A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation

Advances in the carbonic anhydrase (CA, EC 4.2.1.1) research over the last three decades are presented, with an emphasis on the deciphering of the activation mechanism, the development of isoform-selective inhibitors/ activators by the tail approach and their applications in the management of obesity, hypoxic tumors, neurological conditions, and as antiinfectives.

Automated summary

This article presents advances in carbonic anhydrase (CA, EC 4.2.1.1) research over the past three decades, focusing on the understanding of the activation mechanism, the development of isoform-selective inhibitors/activators using the tail approach, and their applications in obesity management, hypoxic tumors, neurological conditions, and as anti-infectives.