellular vesicles (EVs) have emerged as a promising material for biomarker development, containing proteins and molecular material from various organs. Meta-analysis reveals increased levels of alpha-synuclein (aSyn) and leucine-rich repeat kinase 2 (LRRK2) in EVs of PD patients, suggesting their potential as biomarkers for PD diagnosis and monitoring.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Plasma extracellular vesicle tau, & beta;-amyloid, and & alpha;-synuclein and the progression of Parkinson's disease: a follow-up study

Lung Chan et al.

Summary: This study investigated the dynamic changes in plasma extracellular vesicle (EV) contents, including α-synuclein, tau, and β-amyloid, in Parkinson's disease (PD) patients and their correlation with clinical progression. The results suggest that these proteins may serve as biomarkers for evaluating disease deterioration risk.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls

Jonas M. den Heijer et al.

Summary: This study assessed the variability of various GSLs in plasma, PBMCs, and CSF across GBA-PD, iPD, and HVs. Glucosylceramide was found to be a stable biomarker for GBA-PD clinical trials, while lactosylceramide and glucosylsphingosine were affected by leukocyte subtypes in PBMCs. GBA-PD could be differentiated from iPD and HVs based on glucosylceramide levels in plasma.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease

Laura Munoz-Delgado et al.

Summary: The findings from two independent cohorts suggest a relationship between systemic inflammation and dopaminergic degeneration in patients with PD, primarily driven by lymphocyte count.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Clinical Neurology

Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

Ilaria Poggiolini et al.

Summary: The study aimed to assess the diagnostic value of CSF alpha-synuclein RT-QuIC quantitative parameters in regard to disease progression, stratification, and conversion in synucleinopathies. The results showed that alpha-synuclein RT-QuIC adds value in diagnosing Parkinson's disease and may provide a way to distinguish variations within Parkinson's disease phenotype. The assay also showed potential as an early biomarker detecting synucleinopathy in idiopathic REM sleep behaviour disorder patients prior to conversion.

BRAIN (2022)

添加到收藏夹

Review Clinical Neurology

Fluid markers of synapse degeneration in synucleinopathies

Alba Cervantes Gonzalez et al.

Summary: The abnormal accumulation of alpha-synuclein in the brain is a common feature of Parkinson's disease (PD), PD dementia (PDD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Synapse degeneration is the crucial neuropathological event in these synucleinopathies and the neuropathological correlate of connectome dysfunction. A marker of synapse degeneration that can correlate with measures of cognitive or motor impairment could serve as a more objective, surrogate biomarker of the core clinical features of these diseases. This review discusses candidate biomarkers of synapse degeneration in PD, PDD, DLB, and MSA patient-derived biofluids and their relevance to alpha-synuclein-mediated synapse degeneration mechanisms.

JOURNAL OF NEURAL TRANSMISSION (2022)

添加到收藏夹

Review Clinical Neurology

Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies

Federico Verde

Summary: This review discusses the recent developments in the field of plasma tau proteins as diagnostic, pathophysiological and prognostic biomarkers of Alzheimer's disease, as well as additional findings from the fields of genetic forms of AD and non-AD proteinopathies.

JOURNAL OF NEURAL TRANSMISSION (2022)

添加到收藏夹

Article Clinical Neurology

Serum neurofilament light chain and postural instability/gait difficulty (PIGD) subtypes of Parkinson's disease in the MARK-PD study

Monika Poetter-Nerger et al.

Summary: This study found that increased serum neurofilament light chain (NfL) levels were associated with PIGD subtype and PIGD scores in patients with advanced Parkinson's disease.

JOURNAL OF NEURAL TRANSMISSION (2022)

添加到收藏夹

Letter Clinical Neurology

Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson's Disease

Ivan Martinez-Valbuena et al.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Letter Clinical Neurology

Parkinson's Disease and Type 2 Diabetes: HbA1c Is Associated with Motor and Cognitive Severity

Brook Huxford et al.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Letter Clinical Neurology

Glucocerebrosidase Activity Is Not Associated with Parkinson's Disease Risk or Severity

Nurit Omer et al.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Article Neurosciences

Serum Neurofilament Light Chain as a Marker of Progression in Parkinson's Disease: Long-Term Observation and Implications of Clinical Subtypes

Emil Ygland Rodstrom et al.

Summary: This study examined the utility of serum neurofilament light chain (S-NfL) as a biomarker in late-stage Parkinson's disease (PD). The results showed significant correlations between S-NfL levels and disease progression milestones. Higher S-NfL levels were associated with poorer daily living activities and cognitive function. Combining S-NfL with clinical factors improved prognostic accuracy.

JOURNAL OF PARKINSONS DISEASE (2022)

添加到收藏夹

Correction Cell Biology

Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF (vol 10, 38, 2021)

Walter A. Boiten et al.

CELLS (2022)

添加到收藏夹

Article Clinical Neurology

Plasma total tau predicts executive dysfunction in Parkinson's disease

Wei-Ting Lin et al.

Summary: The study found that lower levels of plasma alpha-syn were correlated with motor dysfunction in PD patients, while higher levels of plasma t-tau were associated with lower cognitive performance, especially in attention and executive function. These results suggest the potential use of plasma biomarkers to predict specific cognitive performance in PD subjects.

ACTA NEUROLOGICA SCANDINAVICA (2022)

添加到收藏夹

Article Clinical Neurology

Combining biomarkers for prognostic modelling of Parkinson's disease

Nirosen Vijiaratnam et al.

Summary: This study aimed to determine if blood biomarkers (NfL and genetic status) can serve as additional clinical measures for prognosis in PD patients. The results showed that NfL and genetic variables have similar predictive ability for unfavorable progression as clinical predictors. The combination of clinical, NfL, and genetic data produced a stronger prediction of unfavorable outcomes compared to age and gender.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2022)

添加到收藏夹

Article Clinical Neurology

Impaired brain insulin signalling in Parkinson's disease

Fares Bassil et al.

Summary: The study found higher IRS-1pS312 expression in both PD patients and a preclinical rat model, indicating brain insulin resistance in PD and supporting the repurposing of anti-diabetic drugs for PD treatment.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Diabetes, Glycated Hemoglobin (HbA1c), and Neuroaxonal Damage in Parkinson's Disease (MARK-PD Study)

Merve Uyar et al.

Summary: This study evaluated the relationship between diabetes and HbA1c levels with neuroaxonal damage and cognitive impairment in Parkinson's disease patients. The results showed that diabetes and high HbA1c levels were associated with increased neuroaxonal damage and cognitive impairment.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Review Clinical Neurology

α-Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives

Obada M. Alzghool et al.

Summary: Alpha-synucleinopathies, such as Parkinson's disease and Lewy body dementia, share similar symptoms and pathological features. Currently, there is a lack of imaging biomarkers for the early diagnosis of these diseases. Aggregated alpha-synuclein has shown potential as an imaging biomarker and there are ongoing developments in antibodies and small molecule compounds for therapy. However, there is a need for improvement in imaging methods for aggregated alpha-synuclein.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Article Clinical Neurology

Development and Validation of Automated Magnetic Resonance Parkinsonism Index 2.0 to Distinguish Progressive Supranuclear Palsy-Parkinsonism From Parkinson's Disease

Andrea Quattrone et al.

Summary: This study developed an automated Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0) algorithm to differentiate progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) and validated its diagnostic performance in two large independent cohorts. The automated MRPI 2.0 showed excellent performance in distinguishing PSP-P from PD and control subjects in both cohorts, suggesting its generalizability. The use of the automated MRPI 2.0 algorithm could standardize measures in patients with PSP-P across centers and have a positive impact on multicenter studies and clinical trials.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Review Clinical Neurology

Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis

Yashan Wang et al.

Summary: This meta-analysis evaluated the diagnostic accuracy of RT-QuIC for Lewy body diseases and found that it is a reliable and accurate method for diagnosing these diseases.

NEUROLOGICAL SCIENCES (2022)

添加到收藏夹

Article Neurosciences

Oligomeric α-synuclein and tau aggregates in NDEVs differentiate Parkinson's disease from atypical parkinsonisms

Mario Meloni et al.

NEUROBIOLOGY OF DISEASE (2022)

添加到收藏夹

Article Clinical Neurology

Detection of neuron-derived pathological α-synuclein in blood

Annika Kluge et al.

Summary: To date, no reliable clinically applicable biomarker has been established for Parkinson's disease. Our results suggest that a blood test for Parkinson's disease using neuronal extracellular vesicles may be possible.

BRAIN (2022)

添加到收藏夹

Article Clinical Neurology

Genetics of validated Parkinson's disease subtypes in the Oxford Discovery and Tracking Parkinson's cohorts

Michael Lawton et al.

Summary: This study explores the genetics of four previously described subtypes of Parkinson's disease and finds associations between different subtypes and GBA gene mutations and genetic risk. These findings provide insights into the underlying disease mechanisms and pathogenesis in different subtypes of Parkinson's disease.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2022)

添加到收藏夹

Article Clinical Neurology

The Impact of Type 2 Diabetes in Parkinson's Disease

Dilan Athauda et al.

Summary: In this study, the influence of type 2 diabetes on disease progression in Parkinson's disease was investigated. The results showed that patients with type 2 diabetes had more severe motor and nonmotor symptoms, were more likely to experience loss of independence and depression, and had faster motor symptom progression, worse mood symptoms, and higher risk of gait impairment and mild cognitive impairment compared to patients without type 2 diabetes.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Letter Clinical Neurology

Diabetes and Neuroaxonal Damage in Parkinson's Disease

Nirosen Vijiaratnam et al.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Article Clinical Neurology

Longitudinal Positron Emission Tomography Imaging of Presynaptic Terminals in Early Parkinson's Disease

Aline Delva et al.

