5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione derivatives of brefeldin A: Design, synthesis and cytotoxicity in MDA-MB-231 human breast cancer cells

Article Biochemistry & Molecular Biology

NPASS database update 2023: quantitative natural product activity and species source database for biomedical research

Hui Zhao et al.

Summary: Quantitative activity and species source data of natural products (NPs) are important for drug discovery and medicinal plant research. The NPASS database has been updated to include new data and information.

NUCLEIC ACIDS RESEARCH (2023)

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Article Pharmacology & Pharmacy

Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer

Alejandra Estepa-Fernandez et al.

Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. Inducing senescence and removing senescent cells (senolysis) has been explored as a method to limit tumor progression. In this study, a combination treatment using palbociclib and navitoclax was found to delay tumor growth and reduce metastasis in a mouse model of aggressive TNBC.

PHARMACOLOGICAL RESEARCH (2023)

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Article Engineering, Biomedical

Manganese-enriched photonic/catalytic nanomedicine augments synergistic anti-TNBC photothermal/nanocatalytic/immuno-therapy via activating cGAS-STING pathway

Yi Zheng et al.

Summary: This study presents a combined tumor-therapeutic strategy of Prussian blue (PB)-mediated photothermal therapy and Mn2+-augmented immunotherapy by activating the cGAS-STING pathway. The treatment successfully activates local and systemic immune responses, inhibiting the growth of primary and distant metastatic tumors in mice.

BIOMATERIALS (2023)

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Article Oncology

Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer

Li Liao et al.

Summary: PPP1R14B is upregulated in TNBC and promotes cancer progression and paclitaxel resistance through maintaining the phosphorylation and stability of STMN1. It is a potential therapeutic target for TNBC.

CANCER RESEARCH (2023)

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Review Oncology

Inhibition of WNT signaling by conjugated microRNA nano-carriers: A new therapeutic approach for treating triple-negative breast cancer a perspective review

Manosi Banerjee et al.

Summary: Triple-negative breast cancer (TNBC) is an aggressive type accounting for 15%-25% of all breast cancer, which lacks receptors and is unresponsive to hormonal therapies. TNBC patients mainly rely on cytotoxic chemotherapy. Activation of Wnt pathways is associated with mammary hyperplasia and tumor formation. Tumor suppressor microRNAs can inhibit tumor cell growth, invasion, and migration, as well as down-regulate Wnt signaling. Nanoparticles containing microRNA have shown enhanced effectiveness compared to single release. This review explores the role of Wnt signaling in TNBC, EMT, metastasis, anti-drug resistance, and microRNA regulation of Wnt, as well as the use of nano-carriers for micro-RNA delivery and clinical biomarkers related to Wnt pathways.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2023)

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Review Pharmacology & Pharmacy

Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

Cherry L. Wainwright et al.

Summary: Drug discovery from natural sources is experiencing a renaissance, particularly in the field of immunomodulation. The current research on natural product-derived compounds and their immunomodulatory activity is insufficient, but they do offer new opportunities for the discovery of new drugs.

PHARMACOLOGICAL RESEARCH (2022)

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Article Oncology

RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer

Huijie Yang et al.

Summary: In this study, the tumor-suppressive function of RNF31 in triple negative breast cancer (TNBC) was demonstrated. It was found that RNF31 could regulate the Hippo signaling pathway and its depletion increased TNBC cell proliferation and migration. Clinical data also showed that RNF31 expression was correlated with longer relapse-free survival in TNBC patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Chemistry, Medicinal

Fillet Fish Fortified with Algal Extracts of Codium tomentosum and Actinotrichia fragilis, as a Potential Antibacterial and Antioxidant Food Supplement

Mohamed S. M. Abd El Hafez et al.

Summary: Marine macroalgae or seaweeds, specifically Codium tomentosum and Actinotrichia fragilis from the Red Sea, were investigated for their antibacterial and antioxidant activities. The results showed that Codium tomentosum extract exhibited superior antibacterial and antioxidant effects compared to Actinotrichia fragilis. Additionally, fillet fish fortified with Codium tomentosum extract had the highest overall acceptance score, indicating its potential as a food supplement. These findings suggest that these seaweeds can be cultivated as a sustainable and safe source of therapeutic compounds for treating human and fish diseases.

MARINE DRUGS (2022)

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Article Biochemistry & Molecular Biology

Isolation, Characterization and Anticancer Activity of Two Bioactive Compounds from Arisaema flavum (Forssk.) Schott

Sobia Nisa et al.

Summary: Medicinal plants are important in public health worldwide. In this study, two bioactive compounds were isolated from Arisaema flavum (Forssk.) and their anticancer activity against human breast cancer cells was evaluated.

