期刊
BMC CANCER
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12885-023-11228-z
关键词
Doxorubicin; Liposomes; Liposomal; FUS; Focused ultrasound; Hyperthermia; Pancreatic ductal adenocarcinoma; Targeted drug delivery; Therapeutic ultrasound; ThermoDox (R)
类别
This study aims to enhance drug delivery to patients with pancreatic ductal adenocarcinomas by using ultrasound-mediated hyperthermia.
Background The dense stroma of pancreatic ductal adenocarcinomas is a major barrier to drug delivery. To increase the local drug diffusion gradient, high doses of chemotherapeutic agent doxorubicin can be released from ther-mally-sensitive liposomes (ThermoDox (R)) using ultrasound-mediated hyperthermia at the tumour target. PanDox is designed as a Phase 1 single centre study to investigate enhancing drug delivery to adult patients with non-opera-ble pancreatic ductal adenocarcinomas. The study compares a single cycle of either conventional doxorubicin alone or ThermoDox (R) with focused ultrasound-induced hyperthermia for targeted drug release.Methods Adults with non-resectable pancreatic ductal adenocarcinoma are allocated to receive a single cycle of either doxorubicin alone (Arm A) or ThermoDox (R) with focused ultrasound-induced hyperthermia (Arm B), based on patient-and tumour-specific safety conditions. Participants in Arm B will undergo a general anaesthetic and pre-heating of the tumour by extra-corporal focused ultrasound (FUS). Rather than employing invasive thermometry, ultrasound parameters are derived from a patient-specific treatment planning model to reach the 41 degrees C target tem-perature for drug release. ThermoDox (R) is then concurrently infused with further ultrasound exposure. Tumour biop-sies at the targeted site from all patients are analysed post-treatment using high performance liquid chromatography to quantify doxorubicin delivered to the tumour. The primary endpoint is defined as a statistically significant enhance-ment in concentration of total intra-tumoural doxorubicin, comparing samples from patients receiving liposomal drug with FUS to free drug alone. Participants are followed for 21 days post-treatment to assess secondary endpoints, including radiological assessment to measure changes in tumour activity by Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) criteria, adverse events and patient-reported symptoms.Discussion This early phase study builds on previous work targeting tumours in the liver to investigate whether enhancement of chemotherapy delivery using ultrasound-mediated hyperthermia can be translated to the stroma-dense environment of pancreatic ductal adenocarcinoma. If successful, it could herald a new approach towards managing these difficult-to-treat tumours.
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