4.8 Article

Enzyme-Switch sensors for therapeutic drug monitoring of immunotherapies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemical Research Methods

Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen-Deuterium Exchange Mass Spectrometry

Oladapo Olaleye et al.

Summary: Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is a method to study the solvent accessibility and conformational dynamics of proteins. In this study, HDX-MS was used to determine the binding sites of Affimer reagents on monoclonal antibodies trastuzumab and pertuzumab. The results showed that the affimer binding led to significant protection in the Fab region of the antibodies. The binding sites of the affimer reagents were mainly located in the CDR2 of the heavy chain of the antibodies, as revealed by bottom-up HDX-MS experiments.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2023)

Article Chemistry, Analytical

Accurate and rapid microfluidic ELISA to monitor Infliximab titers in patients with inflammatory bowel diseases

Ines Iria et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting over 6.8 million people worldwide. Biological therapy, specifically anti-TNF-alpha antibodies, is used in severe cases. The development of a microfluidic biosensor for quantifying therapeutic antibodies in IBD patient samples shows promising results for improving therapy scheduling and efficacy.

ANALYST (2022)

Article Oncology

Alternative trastuzumab dosing strategies in HER2-positive early breast cancer are associated with patient out-of-pocket savings

Po-Hung Hsieh et al.

Summary: This study aimed to develop alternative dosing strategies for trastuzumab, analyze their pharmacokinetic effectiveness compared to standard dosing, and assess the financial implications. The results showed that low-dose and reduced frequency trastuzumab can significantly reduce drug utilization and alleviate patients' financial burden when appropriately selected.

NPJ BREAST CANCER (2022)

Article Biophysics

Next generation point-of-care test for therapeutic drug monitoring of adalimumab in patients diagnosed with autoimmune diseases

Henry Ordutowski et al.

Summary: A novel self-powered microfluidic chip was developed for point-of-care therapeutic drug monitoring of adalimumab, enabling detection within 30 minutes directly from whole blood.

BIOSENSORS & BIOELECTRONICS (2022)

Article Multidisciplinary Sciences

Selection and characterisation of Affimers specific for CEA recognition

Shazana Hilda Shamsuddin et al.

Summary: The study focuses on the development of Affimer proteins as a novel alternative binding reagent for CEA detection. Characterization of three anti-CEA Affimers show high affinity binding to CEA protein epitopes, with potential applications in diagnostic imaging, targeted CRC therapy, affinity purification, and biosensors.

SCIENTIFIC REPORTS (2021)

Review Pharmacology & Pharmacy

Unraveling the complexity of therapeutic drug monitoring for monoclonal antibody therapies to individualize dose in oncology

Etienne Chatelut et al.

Summary: Monoclonal antibodies (Mabs) are key drugs in cancer treatment, serving as targeted therapies or immune checkpoint inhibitors (ICIs). However, the individual dosing and therapeutic drug monitoring for these drugs need to take into account their unique pharmacological characteristics.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

Article Chemistry, Analytical

Recombinant Peptide Mimetic NanoLuc Tracer for Sensitive Immunodetection of Mycophenolic Acid

Alvaro Luque-Uria et al.

Summary: In this study, cyclic peptides that mimic the behavior of the immunosuppressant drug mycophenolic acid (MPA) were developed using a phage-displayed peptide library. A recombinant fusion protein containing the peptide sequence and a bioluminescent enzyme, NanoLuc, was created for use as a tracer in competitive immunoassays. The bioluminescent sensor showed good selectivity towards MPA, with a detection limit of 0.26 ng mL(-1) and an IC50 of 2.9 +/- 0.5 ng mL(-1), and was successfully applied to the analysis of clinical samples.

ANALYTICAL CHEMISTRY (2021)

Review Chemistry, Multidisciplinary

Engineering Protein Switches for Rapid Diagnostic Tests

Hope Adamson et al.

ACS SENSORS (2020)

Review Medical Laboratory Technology

Point-of-Care Therapeutic Drug Monitoring for Precision Dosing of Immunosuppressive Drugs

Adriano Taddeo et al.

JOURNAL OF APPLIED LABORATORY MEDICINE (2020)

Article Chemistry, Multidisciplinary

Generalizable Protein Biosensors Based on Synthetic Switch Modules

Zhong Guo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Engineering, Chemical

Product Design: Enzymatic Biosensors for Body Fluid Analysis

Zhiling Zhang et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2019)

Article Chemistry, Multidisciplinary

Phage Display in the Quest for New Selective Recognition Elements for Biosensors

Riikka Peltomaa et al.

