期刊
BIOPHYSICAL JOURNAL
卷 122, 期 16, 页码 3386-3394出版社
CELL PRESS
DOI: 10.1016/j.bpj.2023.07.014
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Circular actin waves propagate on the membrane of Dictyostelium cells, separating an inner domain rich in PIP3 and an external domain decorated with PTEN. The inner domain increases while the external domain decreases during wave propagation. Beyond a size limit, the inner domain breaks into an inner and an external domain.
Circular actin waves that propagate on the substrate-attached membrane of Dictyostelium cells separate two distinct membrane domains from each other: an inner territory rich in phosphatidyl-(3,4,5) trisphosphate (PIP3) and an external area decorated with the PIP3-degrading 3-phosphatase PTEN. During wave propagation, the inner territory increases at the expense of the external area. Beyond a size limit, the inner territory becomes unstable, breaking into an inner and an external domain. The sharp boundary between these domains is demarcated by the insertion of an actin wave. During the conversion of inner territory to external area, the state of the membrane fluctuates, as visualized by dynamic landscapes of formin B binding. Here we analyze the formin B fluctuations in relation to three markers of the membrane state: activated Ras, PIP3, and PTEN.
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