Summary: This study used PET imaging to longitudinally assess presynaptic terminal loss in early Parkinson's disease (PD). The results showed that F-18-FE-PE2I PET was able to detect a significant decline over 2 years in early PD, while C-11-UCB-J PET did not show any changes. However, the changes in F-18-FE-PE2I binding did not correlate with clinical motor progression.

MOVEMENT DISORDERS (2022)

添加到收藏夹

Review Clinical Neurology

alpha-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies The Way Forward

Giovanni Bellomo et al.

Summary: Parkinson disease (PD) is a common neurodegenerative disease associated with misfolding and aggregation of alpha-synuclein. Seed amplification assays (SAAs) can detect misfolded alpha-synuclein in patients with PD and are promising diagnostic biomarkers. However, standardization issues need to be addressed.

NEUROLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease

Javier Pagonabarraga et al.

Summary: The study found that plasma NfL levels can be used to differentiate mild cognitive impairment in Parkinson's disease and predict future dementia progression.

PARKINSONISM & RELATED DISORDERS (2022)

添加到收藏夹

Article Neurosciences

Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson's disease

Lucia Batzu et al.

Summary: Early identification of cognitive impairment in Parkinson's disease has important implications. This study found that plasma NfL concentration is associated with cognitive performance in PD patients and may serve as a biomarker for cognitive progression.

NPJ PARKINSONS DISEASE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Structures of α-synuclein filaments from human brains with Lewy pathology

Yang Yang et al.

Summary: Parkinson's disease (PD) is a common movement disorder characterized by resting tremor, rigidity, bradykinesia and postural instability. It is associated with the presence of alpha-synuclein inclusions in brain cells. Many PD patients develop dementia after several years of diagnosis. PD dementia (PDD) is similar to dementia with Lewy bodies (DLB), which is diagnosed when cognitive impairment precedes parkinsonian motor signs or begins within one year from their onset.

NATURE (2022)

添加到收藏夹

Article Clinical Neurology

Disease-Associated a-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage

Nour Majbour et al.

Summary: This study demonstrated the quantification of aSyn aggregates in PD patients through a combination of seed amplification assay and ELISA, showing that this method is more effective than using SAA alone and can reflect the disease stage of patients.

NEUROLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Assessment of Bioenergetic Deficits in Patients With Parkinson Disease and Progressive Supranuclear Palsy Using 31P-MRSI

Jannik Prasuhn et al.

Summary: Mitochondrial dysfunction and bioenergetic depletion contribute to idiopathic Parkinson disease pathophysiology but not to progressive supranuclear palsy. Combined morphometric and metabolic imaging could serve as an accompanying diagnostic biomarker in the neuroimaging-guided differential diagnosis of these parkinsonian disorders.

NEUROLOGY (2022)

添加到收藏夹

Review Clinical Neurology

Diagnostic value of ?-synuclein seeding amplification assays in ?-synucleinopathies: A systematic review and meta-analysis

Dallah Yoo et al.

Summary: Alpha Syn-SAAs are promising in vivo detectors of abnormal alpha Syn aggregates and may aid the early diagnosis of alpha-synucleinopathies.

PARKINSONISM & RELATED DISORDERS (2022)

添加到收藏夹

Article Clinical Neurology

Initial clinical scans using [ 18 F]ACI‐12589, a novel α‐synuclein PET‐tracer

Ruben Smith et al.

Alzheimers & Dementia (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Aducanumab for the treatment of Alzheimer?s disease

Matteo Tagliapietra

Summary: Alzheimer's disease is the most common neurodegenerative condition causing dementia, and current treatments are limited to symptomatic therapy. No proven effective amyloid-based drug candidate exists.

DRUGS OF TODAY (2022)

添加到收藏夹

Review Clinical Neurology

a-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies The Way Forward

Giovanni Bellomo et al.

Summary: Parkinson's disease is the second most common neurodegenerative disease, and its diagnosis is currently based on motor symptoms. Seed amplification assays have the potential to identify Parkinson's disease at an earlier stage.

NEUROLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

Zerui Wang et al.

Summary: The study demonstrates that skin alpha Syn(P) seeding activity can potentially serve as a novel biomarker for antemortem diagnosis of Parkinson disease (PD) and other synucleinopathies. The analysis of skin samples from autopsies and biopsies shows a significant increase in alpha Syn(P) seeding activity in individuals with PD and synucleinopathies compared to controls with tauopathies and non-neurodegenerative diseases.

JAMA NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson's disease trial

R. Matthew Hutchison et al.

Summary: DaT-SPECT imaging can be a useful tool to verify the clinical diagnosis of Parkinson's disease. In the SPARK clinical trial, a small percentage of participants were excluded due to negative DaT-SPECT findings, which was lower than previous studies. Further research is needed to understand the reasons for this discrepancy and to determine if these results are applicable to future studies.

BMC NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease

Steffen Halbgebauer et al.

Summary: A novel ELISA was established to evaluate beta-synuclein as a potential marker for Alzheimer's disease. The study found increased levels of beta-synuclein in the CSF of some patients, supporting its potential use as a marker of synaptic degeneration. Furthermore, beta-synuclein was localized in glutamatergic synapses, with its expression reduced in AD patients' brain tissue.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

添加到收藏夹

Article Neurosciences

Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease

Cristina Agliardi et al.

Summary: Blood-based biomarkers such as oligomeric alpha-Syn and presynaptic SNARE complex proteins show promising potential in diagnosing and predicting Parkinson's Disease. The concentrations of these biomarkers in neural derived extravesicles (NDEs) from peripheral blood correlate with disease duration and severity, indicating their potential as easily accessible and effective tools for monitoring disease progression.

NEUROBIOLOGY OF DISEASE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Validation of human microRNA target pathways enables evaluation of target prediction tools

Fabian Kern et al.

Summary: MiRNAs are regulators of gene expression, and their target genes are not randomly distributed in the transcriptome, but share functional pathways. The HiTmIR strategy efficiently validates target genes and provides a resource for training or benchmarking other target predictors.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dopamine Transporter Imaging, Current Status of a Potential Biomarker: A Comprehensive Review

Giovanni Palermo et al.

Summary: This review highlights the importance of dopamine transporter imaging in clinical research of PD, discussing its role as a biomarker in diagnosis, preclinical, and predictive aspects. The article emphasizes the use of dopamine transporter imaging in assessing PD pathology, as well as recent studies questioning its correlation with nigral cell or axon counts.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson's disease patients

Zerrin Karaaslan et al.

Summary: By using microarray technology, 361 DEGs were identified in PBMC of PD patients and controls, with involvement in various biological processes and pathways, and validation of expression levels by RT-PCR. PD patients showed increased CD49d(+) Treg proportions, which correlated with disability scores. Upregulation of survival pathway genes might be a compensatory response to neuronal degeneration, with an association between survival and inflammation genes revealed through bioinformatics analysis.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Neurosciences

Neuropathology and molecular diagnosis of Synucleinopathies

Shunsuke Koga et al.

Summary: Synucleinopathies are a group of diseases characterized by pathological aggregates of alpha-synuclein in neurons and glia. The two main disease entities are Lewy body disease and multiple system atrophy, each with different clinical subtypes. Currently, there are no disease-modifying therapies, but research on molecular mechanisms provides hope for future treatments.

MOLECULAR NEURODEGENERATION (2021)

添加到收藏夹

Letter Clinical Neurology

Serum neurofilament light chain predicts future freezing of gait in Parkinson's disease

Ryul Kim et al.

PARKINSONISM & RELATED DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

Alex Iranzo et al.

Summary: The study found that RT-QuIC can detect misfolded alpha-synuclein in the CSF of patients with IRBD with both high sensitivity and specificity, indicating that detection of alpha-synuclein may serve as an early marker for Parkinson's disease and dementia with Lewy bodies.

LANCET NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Euglycemia Indicates Favorable Motor Outcome in Parkinson's Disease

Ioanna Markaki et al.

Summary: This study found that both low and high levels of HbA1c may be associated with motor symptom progression in Parkinson's disease patients, while diabetes mellitus was not an independent predictor of unfavorable motor outcome. Further studies are needed to confirm these findings and enhance understanding of causality.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α-Synuclein in PDGBA

Stefanie Lerche et al.

Summary: This study investigated the biomarker profiles associated with the GBA pathway and found that GBA mutations have a functional impact on biomarker profiles in patients. This allows patient stratification for clinical trials based solely on mutation status. Importantly, these findings were most prominent in PDGBA patients with severe variants.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Longitudinal Changes in Neuromelanin MRI Signal in Parkinson's Disease: A Progression Marker

Rahul Gaurav et al.

Summary: The study found a progressive decrease in neuromelanin-based substantia nigra signal and volume in PD patients, which could serve as a noninvasive assessment marker for disease progression.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression

Harneek Chohan et al.

Summary: The meta-analysis of observational and genetic data showed a significant association between type 2 diabetes and Parkinson's disease risk and progression, providing new evidence for their relationship.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Potential of extracellular vesicles in the Parkinson's disease-Pathological mediators and biomarkers

Yuan Zhao et al.

Summary: Parkinson's disease is an age-related neurodegenerative disorder characterized by the progressive deterioration of motor function, with the main pathogenesis involving the gradual death of dopaminergic neuronal populations and the accumulation of α-syn. The roles of extracellular vesicles in PD include enhancing the spread of α-syn, influencing other aspects of PD pathology, and potentially serving as valuable biomarkers for clinical diagnosis.

NEUROCHEMISTRY INTERNATIONAL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synergistic Association between Plasma Aβ1-42 and p-tau in Alzheimer's Disease but Not in Parkinson's Disease or Frontotemporal Dementia

Ming-Jang Chiu et al.