ACS OMEGA (2019)

Article Biochemical Research Methods

Affimers as anti-idiotypic affinity reagents for pharmacokinetic analysis of biotherapeutics

Hope Adamson et al.

BIOTECHNIQUES (2019)

Article Chemistry, Multidisciplinary

Affimer-Enzyme-Inhibitor Switch Sensor for Rapid Wash-free Assays of Multimeric Proteins

Hope Adamson et al.

ACS SENSORS (2019)

Article Chemistry, Analytical

Dual-Color Bioluminescent Sensor Proteins for Therapeutic Drug Monitoring of Antitumor Antibodies

Martijn van Rosmalen et al.

ANALYTICAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Programmable Nucleic Acid Nanoswitches for the Rapid, Single-Step Detection of Antibodies in Bodily Fluids

Alessandro Porchetta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Rheumatology

Review of Biosimilar Trials and Data on Adalimumab in Rheumatoid Arthritis

Sizheng Zhao et al.

CURRENT RHEUMATOLOGY REPORTS (2018)

Review Immunology

Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment

Fanny Huynh Du et al.

AUTOIMMUNITY HIGHLIGHTS (2017)

Review Pharmacology & Pharmacy

Therapeutic Drug Monitoring of Monoclonal Antibodies in Inflammatory and Malignant Disease: Translating TNF-α Experience to Oncology

T. H. Oude Munnink et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)

Article Biochemistry & Molecular Biology

Modular protein switches derived from antibody mimetic proteins

N. Nicholes et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2016)

Article Chemistry, Analytical

Detection of Antibodies in Blood Plasma Using Bioluminescent Sensor Proteins and a Smartphone

Remco Arts et al.

ANALYTICAL CHEMISTRY (2016)

Article Medical Laboratory Technology

Therapeutic drug monitoring of infliximab: performance evaluation of three commercial ELISA kits

Ellen M. H. Schmitz et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

Review Pediatrics

Therapeutic drug monitoring in inflammatory bowel disease

Jacqueline Jossen et al.

CURRENT OPINION IN PEDIATRICS (2016)

Article Oncology

Direct Oral Anticoagulants Monitoring Anticoagulant Effect

Barbara A. Konkle

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2016)

Article Chemistry, Multidisciplinary

Engineered PQQ-Glucose Dehydrogenase as a Universal Biosensor Platform

Zhong Guo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Article Pharmacology & Pharmacy

Model-based clinical pharmacology profiling of ipilimumab in patients with advanced melanoma

Yan Feng et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2014)

Review Oncology

Review of therapeutic drug monitoring of anticancer drugs part 1-Cytotoxics

Angelo Paci et al.

EUROPEAN JOURNAL OF CANCER (2014)

Article Biochemistry & Molecular Biology

A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes

Bo Zhang et al.

NATURE MEDICINE (2014)

Article Biochemistry & Molecular Biology

Switchable Reporter Enzymes Based on Mutually Exclusive Domain Interactions Allow Antibody Detection Directly in Solution

Sambashiva Banala et al.

ACS CHEMICAL BIOLOGY (2013)

Article Cell Biology

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

Valentina Ciravolo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

Article Oncology

Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma

Evan J. Lipson et al.

CLINICAL CANCER RESEARCH (2011)

Article Biochemistry & Molecular Biology

Antibody Detection by Using a FRET-Based Protein Conformational Switch

Misha V. Golynskiy et al.

CHEMBIOCHEM (2010)

Review Biochemistry & Molecular Biology

Structure-switching biosensors: inspired by Nature

Alexis Vallee-Belisle et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)

Review Biotechnology & Applied Microbiology

The safety and side effects of monoclonal antibodies

Trevor T. Hansel et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Pharmacology & Pharmacy

Clinical Pharmacology of Trastuzumab

Dominique Leveque et al.

CURRENT CLINICAL PHARMACOLOGY (2008)

Article Biochemical Research Methods

Assay development and screening of a serine/threonine kinase in an on-chip mode using caliper nanofluidics technology

Dominique Perrin et al.

JOURNAL OF BIOMOLECULAR SCREENING (2006)

Review Allergy

In vitro assays for the diagnosis of IgE-mediated disorders

RG Hamilton et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

Review Biochemistry & Molecular Biology

Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance

MR Smith

ONCOGENE (2003)