Effect of interstitial fluid pH on transdermal glucose extraction by reverse iontophoresis

Article Chemistry, Multidisciplinary

Hyaluronidase-powered microneedles for significantly enhanced transdermal delivery efficiency

Wanshan Hu et al.

Summary: Hyaluronidase-powered microneedles (MN) can enhance the transdermal delivery of macromolecular drugs, increasing their bioavailability and improving the distribution, bioavailability, and therapeutic efficacy of subcutaneous injections.

JOURNAL OF CONTROLLED RELEASE (2023)

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Review Biophysics

Reverse iontophoresis with the development of flexible electronics: A review

Hao Zheng et al.

Summary: Skin-centric diagnosis techniques, such as reverse iontophoresis, have developed rapidly in recent years. However, the development of reverse iontophoresis was relatively slow around the 2010s due to device limitations. With the rapid development of flexible electronic technology, new progress has been made in reverse iontophoresis, particularly in blood glucose and drug monitoring.

BIOSENSORS & BIOELECTRONICS (2023)

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Article Engineering, Environmental

Wearable, nanofiber-based microfluidic systems with integrated electrochemical and colorimetric sensing arrays for multiplex sweat analysis

Xuecui Mei et al.

Summary: Wearable microfluidic sensors for sweat analysis are important for noninvasive monitoring of human health. A nanofiber-based microfluidic analysis system (NFMAS) was developed in this study for in situ sweat monitoring. The NFMAS can accurately measure multiple sweat components and conformally bond to the skin surface, enabling real-time monitoring of human health.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Nanoscience & Nanotechnology

Highly integrated watch for noninvasive continual glucose monitoring

Tianrui Chang et al.

Summary: This article discusses a highly integrated watch that allows for noninvasive continual blood glucose monitoring. The watch uses a Nafion-coated flexible electrochemical sensor patch to collect interstitial fluid transdermally at the wrist. This method eliminates the pain and inconvenience associated with traditional fingerstick blood tests, making it practical and easy to monitor blood glucose levels continuously.

MICROSYSTEMS & NANOENGINEERING (2022)

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Article Biophysics

A touch-actuated glucose sensor fully integrated with microneedle array and reverse iontophoresis for diabetes monitoring

Yanxiang Cheng et al.

Summary: A touch-actuated biosensor was developed for monitoring glucose in interstitial fluid, using a combination of skin penetration and reverse iontophoresis extraction. The biosensor showed significant improvement in glucose extraction flux compared to traditional reverse iontophoresis, both in vitro and in vivo. The integration of this biosensor, a wireless electrochemical detector, and a smartphone application enabled the development of a wearable glucose monitoring system, which showed high correlation with commercially available blood glucometer results.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Engineering, Environmental

A PEDOT:PSS conductive hydrogel incorporated with Prussian blue nanoparticles for wearable and noninvasive monitoring of glucose

Changshun Xu et al.

Summary: A noninvasive and continuous glucose monitoring method based on an electrochemical biosensor using PEDOT:PSS conductive hydrogel and Prussian blue nano-particles (PBNPs) is presented. The hydrogel showed low detection limit and high sensitivity, and demonstrated good accuracy in comparison to a commercial glucometer.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Analytical

A breathable flexible glucose biosensor with embedded electrodes for long-term and accurate wearable monitoring

Hao Zheng et al.

Summary: This paper presents a breathable flexible glucose biosensor with excellent flexibility and moisture/air permeability. The biosensor's electrodes are embedded in a flexible porous nanofiber polyimide substrate through electrospinning, providing breathability and preventing electrode detachment. The air-permeable film substrate was obtained by optimizing manufacturing parameters, and inkjet printing was used to embed three electrodes. The fabricated biosensor exhibits stable performance and precise glucose detection in a linear range of 0-25 mM.

MICROCHEMICAL JOURNAL (2022)

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Review Engineering, Biomedical

Current Technological Trends in Transdermal Biosensing

Yuyue Zhang et al.

Summary: Transdermal biosensing focuses on collecting and detecting biomarkers on and in the skin layers in a painless, convenient, and infection-avoiding manner. It has applications in daily health monitoring, disease diagnosis, and therapy monitoring.

ADVANCED NANOBIOMED RESEARCH (2022)

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Article Engineering, Biomedical

Iontophoresis-driven porous microneedle array patch for active transdermal drug delivery

Yanjun Li et al.

Summary: The study introduced a novel iontophoresis-driven porous MA patch (IDPMAP) and a portable iontophoresis-driven device for active transdermal delivery of charged liquid drugs. IDPMAP showed robust drug delivery ability with more advanced controllability and efficiency compared to pristine MA or iontophoresis, offering a platform technique for effective drug delivery in an active-controlled manner.

ACTA BIOMATERIALIA (2021)

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Article Multidisciplinary Sciences

Transdermal electroosmotic flow generated by a porous microneedle array patch

Shinya Kusama et al.

Summary: The authors discuss the utilization of porous polymer microneedles combined with electroosmosis powered by enzymatic batteries to deliver small and large molecules across the skin efficiently.

NATURE COMMUNICATIONS (2021)

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Article Biophysics

Integration of interstitial fluid extraction and glucose detection in one device for wearable non-invasive blood glucose sensors

Yao Yao et al.

