期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 167, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2023.115499
关键词
Sirtuins; Diabetic kidney disease; Acute kidney injury; Fibrosis; Inflammation; Oxidative stress; Traditional Chinese medicine
Sirtuins are a family of protein deacetylases that regulate signaling pathways and are involved in kidney disease processes. Traditional Chinese medicine has made advancements in the treatment of kidney diseases, and this review explores the relationship between Sirtuins and common kidney diseases, as well as the role of traditional Chinese medicine in regulating these diseases.
Sirtuins are a family of NAD+ III-dependent histone deacetylases that consists of seven family members, Sirt1Sirt7, which regulate various signalling pathways and are involved in many critical biological processes of kidney diseases. Traditional Chinese medicine (TCM), as an essential part of the global healthcare system, has multi-component and multi-pathway therapeutic characteristics and plays a role in preventing and controlling various diseases. Through ongoing collaboration with modern medicine, TCM has recently achieved many remarkable advancements in theoretical investigation, mechanistic research, and clinical applications related to kidney diseases. Therefore, a comprehensive and systematic summary of TCM that focuses on sirtuins as the intervention target for kidney diseases is necessary. This review introduces the relationship between abnormal sirtuins levels and common kidney diseases, such as diabetic kidney disease and acute kidney injury. Based on the standard biological processes, such as inflammation, oxidative stress, autophagy, mitochondrial homeostasis, and fibrosis, which are underlying kidney diseases, comprehensively describes the roles and regulatory effects of TCM targeting the sirtuins family in various kidney diseases.
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