☆ 4.5 Article

Sex differences in the association of treatment-resistant schizophrenia and serum interleukin-6 levels

BMC PSYCHIATRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Clinical Neurology

Childhood trauma and the plasma levels of IL-6, TNF-α are risk factors for major depressive disorder and schizophrenia in adolescents: A cross-sectional and case-control study

Yi Li et al.

Summary: This study aimed to investigate the alterations of peripheral interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in adolescents with early-onset major depressive disorder (MDD) and schizophrenia (SZ), and explore the correlation between childhood maltreatment and plasma IL-6, TNF-α levels. The results showed that plasma IL-6 and TNF-α levels were significantly elevated in patients with early-onset MDD and SZ compared with healthy subjects, and were closely related to childhood maltreatment.

JOURNAL OF AFFECTIVE DISORDERS (2022)

添加到收藏夹

Article Neurosciences

Pro-inflammatory cytokine levels are elevated in female patients with schizophrenia treated with clozapine

Xiaoping Yuan et al.

Summary: This study found that chronic use of clozapine has a greater effect on the immune function of female patients with schizophrenia, resulting in abnormal expression of serum cytokines. Serum IL-2 levels were lower in female patients compared to male patients, and there was a positive correlation between serum IL-2 levels and clozapine daily dosage in female patients.

PSYCHOPHARMACOLOGY (2022)

添加到收藏夹

Article Psychiatry

Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders A Mendelian Randomization Study

John A. Williams et al.

Summary: This study investigates the relationship between inflammation and changes in brain structures, and explores the transcriptome-driven functional basis with relevance to mental illness. It finds that genetically determined IL-6 is associated with brain structure and potentially affects areas implicated in developmental neuropsychiatric disorders such as schizophrenia and autism.

JAMA PSYCHIATRY (2022)

添加到收藏夹

Article Immunology

Differences in inflammatory marker profiles and cognitive functioning between deficit and nondeficit schizophrenia

Dandan Wang et al.

Summary: This study aimed to compare the differences in cognitive functioning and inflammatory cytokine levels among different types of schizophrenia patients and healthy controls. The results showed that deficit schizophrenia patients had worse cognitive performance and higher levels of certain inflammatory cytokines compared to nondeficit schizophrenia patients and healthy controls. These findings suggest that deficit syndrome may be an independent endophenotype of schizophrenia with unique immune-inflammatory features.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Psychiatry

High Mobility Group Protein 1 and Dickkopf-Related Protein 1 in Schizophrenia and Treatment-Resistant Schizophrenia: Associations With Interleukin-6, Symptom Domains, and Neurocognitive Impairments

Arafat Hussein Al-Dujaili et al.

Summary: The study found significantly higher levels of HMGB1, DKK1, IL-6, and CCL11 in SCZ patients. NRTT patients had significantly higher levels of IL-6 and DDKI compared to PRTT and controls, with IL-10 being higher in NRTT than in controls. HMGB1, IL-6, and CCL11 explained a large part of the variance in PHEMN symptoms and formal thought disorders, while most neurocognitive functions were predicted by HMGB1, DDKI, and CCL11.

SCHIZOPHRENIA BULLETIN (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Serum interleukin-6 in schizophrenia: A system review and meta-analysis

Xin Zhou et al.

Summary: This meta-analysis found that serum IL-6 levels are elevated in schizophrenia, supporting the role of inflammatory abnormalities in the pathogenesis of the disease. Additionally, post-treatment, there is a significant decrease in serum IL-6 levels in schizophrenia patients, suggesting that an anti-inflammatory mechanism may be effective during antipsychotic treatment.

CYTOKINE (2021)

添加到收藏夹

Article Neurosciences

Do proinflammatory cytokines play a role in clozapine-associated glycometabolism disorders?

Tongtong Zhao et al.

Summary: This study found evidence that clozapine has a regulatory effect on immune-related proinflammatory cytokines and influences glycometabolism indicators, both in animal experiments and clinical trials. Clozapine-treated patients showed significant increases in blood glucose, BMI, and proinflammatory cytokines, with higher dosages associated with higher cytokine levels. Positive correlations were observed between blood glucose levels and proinflammatory cytokines.

PSYCHOPHARMACOLOGY (2021)

添加到收藏夹

Article Psychiatry

Serum level of high sensitive C-reactive protein and IL-6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study

Feyissa Challa et al.

Summary: The study found that inflammatory markers hsCRP and IL-6 were significantly increased in patients with schizophrenia compared to controls, even after controlling for potential confounders such as age, sex, and body mass index. This suggests that inflammatory processes may play a role in the pathophysiology of schizophrenia across different settings.

BMC PSYCHIATRY (2021)

添加到收藏夹

Article Immunology

Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6

Sinead King et al.

Summary: The study found that IL-6 may mediate the association between childhood trauma and social cognition by altering default mode network connectivity. Higher IL-6 levels were correlated with higher childhood trauma scores and lower cognitive and social cognitive function.

BRAIN BEHAVIOR AND IMMUNITY (2021)

添加到收藏夹

Article Neurosciences

The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia

Chutima Roomruangwong et al.

MOLECULAR NEUROBIOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors Are Associated with Interleukin-6

Shatha Rouf Moustafa et al.

