期刊
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/bab.2500
关键词
biological activity; Cordyceps cicadae; exopolysaccharide
A new exopolysaccharide named PC-EPS was isolated from Cordyceps cicadae. PC-EPS consists of mannose, glucose, and galactose in a ratio of 28.84:1:19.42, with an average molecular weight of 3.72 x 10(6) Da. It has the potential to enhance phagocytosis, cell proliferation, and immunological activity.
A new exopolysaccharide component named as PC-EPS was isolated from Cordyceps cicadae, and its structure was determined. PC-EPS was identified to be constituted of mannose, glucose, and galactose (28.84:1:19.42), with an average molecular weight of 3.72 x 10(6) Da, according to the results of monosaccharide composition, Fourier transform infrared, nuclear magnetic resonance, periodate oxidation and Smith degradation, and methylation studies. According to structural characterization, PC-EPS's connection type was made up of -> 6) -alpha-D-Manp (1 ->, -> 2) -beta-D-Manp (1 ->, -> 4) -alpha-D-Manp (1 ->, -> 2) - alpha-D-Galf (1 ->, and -> 4) -alpha-D-Galp (1 ->. PC-EPS may significantly increase phagocytosis and RAW264.7 cell proliferation. Additionally, by boosting intracellular lysozyme, cellular acid phosphatase, and cellular superoxide dismutase enzyme concentrations, as well as by promoting the generation of cellular NO, it is the potential to regulate the immunological activity of RAW264.7 cells. Additionally, the effects of PC-EPS on RAW264.7 cells increased their capacities to create tumor necrosis factor-alpha and interleukin 6 cytokines, all of which suggested that PC-EPS had the potential to improve immunomodulatory activity.
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