Summary: In Alzheimer's disease (AD), phosphorylated tau (p-tau) is significantly associated with plasma A beta(1-42) levels, which explains a large portion of the plasma p-tau levels in AD participants. The relationship between p-tau and A beta(1-42) is specific to AD and frontotemporal dementia, suggesting a synergic effect in the genesis of these pathological proteins. Plasma p-tau is also correlated with clinical severity in AD patients.

ACS CHEMICAL NEUROSCIENCE (2021)

添加到收藏夹

Article Clinical Neurology

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy

Suman Dutta et al.

Summary: The study found that measuring α-syn in exosomes from blood can effectively distinguish between patients with PD and MSA with high sensitivity and specificity. A multinomial logistic model combining α-syn concentration, exosome concentration, and a ratio between α-syn concentrations in specific exosomes showed promising results in separating PD from MSA.

ACTA NEUROPATHOLOGICA (2021)

添加到收藏夹

Article Neurosciences

Neurofilament Levels Are Reflecting the Loss of Presynaptic Dopamine Receptors in Movement Disorders

Elena Diekaemper et al.

Summary: The study reveals a strong correlation between NfL and pNfH with pathological changes in presynaptic dopamine transporter density in the putamen concomitant to nigrostriatal degeneration.

FRONTIERS IN NEUROSCIENCE (2021)

添加到收藏夹

Review Geriatrics & Gerontology

The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability

Christine Girges et al.

Summary: Current treatments for neurodegenerative diseases in older adults focus on symptom relief, but there is a growing need to identify disease-modifying drugs. Incretin-based therapies for diabetes may also be beneficial in treating neurodegenerative diseases, with GLP-1 receptor agonists showing potential. Safety, tolerability, and CNS penetration should be considered when repurposing these drugs for neurodegenerative conditions.

DRUGS & AGING (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

PGC-1s in the Spotlight with Parkinson's Disease

Elena Piccinin et al.

Summary: Parkinson's disease is characterized by the progressive loss of dopaminergic neurons, with mitochondrial dysfunction considered central to its pathogenesis. Failure of mitochondrial quality control is a hallmark of the disease, with the PGC-1 family playing a crucial role in regulating mitochondrial biogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Neurosciences

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease

Marco J. Russo et al.

Summary: Alpha Synuclein seed amplification assays (Alpha Syn-SAAs) are considered promising diagnostic tools for Parkinson's disease and related synucleinopathies, showing high diagnostic accuracy in multiple patient cohorts. This study compared results from three independent laboratories and found high reproducibility and diagnostic performance of the assay.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

添加到收藏夹

Article Neurosciences

Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies

Kathrin Brockmann et al.

Summary: The RT-QuIC analysis of cerebrospinal fluid has shown high sensitivity and specificity for detecting misfolded alpha-Syn in patients with PD and DLB. The results indicate that positive alpha-Syn seeding activity is associated with mutation status in both PD and DLB patients.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

添加到收藏夹

Article Clinical Neurology

Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes

Cheng Jiang et al.

Summary: The study demonstrates that measuring alpha-synuclein levels above 14 pg/mL in L1CAM-immunocaptured serum exosomes can robustly differentiate Parkinson's disease from other movement disorders. Furthermore, elevated levels of exosomal clusterin in individuals with 4-repeat tauopathies, combined with alpha-synuclein, improves the assay's performance in distinguishing Parkinson's disease from 4-repeat tauopathies. However, correction for the generic exosomal protein syntenin-1 did not consistently enhance the assay's performance.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease

Anne Stuendl et al.

Summary: This study aimed to examine the diagnostic value of alpha-synuclein in plasma extracellular vesicles from patients with Parkinson's disease (PD). Results showed that alpha-synuclein concentration in plasma extracellular vesicles could provide good discrimination between different neurodegenerative diseases, suggesting its potential as a diagnostic biomarker for PD. The study highlights the importance of extracellular vesicle-derived alpha-synuclein in disease pathology and diagnosis.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Reduced Synaptic Density in Patients with Lewy Body Dementia: An [11C]UCB-J PET Imaging Study

Katrine B. Andersen et al.

Summary: This study evaluated synaptic density in PD and dementia patients using in vivo PET imaging and found widespread cortical reduction in DLB/PDD subjects. The results suggest that synaptic density loss contributes to cognitive impairment in nPD and DLB/PDD.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease

Thomas Kremer et al.

Summary: In this study, CSF levels of monoamine metabolites were quantified in PD patients and healthy controls, showing lower levels of HVA and DOPAC in PD patients. Levels of these metabolites correlated with PD symptoms and dopamine levels. Metabolite levels did not change in drug-naive individuals over 2 years, but some changed upon starting levodopa treatment.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort

Nour K. Majbour et al.

Summary: This study investigated CSF biomarkers levels in newly diagnosed Parkinson's disease patients, finding that CSF oligomeric alpha-synuclein increased with disease severity and reflected PD motor trajectories.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Genetics & Heredity

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease

Ganqiang Liu et al.

Summary: A genome-wide survival study identified variants at RIMS2 associated with progression of Parkinson's disease to dementia and highlights divergence in the genetic architecture of disease onset and progression.

NATURE GENETICS (2021)

添加到收藏夹

Article Clinical Neurology

Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology

Eduardo de Pablo-Fernandez et al.

Summary: Type 2 diabetes may lead to faster disease progression and reduced survival in Parkinson's disease, possibly due to non-specific neurodegeneration related to chronic brain insulin resistance rather than increased vascular, Lewy or Alzheimer's pathologies.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Serum NFL levels predict progression of motor impairment and reduction in putamen dopamine transporter binding ratios in de novo Parkinson's disease: An 8-year longitudinal study

Rong Ye et al.

Summary: Research shows that serum NFL levels in Parkinson's disease patients are associated with motor decline and dopamine transporter loss, but not significantly related to cognitive decline. Higher serum NFL levels also predict progression of PIGD clinical features.

PARKINSONISM & RELATED DISORDERS (2021)

添加到收藏夹

Article Neurosciences

Serum Neurofilament Dynamics Predicts Cognitive Progression in de novo Parkinson's Disease

Ling-Zhi Ma et al.

Summary: The study found that serum NfL concentration can serve as an accessible biomarker for monitoring the severity and progression of cognitive decline in PD patients. Patients with PD had higher levels of serum NfL compared to healthy controls, and the increase in NfL levels was faster in the PD group. Baseline NfL levels and their rate of change were found to predict measurable cognitive decline in early PD, as well as future risk of PD dementia.

JOURNAL OF PARKINSONS DISEASE (2021)

添加到收藏夹

Letter Oncology

MicroRNAs from extracellular vesicles as a signature for Parkinson's disease

Lucas Caldi Gomes et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Plasma extracellular vesicles tau and β-amyloid as biomarkers of cognitive dysfunction of Parkinson's disease

Chen-Chih Chung et al.

Summary: Plasma extracellular vesicle (EV) tau and Aβ42 are significant markers of cognitive function in Parkinson's disease (PD) patients, and can help identify cognitive dysfunction. An artificial neural network model accurately predicts cognitive function in PD patients.

FASEB JOURNAL (2021)

添加到收藏夹

Article Clinical Neurology

Progress towards therapies for disease modification in Parkinson's disease

Nirosen Vijiaratnam et al.

Summary: The development of disease-modifying treatments for Parkinson's disease remains a challenge, due in part to limitations in therapeutic candidate selection and clinical trial design. A better understanding of Parkinson's disease pathogenesis, the use of biomarkers, focus on safe drugs, and precision medicine approaches could greatly increase the likelihood of successful identification of disease-modifying treatments.

LANCET NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease

Whitley W. Aamodt et al.

Summary: The study found that neurofilament light chain protein (NfL) is associated with cognitive function in Parkinson's disease (PD) patients and can predict future cognitive decline. Plasma NfL was identified as a useful prognostic biomarker for PD, predicting the likelihood of PD patients converting to mild cognitive impairment or dementia.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Systematic Assessment of 10 Biomarker Candidates Focusing on α-Synuclein-Related Disorders

Isabel Schulz et al.

Summary: Objective diagnostic biomarkers are needed to support a clinical diagnosis of neurodegenerative disorders, with various markers being analyzed in serum and/or cerebrospinal fluid for alpha-synuclein-related disorders. Levels of most markers tested significantly differed between disease groups and healthy controls, with CSF NfL levels best discriminating between Parkinson's disease and multiple system atrophy.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Peripheral Immune Profile and Neutrophil-to-Lymphocyte Ratio in Parkinson's Disease

Laura Munoz-Delgado et al.

Summary: Parkinson's disease patients exhibit altered peripheral immune profiles and higher neutrophil-to-lymphocyte ratio (NLR) compared to healthy controls. However, there appears to be no significant association between NLR and clinical characteristics of Parkinson's disease. A meta-analysis also suggests higher NLR in Parkinson's disease patients.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB

Stefanie Lerche et al.

Summary: This study evaluated CSF protein profiles related to alpha-synuclein proteostasis in PD and DLB patients, finding lower levels of proteins associated with neurotransmitter secretion, synaptic plasticity, and endolysosomal autophagy in patients compared to healthy controls. These protein levels were positively associated with levels of total alpha-synuclein in CSF, showing a potential biomarker role in monitoring alpha-synuclein pathology in PD and DLB.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Neurosciences

Investigation of α-Synuclein Species in Plasma Exosomes and the Oligomeric and Phosphorylated α-Synuclein as Potential Peripheral Biomarker of Parkinson's Disease

Hengxing Zheng et al.