DIAGNOSTICS (2020)

添加到收藏夹

Article Psychiatry

Changes in serum TNF-α, IL-18, and IL-6 concentrations in patients with chronic schizophrenia at admission and at discharge

Yayan Luo et al.

COMPREHENSIVE PSYCHIATRY (2019)

添加到收藏夹

Article Clinical Neurology

Association between IL-6 and metabolic syndrome in schizophrenia patients treated with second-generation antipsychotics

Xinyu Fang et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2019)

添加到收藏夹

Article Neurosciences

Escitalopram augmentation improves negative symptoms of treatment resistant schizophrenia patients - A randomized controlled trial

Ning Ding et al.

NEUROSCIENCE LETTERS (2018)

添加到收藏夹

Article Psychiatry

Second generation atypical antipsychotics olanzapine and aripiprazole reduce expression and secretion of inflammatory cytokines in human immune cells

Britta Stapel et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2018)

添加到收藏夹

Article Psychiatry

TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia

David R. Goldsmith et al.

SCHIZOPHRENIA RESEARCH (2018)

添加到收藏夹

Review Neurosciences

Sex Differences in Neuroimmunity and Pain

Sarah Rosen et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

添加到收藏夹

Article Psychiatry

Oxidative and nitrosative stress biomarkers in chronic schizophrenia

Karine Maria Boll et al.

PSYCHIATRY RESEARCH (2017)

添加到收藏夹

Review Psychiatry

Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology

Oliver D. Howes et al.

AMERICAN JOURNAL OF PSYCHIATRY (2017)

添加到收藏夹

Article Immunology

Self-rated health and interleukin-6: Longitudinal relationships in older adults

Filip K. Arnberg et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

添加到收藏夹

Article Immunology

Influence of gender on systemic IL-6 levels, complication rates and outcome after major trauma

Katharina Moers et al.

IMMUNOBIOLOGY (2016)

添加到收藏夹

Article Immunology

Gender differences in the association of sleep apnea and inflammation

Jordan Gaines et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age

J. Kulkarni et al.

MOLECULAR PSYCHIATRY (2015)

添加到收藏夹

Article Psychiatry

The practical management of refractory schizophrenia - the Maudsley Treatment REview and Assessment Team service approach

K. Beck et al.

ACTA PSYCHIATRICA SCANDINAVICA (2014)

添加到收藏夹

Article Psychiatry

Cytokine and adipokine alterations in patients with schizophrenia treated with clozapine

Jari-Pekka Klemettila et al.

PSYCHIATRY RESEARCH (2014)

添加到收藏夹

Article Rheumatology

Distinct impacts of syndesmophyte formation on male and female patients with ankylosing spondylitis

Wen-Nan Huang et al.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2012)

添加到收藏夹

Article Psychiatry

Addressing Nonresponse in Schizophrenia

John M. Kane

JOURNAL OF CLINICAL PSYCHIATRY (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide

María Santos-Galindo et al.

Biology of Sex Differences (2011)

添加到收藏夹

Article Neurosciences

Selective Estrogen Receptor Modulators Decrease the Production of Interleukin-6 and Interferon-gamma-Inducible Protein-10 by Astrocytes Exposed to Inflammatory Challenge In Vitro

M. Cerciat et al.

GLIA (2010)

添加到收藏夹

Article Immunology

Gender, race/ethnicity, personality, and interleukin-6 in urban primary care patients

Benjamin P. Chapman et al.

BRAIN BEHAVIOR AND IMMUNITY (2009)

添加到收藏夹

Article Oncology

Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences

Hayato Nakagawa et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

添加到收藏夹

Review Behavioral Sciences

Early-life programming of later-life brain and behavior: a critical role for the immune system

Staci D. Bilbo et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2009)

添加到收藏夹

Review Neurosciences

Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review

Stephane Potvin et al.

BIOLOGICAL PSYCHIATRY (2008)

添加到收藏夹

Review Multidisciplinary Sciences

Origin and physiological roles of inflammation

Ruslan Medzhitov

NATURE (2008)

添加到收藏夹

Article Immunology

The X-files in immunity: sex-based differences predispose immune responses

Eleanor N. Fish

NATURE REVIEWS IMMUNOLOGY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

Willscott E. Naugler et al.

SCIENCE (2007)

添加到收藏夹

Article Physiology

Sex differences in monocyte expression of IL-6: role of autonomic mechanisms

Mary-Frances O'Connor et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)

添加到收藏夹

Review Neurosciences

The neuropoietic cytokine family in development, plasticity, disease and injury

Sylvian Bauer et al.

NATURE REVIEWS NEUROSCIENCE (2007)

添加到收藏夹

Article Neurosciences

Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: Association with psychopathology and response to antipsychotics

XY Zhang et al.

NEUROPSYCHOPHARMACOLOGY (2005)

添加到收藏夹

Review Clinical Neurology

Adjunctive estrogen treatment in women with chronic schizophrenia: a double-blind, randomized, and placebo-controlled trial

S Akhondzadeh et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2003)

添加到收藏夹

Article Psychiatry

Increased serum interleukin-8 and interleukin-10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor

M Maes et al.

SCHIZOPHRENIA RESEARCH (2002)

添加到收藏夹

Article Clinical Neurology

Effects of atypical antipsychotics on the inflammatory response system in schizophrenic patients resistant to treatment with typical neuroleptics

M Maes et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.