期刊
BMC PSYCHIATRY
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12888-023-04957-9
关键词
Bone metabolism; Cognitive impairment; Oldest-old females; Sex hormones
类别
This study found that there are associations between sex hormones and bone metabolism with cognitive impairment in Chinese oldest-old females. The results showed that participants with cognitive impairment had higher levels of age, progesterone, prolactin, and estradiol. Total type I collagen N-terminal elongation peptide and prolactin levels were positively associated with cognitive impairment. Therefore, maintaining a balance in sex hormones and bone metabolism may have significant effects on cognitive function during the aging process.
PurposeWith a rapid increase in older adults, progressive impairment in cognitive function has become an increasing concern owing to high social and economic burdens. The current study was designed to investigate the associations of sex hormones and bone metabolism with cognitive impairment (CI) in Chinese oldest-old females.MethodsThere were 396 oldest-old females from the China Hainan Oldest-old Cohort Study (CHOCS). Following standardized procedures, Mini Mental State Examination was effectively completed, and sex hormones and bone metabolism were assessed in these females.ResultsThe median age of all females was 101 years (range: from 80 to 116). There were 340 females (86%) with CI. Participants with CI had significantly higher levels of age, progesterone, prolactin and estradiol than those without CI (P < 0.05 for all). Total type I collagen N-terminal elongation peptide [hazard ratio (HR): 1.018, 95%CI: 1.001-1.035] and prolactin (HR: 1.065, 95%CI: 1.005-1.129) levels were positively and significantly associated with CI (P < 0.05 for all).ConclusionsProlactin and total type I collagen N-terminal elongation peptide had positive associations with CI in Chinese oldest-old females. Thus, a balance in sex hormones and bone metabolism may have significant effects on cognitive function during the aging process.
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