4.7 Article

Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease

Fan Yin et al.

Summary: The study found that upregulated caspase-11 leads to the cleavage of panx1 in renal I/R injury, facilitating ATP release and NLRP3 inflammasome activation. This provides new insight into the molecular mechanism of NLRP3 inflammasome activation in AKI.

ACTA PHARMACOLOGICA SINICA (2022)

Article Biochemistry & Molecular Biology

Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels

Anne Caufriez et al.

Summary: Multiple drugs previously tested in clinical trials during the COVID-19 pandemic, including favipiravir, hydroxychloroquine, and lopinavir, were found to inhibit Pannexin1 channel activity without affecting protein or mRNA levels. Despite not currently being used for COVID-19 treatment, these drugs could serve as potential candidates for other Pannexin1-related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Cell Biology

Human Pannexin 1 channel: Insight in structure-function mechanism and its potential physiological roles

Eijaz Ahmed Bhat et al.

Summary: Pannexins are a large non-gap junction super family in vertebrates that play multiple roles in cellular functions through ATP release. While PANXs are known for their exclusion from gap junctions and facilitation of ATP release from cells, particularly through PANX1, recent research has focused on the Cryo-EM structure of Panx1 channel and its physiological and pathophysiological implications. This review emphasizes recent advancements in understanding the structure and function of the novel heptameric channel, particularly in the context of ATP release in health and disease.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Article Biology

ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

Adishesh K. Narahari et al.

Summary: The study demonstrated that Panx1 channels activated by caspase allow large molecule permeation, including anionic and large-molecule permeants, while also allowing large cationic molecules to permeate at a slower rate. Additionally, Panx1 channels provide a pathway for the flux of ATP and other signaling metabolites, both anionic (glutamate) and cationic (spermidine).
Article Biotechnology & Applied Microbiology

Trends in peptide drug discovery

Markus Muttenthaler et al.

Summary: This Perspective summarizes key trends in peptide drug discovery and development, including human hormones, elegant medicinal chemistry and rational design strategies, peptide drugs derived from nature, and major breakthroughs in molecular biology and peptide chemistry. It also emphasizes lessons from earlier approaches that are still relevant today and discusses emerging strategies impact on peptide drug discovery.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Cell Biology

Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis

Sensen Zhang et al.

Summary: The expression of PANX1 is upregulated by various stimuli in human macrophages that promote pyroptosis, with structural and functional studies revealing its potential role in pyroptosis during immune responses. Cryo-electron microscopy and molecular dynamics simulations support the model of hPANX1 as a homo-heptamer with N-termini and C-termini extending deep into the channel pore funnel, providing insights into the channel gating mechanism.

CELL DISCOVERY (2021)

Letter Cell Biology

Cryo-EM structure of human heptameric Pannexin 1 channel

Ronggui Qu et al.

CELL RESEARCH (2020)

Article Multidisciplinary Sciences

Metabolites released from apoptotic cells act as tissue messengers

Christopher B. Medina et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Cryo-EM structures of the ATP release channel pannexin 1

Zengqin Deng et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Physiology

Consideration of Pannexin 1 channels in COVID-19 pathology and treatment

Leigh Anne Swayne et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

Review Pharmacology & Pharmacy

Peptide-based targeting of connexins and pannexins for therapeutic purposes

Anne Caufriez et al.

EXPERT OPINION ON DRUG DISCOVERY (2020)

Article Multidisciplinary Sciences

Structures of human pannexin 1 reveal ion pathways and mechanism of gating

Zheng Ruan et al.

NATURE (2020)

Article Hematology

Selective inhibition of Panx1 channels decreases hemostasis and thrombosis in vivo

Filippo Molica et al.

THROMBOSIS RESEARCH (2019)

Article Biochemistry & Molecular Biology

Mechanisms of pannexin1 channel gating and regulation

Paige Whyte-Fagundes et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

Article Biochemistry & Molecular Biology

Protective effect of genetic deletion of pannexinl in experimental mouse models of acute and chronic liver disease

Joost Willebrords et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Review Biochemistry & Molecular Biology

Connexins and Pannexins in Vascular Function and Disease

Filippo Molica et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Toxicology

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

Michael Maes et al.

ARCHIVES OF TOXICOLOGY (2017)

Review Biochemistry & Molecular Biology

Pannexin1 as mediator of inflammation and cell death

Sara Crespo Yanguas et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Article Physiology

Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop

Kevin Michalski et al.

JOURNAL OF GENERAL PHYSIOLOGY (2016)

Article Multidisciplinary Sciences

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

Alexander W. Lohman et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Pannexin1 channels act downstream of P2X7 receptors in ATP-induced murine T-cell death

Kenji F. Shoji et al.

CHANNELS (2014)

Article Neurosciences

Pannexin 2 protein expression is not restricted to the CNS

Maxence Le Vasseur et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Physiology

The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1

Junjie Wang et al.

JOURNAL OF GENERAL PHYSIOLOGY (2013)

Article Biotechnology & Applied Microbiology

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

Joanne Bowes et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Cell Biology

Glycosylation Regulates Pannexin Intermixing and Cellular Localization

Silvia Penuela et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Cell Biology

Probenecid, a gout remedy, inhibits pannexin 1 channels

William Silverman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Article Biochemistry & Molecular Biology

Gap junction-mimetic peptides do work, but in unexpected ways

Gerhard Dahl

CELL COMMUNICATION AND ADHESION (2007)

Article Cell Biology

Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters

Junjie Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

Pablo Pelegrin et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes

R Bruzzone et al.

JOURNAL OF NEUROCHEMISTRY (2005)

Article Multidisciplinary Sciences

Pannexins, a family of gap junction proteins expressed in brain

R Bruzzone et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)