Summary: This study examined the aggregation status, localization, and degradation characteristics of a-syn and p-a-syn in plasma exosomes from PD patients and healthy controls. Results indicated poor solubility of a-syn and p-a-syn after protease K treatment, with aggregates found inside and on the membrane surface of plasma exosomes. The ratios of oligomeric a-syn/total a-syn and oligomeric p-a-syn/total p-a-syn in plasma exosomes showed moderate utility in assisting PD diagnosis.

NEUROSCIENCE (2021)

添加到收藏夹

Article Clinical Neurology

Serum neurofilament is associated with motor function, cognitive decline and subclinical cardiac damage in advanced Parkinson's disease (MARK-PD)

Louisa Niemann et al.

Summary: In advanced PD patients, serum NfL concentrations are associated with motor function, cognitive decline, and subclinical cardiac damage.

PARKINSONISM & RELATED DISORDERS (2021)

添加到收藏夹

Review Clinical Neurology

Emerging Neuroimaging Biomarkers Across Disease Stage in Parkinson Disease A Review

Trina Mitchell et al.

Summary: Imaging biomarkers for different stages of Parkinson's disease are crucial for monitoring progression in clinical trials and improving clinical care. This review highlights the importance of considering disease stage when implementing diagnostic and progression biomarkers in both clinical trials and clinical care settings.

JAMA NEUROLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Serotonergic System Impacts Levodopa Response in Early Parkinson's and Future Risk of Dyskinesia

Jessie F. Fu et al.

Summary: The study found that the serotonergic system contributes to dopamine release and increases the risk for motor complications in early Parkinson's disease. Moreover, this contribution fails to provide sustained therapeutic advantage in early disease.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Article Clinical Neurology

Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease

Manuela M. X. Tan et al.

Summary: The study found that genetic variants associated with Parkinson's disease risk are not linked to disease progression. The APOE epsilon 4 tagging variant was significantly associated with cognitive progression, while ATP8B2 gene showed a nominal association with motor progression. The new method shows promise in improving the measurement of symptom progression in PD.

MOVEMENT DISORDERS (2021)

添加到收藏夹

Correction Clinical Neurology

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration (vol 52, pg 127, 2019)

Eri Saijo et al.

ACTA NEUROPATHOLOGICA (2020)

添加到收藏夹

Article Clinical Neurology

α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients

Sireesha Manne et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls

Linda P. Oosterveld et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

David Matuskey et al.

ANNALS OF NEUROLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders

Sara Hall et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Metabolic network abnormalities in drug-naive Parkinson's Disease

Katharina A. Schindlbeck et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy

Mohammad Shahnawaz et al.

NATURE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Plasma tau protein and Aβ42 level as markers of cognitive impairment in patients with Parkinson's disease

Justyna Chojdak-Lukasiewicz et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

In Vivo Mitochondrial Function in Idiopathic and Genetic Parkinson's Disease

Gabriele Dossi et al.

METABOLITES (2020)

添加到收藏夹

Article Clinical Neurology

Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies

Marcello Rossi et al.

ACTA NEUROPATHOLOGICA (2020)

添加到收藏夹

Article Clinical Neurology

Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations A Nonrandomized, Noncontrolled Trial

Stephen Mullin et al.

JAMA NEUROLOGY (2020)

添加到收藏夹

Article Clinical Neurology

A longitudinal study on α-synuclein in plasma neuronal exosomes as a biomarker for Parkinson's disease development and progression

M. Niu et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

添加到收藏夹

Article Neurosciences

Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson's Disease

Xiaodong Yang et al.

FRONTIERS IN NEUROSCIENCE (2020)

添加到收藏夹

Article Clinical Neurology

Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism

Cheng Jiang et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Increased alpha-synuclein tear fluid levels in patients with Parkinson's disease

Fabian Maass et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Geriatrics & Gerontology

Plasma Levels of α-Synuclein, Aβ-40 and T-tau as Biomarkers to Predict Cognitive Impairment in Parkinson's Disease

Nai-Ching Chen et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

添加到收藏夹

Article Biochemical Research Methods

Development of a novel method for the quantification of tyrosine 39 phosphorylated α- and β-synuclein in human cerebrospinal fluid

Chan Hyun Na et al.

CLINICAL PROTEOMICS (2020)

添加到收藏夹

Article Clinical Neurology

Dopamine Buffering Capacity Imaging: A Pharmacodynamic fMRI Method for Staging Parkinson Disease

Kevin J. Black et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Article Clinical Neurology

Magnetic Resonance Imaging and Neurofilament Light in the Differentiation of Parkinsonism

Derek B. Archer et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Mitochondrial Complex 1, Sigma 1, and Synaptic Vesicle 2A in Early Drug-Naive Parkinson's Disease

Heather Wilson et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Neurosciences

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers

Nour K. Majbour et al.

TRANSLATIONAL NEURODEGENERATION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structures of α-synuclein filaments from multiple system atrophy

Manuel Schweighauser et al.

NATURE (2020)

添加到收藏夹

Article Clinical Neurology

The TRACK-PD study: protocol of a longitudinal ultra-high field imaging study in Parkinson's disease

A. F. Wolters et al.

BMC NEUROLOGY (2020)

添加到收藏夹

Article Immunology

Relationship between circulating CD4+T lymphocytes and cognitive impairment in patients with Parkinson's disease

Luca Magistrelli et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson's Disease Patients and Is Present within Lewy Bodies

Madhurima Chatterjee et al.

BIOMOLECULES (2020)

添加到收藏夹

Article Chemistry, Analytical

Facile Impedimetric Analysis of Neuronal Exosome Markers in Parkinson's Disease Diagnostics

Ying Fu et al.

ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Article Clinical Neurology

Spatiotemporal changes in substantia nigra neuromelanin content in Parkinson's disease

Emma Biondetti et al.

BRAIN (2020)

添加到收藏夹

Article Neurosciences

Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach

Inger van Steenoven et al.

MOLECULAR NEURODEGENERATION (2020)

添加到收藏夹

Article Neurosciences

Utility of plasma Neurofilament light as a diagnostic and prognostic biomarker of the postural instability gait disorder motor subtype in early Parkinson's disease

Adeline Su Lyn Ng et al.

MOLECULAR NEURODEGENERATION (2020)

添加到收藏夹

Article Clinical Neurology

Subclinical Cardiac Microdamage, Motor Severity, and Cognition in Parkinson's Disease

Chi-un Choe et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease with Orthostatic Hypotension

Vincenzo Donadio et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease

Aline Delva et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease

Lana M. Chahine et al.

NEUROLOGY (2020)

添加到收藏夹

Article Neurosciences

Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease

Daniela Enache et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

添加到收藏夹

Article Cell Biology

Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results

Ningshan Wang et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2020)

添加到收藏夹

Article Clinical Neurology

Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue from Parkinson's Disease Patients

Sireesha Manne et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson's Disease Progression

Brit Mollenhauer et al.

MOVEMENT DISORDERS (2020)

添加到收藏夹

Article Neurosciences

Association of inflammatory factors and aging in Parkinson's disease

Hong Jin et al.

NEUROSCIENCE LETTERS (2020)

添加到收藏夹

Article Clinical Neurology

Optimization of the Detection Method for Phosphorylated α-Synuclein in Parkinson Disease by Skin Biopsy

Xiaojing Liu et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Review Clinical Neurology

Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes

Usman Saeed et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Article Geriatrics & Gerontology

Alpha-Synuclein Accumulation and Its Phosphorylation in the Enteric Nervous System of Patients Without Neurodegeneration: An Explorative Study

Lu-Lu Bu et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

添加到收藏夹

Article Clinical Neurology

No enhanced (p-) α-synuclein deposition in gastrointestinal tissue of Parkinson's disease patients

Biyan Nathanael Harapan et al.

PARKINSONISM & RELATED DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Neurofilament light chain level in plasma extracellular vesicles and Parkinson's disease

Chen-Chih Chung et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2020)

添加到收藏夹

Article Clinical Neurology

Serum FGF-21, GDF-15, and blood mtDNA copy number are not biomarkers of Parkinson disease

Ryan L. Davis et al.

NEUROLOGY-CLINICAL PRACTICE (2020)

添加到收藏夹

Article Neuroimaging

Imaging the Nigrosome 1 in the substantia nigra using susceptibility weighted imaging and quantitative susceptibility mapping: An application to Parkinson's disease

Zenghui Cheng et al.

NEUROIMAGE-CLINICAL (2020)

添加到收藏夹

Article Clinical Neurology

Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease

Un Jung Kang et al.

MOVEMENT DISORDERS (2019)

添加到收藏夹

Article Clinical Neurology

Serum NFL discriminates Parkinson disease from atypical parkinsonisms

Taina M. Marques et al.

NEUROLOGY (2019)

添加到收藏夹

Article Neurosciences

α-Synuclein in salivary extracellular vesicles as a potential biomarker of Parkinson's disease

Zhentang Cao et al.

NEUROSCIENCE LETTERS (2019)

添加到收藏夹

Article Clinical Neurology

Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy

Giorgio Vivacqua et al.

PARKINSONISM & RELATED DISORDERS (2019)

添加到收藏夹

Article Clinical Neurology

Selected serum cytokines and nitric oxide as potential multi-marker biosignature panels for Parkinson disease of varying durations: a case-control study

Dilini Rathnayake et al.

BMC NEUROLOGY (2019)

添加到收藏夹

Article Neurosciences

Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson's Disease

Xiaoli Si et al.

NEUROSCIENCE (2019)

添加到收藏夹

Review Clinical Neurology

C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

Xiaohui Qiu et al.

FRONTIERS IN NEUROLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Oligomeric α-synuclein is increased in basal tears of Parkinson's patients

Sarah F. Hamm-Alvarez et al.

