Targeting abnormal lipid metabolism of T cells for systemic lupus erythematosus treatment

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues and organs. However, the causes of SLE remain unknown. Dyslipidemia is a common symptom observed in SLE patients and animal models and is closely correlated to disease activity. Lipid metabolic reprogramming has been considered as a hallmark of the dysfunction of T cells in patients with SLE, therefore, manipulating lipid metabolism provides a potential therapeutic target for treating SLE. A better understanding of the underlying mechanisms for the metabolic events of immune cells under pathological conditions is crucial for tuning immunometabolism to manage autoimmune diseases such as SLE. In this review, we aim to summarize the cross-link between lipid metabolism and the function of T cells as well as the underlying mechanisms, and provide light on the novel therapeutic strategies of active compounds from herbals for the treatment of SLE by targeting lipid metabolism in immune cells.

Automated summary

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the immune system attacking its own tissues and organs. Dyslipidemia, which is closely related to disease activity, is commonly observed in SLE patients and animal models. Manipulating lipid metabolism has the potential to be a therapeutic target for treating SLE, as it plays a role in the dysfunction of T cells in SLE patients.