Summary: The article introduces a simple two-electrode non-invasive blood glucose sensor, which extracts glucose concentration in ISF through RI process for blood glucose monitoring and validates its feasibility on different animals and human subjects.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Multidisciplinary Sciences

A thermal activated and differential self-calibrated flexible epidermal biomicrofluidic device for wearable accurate blood glucose monitoring

Zhihua Pu et al.

Summary: This paper describes a flexible electronics-based epidermal biomicrofluidics technique for continuous blood glucose monitoring. By proposing a thermal activation method, an Na+ sensor, and a correction model, the drawbacks of unreliable measurements from current wearables are overcome. Through the design of a specialized electrochemical sensor and a differential structure, more accurate blood glucose measurement is achieved.

SCIENCE ADVANCES (2021)

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Review Chemistry, Multidisciplinary

Printing Flexible and Hybrid Electronics for Human Skin and Eye-Interfaced Health Monitoring Systems

Kyunghun Kim et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Analytical

Optimization of Extraction Parameters of Reverse Iontophoretic Determination of Blood Glucose in an Artificial Skin Model

Cigdem Yengin et al.

CURRENT ANALYTICAL CHEMISTRY (2020)

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Review Chemistry, Multidisciplinary

Electrochemical glucose sensors in diabetes management: an updated review (2010-2020)

Hazhir Teymourian et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Review Biotechnology & Applied Microbiology

Wearable biosensors for healthcare monitoring

Jayoung Kim et al.

NATURE BIOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring

Yuanjing Lin et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Endocrinology & Metabolism

High Diabetes Distress Among Ethnic Minorities Is Not Explained by Metabolic, Cardiovascular, or Lifestyle Factors: Findings From the Dutch Diabetes Pearl Cohort

Behiye Ozcan et al.

DIABETES CARE (2018)

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Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Article Engineering, Electrical & Electronic

Facile synthesis of copper oxide microflowers for nonenzymatic glucose sensor applications

Victor Vinoth et al.

MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING (2018)

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Article Chemistry, Multidisciplinary

Simultaneous Monitoring of Sweat and Interstitial Fluid Using a Single Wearable Biosensor Platform

Jayoung Kim et al.

ADVANCED SCIENCE (2018)

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Review Chemistry, Multidisciplinary

Transdermal reverse iontophoresis: A novel technique for therapeutic drug monitoring

Tapan Kumar Giri et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Multidisciplinary Sciences

Skin-like biosensor system via electrochemical channels for noninvasive blood glucose monitoring

Yihao Chen et al.

SCIENCE ADVANCES (2017)

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Article Multidisciplinary Sciences

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

Hyunjae Lee et al.

SCIENCE ADVANCES (2017)

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Article Biophysics

Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor

Takahiro Arakawa et al.

BIOSENSORS & BIOELECTRONICS (2016)

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Article Multidisciplinary Sciences

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

Wei Gao et al.

NATURE (2016)

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Article Cell Biology

A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat

Ahyeon Koh et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Article Chemistry, Multidisciplinary

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System

Jayoung Kim et al.

ACS SENSORS (2016)

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Article Chemistry, Analytical

Tattoo-Based Noninvasive Glucose Monitoring: A Proof-of-Concept Study

Amay J. Bandodkar et al.

ANALYTICAL CHEMISTRY (2015)

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Article Endocrinology & Metabolism

The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview

David M. Nathan

DIABETES CARE (2014)

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Article Endocrinology & Metabolism

Neuropathy and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

Catherine L. Martin et al.

DIABETES CARE (2014)

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Article Chemistry, Analytical

Towards blood free measurement of glucose and potassium in humans using reverse iontophoresis

Christopher McCormick et al.

SENSORS AND ACTUATORS B-CHEMICAL (2012)

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Article Chemistry, Multidisciplinary

Monitoring of urea and potassium by reverse iontophoresis in vitro

Valentine Wascotte et al.

PHARMACEUTICAL RESEARCH (2007)

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Review Pharmacology & Pharmacy

Iontophoretic drug delivery

YN Kalia et al.

ADVANCED DRUG DELIVERY REVIEWS (2004)

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Article Pharmacology & Pharmacy

Non-invasive monitoring of phenytoin by reverse iontophoresis

B Leboulanger et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2004)

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Article Biophysics

Electroosmosis in transdermal iontophoresis: implications for noninvasive and calibration-free glucose monitoring

A Sieg et al.

BIOPHYSICAL JOURNAL (2004)

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Article Medical Laboratory Technology

Lithium monitoring by reverse iontophoresis in vivo

B Leboulanger et al.

CLINICAL CHEMISTRY (2004)

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Review Biophysics

Reverse iontophoresis for non-invasive transdermal monitoring

B Leboulanger et al.

PHYSIOLOGICAL MEASUREMENT (2004)

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Article Chemistry, Multidisciplinary

Transdermal reverse iontophoresis of valproate: A noninvasive method for therapeutic drug monitoring

MB Delgado-Charro et al.

PHARMACEUTICAL RESEARCH (2003)

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Article Chemistry, Medicinal

Reverse iontophoresis for noninvasive glucose monitoring: The internal standard concept

A Sieg et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2003)

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Article Biophysics

Clinical evaluation of the GlucoWatch® biographer:: a continual, non-invasive glucose monitor for patients with diabetes

MJ Tierney et al.

BIOSENSORS & BIOELECTRONICS (2001)

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Effect of interstitial fluid pH on transdermal glucose extraction by reverse iontophoresis

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