MOLECULES (2022)

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Review Biochemistry & Molecular Biology

Natural Products as Anticancer Agents: Current Status and Future Perspectives

Abid Naeem et al.

Summary: Natural products have been a valuable source of anticancer agents, providing high molecular diversity and novel biofunctionality. They are currently being investigated for their potential as cytotoxic agents and have prompted innovative strategies in cancer treatment. This review provides an overview of the emergence of natural products in cancer treatment and prevention, including their molecular mechanisms and various therapeutic approaches.

MOLECULES (2022)

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Review Oncology

Natural Blockers of PD-1/PD-L1 Interaction for the Immunotherapy of Triple-Negative Breast Cancer-Brain Metastasis

Maryam Nakhjavani et al.

Summary: The treatment of breast cancer that spreads to the brain is challenging due to the brain's protective membrane. This study explores the potential of drug candidates derived from plants and traditional herbal medicines to activate the immune system and kill cancer cells in the brain.

CANCERS (2022)

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Article Oncology

An Evaluation of the Anticancer Properties of SYA014, a Homopiperazine-Oxime Analog of Haloperidol in Triple Negative Breast Cancer Cells

Gladys M. M. Asong et al.

Summary: SYA014 has been found to have anticancer properties, killing triple negative breast cancer cells by interfering with key cellular events associated with cell proliferation. It has been shown to interact with the sigma-2 receptor and can improve treatment outcome when used in combination with cisplatin.

CANCERS (2022)

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Article Cell Biology

Metabolomic profiling of triple negative breast cancer cells suggests that valproic acid can enhance the anticancer effect of cisplatin

Avital Granit et al.

Summary: Cisplatin-resistance in triple negative breast cancer (TNBC) may be caused by metabolic reprogramming. Supplementation of valproic acid (VPA) alters lipid metabolism, particularly fatty acid oxidation and lipid synthesis, in cisplatin-treated TNBC cells. This finding may lead to the discovery of new therapeutic targets to reduce side effects and counter drug tolerance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

DAB2IP attenuates chemoresistance of triple-negative breast cancer through sequestration of RAC1 to prevent β-catenin nuclear accumulation

Zhenchong Xiong et al.

Summary: This study revealed that DAB2IP attenuates chemoresistance of TNBC by inhibiting RAC1-mediated beta-catenin nuclear accumulation. Decitabine treatment results in re-expression of DAB2IP by inhibiting DNA methylation and could be a potential therapeutic strategy for chemoresistance in TNBC.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Brefeldin A from the Deep-Sea-Derived Fungus Fusarium sp. Targets on RIPK3 to Inhibit TNFα-Induced Necroptosis

Jia-Yi Shi et al.

Summary: In this study, four known compounds were isolated from deep-sea-derived Fusarium sp. ZEN-48, and their structures were determined. Among them, it was found that one of the compounds, BFA, showed significant inhibition on TNF alpha-induced necroptosis by disrupting necrosome formation and suppressing RIPK3 and MLKL phosphorylation. This finding has important implications for the treatment of necroptosis-related inflammatory diseases and the development of new drugs.

CHEMISTRY & BIODIVERSITY (2022)

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Article Chemistry, Medicinal

New brefeldin A-cinnamic acid ester derivatives as potential antitumor agents: Design, synthesis and biological evaluation

Yao-Yao Jiang et al.

Summary: This study designed and synthesized a series of BFA-cinnamic acid ester derivatives, and evaluated their in vitro cytotoxic activities on different cancer cell lines. The most potent derivative 33 showed improved aqueous solubility and strong cytotoxic activity against HepG2 and BEL-7402 cell lines, while exhibiting low toxicity on normal liver cell line L02. Mechanistic studies revealed that 33 achieved its anti-tumor effects by blocking the cell cycle and inducing apoptosis, and displayed favorable pharmacokinetic properties.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Oncology

HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition

Shao-Feng Duan et al.

Summary: The novel conjugate HA-ADT, formed by connecting hyaluronic acid with a hydrogen sulfide donor, showed stronger inhibitory effects on the growth of esophageal squamous cell carcinoma compared to other H2S-releasing donors. HA-ADT promoted apoptosis and suppressed autophagy, suggesting its potential efficacy in cancer treatment.

EXPERIMENTAL CELL RESEARCH (2022)

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Article Plant Sciences

Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules' fifth labour

Mazdida Sulaiman et al.

Summary: This review explores natural products isolated from Asian and Pacific medicinal plants with in vitro and in vivo antiviral activity towards RNA viruses. Among the 350 molecules identified, phenolics, alkaloids, and terpenes showed strong activity against RNA viruses, mainly targeting viral genome replication. Promising candidates for the development of antiviral drugs include Hydroxytyrosol, silvestrol, lycorine, tylophorine, and 12-O-tetradecanoylphorbol 13-acetate.

