期刊
BONE MARROW TRANSPLANTATION
卷 -, 期 -, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41409-023-02107-z
关键词
-
This study investigated the prognostic value of the dynamic progression of cutaneous to visceral involvement in acute graft-versus-host disease (a-GVHD). The results showed that the dynamic of skin GVHD could be used to classify a-GVHD and guide treatment for skin-only Grade 1 GVHD.
We conducted a prospective study aimed at investigating the prognostic value of the dynamic of a-GVHD progression from cutaneous to visceral involvement. In 108 consecutive patients who underwent allogeneic HSCT, we classified a-GVHD according to a GHVD skin dynamic: 18/82 patients started Corticosteroid (CS) within 48 h (Group 1); 13/82 started CS within days 3-7 (Group 2); Group 3A (n 31) was defined when Skin GVHD Overall Grade 1, left untreated for 1 week, showed an increase in involved body surface area <5 %; Group 3B (n 20), was defined when Skin GVHD Overall Grade 1, left untreated at 1 week, had an increase in involved body surface area >5%. These four groups had distinctive 2-y OS. Patients could be then grouped into poor risk (Group 1 and Group 3B) and good risk (Group 2 and Group 3A). Poor risk had inferior OS in univariate and multivariate analysis, (HR 2.222; 95% CL: 1.017-4.855; p 0.04). Among the patients with skin-only Grade 1 GVHD, subgroup 3A had an OS of 75.1% versus 39.8% found in subgroup 3B (p = 0.03). The dynamic of skin GVHD may be used to classify a-GVHD and guide treatment in Overall Grade 1 skin-only GVHD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据