☆ 4.7 Article

Tinopanoids K-T, clerodane diterpenoids with anti-inflammatory activity from Tinospora crispa

BIOORGANIC CHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Agriculture, Multidisciplinary

Quassinoids from Picrasma chinensis with Insecticidal Activity against Adults and Larvae of Diaphorina citri Kuwayama and Neuroprotective Effect

Xianzhe Fan et al.

Summary: Eleven new tetracyclic quassinoids, named picrachinensin A-K (1-11), were isolated from the stems and leaves of Picrasma chinensis, together with six known congeners. Their structures were determined by various spectral techniques, crystallographic analysis, and circular dichroism. Compound 7 showed better insecticidal activity against Diaphorina citri Kuwayama than the positive control, with an LD50 of 55.69 mg/L for adults and a mortality rate of 30.42 +/- 2.78% for larvae (100 mg/L). The hydroxymethyl group at C-13 position of quassinoids was found to be beneficial for their insecticidal activity. Additionally, compounds 1, 4, and 12 exhibited significant neuroprotective effect against oxidative injury in SH-SY5Y cells.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

添加到收藏夹

Article Chemistry, Medicinal

New polychlorinated bibenzyls from Rhododendron minutiflorum

Yang-Li Zhu et al.

Summary: Five new polychlorinated bibenzyls (1-5) and three known compounds (6-8) were isolated from Rhododendron minutiflorum stems and leaves. The chemical structures of all isolates were determined using spectroscopic methods, and compounds 1 and 2 were verified using single-crystal X-ray diffraction analyses. Compounds 1-5 were halogenated compounds with three to five chlorine atoms in their chemical structures. Biologically, compounds 2, 5, and 6 showed varying levels of toxicity against Asian citrus psyllid (Diaphorina citri) with LD50 values of 27.15, 17.02, and 16.20 mg/L, respectively. These values were comparable to the positive control matrine (LD50 = 11.86 mg/L) based on observations on day 6. Additionally, compound 4 exhibited alpha-glucosidase inhibitory activity with an IC50 value of 17.87 +/- 0.74 μM.

NATURAL PRODUCTS AND BIOPROSPECTING (2023)

添加到收藏夹

Review Plant Sciences

An updated and comprehensive review on the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of Tinospora crispa (L.) Hook. f. & Thomson

Ehfazul Haque et al.

Summary: This review provides a comprehensive update and analysis on the ethnomedicinal uses, phytochemistry, pharmacological activity, and toxicological profile of T. crispa. It summarizes the traditional uses of this plant in treating various diseases and discusses its potential in pharmaceutical research.

PHYTOCHEMISTRY REVIEWS (2023)

添加到收藏夹

Article Plant Sciences

Anti-neuroinflammatory activity of 6,7-dihydroxy-2,4-dimethoxy phenanthrene isolated from Dioscorea batatas Decne partly through suppressing the p38 MAPK/NF-κB pathway in BV2 microglial cells

Ji Sun Lim et al.

Summary: DHDMP extracted from Dioscorea batatas Decne showed anti-neuroinflammatory activity by suppressing inflammatory mediators in microglial cells and promoting neuronal cell survival.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa

Jin-Qiu You et al.

Summary: Twelve new cis-clerodane diterpenoids, named crispinoids A-L (1-12), along with three known analogues (13-15), were isolated from Tinospora crispa. Their structures were fully determined using comprehensive spectroscopic techniques, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) analyses. The isolated compounds exhibited diverse heterocyclic frameworks and demonstrated inhibition of key pathways and inflammatory responses.

CHINESE JOURNAL OF CHEMISTRY (2022)

添加到收藏夹

Article Immunology

Magnoflorine from Tinospora crispa upregulates innate and adaptive immune responses in Balb/c mice

Waqas Ahmad et al.

Summary: Magnoflorine demonstrates immunomodulatory, antioxidant, and neuropharmacological activities. This study reveals that magnoflorine stimulates innate and adaptive immune responses, increasing immune cell populations, cytokine production, and antibody levels. These findings suggest the potential of magnoflorine as an effective immunostimulant.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Chemistry, Organic

Clerodane diterpenoids with anti-inflammatory and synergistic antibacterial activities from Tinospora crispa

Yang-Li Zhu et al.

Summary: Ten new and four known clerodane diterpenoids were isolated from Tinospora crispa. These compounds possess diverse lactone ring structures and exhibit anti-inflammatory and antibacterial activities.

ORGANIC CHEMISTRY FRONTIERS (2022)

添加到收藏夹

Article Chemistry, Applied

Rearranged clerodane diterpenoid from Tinospora crispa

Abidah Parveen et al.

Summary: A new rearranged clerodane diterpenoid, tinocrispide, was isolated from the stems of Tinospora crispa along with thirteen known compounds, including eight clerodane diterpenoids. Among the known compounds, baenzigeride A, (6S, 9 R)-vomifoliol, and steponine were reported for the first time from T. crispa. Structures were elucidated using 1D and 2D NMR and confirmed by HRESIMS. Additionally, the C-13 NMR data of borapetol A has been revised.

