Abnormalities of the Amygdala in schizophrenia: a real world study

BackgroundAmygdala plays an important role in schizophrenia (SC), but its mechanisms are still unclear. Therefore, we investigated the relationship between the resting-state magnetic resonance imaging (rsMRI) signals of the amygdala and cognitive functions, providing references for future research in this area.MethodsWe collected 40 drug-naive SC patients and 33 healthy controls (HC) from the Third People's Hospital of Foshan. We used rsMRI and the automatic segmentation tool to extract the structural volume and local neural activity values of the amygdala and conducted Pearson correlation analysis with the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores. Finally, we compared the clinical data, as well as the volume and functional changes of the amygdala in SC patients before and after treatment.ResultsCompared with HC, SC had widespread cognitive impairments, significant abnormalities in left amygdala function, while the reduction in volume of SC was not significant. Further Pearson correlation analysis with Bonferroni correction showed that only Immediate memory (learning) was significantly negatively correlated with fractional amplitude of low-frequency fluctuation (FALFF, r = -0.343, p = 0.001, p' = 0.014 (Bonferroni correction)). When compared and analyzed the data difference of SC before and after treatment, we found that immediate memory and delayed memory of SC showed varying degrees of recovery after treatment (t(learning) = -2.641, p(learning) = 0.011; t(story memory) = -3.349, p(story memory) = 0.001; t(list recall) = -2.071, p(list recall) = 0.043; t(story recall) = -2.424, p(story recall) = 0.018). But the brain structure and function did not recover.ConclusionThere was significant dysfunction in the amygdala in SC, and after conventional treatment, the function of the amygdala did not improve with the improvement of clinical symptoms and cognitive function.

Automated summary

This study investigated the relationship between cognitive functions and resting-state magnetic resonance imaging (rsMRI) signals of the amygdala in patients with schizophrenia. The results showed widespread cognitive impairments and significant abnormalities in the function of the left amygdala in schizophrenia patients. Furthermore, the function of the amygdala did not improve with the improvement of clinical symptoms and cognitive function after conventional treatment.