Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity

Six griseofulvin analogues named penigriseofulvins A -F (1-6), including three undescribed compounds and three undescribed natural products, were isolated from the fungus Penicillium griseofulvum. Their structures and absolute configurations were determined by NMR spectroscopic analyses, HRESIMS, and X-ray diffraction experiments. All compounds were evaluated for their anti-inflammatory activity, of which compounds 1 and 4 showed potential anti-inflammatory effects in RAW264.7 macrophages and ulcerative colitis mice.

Automated summary

Six griseofulvin analogues (penigriseofulvins A-F) were isolated from Penicillium griseofulvum, including three undescribed compounds and three undescribed natural products. Their structures and configurations were determined using NMR spectroscopy, HRESIMS, and X-ray diffraction. Compounds 1 and 4 exhibited potential anti-inflammatory effects in RAW264.7 macrophages and ulcerative colitis mice.