BIOMARKERS IN MEDICINE (2019)

添加到收藏夹

Article Clinical Neurology

Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naive Parkinson's disease

Hidetomo Murakami et al.

BMC NEUROLOGY (2019)

添加到收藏夹

Article Clinical Neurology

Differential diagnosis of multiple system atrophy with predominant parkinsonism and Parkinson's disease using neural networks

Mitsunori Tsuda et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2019)

添加到收藏夹

Review Clinical Neurology

CSF and blood biomarkers for Parkinson's disease

Lucilla Parnetti et al.

LANCET NEUROLOGY (2019)

添加到收藏夹

Review Clinical Neurology

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Claire Bridel et al.

JAMA NEUROLOGY (2019)

添加到收藏夹

Article Clinical Neurology

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Dimitrios Kapogiannis et al.

JAMA NEUROLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies

Inger van Steenoven et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Insights into ubiquitin chain architecture using Ub-clipping

Kirby N. Swatek et al.

NATURE (2019)

添加到收藏夹

Article Neurosciences

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Alexis Fenyi et al.

NEUROBIOLOGY OF DISEASE (2019)

添加到收藏夹

Article Clinical Neurology

Blood NfL A biomarker for disease severity and progression in Parkinson disease

Chin-Hsien Lin et al.

NEUROLOGY (2019)

添加到收藏夹

Article Neurosciences

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay

Cristina Cariulo et al.

FRONTIERS IN NEUROSCIENCE (2019)

添加到收藏夹

Article Neurosciences

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson's disease and multiple system atrophy

Chiara Maria Giulia De Luca et al.

TRANSLATIONAL NEURODEGENERATION (2019)

添加到收藏夹

Article Immunology

Regulatory impairment in untreated Parkinson's disease is not restricted to Tregs: other regulatory populations are also involved

Diana D. Alvarez-Luquin et al.

JOURNAL OF NEUROINFLAMMATION (2019)

添加到收藏夹

Letter Clinical Neurology

Neuronal exosomes in saliva of Parkinson's disease patients: A pilot study

Komal Rani et al.

PARKINSONISM & RELATED DISORDERS (2019)

添加到收藏夹

Article Clinical Neurology

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology

Asa Sandelius et al.

ALZHEIMERS & DEMENTIA (2019)

添加到收藏夹

Article Medicine, General & Internal

Plasma pS129-α-Synuclein Is a Surrogate Biofluid Marker of Motor Severity and Progression in Parkinson's Disease

Chin-Hsien Lin et al.

JOURNAL OF CLINICAL MEDICINE (2019)

添加到收藏夹

Article Oncology

Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson's disease

Congcong Sun et al.

ANNALS OF TRANSLATIONAL MEDICINE (2019)

添加到收藏夹

Article Neurosciences

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment

Patrick Oeckl et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

添加到收藏夹

Review Neurosciences

Neurofilament Light Chain in Cerebrospinal Fluid and Blood as a Biomarker for Neurodegenerative Diseases: A Systematic Review and Meta-Analysis

Shao-Yang Wang et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

添加到收藏夹

Article Clinical Neurology

Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases

Takuma Ohmichi et al.

PARKINSONISM & RELATED DISORDERS (2019)

添加到收藏夹

Article Geriatrics & Gerontology

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson's Disease

Zhen-Hua Zhao et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

添加到收藏夹

Article Clinical Neurology

Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease A Secondary Analysis of the Exenatide-PD Trial

Dilan Athauda et al.

JAMA NEUROLOGY (2019)

添加到收藏夹

Article Neuroimaging

FDG-PET hypometabolism is more sensitive than MRI atrophy in Parkinson's disease: A whole-brain multimodal imaging meta-analysis

Franziska Albrecht et al.

NEUROIMAGE-CLINICAL (2019)

添加到收藏夹

Article Genetics & Heredity

Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts

Hirotaka Iwaki et al.

NEUROLOGY-GENETICS (2019)

添加到收藏夹

Article Neuroimaging

Assessment of a prognostic MRI biomarker in early de novo Parkinson's disease

Yashar Zeighami et al.

NEUROIMAGE-CLINICAL (2019)

添加到收藏夹

Article Neuroimaging

Cerebellar resting-state functional connectivity in Parkinson's disease and multiple system atrophy: Characterization of abnormalities and potential for differential diagnosis at the single-patient level

Hugo C. Baggio et al.

NEUROIMAGE-CLINICAL (2019)

添加到收藏夹

Article Neurosciences

Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson's Disease

Natalia Pessoa Rocha et al.

MOLECULAR NEUROBIOLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology

Erik Portelius et al.

ACTA NEUROPATHOLOGICA (2018)

添加到收藏夹

Article Clinical Neurology

Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies

Ivan Martinez-Valbuena et al.

ACTA NEUROPATHOLOGICA (2018)

添加到收藏夹

Article Clinical Neurology

Substantia Nigra Free Water Increases Longitudinally in Parkinson Disease

T. Guttuso et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Serotonin, beta-amyloid, and cognition in Parkinson disease

Vikas Kotagal et al.

ANNALS OF NEUROLOGY (2018)

添加到收藏夹

Article Cell Biology

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Xu Hou et al.

AUTOPHAGY (2018)

添加到收藏夹

Article Clinical Neurology

Nucleus basalis of Meynert degeneration precedes and predicts cognitive impairment in Parkinson's disease

Jonathan Schulz et al.

BRAIN (2018)

添加到收藏夹

Review Cell Biology

The genetic architecture of mitochondrial dysfunction in Parkinson's disease

S. B. Larsen et al.

CELL AND TISSUE RESEARCH (2018)

添加到收藏夹

Article Cell Biology

Interleukin-1 beta, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-alpha levels in CSF and serum in relation to the clinical diversity of Parkinson's disease

M. N. Karpenko et al.

CELLULAR IMMUNOLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Increased serum levels of TNF-alpha and decreased serum levels of IL-27 in patients with Parkinson disease and their correlation with disease severity

Ebrahim Kouchaki et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2018)

添加到收藏夹

Article Neurosciences

Plasma Amyloid-beta (A beta(42)) Correlates with Cerebrospinal Fluid A beta(42) in Alzheimer's Disease

Charlotte E. Teunissen et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

添加到收藏夹

Article Clinical Neurology

Interleukin 6 and complement serum level study in Parkinson's disease

Branislav Vesely et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

添加到收藏夹

Article Immunology

Parkinson's disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+Th1/Th2/T17 and Treg in drug-naive and drugtreated patients

Natasa Kustrimovic et al.

JOURNAL OF NEUROINFLAMMATION (2018)

添加到收藏夹

Article Clinical Neurology

Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort

Tanya Simuni et al.

MOVEMENT DISORDERS (2018)

添加到收藏夹

Article Clinical Neurology

Distinct Progression Pattern of Susceptibility MRI in the Substantia Nigra of Parkinson's Patients

Guangwei Du et al.

MOVEMENT DISORDERS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

Chao Peng et al.

NATURE (2018)

添加到收藏夹

Article Neurosciences

Plasma alpha-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study

Hua Wang et al.

NEUROBIOLOGY OF DISEASE (2018)

添加到收藏夹

Article Neurosciences

Alpha-synuclein dimerization in erythrocytes of patients with genetic and non-genetic forms of Parkinson's Disease

Nikolaos Papagiannakis et al.

NEUROSCIENCE LETTERS (2018)

添加到收藏夹

Article Neurosciences

Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease

Chunna An et al.

NEUROSCIENCE LETTERS (2018)

添加到收藏夹

Article Clinical Neurology

Expression of the gene coading for PGC-1α in peripheral blood leukocytes and related gene variants in patients with Parkinson's disease

Xiao-Dong Yang et al.

PARKINSONISM & RELATED DISORDERS (2018)

添加到收藏夹

Article Clinical Neurology

A new enzyme-linked immunosorbent assay for neurofilament light in cerebrospinal fluid: analytical validation and clinical evaluation

Lorenzo Gaetani et al.

ALZHEIMERS RESEARCH & THERAPY (2018)

添加到收藏夹

Article Geriatrics & Gerontology

Plasma Biomarkers Differentiate Parkinson's Disease From Atypical Parkinsonism Syndromes

Chin-Hsien Lin et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

添加到收藏夹

Article Neurosciences

High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects with Parkinson's Disease

Elliot Hogg et al.

JOURNAL OF PARKINSONS DISEASE (2018)

添加到收藏夹

Article Neurosciences

α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson's Disease Patients and Correlate with Disease Severity

Simona Daniele et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

添加到收藏夹

Article Clinical Neurology

Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease

Hossein Sanjari Moghaddam et al.

FRONTIERS IN NEUROLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study

V. Donadio et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Reduced glucocerebrosidase activity in monocytes from patients with Parkinson's disease

Farzaneh Atashrazm et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Clinical Neurology

Peripheral blood inflammatory markers in early Parkinson's disease

Ryul Kim et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2018)

添加到收藏夹

Article Clinical Neurology

α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies

Inger van Steenoven et al.

MOVEMENT DISORDERS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease

Yung-Shuan Lin et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Clinical Neurology

Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease

Jens B. Schroeder et al.

FRONTIERS IN NEUROLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Evaluation of the noradrenergic system in Parkinson's disease: an C-11-MeNER PET and neuromelanin MRI study

Michael Sommerauer et al.

BRAIN (2018)

添加到收藏夹

Article Immunology

Microglial activation in Parkinson's disease using [18F]-FEPPA

Christine Ghadery et al.