PHARMACEUTICAL BIOLOGY (2022)

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Review Pharmacology & Pharmacy

Multifunctional role of natural products for the treatment of Parkinson's disease: At a glance

Md. Mominur Rahman et al.

Summary: Natural substances from plants have been used to treat neurodegenerative disorders like Parkinson's disease (PD). However, conventional treatments for PD have harmful side effects and are expensive. Therefore, new therapeutic strategies that control the mechanisms of neuronal death and dysfunction are needed. Natural resources offer potential treatments, including medicinal herbs, fruits, and vegetables. This research focuses on characterizing the currently available medications for PD and their therapeutic effects targeting diverse pathways.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Yuyu Zhu et al.

Summary: This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer. It introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients. The paper also summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Public, Environmental & Occupational Health

The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects

Ashok K. Shakya et al.

Summary: Research on natural products mainly focuses on developing suitable drugs for treating human diseases. Although a large number of drugs from terrestrial natural products have been developed, the study of marine natural products remains relatively unexplored. This article reviews the anticancer potential of natural sources such as plants, fungi, microorganisms, marine organisms, and bacteria, with an emphasis on compounds from marine, plant, and bacterial origins.

JOURNAL OF TROPICAL MEDICINE (2022)

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Article Chemistry, Medicinal

Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug CHNQD-01255 with Potent Anti-Hepatocellular Carcinoma Efficacy In Vivo

Yao-Yao Jiang et al.

Summary: A series of BFA prodrugs were synthesized and evaluated, and CHNQD-01255 showed improved drug properties and anti-tumor activity, making it a potential safe and effective new anti-HCC prodrug.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Review Chemistry, Medicinal

Research progress of indole compounds with potential antidiabetic activity

Yuqian Zhu et al.

Summary: Indole alkaloids play an important role in natural products due to their versatile biological activities, which are a potential source for novel antidiabetic drugs. The synthesized indole derivatives possess properties similar to natural indole alkaloids. In recent years, more and more indole derivatives have been designed and synthesized for exploring their bioactivities.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Pharmacology & Pharmacy

Brefeldin A delivery nanomicelles in hepatocellular carcinoma therapy: Characterization, cytotoxic evaluation in vitro, and antitumor efficiency in vivo

Jin-Man Zhang et al.

Summary: This study encapsulated the macrolide brefeldin A (BFA) in mixed nanomicelles to improve its solubility, stability, and sustained release capability. M-BFA showed significant inhibitory effects on HepG2 liver carcinoma cells in vitro, inducing cell cycle arrest, apoptosis, and autophagic cell death. In a HepG2 tumor-bearing xenograft mouse model, M-BFA effectively delayed tumor progression and induced extensive necrosis. These findings suggest the promising potential of M-BFA in therapy for hepatocellular carcinoma.

PHARMACOLOGICAL RESEARCH (2021)

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Article Medicine, General & Internal

Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020

Wei Cao et al.

Summary: This study summarized the recent changing profiles of cancer burden worldwide and in China, revealing that breast cancer became the most diagnosed cancer globally in 2020. China accounted for 24% of newly diagnosed cases and 30% of cancer-related deaths worldwide in 2020, with a high cancer mortality rate.

CHINESE MEDICAL JOURNAL (2021)

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Article Virology

Unconventional p97/VCP-Mediated Endoplasmic Reticulum- to-Endosome Trafficking of a Retroviral Protein

Wendy Kaichun Xu et al.

Summary: The Rem-CT protein of MMTV, lacking a transmembrane domain or ER retention signal, is primarily localized in the ER and requires glycosylation and p97 ATPase for trafficking to early endosomes, suggesting a novel intracellular trafficking pathway.

JOURNAL OF VIROLOGY (2021)

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Article Oncology

The ever-increasing importance of cancer as a leading cause of premature death worldwide

Freddie Bray et al.

Summary: CVD and cancer are now leading causes of premature death in 127 countries with cancer poised to overtake CVD in most countries over the course of this century. Governments must consider these transitions in disease profiles when developing cancer policies at the local level.

CANCER (2021)

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Review Oncology

Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review

Sergiusz Lukasiewicz et al.

Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, with molecular subtypes providing new insights into treatment strategies and patient stratifications that impact the management of breast cancer patients.

CANCERS (2021)

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Review Plant Sciences

A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents

Narges Marefati et al.

Summary: Onion and its derivatives possess anti-inflammatory, antioxidant, and immunomodulatory effects, indicating their therapeutic value in treating diseases associated with oxidative stress, inflammation, and immune dysregulation.

PHARMACEUTICAL BIOLOGY (2021)

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Article Oncology