4.6 Article

Epigenomic perturbation of novel EGFR enhancers reduces the proliferative and invasive capacity of glioblastoma and increases sensitivity to temozolomide

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy

Qi Zhan et al.

Summary: The study demonstrated that combination therapy using blood exosomes (Exos) as carriers can regulate the energy metabolism of glioblastoma (GBM) for personalized treatment. Exos co-loaded cytoplasmic phospholipase A2 siRNA (sicPLA2) and metformin, delivering them across the blood-brain barrier to GBM tissue. In a PDX GBM model, systemic administration of Exos-Met/sicPLA2 reduced tumor growth and prolonged survival.

NEURO-ONCOLOGY (2022)

Review Biochemistry & Molecular Biology

Current challenges in understanding the role of enhancers in disease

Judith Barbara Zaugg et al.

Summary: Enhancers are crucial for the spatiotemporal control of gene expression and are cell-type-specific. They are suggested to contribute to phenotypic variation, evolution, and disease. Dysfunction of enhancers, caused by genetic, structural, or epigenetic mechanisms, has been linked to a broad range of human diseases, known as enhanceropathies. Understanding how enhancer dysfunction affects gene expression remains a challenge.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)

Review Immunology

Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities

Guoqing Wang et al.

Summary: This review discusses the characteristics and functions of TAMs in GBM, and evaluates the current state of TAMs-targeting strategies. TAMs are logical therapeutic targets for GBM, and understanding how TAMs promote GBM progression is of great significance for new immune therapeutic approaches for GBM patients.

FRONTIERS IN IMMUNOLOGY (2022)

Article Oncology

EGFR, the Lazarus target for precision oncology in glioblastoma

Benjamin Lin et al.

Summary: This article discusses the unique biology of EGFR in GBM, the challenges in treatment, and how they have influenced past and present EGFR-targeted therapeutic design and clinical trials. It also explores the adjustments needed to exploit EGFR in this disease.

NEURO-ONCOLOGY (2022)

Review Oncology

Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities

Tongxin Ge et al.

Summary: Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic homeostasis are prominent hallmarks of carcinogenesis. This review summarizes the interplay between metabolism and epigenetics in cancer, highlighting their reciprocal modulation and potential therapeutic opportunities.

CANCER COMMUNICATIONS (2022)

Review Oncology

The role of ROS in tumour development and progression

Eric C. Cheung et al.

Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.

NATURE REVIEWS CANCER (2022)

Article Cell Biology

Chick fetal organ spheroids as a model to study development and disease

Soran Dakhel et al.

Summary: The study introduces an efficient method to generate healthy and proliferating 3D organ spheroids from chick embryos, demonstrating their potential applications in analyzing cell-cell interactions and cancer cell invasion patterns. This broad-ranging method may also have future implications in areas such as viral infections, drug screening, cancer diagnostics, and tissue engineering.

BMC MOLECULAR AND CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma

Jason Miska et al.

Summary: The survival of tumor-associated myeloid cells in glioblastoma is supported by upregulation of the arginine-ornithine-polyamine axis, which buffers low intracellular pH. This promotes immunosuppression and tumor evolution, and can be targeted for therapeutic benefit.

SCIENCE ADVANCES (2021)

Article Clinical Neurology

De novo purine biosyntesis is a major driver of chemoresistance in glioblastoma

Jack M. Shireman et al.

Summary: Glioblastoma is a primary brain cancer with a near 100% recurrence rate. A molecular circuit involving the interaction between ARL13B and IMPDH2 has been identified, which affects the efficacy of chemotherapy.
Review Oncology

Tumour treating fields therapy for glioblastoma: current advances and future directions

Ola Rominiyi et al.

Summary: TTFields, a non-invasive anticancer modality utilizing alternating electric fields to exert biophysical force on charged and polarisable molecules, have shown potential therapeutic effects in treating GBM and other cancers. By interfering with various biological processes, including DNA repair, cell permeability, and immunological responses, TTFields demonstrate a broad mechanism of action in eliciting therapeutic effects.

BRITISH JOURNAL OF CANCER (2021)

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Genetics & Heredity

The evolving metabolic landscape of chromatin biology and epigenetics

Ziwei Dai et al.

NATURE REVIEWS GENETICS (2020)

Article Biotechnology & Applied Microbiology

Prognostic significance of epidermal growth factor receptor expression in glioma patients

Junhong Li et al.

ONCOTARGETS AND THERAPY (2018)

Review Developmental Biology

Gene regulation during development in the light of topologically associating domains

Silvia Remeseiro et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Oncology

The role of enhancers in cancer

Inderpreet Sur et al.

NATURE REVIEWS CANCER (2016)

Article Medicine, General & Internal

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma A Randomized Clinical Trial

Roger Stupp et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Biochemistry & Molecular Biology

The Somatic Genomic Landscape of Glioblastoma

Cameron W. Brennan et al.

Article Pathology

Paradoxical Relationship Between the Degree of EGFR Amplification and Outcome in Glioblastomas

Jonathan Hobbs et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2012)

Review Oncology

Chemotaxis in cancer

Evanthia T. Roussos et al.

NATURE REVIEWS CANCER (2011)

Article Medicine, General & Internal

MGMT gene silencing and benefit from temozolomide in glioblastoma

ME Hegi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)