JOURNAL OF NEUROINFLAMMATION (2017)

添加到收藏夹

Article Clinical Neurology

CSF biomarkers β-amyloid, tau proteins and a-synuclein in the differential diagnosis of Parkinson-plus syndromes

Vasilios C. Constantinides et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid β-Glucocerebrosidase Activity Is Reduced in Parkinson's Disease Patients

Lucilla Parnetti et al.

MOVEMENT DISORDERS (2017)

添加到收藏夹

Review Clinical Neurology

The Role of High-Field Magnetic Resonance Imaging in Parkinsonian Disorders: Pushing the Boundaries Forward

Stephane Lehericy et al.

MOVEMENT DISORDERS (2017)

添加到收藏夹

Article Clinical Neurology

Meta-Analysis of Dorsolateral Nigral Hyperintensity on Magnetic Resonance Imaging as a Marker for Parkinson's Disease

Philipp Mahlknecht et al.

MOVEMENT DISORDERS (2017)

添加到收藏夹

Review Clinical Neurology

Diagnostic Utility of Cerebrospinal Fluid α-Synuclein in Parkinson's Disease: A Systematic Review and Meta-Analysis

Paolo Eusebi et al.

MOVEMENT DISORDERS (2017)

添加到收藏夹

Article Geriatrics & Gerontology

Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease

Elijah Mak et al.

NEUROBIOLOGY OF AGING (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Homovanillic acid in CSF of mild stage Parkinson's disease patients correlates with motor impairment

Alessandro Stefani et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

添加到收藏夹

Article Clinical Neurology

Blood-based NfL A biomarker for differential diagnosis of parkinsonian disorder

Oskar Hansson et al.

NEUROLOGY (2017)

添加到收藏夹

Article Neurosciences

Evaluation of the Braak staging of brain pathology with 1H-MRS in patients with Parkinson's disease

Hongmei Cao et al.

NEUROSCIENCE LETTERS (2017)

添加到收藏夹

Article Clinical Neurology

Quantitative susceptibility mapping differentiates between parkinsonian disorders

Henrik Sjostrom et al.

PARKINSONISM & RELATED DISORDERS (2017)

添加到收藏夹

Article Cell Biology

Neurofilaments and Neurofilament Proteins in Health and Disease

Aidong Yuan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

添加到收藏夹

Review Neurosciences

Glucocerebrosidase Mutations in Parkinson Disease

Grace O'Regan et al.

JOURNAL OF PARKINSONS DISEASE (2017)

添加到收藏夹

Article Behavioral Sciences

Detection and application of neurochemical profile by multiple regional 1H-MRS in Parkinson's disease

Jitian Guan et al.

BRAIN AND BEHAVIOR (2017)

添加到收藏夹

Article Clinical Neurology

Impaired synaptic function is linked to cognition in Parkinson's disease

Per Selnes et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)

添加到收藏夹

Article Neurosciences

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Shijie Wang et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)

添加到收藏夹

Article Neurosciences

Synaptic proteins in CSF relate to Parkinson's disease stage markers

Erika Bereczki et al.

NPJ PARKINSONS DISEASE (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Amyloid beta: structure, biology and structure-based therapeutic development

Guo-fang Chen et al.

ACTA PHARMACOLOGICA SINICA (2017)

添加到收藏夹

Article Clinical Neurology

Progression marker of Parkinson's disease: a 4-year multi-site imaging study

Roxana G. Burciu et al.

BRAIN (2017)

添加到收藏夹

Article Clinical Neurology

Insulin resistance and exendin-4 treatment for multiple system atrophy

Fares Bassil et al.

BRAIN (2017)

添加到收藏夹

Article Clinical Neurology

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies

Anne Stuendl et al.

BRAIN (2016)

添加到收藏夹

Article Clinical Neurology

Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's

Ganqiang Liu et al.

ANNALS OF NEUROLOGY (2016)

添加到收藏夹

Article Biochemical Research Methods

Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies

Patrick Oeckl et al.

MOLECULAR & CELLULAR PROTEOMICS (2016)

添加到收藏夹

Article Neurosciences

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease

Nour K. Majbour et al.

MOLECULAR NEURODEGENERATION (2016)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid Biomarkers in Alzheimer's and Parkinson's Diseases-From Pathophysiology to Clinical Practice

Kaj Blennow et al.

MOVEMENT DISORDERS (2016)

添加到收藏夹

Article Clinical Neurology

Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

Kyle B. Fraser et al.

MOVEMENT DISORDERS (2016)

添加到收藏夹

Article Clinical Neurology

Motor and Nonmotor Features of Carriers of the p.A53T Alpha-Synuclein Mutation: A Longitudinal Study

Dimitra Papadimitriou et al.

MOVEMENT DISORDERS (2016)

添加到收藏夹

Article Clinical Neurology

Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD)

Caroline H. Williams-Gray et al.

MOVEMENT DISORDERS (2016)

添加到收藏夹

Article Clinical Neurology

Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression

Nour K. Majbour et al.

MOVEMENT DISORDERS (2016)

添加到收藏夹

Article Clinical Neurology

Levels of IL-8 and TNF-α decrease in Parkinson's disease

Vineeta Gupta et al.

NEUROLOGICAL RESEARCH (2016)

添加到收藏夹

Article Clinical Neurology

Stage-dependent loss of cortical gyrification as Parkinson disease unfolds

Nicholas W. Sterling et al.

NEUROLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes

Roxana G. Burciu et al.

NEUROLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases

Paul J. Mattis et al.

NEUROLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Increased CSF neurogranin concentration is specific to Alzheimer disease

Henrietta Wellington et al.

NEUROLOGY (2016)

添加到收藏夹

Article Neurosciences

A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson's disease

Keita Matsuura et al.

NEUROSCIENCE LETTERS (2016)

添加到收藏夹

Article Clinical Neurology

Scan without evidence of dopaminergic deficit: A 10-year retrospective study

Nicolas Nicastro et al.

PARKINSONISM & RELATED DISORDERS (2016)

添加到收藏夹

Article Clinical Neurology

Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease

Haixia Ding et al.

PARKINSONISM & RELATED DISORDERS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson's Disease Stages?

Lucie Hopes et al.

PLOS ONE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease

Istvan Horvath et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Review Neurosciences

Insulin resistance and Parkinson's disease: A new target for disease modification?

D. Athauda et al.

PROGRESS IN NEUROBIOLOGY (2016)

添加到收藏夹

Article Biochemical Research Methods

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease

Julia Remnestal et al.

PROTEOMICS CLINICAL APPLICATIONS (2016)

添加到收藏夹

Review Multidisciplinary Sciences

How neuroinflammation contributes to neurodegeneration

Richard M. Ransohoff

SCIENCE (2016)

添加到收藏夹

Article Clinical Neurology

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease A Systematic Review and Meta-analysis

Xiao-Yan Qin et al.

JAMA NEUROLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease

Marie Y. Davis et al.

JAMA NEUROLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Graham Fairfoul et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson's Disease

Giorgio Vivacqua et al.

PLOS ONE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging

Jin Yong Hong et al.

PLOS ONE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Diagnostic Accuracy of Transcranial Sonography of the Substantia Nigra in Parkinson's disease: A Systematic Review and Meta-analysis

Dun-Hui Li et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients

Wenyan Kang et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal fluid neurogranin and YKL-40 as biomarkers of Alzheimer's disease

Shorena Janelidze et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations

Roy N. Alcalay et al.

BRAIN (2015)

添加到收藏夹

Article Clinical Neurology

Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study

Elijah Mak et al.

BRAIN (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

Fabienne C. Fiesel et al.

EMBO REPORTS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling

Shanshan Gao et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)

添加到收藏夹

Article Clinical Neurology

A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes

N. K. Magdalinou et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2015)

添加到收藏夹

Article Clinical Neurology

Automated Neuromelanin Imaging as a Diagnostic Biomarker for Parkinson's Disease

Gabriel Castellanos et al.

MOVEMENT DISORDERS (2015)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Plasma amyloid β-quo vadis?

Henrik Zetterberg

NEUROBIOLOGY OF AGING (2015)

添加到收藏夹

Article Geriatrics & Gerontology

Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

Edward Ofori et al.

NEUROBIOLOGY OF AGING (2015)

添加到收藏夹

Article Neurosciences

Detection of α-synuclein oligomers in red blood cells as a potential biomarker of Parkinson's disease

Xuemei Wang et al.

NEUROSCIENCE LETTERS (2015)

添加到收藏夹

Article Clinical Neurology

Neurodegenerative CSF markers in genetic and sporadic PD: Classification and prediction in a longitudinal study

Kathrin Brockmann et al.

PARKINSONISM & RELATED DISORDERS (2015)

添加到收藏夹

Article Clinical Neurology

Longitudinal midbrain changes in early Parkinson's disease: Iron content estimated from R2*/MRI

Marguerite Wieler et al.

PARKINSONISM & RELATED DISORDERS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer's but Not Parkinson's Disease or Dementia with Lewy Bodies

Malin Wennstrom et al.

PLOS ONE (2015)

添加到收藏夹

Article Oncology

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

YaXing Gui et al.

ONCOTARGET (2015)

添加到收藏夹

Article Clinical Neurology

Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease

Lorraine V. Kalia et al.

JAMA NEUROLOGY (2015)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease

David C. Backstrom et al.

JAMA NEUROLOGY (2015)

添加到收藏夹

Article Neurosciences

Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity

Tessandra Stewart et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)

添加到收藏夹

Article Clinical Neurology

Susceptibility-Weighted Imaging Improves the Diagnostic Accuracy of 3T Brain MRI in the Work-Up of Parkinsonism

F. J. A. Meijer et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2015)

添加到收藏夹

Article Clinical Neurology

Mutual Exacerbation of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Deregulation and α-Synuclein Oligomerization

Judith Eschbach et al.

