Glioma-BioDP: database for visualization of molecular profiles to improve prognosis of brain cancer

Cancer researchers often seek user-friendly interactive tools for validation, exploration, analysis, and visualization of molecular profiles in cancer patient samples. To aid researchers working on the both low- and high-grade gliomas, we developed Glioma-BioDP, a web tool for exploration and visualization of RNA and protein expression profiles of interest in these tumor types. Glioma-BioDP is user friendly application that include expression data from both the low- and high-grade glioma patient samples from The Cancer Genome Atlas and enabled querying by mRNA, microRNA, and protein level expression data from Illumina HiSeq and RPPA platforms respectively. Glioma-BioDP provides advance query interface and enables users to explore the association of genes, proteins, and miRNA expression with molecular and/or histological subtypes of gliomas, surgical resection status and survival. The prognostic significance and visualization of the selected expression profiles can be explored using interactive utilities provided. This tool may also enable validation and generation of new hypotheses of novel therapies impacting gliomas that aid in personalization of treatment for optimum outcomes.

Automated summary

To assist cancer researchers in validation, exploration, analysis, and visualization of molecular profiles in cancer patient samples, we developed Glioma-BioDP, a user-friendly web tool for exploring and visualizing RNA and protein expression profiles in low- and high-grade gliomas. Glioma-BioDP includes expression data from The Cancer Genome Atlas and allows querying by mRNA, microRNA, and protein levels. Advanced query interface enables exploring the association of expression profiles with molecular and histological subtypes, surgical resection status, and survival. The tool facilitates the validation and generation of hypotheses for novel therapies and personalized treatment for gliomas.