NATURAL PRODUCT RESEARCH (2021)

添加到收藏夹

Article Neurosciences

Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial

Maria Antonietta Nettis et al.

Summary: The study aimed to investigate the effectiveness of minocycline augmentation in patients with treatment-resistant depression based on baseline levels of peripheral inflammation. Results showed that the efficacy of minocycline as an adjunct treatment was only seen in patients with low-grade inflammation defined as CRP >= 3 mg/L. These findings suggest that baseline inflammation levels may play a role in predicting response to minocycline in MDD patients.

NEUROPSYCHOPHARMACOLOGY (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Quassinoids with Insecticidal Activity against Diaphorina citri Kuwayama and Neuroprotective Activities from Picrasma quassioides

Cui He et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Article Cell Biology

Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression

Fu Xiu-Qiong et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Review Immunology

Cathelicidins Modulate TLR-Activation and Inflammation

Maaike R. Scheenstra et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Biochemical and Computational Approach of Selected Phytocompounds fromTinospora crispain the Management of COVID-19

Ahmed Rakib et al.

MOLECULES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Engineering, Biomedical

Microglia-targeting nanotherapeutics for neurodegenerative diseases

Nanxia Zhao et al.

APL BIOENGINEERING (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1

Ji Geng et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

Gunnar R. Leitner et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

添加到收藏夹

Article Immunology

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Ka-Young Ryu et al.

JOURNAL OF NEUROINFLAMMATION (2019)

添加到收藏夹

Article Plant Sciences

Crispenes F and G, cis-Clerodane Furanoditerpenoids from Tinospora crispa, Inhibit STAT3 Dimerization

Md. Abdullah Al Noman et al.

JOURNAL OF NATURAL PRODUCTS (2018)

添加到收藏夹

Article Integrative & Complementary Medicine

Antiprotozoal properties of Indonesian medicinal plant extracts

Arba P. Ramadani et al.

JOURNAL OF HERBAL MEDICINE (2018)

添加到收藏夹

Article Plant Sciences

Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways

Chao Guo et al.

PHYTOMEDICINE (2016)

添加到收藏夹

Review Chemistry, Medicinal

The Significance of Tinospora crispa in Treatment of Diabetes Mellitus

Alex Thomas et al.

PHYTOTHERAPY RESEARCH (2016)

添加到收藏夹

Article Chemistry, Medicinal

Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

Yuan Gao et al.

NATURAL PRODUCTS AND BIOPROSPECTING (2016)

添加到收藏夹

Article Chemistry, Organic

Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

Julia Mantaj et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

添加到收藏夹

Article Plant Sciences

Anti-HIV-1 integrase diterpenoids from Dichrocephala benthamii

Bo Song et al.

PHYTOCHEMISTRY LETTERS (2015)

添加到收藏夹

Article Plant Sciences

Ethnopharmacological survey of medicinal plants used by traditional health practitioners in Thanchi, Bandarban Hill Tracts, Bangladesh

Mohammad Fahim Kadir et al.

JOURNAL OF ETHNOPHARMACOLOGY (2014)

添加到收藏夹

Article Plant Sciences

Hypoglycemic action of borapetoside A from the plant Tinospora crispa in mice

Chi-Tun Ruan et al.

PHYTOMEDICINE (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hypercohin A, a new polycyclic polyprenylated acylphloroglucinol possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens

Xing-Wei Yang et al.

CHEMICAL COMMUNICATIONS (2012)

添加到收藏夹

Article Plant Sciences

Hypoglycemic Diterpenoids from Tinospora crispa

Sio-Hong Lam et al.

JOURNAL OF NATURAL PRODUCTS (2012)

添加到收藏夹

Article Plant Sciences

cis-Clerodane-Type Furanoditerpenoids from Tinospora crispa

M. Iqbal Choudhary et al.

JOURNAL OF NATURAL PRODUCTS (2010)

添加到收藏夹

Article Chemistry, Medicinal

New phenolic esters from the resinous exudate of Haplopappus taeda

Francesca Faini et al.

FITOTERAPIA (2007)

添加到收藏夹

Article Plant Sciences

Herbs for medicinal baths among the traditional Yao communities of China

Sumei Li et al.

JOURNAL OF ETHNOPHARMACOLOGY (2006)

添加到收藏夹

Article Biochemical Research Methods

Quantitative determination of four constituents of Tinospora sps. by a reversed-phase HPLC-UV-DAD method.: Broad-based studies revealing variation in content of four secondary metabolites in the plant from different eco-geographical regions of India

S. M. Ahmed et al.

JOURNAL OF CHROMATOGRAPHIC SCIENCE (2006)

添加到收藏夹

Article Clinical Neurology

Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases

L Minghetti

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.