ANNALS OF NEUROLOGY (2015)

添加到收藏夹

Article Clinical Neurology

Clinical evolution of Parkinson's disease and prognostic factors affecting motor progression: 9-year follow-up study

G. Reinoso et al.

EUROPEAN JOURNAL OF NEUROLOGY (2015)

添加到收藏夹

Article Neurosciences

Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson's disease diagnosis: a systematic review and meta-analysis

Liang Gao et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2015)

添加到收藏夹

Article Clinical Neurology

GBA-Associated Parkinson's Disease: Reduced Survival and More Rapid Progression in a Prospective Longitudinal Study

Kathrin Brockmann et al.

MOVEMENT DISORDERS (2015)

添加到收藏夹

Article Clinical Neurology

The increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson's disease

Esref Akil et al.

NEUROLOGICAL SCIENCES (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Baseline C-Reactive Protein Levels and Life Prognosis in Parkinson Disease

Hideyuki Sawada et al.

PLOS ONE (2015)

添加到收藏夹

Article Clinical Neurology

Identification of distinct circulating exosomes in Parkinson's disease

Paul R. Tomlinson et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Imaging Brain Iron and Diffusion Patterns: A Follow-up Study of Parkinson's Disease in the Initial Stages

Maija Elina Rossi et al.

ACADEMIC RADIOLOGY (2014)

添加到收藏夹

Article Clinical Neurology

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease

Min Shi et al.

ACTA NEUROPATHOLOGICA (2014)

添加到收藏夹

Article Clinical Neurology

Neuroimaging Biomarkers for Parkinson Disease: Facts and Fantasy

Joel S. Perlmutter et al.

ANNALS OF NEUROLOGY (2014)

添加到收藏夹

Article Clinical Neurology

Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally

Alexandru Hanganu et al.

BRAIN (2014)

添加到收藏夹

Article Neurosciences

Progression of Brain Atrophy in the Early Stages of Parkinson's Disease: A Longitudinal Tensor-Based Morphometry Study in De Novo Patients Without Cognitive Impairment

Carlo Tessa et al.

HUMAN BRAIN MAPPING (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

Anna Mietelska-Porowska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

添加到收藏夹

Article Medicine, General & Internal

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

Stephane Palfi et al.

LANCET (2014)

添加到收藏夹

Article Medicine, General & Internal

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

A. Jon Stoessl et al.

LANCET (2014)

添加到收藏夹

Review Clinical Neurology

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

Bruno Dubois et al.

LANCET NEUROLOGY (2014)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid Lysosomal Enzymes and Alpha-Synuclein in Parkinson's Disease

Lucilla Parnetti et al.

MOVEMENT DISORDERS (2014)

添加到收藏夹

Article Clinical Neurology

Reduced Alpha-Synuclein in Cerebrospinal Fluid in Synucleinopathies: Evidence From a Meta-analysis

Wataru Sako et al.

MOVEMENT DISORDERS (2014)

添加到收藏夹

Article Clinical Neurology

CSF Aβ42 predicts early-onset dementia in Parkinson disease

Guido Alves et al.

NEUROLOGY (2014)

添加到收藏夹

Article Clinical Neurology

Functional connectivity in the basal ganglia network differentiates PD patients from controls

Konrad Szewczyk-Krolikowski et al.

NEUROLOGY (2014)

添加到收藏夹

Review Clinical Neurology

Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration

Mari Yoshida

NEUROPATHOLOGY (2014)

添加到收藏夹

Article Cell Biology

Correlation between Serum RANTES Levels and the Severity of Parkinson's Disease

Peng Tang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

添加到收藏夹

Article Clinical Neurology

Differentiation of early-stage parkinsonisms using neuromelanin-sensitive magnetic resonance imaging

Chigumi Ohtsuka et al.

PARKINSONISM & RELATED DISORDERS (2014)

添加到收藏夹

Article Clinical Neurology

CSF levels of DJ-1 and tau distinguish MSA patients from PD patients and controls

Megan K. Herbert et al.

PARKINSONISM & RELATED DISORDERS (2014)

添加到收藏夹

Article Clinical Neurology

Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease

Oskar Hansson et al.

ALZHEIMERS RESEARCH & THERAPY (2014)

添加到收藏夹

Article Geriatrics & Gerontology

Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease

Lucilla Parnetti et al.

FRONTIERS IN AGING NEUROSCIENCE (2014)

添加到收藏夹

Article Clinical Neurology

Measuring Disease Progression in Early Parkinson Disease The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) Experience

Sotirios A. Parashos et al.

JAMA NEUROLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

May the Evaluation of Nitrosative Stress Through Selective Increase of 3-Nitrotyrosine Proteins Other Than Nitroalbumin and Dominant Tyrosine-125/136 Nitrosylation of Serum -Synuclein Serve for Diagnosis of Sporadic Parkinson's Disease?

Emilio Fernandez et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

添加到收藏夹

Article Clinical Neurology

Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort

Sophie E. Winder-Rhodes et al.

BRAIN (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

Jing L. Guo et al.

CELL (2013)

添加到收藏夹

Article Neurosciences

The Topography of Brain Damage at Different Stages of Parkinson's Disease

Federica Agosta et al.

HUMAN BRAIN MAPPING (2013)

添加到收藏夹

Article Clinical Neurology

Levels of HVA, 5-HIAA, and MHPG in the CSF of vascular parkinsonism compared to Parkinson's disease and controls

Megan K. Herbert et al.

JOURNAL OF NEUROLOGY (2013)

添加到收藏夹

Article Clinical Neurology

Differentiation between idiopathic and atypical parkinsonian syndromes using three-dimensional magnetic resonance spectroscopic imaging

Adriane Groeger et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2013)

添加到收藏夹

Meeting Abstract Clinical Neurology

WHICH CLINICAL MEASURES ARE MOST APPROPRIATE FOR MEASURING DISEASE PROGRESSION IN PARKINSON'S DISEASE?

David McGhee et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2013)

添加到收藏夹

Article Clinical Neurology

The Glial Marker YKL-40 Is Decreased in Synucleinopathies

Bob Olsson et al.

MOVEMENT DISORDERS (2013)

添加到收藏夹

Review Neurosciences

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

David J. Irwin et al.

NATURE REVIEWS NEUROSCIENCE (2013)

添加到收藏夹

Article Clinical Neurology

α-Synuclein in cutaneous autonomic nerves

Ningshan Wang et al.

NEUROLOGY (2013)

添加到收藏夹

Article Clinical Neurology

Differential diagnosis of parkinsonian syndromes using F-18 fluorodeoxyglucose positron emission tomography

Madhavi Tripathi et al.

NEURORADIOLOGY (2013)

添加到收藏夹

Article Neurosciences

Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects

Brit Mollenhauer et al.

NEUROSCIENCE LETTERS (2013)

添加到收藏夹

Article Clinical Neurology

Diabetes is associated with postural instability and gait difficulty in Parkinson disease

Vikas Kotagal et al.

PARKINSONISM & RELATED DISORDERS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Is R2* a New MRI Biomarker for the Progression of Parkinson's Disease? A Longitudinal Follow-Up

Miguel Ulla et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study

Michelle M. Mielke et al.

PLOS ONE (2013)

添加到收藏夹

Article Critical Care Medicine

Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: Results of a pilot study

Jeffrey Randall et al.

RESUSCITATION (2013)

添加到收藏夹

Article Multidisciplinary Sciences

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease

Penelope G. Foulds et al.

SCIENTIFIC REPORTS (2013)

添加到收藏夹

Article Neuroimaging

Diffusion tensor imaging of nigral degeneration in Parkinson's disease: A region-of-interest and voxel-based study at 3T and systematic review with meta-analysis

Stefan T. Schwarz et al.

NEUROIMAGE-CLINICAL (2013)

添加到收藏夹

Article Neurosciences

α-synuclein Imaging: A Critical Need for Parkinson's Disease Research

Jamie L. Eberling et al.

JOURNAL OF PARKINSONS DISEASE (2013)

添加到收藏夹

Article Clinical Neurology

Metabolic brain networks in translational neurology: Concepts and applications

Martin Niethammer et al.

ANNALS OF NEUROLOGY (2012)

添加到收藏夹

Article Clinical Neurology

Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients With Dementia and/or Parkinsonian Disorders

Sara Hall et al.

ARCHIVES OF NEUROLOGY (2012)

添加到收藏夹

Article Clinical Neurology

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

David J. Irwin et al.

BRAIN (2012)

添加到收藏夹

Article Clinical Neurology

Resting state functional connectivity of the striatum in Parkinson's disease

Carl D. Hacker et al.

BRAIN (2012)

添加到收藏夹

Article Clinical Neurology

Correlational study of the serum levels of the glial fibrillary acidic protein and neurofilament proteins in Parkinson's disease patients

Wen Su et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2012)

添加到收藏夹

Review Neurosciences

Patient Diaries As a Clinical Endpoint in Parkinson's Disease Clinical Trials

Spyridon (Spyros) Papapetropoulos

CNS NEUROSCIENCE & THERAPEUTICS (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [18F]-FEPPA

Romina Mizrahi et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

添加到收藏夹

Article Neurosciences

CD4+Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson's Disease

Jessica A. Hutter Saunders et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2012)

添加到收藏夹

Article Clinical Neurology

Comparison of patient rated treatment response with measured improvement in Parkinson's disease

Matthew B. Davidson et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)

添加到收藏夹

Article Clinical Neurology

Dementia is associated with Insulin Resistance in patients with Parkinson's Disease

Domenico Bosco et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)

添加到收藏夹

Article Clinical Neurology

Imaging nigral pathology and clinical progression in Parkinson's disease

Guangwei Du et al.

MOVEMENT DISORDERS (2012)

添加到收藏夹

Article Neurosciences

Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies

P. G. Foulds et al.

NEUROBIOLOGY OF DISEASE (2012)

添加到收藏夹

Letter Clinical Neurology

The DJ-1 concentration in cerebrospinal fluid does not differentiate among parkinsonian syndromes

Lisette Salvesen et al.

PARKINSONISM & RELATED DISORDERS (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid

Christian Czech et al.

PLOS ONE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Non-Motor Symptoms in Patients with Parkinson's Disease - Correlations with Inflammatory Cytokines in Serum

Daniel Lindqvist et al.

PLOS ONE (2012)

添加到收藏夹

Article Cell Biology

Phosphorylated α-Synuclein in Parkinson's Disease

Yu Wang et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

添加到收藏夹

Article Cell Biology

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

Oliver Cooper et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

添加到收藏夹

Letter Clinical Neurology

Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease

Ivana Devic et al.

BRAIN (2011)

添加到收藏夹

Article Clinical Neurology

Longitudinal evolution of compensatory changes in striatal dopamine processing in Parkinson's disease

Ramachandiran Nandhagopal et al.

BRAIN (2011)

添加到收藏夹

Article Neurosciences

CSF xanthine, homovanillic acid, and their ratio as biomarkers of Parkinson's disease

Peter LeWitt et al.

BRAIN RESEARCH (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease

Penelope G. Foulds et al.

FASEB JOURNAL (2011)

添加到收藏夹

Article Clinical Neurology

Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naive Patients with Parkinson's Disease

Min Jeong Park et al.

JOURNAL OF CLINICAL NEUROLOGY (2011)

添加到收藏夹

Article Clinical Neurology

Diffusion tensor imaging and olfactory identification testing in early-stage Parkinson's disease

Tyler M. Rolheiser et al.

JOURNAL OF NEUROLOGY (2011)

添加到收藏夹

Article Neurosciences

Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease

Syed Z. Imam et al.

JOURNAL OF NEUROSCIENCE (2011)

添加到收藏夹

Correction Clinical Neurology

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study (vol 10, pg 230, 2011)

B. Mollenhauer et al.

LANCET NEUROLOGY (2011)

添加到收藏夹

Article Clinical Neurology

Cerebrospinal Fluid Tau and Phosphorylated Tau Protein are Elevated in Corticobasal Syndrome

M. B. Aerts et al.

MOVEMENT DISORDERS (2011)

添加到收藏夹

Article Multidisciplinary Sciences

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

Kiran Yanamandra et al.

PLOS ONE (2011)

添加到收藏夹

Article Clinical Neurology

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

Brit Mollenhauer et al.

LANCET NEUROLOGY (2011)

添加到收藏夹

Article Clinical Neurology

CSF and plasma concentrations of free norepinephrine, dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), 3,4-dihydroxyphenylalanine (DOPA), and epinephrine in Parkinson's disease.

E. Eldrup et al.

ACTA NEUROLOGICA SCANDINAVICA (2010)

添加到收藏夹

Article Clinical Neurology

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

Thomas G. Beach et al.

ACTA NEUROPATHOLOGICA (2010)

添加到收藏夹

Article Clinical Neurology

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease

Zhen Hong et al.

BRAIN (2010)

添加到收藏夹

Article Neurosciences

Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline

Lani K. Clinton et al.

JOURNAL OF NEUROSCIENCE (2010)

添加到收藏夹

Article Clinical Neurology

Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis

Chris C. Tang et al.

LANCET NEUROLOGY (2010)

添加到收藏夹

Article Clinical Neurology

Plasma α-Synuclein in Patients with Parkinson's Disease With and Without Treatment

Raquel Duran et al.

MOVEMENT DISORDERS (2010)

添加到收藏夹

Article Neurosciences

Staging of serotonergic dysfunction in Parkinson's Disease: An in vivo 11C-DASB PET study

Marios Politis et al.

NEUROBIOLOGY OF DISEASE (2010)

添加到收藏夹

Article Clinical Neurology

Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease

T. Tokuda et al.

NEUROLOGY (2010)

添加到收藏夹

Article Clinical Neurology

CSF amyloid β 1-42 predicts cognitive decline in Parkinson disease

A. Siderowf et al.

NEUROLOGY (2010)

添加到收藏夹

Article Neurosciences

Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease

Min Shi et al.

NEUROSCIENCE LETTERS (2010)

添加到收藏夹

Article Clinical Neurology

Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease

Elke Hattingen et al.

BRAIN (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Philipp J. Kahle et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

添加到收藏夹

Article Clinical Neurology

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

Anna Bruck et al.

MOVEMENT DISORDERS (2009)

添加到收藏夹

Article Clinical Neurology

Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET

H. Shimada et al.

NEUROLOGY (2009)

添加到收藏夹

Article Clinical Neurology

High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease

D. E. Vaillancourt et al.

NEUROLOGY (2009)

添加到收藏夹

Article Clinical Neurology

Serum inflammatory biomarkers in Parkinson's disease

M. Dufek et al.

PARKINSONISM & RELATED DISORDERS (2009)

添加到收藏夹

Review Neurosciences

Metabolic brain networks in neurodegenerative disorders: a functional imaging approach

David Eidelberg

TRENDS IN NEUROSCIENCES (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cathepsin D is the main lysosomal enzyme involved in the degradation of α-synuclein and generation of its carboxy-terminally truncated species

Daniel Sevlever et al.

BIOCHEMISTRY (2008)

添加到收藏夹

Article Neurosciences

Cerebrospinal Fluid Biomarkers in Parkinson's Disease with Dementia and Dementia with Lewy Bodies

Lucilla Parnetti et al.

BIOLOGICAL PSYCHIATRY (2008)

添加到收藏夹

Article Clinical Neurology

Lewy body pathology involves cutaneous nerves

Masako Ikemura et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

添加到收藏夹

Article Clinical Neurology

The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study

Alexandra Gaenslen et al.

LANCET NEUROLOGY (2008)

添加到收藏夹

Article Neurosciences

Secretion of DJ-1 into the serum of patients with Parkinson's disease

Chinatsu Maita et al.

NEUROSCIENCE LETTERS (2008)

添加到收藏夹

Article Clinical Neurology

Circulating interleukin-15 and RANTES chemokine in Parkinson's disease

M. Rentzos et al.

ACTA NEUROLOGICA SCANDINAVICA (2007)

添加到收藏夹

Article Neurosciences

Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease

Masaaki Waragai et al.

NEUROSCIENCE LETTERS (2007)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

Frederic Tremblay et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

添加到收藏夹

Article Neurosciences

Enhanced accumulation of phosphorylated α-synuclein in double transgenic mice expressing mutant β-amyloid precursor protein and presenilin-1

Tomoko Kurata et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

添加到收藏夹

Article Clinical Neurology

Changes in network activity with the progression of Parkinson's disease

Chaorui Huang et al.

BRAIN (2007)

添加到收藏夹

Article Clinical Neurology

Magnetic resonance spectroscopic evidence for pre supplementary motor area neuronal dysfunction in Parkinson's disease

Richard M. Camicioli et al.

MOVEMENT DISORDERS (2007)

添加到收藏夹

Article Neurosciences

Metabolic brain networks associated with cognitive function in Parkinson's disease

Chaorui Huang et al.

NEUROIMAGE (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease

Takahiko Tokuda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

添加到收藏夹

Article Clinical Neurology

Network modulation in the treatment of Parkinson's disease

Kotaro Asanuma et al.

BRAIN (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease

Masaaki Waragai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

添加到收藏夹

Article Clinical Neurology

Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson's disease

J Spiegel et al.

BRAIN (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

Omar M. A. El-Agnaf et al.

FASEB JOURNAL (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Presenilin clinical mutations can affect γ-secretase activity by different mechanisms

M Bentahir et al.

JOURNAL OF NEUROCHEMISTRY (2006)

添加到收藏夹

Article Clinical Neurology

Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia

N Pankratz et al.

MOVEMENT DISORDERS (2006)

添加到收藏夹

Article Neurosciences

FDG PET in the differential diagnosis of parkinsonian disorders

T Eckert et al.

NEUROIMAGE (2005)

添加到收藏夹

Article Clinical Neurology

Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease

D Berg et al.

MOVEMENT DISORDERS (2005)

添加到收藏夹

Article Clinical Neurology

Microglial activation and dopamine terminal loss in early Parkinson's disease

Y Ouchi et al.

ANNALS OF NEUROLOGY (2005)

添加到收藏夹

Article Clinical Neurology

Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls

EJ Burton et al.

BRAIN (2004)

添加到收藏夹

Article Geriatrics & Gerontology

A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease

MJ Firbank et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2002)

添加到收藏夹

Article Clinical Neurology

Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease

KA Jellinger et al.

JOURNAL OF NEURAL TRANSMISSION (2002)

添加到收藏夹

Article Neurosciences

β-synuclein inhibits α-synuclein aggregation:: A possible role as an anti-parkinsonian factor

M Hashimoto et al.

NEURON (2001)

添加到收藏夹

Article Clinical Neurology

Echogenicity of the substantia nigra in Parkinsons disease and its relation to clinical findings

D Berg et al.

JOURNAL OF NEUROLOGY (2001)

添加到收藏夹

Article Clinical Neurology

Cortical dysfunction in non-demented Parkinson's disease patients -: A combined 31P-MRS and 18FDG-PET study

MTM Hu et al.

BRAIN (2000)

添加到收藏夹

Article Clinical Neurology

CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging

M Sjogren et al.

JOURNAL OF NEURAL TRANSMISSION (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.